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Subacute Sclerosing Panencephalitis SSPE - Biotech, Pharma and Life Science Channel

12:14 EDT 24th April 2014 | BioPortfolio

PubMed Articles [190 Associated PubMed Articles listed on BioPortfolio]

Cholangiocarcinoma and High-Grade Dysplasia in Young Patients with Primary Sclerosing Cholangitis.

Cholangiocarcinoma (CCA) is very often an adulthood disease with primary sclerosing cholangitis (PSC) as one of the risk factors. It is rarely seen in the pediatric population, and when it is diagnose...

Ursodeoxycholic acid in primary sclerosing cholangitis: If withdrawal is bad, then administration is good (right?).

Thoracic Aortic Rupture and Aortopulmonary Fistulation in the Friesian Horse: Histomorphologic Characterization.

Aortic rupture in horses is a rare condition. Although it is relatively common in the Friesian breed, only limited histopathologic information is available. Twenty Friesian horses (1-10 years old) wer...

Efficacy of SpyGlass(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures.

To evaluate the diagnostic yield (inflammatory activity) and efficiency (size of the biopsy specimen) of SpyGlass(TM)-guided biopsy vs standard brush cytology in patients with and without primary scle...

Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice.

Astrocytes limit inflammation after CNS injury, at least partially by physically containing it within an astrocytic scar at the injury border. We report here that astrocytic transforming growth factor...

HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation.

To investigate influence of human leukocyte antigen (HLA) and killer immunoglobuline-like receptor (KIR) genotypes on risks of acute rejection (AR) after liver transplantation (LTX).

An uncommon cause of acquired osteosclerosis in adults: hepatitis C-associated osteosclerosis.

Hepatitis C-associated osteosclerosis (HCAO) is a rare sclerosing bone condition characterized by debilitating, predominantly lower extremity bone pain, accelerated bone turnover, and a generalized in...

Splintage in the treatment of sagittal band incompetence and extensor tendon subluxation.

This study assessed the success of splintage for traumatic and atraumatic sagittal band incompetence and its relationship to the duration of symptoms before treatment. A retrospective review of all pa...

Evidence for the effectiveness of walking training on walking and self-care after stroke: A systematic review and meta-analysis of randomized controlled trials.

Objective: To examine the effect of randomized controlled trials of walking training on walking and self-care in patients with stroke. Data sources: MEDLINE, CINAHL, Embase, PEDro, OTSeeker, Central,...

Sclerosing Angiomatoid Nodular Transformation of the Spleen: A New Entity or a New Name?

Sclerosing angiomatoid nodular transformation of the splenic red pulp has been described quite recently; many of the lesions previously diagnosed as splenic exuberant granulation tissue, multinodular...

News Articles [18 Associated News Articles listed on BioPortfolio]

Albireo’s Lead Compound in Cholestatic Liver Diseases, A4250, Protects Against Bile ...

Gothenburg, Sweden, April 11, 2014 / B3C newswire / -Albireo today announced that inhibition of ileal bile acid transport by A4250, the company’s lead compound for cholestatic liver diseases, p...

SCLE: a paraneoplastic presentation

A 38 year old woman presented with a three month history of a widespread annular erythematous rash. Skin biopsy confirmed a clinical diagnosis of subacute cutaneous lupus erythematosus (SCLE). On......

Lumena files for IPO

Lumena Pharmaceuticals Inc. (San Diego, Calif.) filed to raise up to $75 million in an IPO on NASDAQ underwritten by Citigroup; Cowen; and Leerink. The offering comes on the heels of a $45 million ser...

Hepatocellular carcinoma: Low risk of HCC in patients who have PSC and cirrhosis

Primary sclerosing cholangitis (PSC) is understood to be associated with an increased risk of malignancy in the bile ducts, gallbladder and colon. The risk of hepatocellular carcinoma in the setting o...

[Comment] Colchicine for treatment of acute or recurrent pericarditis

Acute pericarditis is a common and usually benign disease and is assessed by auscultation, electrocardiograph, echocardiography, blood markers (C-reactive protein, troponin), and chest radiography. In...

South Florida Foot & Ankle Centers Welcomes Dr. Kazamias, DPM

Dr. Kazamias brings extensive knowledge and experience in reconstructive foot surgery and sclerotherapy, a varicose vein removal and spider vein treatment procedure. West Palm Beach, Florida (PRWEB) M...

NBC: Herpes Can Invade the Brain and Cause Encephalitis; polyDNA Recommends That Individuals Ask Their Doctors about Gene-Eden-VIR

The herpes virus can inflame the lining around the brain in a condition called herpes encephalitis, according to a report published on February 27, 2014 on the NBC News affiliate kplctv.com (1). polyD...

Acute kidney injury: Late-onset acute kidney injury—subacute or more of the same?

Fujii and colleagues define 'subacute' kidney injury (s-AKI) as AKI that takes >7 days to develop, timed from admission or lowest creatinine measurement after admission. Although s-AKI is unlikely to...

Spiracur Secures TGA Approval for SNaP Wound Care System and Announces Distribution Partnership in Australia

Spiracur and AinsCorp Team up to Bring Proven, Advanced Wound Care System to Australia and New Zealand Sunnyvale, CA (PRWEB) January 14, 2014 Spiracur Inc., developer of the only mechanically powered...

National stroke summit tour convenes physicians across the U.S. to advance optimal stroke care delivery

FAIRFAX, Va., Jan. 9, 2014 /PRNewswire/ -- The Society of NeuroInterventional Surgery (SNIS) today has launched a 2014 national tour that will bring together physicians and medical personnel acro...

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Companies [1 Associated Companies listed on BioPortfolio]

Albert Einstein Healthcare Network

Albert Einstein Healthcare Network is a 1,200 bed integrated delivery network with nearly 7,400 employees serving the communities of North Philadelphia and Montgomery County, PA....

Clinical Trials [77 Associated Clinical Trials listed on BioPortfolio]

Feasibility Study of Photopheresis Post Angioplasty

The primary objective of the study is to evaluate the difference in 6-month restenosis rates in coronary artery lesions treated by photopheresis in addition to angioplasty with stent place...

Tc-99m Renography and Cisplatin-Induced Nephrotoxicity

Cisplatin is a heavy-metal complex widely used in the treatment of a variety of malignancies, including small cell and non-small cell lung cancer, ovarian, bladder, head and neck, esophage...

Pilot Study of Budesonide for Patients With Primary Sclerosing Cholangitis

OBJECTIVES: I. Assess the safety and effectiveness of budesonide in patients with primary sclerosing cholangitis or primary biliary cirrhosis experiencing a suboptimal response to ursode...

Phase II Pilot Study of Cladribine (2-Chlorodeoxyadenosine; 2-CdA) for Early Stage Primary Sclerosing Cholangitis

OBJECTIVES: I. Evaluate the effects of cladribine (2-chlorodeoxyadenosine; 2-CdA) on biochemical, radiologic, and histologic parameters in patients with early stage primary sclerosing...

Randomized Study of Intravenous Immunoglobulin (IVIg) in Patients With Subacute Proximal Diabetic Neuropathy

OBJECTIVES: I. Determine the effect of intravenous immunoglobulin on recovery time of patients with proximal diabetic neuropathy. II. Determine whether rate of response is dose depende...

Evaluation of Treated and Untreated Stroke

This project will investigate the evolution of treated and untreated stroke in patients recruited from the collaborative brain stroke program between NINDS, CC, and Suburban Hospital. The...

PEG-Glucocerebrosidase for the Treatment of Gaucher Disease

Gaucher disease is a lysosomal storage disease resulting from glucocerebroside accumulation in macrophages due to a genetic deficiency of the enzyme glucocerebrosidase. It may occur in pa...

Subacute and Chronic, Non-specific Back and Neck Pain: Cognitive-behavioral Rehabilitation vs. Traditional Primary Care

BACKGROUND Non-specific back and neck pain (BNP) dominates sick-listing. A program of cognitive-behavioral rehabilitation for subacute and chronic BNP was compared, with 18-month fo...

Placebo-Controlled Trial, Testing the Efficacy of Polidocanol Injections as a Treatment of Chronic Achilles Tendinopathy

Chronic Achilles tendinopathy is a common disease especially in adults. The golden standard in treatment has up to now been excentric exercise, but with varying success.A new hypothesis is...

Chiropractic Prone Distraction for Lower Back Pain

Back pain is a major cause of disability in the United States. The lifetime prevalence of low back pain is estimated at 60-90%. Back pain has conservatively been estimated to involve total...

Medical and Biotech [MESH] Definitions

A defective variant of MEASLES VIRUS that has been isolated from the brain tissue of patients with subacute sclerosing panencephalitis.

A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)

Diseases of viral origin, characterized by incubation periods of months to years, insidious onset of clinical manifestations, and protracted clinical course. Though the disease process is protracted, viral multiplication may not be unusually slow. Conventional viruses produce slow virus diseases such as SUBACUTE SCLEROSING PANENCEPHALITIS, progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL), and AIDS. Diseases produced by unconventional agents were originally considered part of this group. They are now called PRION DISEASES.

ENDOCARDIUM infection that is usually caused by STREPTOCOCCUS. Subacute infective endocarditis evolves over weeks and months with modest toxicity and rare metastatic infection.

The sodium salts of the fatty acids in cod liver oil; an irritant and sclerosing agent used to treat varicose veins and arthritic joints.

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