Screening for disease - Biotech, Pharma and Life Science Channel
PubMed Articles
The present study was performed to evaluate the clinical characteristics and survival outcomes in patients with small cell lung cancer (SCLC) detected by low-dose computed tomography (CT). We retrospe...
The gluten-sensitive enteropathy celiac disease is tightly associated with the production of autoantibodies specific for the enzyme transglutaminase 2 (TG2). The mechanisms underlying the activation o...
Newborn screening in urine is important for the diagnosis of many inborn errors of metabolism (IEM). Capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) is a major technologic...
1-(1,3,5-Triazin-yl)piperidine-4-carboxamide inhibitors of soluble epoxide hydrolase were identified from high through-put screening using encoded library technology. The triazine heterocycle proved t...
Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening.
Through structure-based virtual screening, some dozen of benzene sulfonamides with novel scaffolds are identified as potent inhibitors against carbonic anhydrase (CA) IX with IC50 values ranging from...
Benzobisthiazole derivatives were identified as novel helicase inhibitors through high throughput screening against purified Staphylococcus aureus (Sa) and Bacillus anthracis (Ba) replicative helicase...
We report the analysis of an in-house fragment screening campaign for the oncology target MEK1. The application of virtual screening (VS) as a primary fragment screening approach, followed by biophysi...
Novel 7-oxabicyclo[2.2.1]hept-5-en-2-yl derivatives have been synthesized using boron trifluoride diethyl etherate catalyzed Diels-Alder reaction. This method presents considerable synthetic advantage...
Brain metal accumulation in Wilson's disease.
Brain metal accumulation is suggested in the pathogenesis of numerous neurodegenerative disorders. In Wilson's disease (WD), only copper has been examined. The aim of the present study was to evaluate...
Dynamic combinatorial libraries of artificial repeat proteins.
Repeat proteins are found in almost all cellular systems, where they are involved in diverse molecular recognition processes. Recent studies have suggested that de novo designed repeat proteins may se...
News Articles
SPE Method for Production of High Quality RNA
INTEGRA has released a new video demonstrating a solid phase extraction (SPE) microplate method for reproducible, high throughput isolation of high-quality DNA-free total RNA. Large scale gene expres...
Teaching Kenyan women to collect their own genital specimens to be used in testing for human papillomavirus (HPV)—the primary risk factor for cervical cancer—shows promise in the detection of this...
New insights into the causes, incidence, and clinical outcome of moderate to severe cases of diarrheal disease in infants and young children have emerged from a large prospective case-control study in...
Incidence Rate of Breast Cancer in Young Women—Reply
In Reply: Drs Hou and Huo suggest that we should correct for missing data on receptor status in the SEER database. Using the method cited by Hou and Huo, we calculated that for 25- to 39-year-old wome...
The Health Checkup Was It Ever Effective? Could It Be Effective?
In this issue of JAMA, the JAMA Clinical Evidence Synopsis by Krogsbøll et al summarizes a systematic review of 9 randomized trials of a general health check. A general health check is defined as hea...
Clinical QuestionWhat are the benefits and harms of general health checks for adult populations?Bottom LineCompared with usual care, offers of health checks were not associated with lower rates of all...
ImportanceInjection of contaminated methylprednisolone has resulted in an unprecedented nationwide outbreak of Exserohilum rostratum fungal infections, manifested initially as meningitis and/or basila...
U.S. doctor group votes to recognize obesity as a disease
CHICAGO, June 18 (Reuters) - In order to fight what it described as an "obesity epidemic," the American Medical Association voted on Tuesday to recognize obesity as a disease and recommended a number...
Pharmacy clinics highlighted in SIGN anticoagulant guideline
Pharmacists can play an important role in improving anticoagulant control by running anticoagulant clinics in both hospital and primary care. This is one of the recommendations of a completely revis...
From ASCO—gynaecological cancer: Advances in cervical cancer screening and treatment
Events
5th annual COPD: Novel Therapeutics and Management Strategies conference
SMi Presents the 5th annual conference on COPD
Academic Screening Workshop 2013
Welcome to AgriGenomics World Congress 2013.
Select Bio is pleased to present the 3rd Screening Asia conference, which will take place at the Biopolis, Singapore, on November 12th & 13th
14th INTERNATIONAL CONFERENCE ON ALZHEIMER'S DRUG DISCOVERY
The annual Alzheimer's Drug Discovery Foundation (ADDF) conference brings together academic and industry scientists intent on accelerating the development of innovative treatments for Alzheimer’s di...
Predictive ADME, Screening Approaches, Pre-clinical Screening Approaches, and Predictive Toxicology, emerging issues such as, regulatory changes and Drug-Drug interactions.
6TH ANNUAL RECOMBINANT ANTIBODIES Conference
An insight into novel therapeutics and future technologies
Over 200 delegates working in Stem Cell Research, Bioprocessing and Manufacturing
Companies
Overlake Hospital Medical Center is a nonprofit, non-tax-supported regional medical center with a network of medical clinics throughout the Eastside. The hospital is licensed for...
Resverlogix Corp. (TSX: RVX) is a clinical stage cardiovascular company with an epigenetic platform technology that modulates protein production. Resverlogix is developing RVX-208, a first-in-class...
Life Line Screening is a preventive health company and a leading provider of community-based screenings in the United States, United Kingdom, and Australia. Since inception in 199...
Reverse Medical Corporation is a privately-held medical device company focused on expanding the endovascular management of acute stroke and neurovascular disease. The technology p...
Kadimastem is a biotechnology company focusing on the development and industrial commercialization of products based on human pluripotent stem cells. Kadimastemâs technology...
Aegerion Pharmaceuticals, Inc.
Aegerion Pharmaceuticals is a biopharmaceutical company dedicated to the development and commercialization of innovative, life-altering therapies for patients with debilitating often fatal, rare dis...
Avaxia is a leader in the growing field of gut-targeted therapeutics â orally administered, minimally absorbed drugs that are designed to act locally in the gastrointestinal...
GiveForward is the leading crowdfunding site focused on helping families and friends raise money to help offset a loved oneâs medical bills. Co-founded in 2008 by Desi...
Fluxion Biosciences provides cellular analysis tools for use in critical life science research and drug discovery applications. Fluxionâs proprietary microfluidic platform en...
Sequenta, Inc. is a privately held company developing and commercializing molecular diagnostic assays based on a proprietary sequencing approach to the profiling of T and B cell r...
Clinical Trials
This is a Phase III multicenter, randomized, double-blind, double-dummy, parallel-group study to evaluate the efficacy and safety of two doses of GSK573719/GW642444 Inhalation Powder and G...
A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD)
The main purpose of the study is to evaluate the efficacy and safety of the study drug known as prasugrel for the reduction of Vaso-Occlusive Crisis events in pediatric participants with s...
A Type 2 Diabetes Study of the Longer-Term Glycemic Effect of AVANDAMET vs. Metformin
This study will evaluate the longer-term glycemic effect of two medicines approved for initial treatment of type 2 diabetes. The study consists of a 2 week screening period (2 study visits...
Data and Sample Collection Study to Elucidate the Mechanisms of Eosinophilic Disorders
The purpose of this study is to elucidate the mechanisms underlying eosinophil growth, survival, migration, and function and to investigate and further characterize the pathophysiology of,...
An Efficacy and Safety Study of Galantamine for the Treatment of Patients With Alzheimer's Disease
The purpose of this study is to evaluate the efficacy and safety of two fixed doses (16mg/day and 24mg/day) of galantamine (a drug for treating dementia) versus placebo for the treatment o...
A Study in Patients With Diabetic Kidney Disease
The purpose of this study is to determine if LY2382770 is safe and effective at protecting kidney function in patients with kidney disease due to diabetes.
Parkinson's Disease Registry of the Muhammad Ali Parkinson Center
The purpose of the Parkinson’s disease Registry is to develop a national and international database of persons with Parkinson’s disease (PD). The Registry will be used to facilitate t...
D-Serine Adjuvant Treatment for Parkinson's Disease
The proposed experiment will evaluate the effects of the NMDA receptor full agonist D-serine (~2g/day) on persistent symptoms of Parkinson's Disease and on antiparkinsonian drugs-induced d...
Can Screening People Registering With Primary Care Improve the Detection of Tuberculosis?
This randomised controlled trial tests whether screening people registering with general practices cost-effectively increases the detection of tuberculosis. The study objectives are to:...
Using Sugar Water to Relieve Pain in Infants
This study will examine the safety and effectiveness of sugar water to relieve pain in newborn infants during painful blood tests and injections. Infants of diabetic mothers who receive re...
Videos
SCREENING FOR DISEASE
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Medical and Biotech [MESH] Definitions
Casuistry
A method of ETHICAL ANALYSIS that emphasizes practical problem solving through examining individual cases that are considered to be representative; sometimes used to denote specious argument or rationalization. Differentiate from casuistics, which is the recording and study of cases and disease.
Incidental Findings
Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.
Wasting Disease, Chronic
A transmissible spongiform encephalopathy (prion disease) of DEER and elk characterized by chronic weight loss leading to death. It is thought to spread by direct contact between animals or through environmental contamination with the prion protein (PRIONS).
Ulmus
A plant genus of the family ULMACEAE that is susceptible to Dutch elm disease which is caused by the ASCOMYCOTA fungus, Ophiostoma.
Virulence Factors
Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)
