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Thimerosal Preservative - Biotech, Pharma and Life Science Channel

06:18 EDT 20th June 2013 | BioPortfolio

Thimerosal is a mercury-based preservative that has been used for decades in the United States in multi-dose vials (vials containing more than one dose) of some vaccines to prevent the growth of germs, bacteria and fungi, that can contaminate them.

What are preservatives and why are they sometimes used in vaccines?

Preservatives have been used in vaccines for more than 70 years and are added to vaccines to prevent the growth of bacteria or fungi that could possibly make the vaccine in multi-dose vials unsafe. This may occur when a syringe needle enters a vial as a vaccine is being prepared for administration. Contamination by germs in a vaccine could cause serious infections.

Source: CDC

PubMed Articles [ 23 Associated PubMed Articles listed on BioPortfolio]

The effects of para-chloromercuribenzoic acid and different oxidative and sulfhydryl agents on a novel, non-AT1, non-AT2 angiotensin binding site identified as neurolysin.

A novel, non-AT1, non-AT2 brain binding site for angiotensin peptides that is unmasked by p-chloromercuribenzoate (PCMB) has been identified as a membrane associated variant of neurolysin. The ability...

A highly selective fluorescent probe for BO(3)(-) based on acetate derivatives of coumarin in aqueous solution and thimerosal.

The acetate derivatives of coumarin exhibited a prominent turn-on type signaling behavior toward BO(3)(-) ions over other common anions. Signaling is based on the selective deprotection of acetate gro...

Obstetricians and the 2009-2010 H1N1 Vaccination Effort: Implications for Future Pandemics.

Our objective was to describe the experiences of obstetricians during the 2009-2010 H1N1 vaccination campaign in order to identify possible improvements for future pandemic situations. We conducted a...

Influenza vaccine safety in pregnancy: can we identify exposures?

PURPOSE: To assess the feasibility of identifying influenza vaccine exposure in pregnancy. METHODS: Two study designs were used. (i) Women who contacted the Organization of Teratology Information Spec...

Maternal Thimerosal Exposure Results in Aberrant Cerebellar Oxidative Stress, Thyroid Hormone Metabolism, and Motor Behavior in Rat Pups; Sex- and Strain-Dependent Effects.

Methylmercury (Met-Hg) and ethylmercury (Et-Hg) are powerful toxicants with a range of harmful neurological effects in humans and animals. While Met-Hg is a recognized trigger of oxidative stress and...

The most important contact sensitizers in Polish children and adolescents with atopy and chronic recurrent eczema as detected with the extended European Baseline Series.

Czarnobilska E, Obtulowicz K, Dyga W, Spiewak R. The most important contact sensitizers in Polish children and adolescents with atopy and chronic recurrent eczema as detected with the extended Europea...

Prenatal and Infant Exposure to Thimerosal From Vaccines and Immunoglobulins and Risk of Autism.

Objective: Exposure to thimerosal, a mercury-containing preservative that is used in vaccines and immunoglobulin preparations, has been hypothesized to be associated with increased risk of autism spec...

Making sense of epidemiological studies of young children exposed to thimerosal in vaccines.

OBJECTIVE: To compare epidemiological studies dealing with neurological issues (compatible with Hg toxicity) linked to exposing newborns and infants to intramuscular doses of preservative-Hg resulting...

Canonical transient receptor potential 6 (TRPC6), a redox-regulated cation channel.

This study examined the effect of H(2)O(2) on the TRPC6 channel and its underlying mechanisms using a TRPC6 heterologous expression system. In TRPC6-expressing HEK293T cells, H(2)O(2) significantly st...

Low molecular weight thiols reduce thimerosal neurotoxicity in vitro: modulation by proteins.

Thimerosal (TH), an ethylmercury complex of thiosalicylic acid has been used as preservative in vaccines. In vitro neurotoxicity of TH at high nM concentrations has been reported. Although a number of...

News Articles [ 36 Associated News Articles listed on BioPortfolio]

Robert F. Kennedy Jr. to Advance Autism Awareness to Action as Keynote of AutismOne Conference

Congressmen and Celebrities to educate parents and professionals at AutismOne and Generation Rescue Conference in Chicago CHICAGO, April 10, 2013 /PRNewswire-USNewswire/ -- Once a year, families...

Same Problems in "New" Research on Autism and Vaccines

"New" study from DeStefano et al., rehashes flawed data - says SafeMinds WASHINGTON, April 8, 2013 /PRNewswire-USNewswire/ -- A new book chapter on statistical methods in Recent Advances in Autis...

Same Problems in "New" Research on Autism and Vaccines

WASHINGTON , April 8, 2013 /PRNewswire-USNewswire/ -- A new book chapter on statistical methods in Recent Advances in Autism Spectrum Disorders by University of Northern Iowa researchers, DeSoto an...

Multiple Vaccines Not Linked To Autism Risk, CDC

There is no casual link between certain vaccine types and autism, says a new study carried out by the CDC (Centers for Disease Control and Prevention) and published in The Journal of Pediatrics. Paren...

Meriden Department of Health & Human Services to Host Free Flublok® Influenza Vaccine Clinic Thursday February 21th, 2013

MERIDEN, Conn., Feb. 20, 2013 /PRNewswire/ -- The Meriden Department of Health and Human Services will host a free walk-in Flublok influenza vaccine clinic on Thursday, February 21, from 9:00am t...

Dr. Wayne Hachey Joins Protein Sciences' Leadership Team

MERIDEN, Conn., Feb. 20, 2013 /PRNewswire/ -- Protein Sciences Corporation announced today that Wayne Hachey, DO (Colonel, U.S. Army, ret.) has joined the Company's management as Head, Government...

FFF Enterprises Announces New Flu Vaccine Available for Immediate Shipment

TEMECULA, CA -- (Marketwire) -- 02/13/13 -- In response to the country's continuing flu epidemic in the West and Southwest, FFF Enterprises announced today that single-dose vials of the newly FDA-app...

Thimerosal Gets a Reprieve

By Todd Neale An international treaty aimed at reducing environmental exposure to mercury was adopted on Jan. 19 minus a proposed ban on the use of mercury-based thimerosal as a vaccine preservative...

Brainless precaution at UN Environmental Program.

Stick With the Science - NYTimes.comBy SETH BERKLEY Published: January 17, 2013GOVERNMENT representatives are meeting in Geneva this week to decide whether to introduce a global ban on mercury th...

U.S. FDA Approves Flublok, the World's First Recombinant, Highly Purified, Egg-Free Influenza ...

The U.S. FDA approved Flublok for people 18-49 years old – making it the first recombinant vaccine for influenza available on the market. Approval for all people 18 years and above is expected l...

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Clinical Trials [ 3 Associated Clinical Trials listed on BioPortfolio]

Research in Skin Inflammation

This study will examine the production of proteins called chemokines in inflammatory skin reactions. It is thought that chemokines attract or recruit white blood cells from the blood stre...

Mercury Levels in Premature and LBW Infants Receiving Thimerosal-containing Vaccines

The goal of the study is to find out how much mercury is in the blood, urine, and stools of premature and low birth weight infants who have received standard childhood vaccines that are gi...

Clinical Evaluation of T.R.U.E. TEST® Fragrance Mix and Thimerosal Allergens:Bioequivalence of PVP Formulations

An open, prospective, multi-center study to evaluate the bioequivalence of polyvinylpyrrolidone formulations of T.R.U.E. TEST fragrance mix and thimerosal allergens.

Medical and Biotech [MESH] Definitions

Thimerosal

An ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate.

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