Sensorimotor neuropathies - Biotech, Pharma and Life Science Channel
PubMed Articles
HIV-1-associated neurocognitive disorders (HAND) afflict up to 50 % of HIV-1+ individuals, despite the effectiveness of combination antiretroviral therapy (CART) in reducing the prevalence of more se...
BACKGROUND: The Grin1 (glutamate receptor, ionotropic, NMDA1) gene expresses a subunit of N-methyl-D-aspartate (NMDA) receptors that is considered to play an important role in excitatory neurotransmis...
Brain effective connectivity can be tracked by cerebral recruitments evoked by transcranial magnetic stimulation (TMS), as measured by simultaneous electroencephalography (TMS-EEG). When TMS is target...
"Moving to the beat" improves timing perception.
Here, we demonstrate that "moving to the beat" can improve the perception of timing, providing an intriguing explanation as to why we often move when listening to music. In the first experiment, parti...
Fast astrocyte isolation by sedimentation field flow fractionation.
Astrocytes play a key role during central nervous system (CNS) repair and glial scar formation. After CNS damage, an extensive deposition of the extracellular matrix produced by the activated astrocyt...
Decreasing perceived optic flow rigidity increases postural sway.
Optic flow simulating self-motion through the environment can induce postural adjustments in observers. Some studies investigating this phenomenon have used optic flow patterns increasing in speed fro...
The blood-brain-barrier (BBB) is formed by different cell types, of which brain microvascular endothelial cells are major structural constituents. The goal of this study was to examine the effects of...
The contemporary view is that a disruption in phonological encoding underlies the speech production deficit in conduction aphasia. We therefore expect to observe a commonality in phonological errors r...
The cerebellum has been implicated in both sensorimotor and cognitive function, but is known to undergo volumetric declines with advanced age. Individual differences in regional cerebellar volume may...
Research into therapeutics for neuropsychiatric disorders is increasingly focusing on drugs with new mechanisms of action, and such agents are often assessed in preclinical studies using nonhuman prim...
News Articles
Neuropathy Diagnosis Obstacles Damaging to Patients' Health
For National Neuropathy Awareness Week (May 13-17), The Neuropathy Association and the Hereditary Neuropathy Foundation Call Attention to the Diagnostic Challenges Hurting Millions of Neuropathy Patie...
Sociocommunicative and Sensorimotor Impairments in Male P2X4-Deficient Mice
Corrigendum: Functional organization of human sensorimotor cortex for speech articulation
Eisai Building Second Production Facility in Suzhou
Eisai, the Japanese biopharma, announced plans to build a new production facility in Suzhou, alongside its current China plant. The new facility will make injectible drugs, especially Methycobal®,...
NeuroMetrix Reports Q1 2013 Results
NeuroMetrix, Inc. (Nasdaq: NURO), a medical device company focused on the treatment of diabetic peripheral neuropathy (DPN), today reported business and financial highlight...
NeuroMetrix to Partner with Omron Healthcare for Distribution of NC-stat DPNCheck in Japan
NeuroMetrix, Inc. (Nasdaq: NURO), a medical device company focused on the treatment of diabetic peripheral neuropathy (DPN), announced that it had entered into an agreement...
Neural codes for memory implants
(Medical Xpress)—The ability to short-circuit debilitating tremors in disease states with implantable stimulators is nothing short of remarkable. The same can be said for cochlear prosthetics which...
NeuroMetrix, Inc. Announces Date for 2013 First Quarter Financial Results Conference Call
NeuroMetrix, Inc. (Nasdaq: NURO), today said it plans to issue its 2013 first quarter financial results before the opening of the market on April 25, 2013. The Company will...
[ChromaDex] gets rights to [Washington Univ.] patents covering nicotinamide riboside vitamin
Natural ingredients maker [ChromaDex Corp.] has received exclusive global rights to [Washington University]’s patents protecting nicotinamide riboside (NR), a vitamin for the prevention or treatment...
β-Tubulin mutations that cause severe neuropathies disrupt axonal transport
β-Tubulin mutations that cause severe neuropathies disrupt axonal transportMutations in β-tubulin associated with hereditary diseases that affect both central and peripheral neurons disrupt kinesin...
Events
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Companies
NeuroMetrix is a science-based health care company transforming patient care through neurotechnology. To date, our focus has been primarily on the assessment of neuropathies. We a...
EpiCept is focused on the development and commercialization of pharmaceutical products for the treatment of cancer and pain. The Company's lead product is Ceplene®, which has b...
Clinical Trials
This phase 3 trial is being conducted at approximately 80 sites in the United States (U.S.) to investigate whether lacosamide (SPM 927) at different doses reduces pain in subjects with dia...
A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension
We are seeking male and female patients to voluntarily take part in a clinical research study. Patients must be aged 18 or older and diagnosed with symptomatic orthostatic hypotension (lo...
Phenotype/Genotype Correlations in Neuromuscular Disorders
The Neuromuscular Diseases Section (NDS) is conducting research on certain inherited myopathies and neuropathies, disorders that lead to disability and sometimes death. NDS, along with oth...
OBJECTIVES: I. Assess the ability of patients with and without sensorimotor loss below the thoracic spinal cord injury to execute coordinated whole-limb synergies sufficient for walking w...
Study of Inherited Neurological Disorders
This study is designed to learn more about the natural history of inherited neurological disorders and the role of heredity in their development. It will examine the genetics, symptoms, d...
The Effects of Dextroamphetamine on Brain Function
The purpose of this study is to determine the effects of the drug dextroamphetamine on the brain function and mood of healthy volunteers. Monoaminergic drugs are substances that affect th...
OBJECTIVES: I. Determine the effect of intravenous immunoglobulin on recovery time of patients with proximal diabetic neuropathy. II. Determine whether rate of response is dose depende...
Autonomic nervous system (ANS) is an essential regulator for the homeostasis, circulatory and respiratory systems. Heart rate variability, under the dependence of the parasympathetic and o...
Herbal Preparation Used as Adjuvant Therapy on Diabetic Ulcers
Chronic foot ulcers occurring among diabetic patients are difficult to heal. The frequent elderly age with co-morbidities, vascular insufficiencies, peripheral neuropathies and super impo...
Moving a Paralyzed Hand Through Use of a Brain-Computer Interface
This study will gain information on methods of control of a prosthetic arm in stroke patients or traumatic brain inury patients through a technique called "brain-computer interface" (BCI)....
Videos
rotweiller distal sensorimotor polyneuropathy
bianca, 4 anos. Há cerca de 8 meses apresentou tremores nos MPs, refere que tem tido dificuldade para se levantar e subir, mantendo-se mais deitada, cansaço,...
Medical and Biotech [MESH] Definitions
Early Growth Response Protein 2
An early growth response transcription factor that controls the formation of the MYELIN SHEATH around peripheral AXONS by SCHWANN CELLS. Mutations in EGR2 transcription factor have been associated with HEREDITARY MOTOR AND SENSORY NEUROPATHIES such as CHARCOT-MARIE-TOOTH DISEASE.
Cerebrum
Derived from TELENCEPHALON, cerebrum is composed of a right and a left hemisphere. Each contains an outer cerebral cortex and a subcortical basal ganglia. The cerebrum includes all parts within the skull except the MEDULLA OBLONGATA, the PONS, and the CEREBELLUM. Cerebral functions include sensorimotor, emotional, and intellectual activities.
Slit Ventricle Syndrome
An intermittent and self-limiting headache disorder in individuals with CEREBROSPINAL FLUID SHUNTS emplaced for the treatment of HYDROCEPHALUS. The symptoms of headache, vomiting, and cranial neuropathies are associated with intermittent obstruction of the shunt.
Giant Axonal Neuropathy
Rare autosomal recessive disorder of INTERMEDIATE FILAMENT PROTEINS. The disease is caused by mutations in the gene that codes gigaxonin protein. The mutations result in disorganization of axonal NEUROFILAMENT PROTEINS, formation of the characteristic giant axons, and progressive neuropathy. The clinical features of the disease include early-onset progressive peripheral motor and sensory neuropathies often associated with central nervous system involvement (mental retardation, seizures, DYSMETRIA, and CONGENITAL NYSTAGMUS).
Sleep
A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.
