Sepsis - Biotech, Pharma and Life Science Channel
PubMed Articles
Objective: To identify the factors at surgical intensive care unit (SICU) admission and during the following SICU course that influence hospital mortality of patients with prolonged SICU stay (>14 day...
Characterization of the LPS-induced inflammation of the adrenal gland in mice.
Systemic administration of endotoxin, which closely mimics the bacteria-induced systemic inflammatory response syndrome (SIRS) can ultimately lead to organ failure. Adrenal gland insufficiency is freq...
Retrograde Versus Antegrade Intramedullary Nailing of Gunshot Diaphyseal Femur Fractures.
BACKGROUND: The use of retrograde nailing for gunshot wound femur fractures is controversial due to concerns of knee sepsis after this procedure since the knee is entered to introduce the nail into th...
ETHNOPHARMACOLOGICAL EVIDENCE: Inflammation plays an important role in sepsis, and NF-κB is a key mediator of inflammation. Xuebijing (XBJ) injection is a traditional Chinese medicine injection that...
BACKGROUND: Increased vascular leakage leading to hypovolaemia and tissue oedema is common in severe sepsis. Hypovolaemia together with oedema formation may contribute to hypoxia and result in multior...
Metabolomics in pneumonia and sepsis: an analysis of the GenIMS cohort study.
PURPOSE: To determine the global metabolomic profile as measured in circulating plasma from surviving and non-surviving patients with community-acquired pneumonia (CAP) and sepsis. METHODS: Random, ou...
Associations of T helper 1, 2, 17 and regulatory T lymphocytes with mortality in severe sepsis.
OBJECTIVE AND DESIGN: T helper 17 (Th17) and regulatory T (Treg) lymphocytes might play important roles in patients with severe sepsis. The association of Th17 or Treg lymphocytes with survival is als...
BACKGROUND: Pathogen inactivation (PI) technology for blood components enhances blood safety by inactivating viruses, bacteria, parasites, and white blood cells. Additionally, PI for platelet (PLT) co...
PURPOSE: Colistin is increasingly used as the last-resort treatment option against infections caused by multidrug-resistant (MDR) Gram-negative pathogens, but its nephrotoxicity is of concern, especia...
Severe septic syndrome, which is the most prevalent and lethal cause of acute respiratory distress syndrome, remains one of the most frequent causes of admission and death in intensive care units (ICU...
News Articles
Neisseria meningitidis causes life threatening meningitis, meningococcal sepsis in humans
"Neisseria meningitidis is an important human pathogen that can cause rapidly progressing, life threatening meningitis and meningococcal sepsis in humans," Professor Jennings said.
Neisseria meningitidis is an important human pathogen that can cause rapidly progressing, life threatening meningitis and meningococcal sepsis in humans, according to authors of a new study. People ca...
Study identifies specific genetic factors that influence occurrence and severity of sepsis
A study published in the June issue of Anesthesiology represents an important first step in establishing new therapeutic options targeting specific genetic areas that influence the occurrence and seve...
Nurses Critical to Implementing New Sepsis Guidelines
Early recognition of sepsis in hospitalized patients and timely, protocol-based interventions spelled out for critical care nurses in new international guidelines. Medscape Medical News
Important genetic factors that could influence survival in sepsis patients
Scientists have made an important first step in establishing new therapeutic options targeting specific genetic areas that influence the occurrence and severity of sepsis – a life-threatening, whole...
MOUNTAIN VIEW, Calif., May 20, 2013 /PRNewswire-iReach/ -- Today at American Society for Microbiology conference, award lecturer Dr. Christine Ginocchio discussed Specific Technologies b...
Table 1: Diseases Associated With DIC
Table 1: Diseases Associated With DIC9 Sepsis Severe infection...
Infection And Sepsis-Related Mortality Hotspots Identified Across The US
In the past, researchers have sought to determine the geographic distribution of many life-threatening conditions, including stroke and cardiac arrest. Now, researchers at the Perelman School of Medic...
Clinical Vigilance™ for Sepsis: Cooper University Hospital Study Presented at SAEM
SAN DIEGO, May 16, 2013 /PRNewswire-iReach/ -- Amara Health Analytics today announced that the company's software, Clinical Vigilance™ for Sepsis, was used to study the impact of timely adm...
Efficacy of Thymosin Alpha 1 for Severe Sepsis
Severe sepsis is associated with a high mortality rate despite implementation of guideline recommendations. Will thymosin alpha 1 change that? Critical Care
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Companies
Premier Biomedical, Inc. is a research-based company that intends to discover and develop medical treatments for humans, specifically targeting the treatment of Alzheimer's Diseas...
Sepsis Alliance is a nonprofit patient advocacy organization in the U.S. promoting awareness of sepsis. Sepsis Alliance operates by providing information and education to raise aw...
San Marino, California-based VG Life Sciences Inc., formerly known as Viral Genetics, discovers and develops drug therapies from two exclusively licensed platform technologies bas...
Abingdon Health is a specialist medical diagnostics company based in London. The Company works with the world’s best scientists to acquire, develop and distribute state-of-the art diagnostic t...
The Trudeau Institute is an independent, not-for-profit, biomedical research organization, whose scientific mission is to make breakthrough discoveries leading to improved human h...
Privately held ExThera Medical, based in Berkeley, Calif., is a joint venture company formed in 2007 by Emergence LLC, a life science incubator headquartered in Berkeley, Calif.,...
Clinical Trials
Procalcitonin in Diagnosing Bacteremia in the Emergency Department
Nowadays, a physician plays a more important role in managing patients with potential infectious complications in the emergency room. Previous studies demonstrated the importance of early...
Studies of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome
Nitric oxide (NO) plays a pivotal role in maintenance of normal vascular tone. However, in sepsis the excessive production of NO results in myocardial depression, vasoplegia, and cytotoxic...
Procalcitonin Increase Identifies Critically Ill Patients at High Risk of Mortality
Procalcitonin, a marker of infection has often been compared to clinical pictures as for instance "clinical sepsis". This has given som problems in the interpretation of these studies, bec...
This is a randomized 2-arm study to compare two different times of giving the drug vancomycin. Half of the patients will begin vancomycin two days before a bone marrow transplant. The ot...
Central venous catheters (CVCs) are used in patient care for such purposes as the administration of medication, fluids, blood products and for functions such as hemodialysis and plasmapher...
Acupuncture and Herbal Treatment of Chronic HIV Sinusitis
To compare Traditional Chinese Medicine versus standard antibiotic therapy consisting of pseudoephedrine ( Sudafed ) plus amoxicillin / clavulanate potassium combination ( Augmentin ) in r...
This is a prospective, randomized Phase III trial of FLAC chemotherapy with GM-CSF versus PIXY321 in advanced breast cancer. The primary endpoints of this study will be the duration of th...
A Possible Therapeutic Role for Adenosine During Inflammation
The adenosine receptor is known for its anti-inflammatory actions and could therefore be a potential target in the treatment of sepsis and septic shock. Stimulation of the adenosine recept...
The Effect of Nitroglycerine on Microcirculatory Abnormalities During Sepsis
The purpose of this study is to evaluate the effect of nitro-glycerine on the microcirculation (smallest vessel type) in patients with severe sepsis and septic shock. Nitro-glycerine is a...
Safety and Local Tolerability of Prevenar in Indian Children
This postmarketing surveillance study will evaluate the safety profile of Prevenar in Indian children. Prevenar is indicated for active immunization of infants and children from 6 weeks o...
Videos
SEPSIS: Emergency LECTURE made simple in HD!
Watch More Videos at http://www.ftplectures.com◁◁◁ Sepsis is a systemic inflammatory response syndrome or SIRS) and the presence of a known or suspected ...
Medical and Biotech [MESH] Definitions
Bilophila
A genus of gram-negative, anaerobic bacteria in the family Desulfovibrionaceae. It was originally recovered from infections in patients with gangrenous and PERFORATED APPENDICITIS. It is also associated with ABSCESS; BACTEREMIA; and BILIARY TRACT sepsis.
Vasoplegia
Condition of low SYSTEMIC VASCULAR RESISTANCE that develops secondary to other conditions such as ANAPHYLAXIS; SEPSIS; SURGICAL SHOCK; and SEPTIC SHOCK. Vasoplegia that develops during or post surgery (e.g., CARDIOPULMONARY BYPASS) is called postoperative vasoplegic syndrome or vasoplegic syndrome.
Shock, Septic
Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
Fungemia
The presence of fungi circulating in the blood. Opportunistic fungal sepsis is seen most often in immunosuppressed patients with severe neutropenia or in postoperative patients with intravenous catheters and usually follows prolonged antibiotic therapy.
Myelinolysis, Central Pontine
A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)
