Subacute Sclerosing Panencephalitis SSPE - Biotech, Pharma and Life Science Channel

00:59 EST 6th March 2015 | BioPortfolio

PubMed Articles [228 Associated PubMed Articles listed on BioPortfolio]

Tetraparesis as clinical correlate of subacute cervical flexion myelopathy.

Context We report the case of a 20-year-old woman who underwent tracheal resection with postoperative chin-to-chest suture for 10 days, presenting with severe tetraparesis at our institution. Similar ...

Ultrasound and Doppler Features of Budd-Chiari Syndrome in Pediatric Population.

Budd-Chiari syndrome (BCS) occurs as a result of hepatic venous outflow obstruction. In the pediatric population, the etiologies vary as compared with the adult population. Decompensation can occur fa...

Well-differentiated liposarcoma arising in the parapharyngeal space: a case report and review of the literature.

Background: Liposarcomas rarely occur in the parapharyngeal space and only a few case reports exist. For curative therapy of liposarcoma, surgical excision remains the dominant modality. Although a wi...

Arthritis, Eosinophilia, and Autoimmune Liver Disease: A Diagnostic Challenge.

Autoimmune hepatitis (AIH) is a chronic liver disease of unknown etiology. It is composed of immune-mediated liver injury and significant immunological aspects. Arthritis can be observed in patients w...

Primary sclerosing cholangitis and the risk of colon neoplasia in patients with Crohn's colitis.

Crohn's colitis (CC) is associated with primary sclerosing cholangitis (PSC). However the risk of colon cancer or dysplasia in CC and PSC is unclear. Our aim was to study the risk of colon neoplasia i...

Impact of treatment duration and lesion size on effectiveness of chondroitinase treatment post-SCI.

The effects of 2weeks of intralesional chondroitinase abc (ch'abc) treatment on anatomical plasticity and behavioral recovery are examined in adult cats and compared to results achieved with 4weeks of...

Biomarkers for disease progression of primary sclerosing cholangitis.

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown origin. There is no medical treatment of proven benefit on survival; once patients have progressed to end-stage l...

Effects of repetitive transcranial magnetic stimulation of the unaffected hemisphere leg motor area in patients with subacute stroke and substantial leg impairment: A pilot study.

Objective: To evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on mobility among patients with substantial leg impairment after subacute stroke. Design: Double-blinded, stra...

HAMI 3379, A CysLT2R Antagonist, Dose- and Time-Dependently Attenuates Brain Injury and Inhibits Microglial Inflammation After Focal Cerebral Ischemia in Rats.

Cysteinyl leukotrienes (CysLTs) induce inflammatory responses by activating their receptors, CysLT1R and CysLT2R. We have reported that CysLT2R is involved in neuronal injury, astrocytosis, and microg...

Melioidosis: Evolving Concepts in Epidemiology, Pathogenesis, and Treatment.

Infection with Burkholderia pseudomallei can result in asymptomatic seroconversion, a single skin lesion that may or may not heal spontaneously, a pneumonia which can be subacute or chronic and mimic ...

News Articles [30 Associated News Articles listed on BioPortfolio]

SSPE: A Deadly and Not-That-Rare Complication of Measles

[Editor’s note: We have two posts today, this post by our regular contributor Dr. Clay Jones, and an excellent guest post by William London about a chiropractor’s dubious neuropathy treatm...

Biotie Financial Statement Release 2014

BIOTIE THERAPIES CORP.      Financial Statement Release     27 February, 2015 at 8.45 a.m. Biotie Financial Statement Release 2014 This is a summary of the financial statement r...

Biotie updates outlook - completion of annual impairment review

BIOTIE THERAPIES CORP.     STOCK EXCHANGE RELEASE                  27 February 2015 at 8.40 a.m. Biotie updates outlook - completion of annual impairment review Bio...

Primary Sclerosing Cholangitis - Pipeline Review, H1 2015

Recently added to the BioPortfolio report store, Primary Sclerosing Cholangitis - Pipeline Review, H1 2015 is a new report from Global Markets Direct published on 2015-01-21. This 49-page report is a...

Biotie: BTT1023 receives positive opinion for Orphan Drug Designation

The Committee for Orphan Medicinal Products (COMP) of the European Medicines Agency (EMA) has issued a positive opinion recommending orphan drug designation for Biotie's BTT1023 drug candidate for the...

Biotie: BTT1023 receives positive opinion for Orphan Drug Designation from COMP

BIOTIE THERAPIES CORP.     STOCK EXCHANGE RELEASE                  17 February 2015 at 10.30 a.m. Biotie: BTT1023 receives positive opinion for Orphan Drug Designati...

Biotie’s BTT1023 receives positive opinion for Orphan Drug Designation from COMP

COMP has issued a positive opinion recommending orphan drug designation for Biotie's BTT1023 for the treatment of primary sclerosing cholangitis (PSC)... The post Biotie’s BTT1023 receives posit...

Abzena biotech portfolio can contribute significant value, says CEO John Burt

Chief executive John Burt says Abzena’s (LON:ABZA) portfolio of proprietary bio-techology has the potential to contribute significant value. Six humanized therapeutic antibodies created using Ab...

Intercept provides OCA clinical update

Intercept Pharmaceuticals Inc. (NASDAQ:ICPT) gained $6.78 to $152.70 on Tuesday after updating investors on its clinical development plans for OCA obeticholic acid to treat liver diseases.In December,...

Unexpected complication in a rat stroke model: exacerbation of secondary pathology in the thalamus by subacute intraarterial administration of human bone marrow-derived mesenchymal stem cells

Events [0 Results]

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Companies [1 Associated Companies listed on BioPortfolio]

Albert Einstein Healthcare Network

Albert Einstein Healthcare Network is a 1,200 bed integrated delivery network with nearly 7,400 employees serving the communities of North Philadelphia and Montgomery County, PA. ...

Clinical Trials [84 Associated Clinical Trials listed on BioPortfolio]

Development of a Patient-Reported Outcome Measure to Assess Symptoms in Patients With Primary Sclerosing Cholangitis (PSC)

The objectives of this qualitative study are to elicit concepts about symptoms that are important to patients with primary sclerosing cholangitis (PSC), as well as the key impacts of sympt...

Prevention of Retained-Blood Outcomes With Active Clearance Technology

Postoperative bleeding is a common consequence after heart surgery which can significantly impact outcomes and costs [Wynne R, Christensen MC, Dixon B]. When bleeding occurs, reliable post...

Fractional Concentration of Exhaled NO(FENO) to Direct Montelukast Treatment of Sub-acute Cough

Cough is a common symptom of respiratory medicine clinic patients, which has complex etiology and wide-ranging. Cough is usually divided into three categories by time: acute cough, subacut...

Open-Label, Dose-Escalating Study to Assess Safety, Tolerability, Efficacy, PK and PD of RP103 in Children With Inherited Mitochondrial Disease

Patients (male or female) with either documented genetically confirmed diagnosis of inherited mitochondrial diseases, who are ≥ 2 years old and < 18 years, and meet other specified inclu...

Robotic-assisted Gait Training Combined With Transcranial Direct Current Stimulation to Maximize Gait Recovery After Stroke

1. Study objective To evaluate the effect of robotic-assisted gait training combined with transcranial direct current stimulation (tDCS) as compared to that of robotic-assisted g...

A Pilot Study of Xifaxan to Treat Patients With PSC

In the current protocol, we propose the assessment of potential beneficial effects of the antibiotic Xifaxan on liver biochemistries, liver related symptoms and Mayo risk score in 15 adult...

Effects and Mechanisms of Treatment Intensity of Mirror Therapy in Patients With Subacute Stroke

The purpose of this study will evaluate the long-term benefits, optimal dose and mechanisms of mirror therapy and its effects on physiological markers.

PEG-Glucocerebrosidase for the Treatment of Gaucher Disease

Gaucher disease is a lysosomal storage disease resulting from glucocerebroside accumulation in macrophages due to a genetic deficiency of the enzyme glucocerebrosidase. It may occur in pa...

Evaluation of Treated and Untreated Stroke

This project will investigate the evolution of treated and untreated stroke in patients recruited from the collaborative brain stroke program between NINDS, CC, and Suburban Hospital. The...

Pilot Study of Budesonide for Patients With Primary Sclerosing Cholangitis

OBJECTIVES: I. Assess the safety and effectiveness of budesonide in patients with primary sclerosing cholangitis or primary biliary cirrhosis experiencing a suboptimal response to ursode...

Medical and Biotech [MESH] Definitions

A defective variant of MEASLES VIRUS that has been isolated from the brain tissue of patients with subacute sclerosing panencephalitis.

A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)

Diseases of viral origin, characterized by incubation periods of months to years, insidious onset of clinical manifestations, and protracted clinical course. Though the disease process is protracted, viral multiplication may not be unusually slow. Conventional viruses produce slow virus diseases such as SUBACUTE SCLEROSING PANENCEPHALITIS, progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL), and AIDS. Diseases produced by unconventional agents were originally considered part of this group. They are now called PRION DISEASES.

ENDOCARDIUM infection that is usually caused by STREPTOCOCCUS. Subacute infective endocarditis evolves over weeks and months with modest toxicity and rare metastatic infection.

The sodium salts of the fatty acids in cod liver oil; an irritant and sclerosing agent used to treat varicose veins and arthritic joints.

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