Sperm Disorders - Biotech, Pharma and Life Science Channel
A sperm is the male reproductive component that fertilizes an egg. Sperm are of a surprising low quality, but additional problems can hinder reproductive efforts.
The sperm may be unable to swim strongly enough through the females reproductive tract or be able to break through the outer casing of the egg to fertilize the egg. In these cases, IVF and ICSI can be used respectively, to over come these problems. Further problems occur with sperm that are unable to be ejaculated from the mans penis, due to congenital or other obstructions of the vas deferns - IVF can overcome this too.
Genetic problems are harder to solve, and may originate from cancer therapy or congenital absence of the testes.
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PubMed Articles
Several structural and cellular changes, including marked glial anomalies, have been observed in association with major depressive disorder. Here we review these cellular alterations and highlight the...
Marine invertebrates exhibit both chemokinesis and chemotaxis phenomena, induced in most cases by the release of water-borne peptides or pheromones. In mollusks, several peptides released during egg-l...
GABA-B-receptor antibodies in paraneoplastic brainstem encephalitis.
Gamma-aminobutyric-acid B (GABA-B)-receptor encephalitis represents a novel entity among autoimmune CNS disorders. Most cases are characterised by limbic encephalitis.
Brain metal accumulation in Wilson's disease.
Brain metal accumulation is suggested in the pathogenesis of numerous neurodegenerative disorders. In Wilson's disease (WD), only copper has been examined. The aim of the present study was to evaluate...
Transcriptomic analysis of cultured whale skin cells exposed to hexavalent chromium Cr(VI).
Hexavalent chromium Cr(VI) is known to produce cytotoxic effects in humans and is a highly toxic environmental contaminant. Interestingly, it has been shown that free ranging sperm whales (Phyester ma...
The effect of nano ZnO (nZnO) upon the fertilization and early development of embryos of the Mediterranean sea urchin Paracentrotus lividus is reported herein for the first time. Zn ion (ZnCl2) and bu...
Deregulation of the non-receptor tyrosine kinase ACK1 (Activated Cdc42-associated kinase) correlates with poor prognosis in cancers and has been implicated in promoting metastasis. To further understa...
The glutamate system is thought to play an important role in modulating mood and anxiety. Ionotropic NMDA receptors critically influence neuronal circuits regulating emotional behaviour. Their pharmac...
Psychiatric disorders represent a large economic burden in modern societies. However, pharmacological treatments are still far from optimal. Drugs used in the treatment of major depressive disorder (M...
Tapetum: regulation and role in sporopollenin biosynthesis in Arabidopsis.
Pollen acts as a biological protector for protecting male sperm from various harsh conditions and is covered by an outer cell wall polymer called the exine, a major constituent of which is sporopollen...
News Articles
In Vietnam, New Virus Isolated From Patients With Severe Brain Infections
Researchers have identified a new virus in patients with severe brain infections in Vietnam. Further research is needed to determine whether the virus is responsible for the symptoms of disease. The v...
Brain Not Working? Minor Symptoms Now Could Mean MS, Alzheimer's, or Parkinson's Later
Why Isn’t My Brain Working?, the newest book from functional medicine pioneer Datis Kharrazian, explains how seemingly minor problems with brain function—brain fog, memory loss, fatigue, depressio...
Abington Memorial Hospital’s Neurosciences Institute Opens Movement Disorders Center
The Neurosciences Institute at Abington Memorial Hospital recently opened the Movement Disorders Center to treat neurological disorders in which there is either an excess of movement or a deficiency o...
Fairhaven Health's Dr. Amos Grunebaum Says Fertility Awareness Leads to Babies
Recent research suggests that many trying-to-conceive couples resort to invasive fertility treatment before exhausting natural options like tracking ovulation, preconception care, and maintaining a he...
SimuCase avatars allow graduate students to evaluate speech-language disorders
A new commercial venture, using technology developed at Case Western Reserve University's College of Arts and Sciences and Case School of Engineering, has made available avatars-virtual patients-to tr...
Validating maps of the brain's resting state
Kick back and shut your eyes. Now stop thinking. You have just put your brain into what neuroscientists call its resting state. What the brain is doing when an individual is not focused on the outside...
Safinamide improves responder rates in fluctuating Parkinson's patients in Phase III study
Newron Pharmaceuticals S.p.A. ("Newron"), a research and development company focused on novel CNS and pain therapies, and its partner Zambon S.p.A., a pharmaceutical company strongly committed to the...
New technologies for retinal therapies
The future of the investigation and treatment of retinal disorders is already here at the MedUni Vienna: in the new Christian Doppler "OPTIMA" (Ophthalmic Image Analysis) laboratory headed by Ursula S...
Adamas reports positive PII/III data for ADS-5102
Adamas presented data from the Phase II/III EASED clinical trial during the Movement Disorders Society's 17th International Congress of Parkinson's Disease and Movement Disorders from 16 to 20 June in...
Risk For Insulin Resistance In Offspring Increased By Directed In Vitro Technique
A special type of in vitro fertilization, or IVF, may increase the risk for insulin resistance among children conceived in this way, according to a new study from Greece. The results were presented at...
Events
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Companies
Institute of Human Virology (IHV) at the University of Maryland School of Medicine
Formed in 1996 as a partnership between the State of Maryland, the City of Baltimore, the University System of Maryland and the University of Maryland Medical System, IHV is an in...
AstraZeneca and Bristol-Myers Squibb
Dedicated to addressing the global burden of diabetes by advancing individualized patient care, AstraZeneca and Bristol-Myers Squibb are working in collaboration to research, deve...
Nautilus Neurosciences, Inc. is a neurology-focused specialty pharmaceutical company committed to providing the healthcare community with medically relevant products and services...
Reverse Medical Corporation is a privately-held medical device company focused on expanding the endovascular management of acute stroke and neurovascular disease. The technology p...
NeuroMetrix, Inc. was founded in June 1996 as a spin-off from the Harvard-M.I.T. Division of Health Sciences and Technology. The Company’s mission is to: Create value for our customers by developi...
Concert Pharmaceuticals is a clinical stage biotechnology company with a broad development pipeline targeting renal disease, CNS disorders, inflammation and hematologic disorders....
Akebia Therapeutics is a discovery and development company focused on anemia and vascular disorders. Akebiaâs lead program, AKB-6548, an orally bioavailable HIF-prolyl hydrox...
Bioness offers innovative Neuromodulation products designed to help certain individuals with central nervous system disorders and diseases such as Stroke, Multiple Sclerosis, Trau...
SYGNIS Pharma AG, headquartered in Heidelberg, is a specialty pharmaceutical company listed on the Prime Standard of the German stock exchange. The Company is focused on the research, development an...
DOV is a biopharmaceutical company historically focused on the development of novel product candidates for disorders of the central nervous system. DOV has previously funded drug development and disco...
Clinical Trials
Pyroxamide in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of pyroxamide in...
Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism
Autism Spectrum Disorders (ASD) include Autistic disorder, Asperger's syndrome and Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS). These are developmental disorders be...
Omega-3 Fatty Acids in Autism Spectrum Disorders
This is a 12-week open label trial to evaluate whether omega-3 fatty acids is effective in reducing the severity of autism and its comorbidities.
Data and Sample Collection Study to Elucidate the Mechanisms of Eosinophilic Disorders
The purpose of this study is to elucidate the mechanisms underlying eosinophil growth, survival, migration, and function and to investigate and further characterize the pathophysiology of,...
This is a Phase III, multicenter, open-label study of RI-002 administered as an intravenous infusion of RI-002 (IGIV) every 21 or 28 days in approximately 60 subjects with Primary Immunode...
The purpose of this study is to assess the pain reduction rate after 8 weeks treatment of NORSPAN® from baseline. And secondary purpose are: pain reduction rate after 4 weeks treatment f...
Both pharmacotherapeutic and psychosocial interventions have domenstrated efficacy for PTSD. However, although these interventions can be helpful, many patients remain symptomatic despite...
Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-Year Manometric Follow-Up
Small bowel involvement is still recognized to be associated with great morbidity and mortality in SSc patients, leading particularly to malabsorption and intestinal pseudo-obstruction. In...
Topical treatment of mild to moderate actinic keratosis located on the face and head with Solaraze® is known to be a safe and efficient treatment option. However, it is unclear if an expa...
Glycosphingolipid Inhibition and Spermatogenesis in Man: A Pilot Study (MIG 2)
The purpose of this research study is to help in the development of safe, effective and reversible male contraception. We are examining the impact of the drug Miglustat on sperm production...
Videos
How can sperm disorders be diagnosed?
http://ivf.isida.ua/en.html To find out what kind of sperm disorders are at work, the male partner has to provide a sperm sample (after three to five days of...
Medical and Biotech [MESH] Definitions
Tribulus
A plant genus of the family ZYGOPHYLLACEAE. Members contain steroidal saponins. Ingestion by grazing animals causes PHOTOSENSITIVITY DISORDERS called geeldikkop (yellow thick head) in South Africa.
Sperm Midpiece
The middle piece of the spermatozoon is a highly organized segment consisting of MITOCHONDRIA, the outer dense fibers and the core microtubular structure.
Genetic Services
Organized services to provide diagnosis, treatment, and prevention of genetic disorders.
Gordonia Bacterium
A genus of gram-positive BACTERIA in the family Gordoniaceae, isolated from soil and from sputa of patients with chest disorders. It is also used for biotransformation of natural products.
Mastocytosis, Systemic
A group of disorders caused by the abnormal proliferation of MAST CELLS in a variety of extracutaneous tissues including bone marrow, liver, spleen, lymph nodes, and gastrointestinal tract. Systemic mastocytosis is commonly seen in adults. These diseases are categorized on the basis of clinical features, pathologic findings, and prognosis.
