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Thimerosal Preservative - Biotech, Pharma and Life Science Channel

23:00 EDT 29th July 2014 | BioPortfolio

Thimerosal is a mercury-based preservative that has been used for decades in the United States in multi-dose vials (vials containing more than one dose) of some vaccines to prevent the growth of germs, bacteria and fungi, that can contaminate them.

What are preservatives and why are they sometimes used in vaccines?

Preservatives have been used in vaccines for more than 70 years and are added to vaccines to prevent the growth of bacteria or fungi that could possibly make the vaccine in multi-dose vials unsafe. This may occur when a syringe needle enters a vial as a vaccine is being prepared for administration. Contamination by germs in a vaccine could cause serious infections.

Source: CDC

PubMed Articles [7 Associated PubMed Articles listed on BioPortfolio]

Thimerosal compromises human dendritic cell maturation, IL-12 production, chemokine release, and T-helper polarization.

Thimerosal is a preservative used in multidose vials of vaccine formulations to prevent bacterial and fungal contamination. We recently reported that nanomolar concentrations of thimerosal induce cell...

A meta-analysis of the evidence on the impact of prenatal and early infancy exposures to mercury on autism and attention deficit/hyperactivity disorder in the childhood.

Although a measurable number of epidemiological studies have been conducted to clarify the associations between mercury exposure during embryo or early infancy and later incidences of autism spectrum...

On-line species-unspecific isotope dilution analysis in the picomolar range reveals the time- and species-depending mercury uptake in human astrocytes.

In order to reveal the time-depending mercury species uptake by human astrocytes, a novel approach for total mercury analysis is presented, which uses an accelerated sample introduction system combine...

Acute exposure to thimerosal induces antiproliferative properties, apoptosis, and autophagy activation in human Chang conjunctival cells.

Previously we have shown that acute exposure to thimerosal (Thi) can induce oxidative stress and DNA damage in a human conjunctival cell line. However, the long-term effect of Thi on Chang conjunctiva...

Cloning, expression, purification and preliminary X-ray crystallographic analysis of mouse protein arginine methyltransferase 7.

Protein arginine methyltransferase 7 (PRMT7) is a unique but less characterized member of the family of protein arginine methyltransferases (PRMTs) that plays a role in male germline gene imprinting....

A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States.

Autism spectrum disorder (ASD) is defined by standardized criteria of qualitative impairments in social interaction, qualitative impairments in communication, and restricted and stereotyped patterns o...

Mitochondrial dysfunction, impaired oxidative-reduction activity, degeneration, and death in human neuronal and fetal cells induced by low-level exposure to thimerosal and other metal compounds.

Thimerosal (ethylmercurithiosalicylic acid), an ethylmercury (EtHg)-releasing compound (49.55% mercury (Hg)), was used in a range of medical products for more than 70 years. Of particular recent conce...

News Articles [16 Associated News Articles listed on BioPortfolio]

Pay and Practice: Kennedy Stirs Thimerosal Debate

(MedPage Today) -- Robert F. Kennedy Jr. is putting out a book on the dangers of thimerosal in vaccines, raising an issue that many in the medical and scientific communities hoped was long settled.

Robert Kennedy’s Dangerous Anti-Vaccine Activism

Robert F. Kennedy Jr. is coming out with a new book that claims thimerosal in vaccines causes autism. This claim has been thoroughly discredited, but RFK Jr. believes that it's all a big conspiracy an...

Protein Sciences and Partners Launch Health-At-Work to Bring Flublok® and Other Vaccines to the Workplace

MERIDEN, Conn., July 17, 2014 /PRNewswire/ -- Protein Sciences Corporation announced today that they have partnered with physicians from Velocity Urgent Care and launched a new initiative called...

Autism Speaks Flip-Flops on Vaccines and Autism, Walks Away From Prevention

WATCHUNG, N.J., July 10, 2014 /PRNewswire-iReach/ -- There was a time when the world's largest autism charity strongly urged the U.S. government to examine the possibility of a vaccine-autism link. "W...

Protein Sciences Receives Approval from FDA for 2014/15 Formulation of Flublok® Influenza Vaccine

MERIDEN, Conn., July 8, 2014 /PRNewswire/ -- Protein Sciences Corporation announced today that the FDA has approved the Company's strain change amendment for its seasonal influenza vaccine, Flubl...

U.S. Biomedical Advanced Research and Development Authority (BARDA) Extends Contract with Protein Sciences Corporation

MERIDEN, Conn., June 17, 2014 /PRNewswire/ -- Protein Sciences Corporation announced today that BARDA, within the U.S. Department of Health and Human Services, exercised Option Period 2 of its contrac...

CDC's Vaccine Safety Research is Exposed as Flawed and Falsified in Peer-Reviewed Scientific Journal

WATCHUNG, N.J., June 13, 2014 /PRNewswire-iReach/ -- Just months after U.S. Congressman Bill Posey compared the Center for Disease Control (CDC)'s vaccine safety studies to the SEC's Bernie Madof...

Protein Sciences Adds Distributor for Flublok® Recombinant Influenza Vaccine to Increase Access

MERIDEN, Conn., June 10, 2014 /PRNewswire/ -- Protein Sciences Corporation announced it will have more doses, earlier availability and broader distribution coverage of its modern, egg-free Flublok...

Protein Sciences Partners File for Marketing Approval of Flublok® Influenza Vaccine in Japan

MERIDEN, Conn., May 30, 2014 /PRNewswire/ -- Protein Sciences Corporation announced today that Astellas Pharma has submitted an application for marketing approval of recombinant influenza HA vaccine A...

Vaccines Still Not Linked to Autism

Myths tend to be persistent and require periodic maintenance debunking. The anti-vaccine movement arguably can credit its recent increase in effect to successfully spreading fears that vaccines in gen...

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Clinical Trials [3 Associated Clinical Trials listed on BioPortfolio]

Clinical Evaluation of T.R.U.E. TEST® Fragrance Mix and Thimerosal Allergens:Bioequivalence of PVP Formulations

An open, prospective, multi-center study to evaluate the bioequivalence of polyvinylpyrrolidone formulations of T.R.U.E. TEST fragrance mix and thimerosal allergens.

Research in Skin Inflammation

This study will examine the production of proteins called chemokines in inflammatory skin reactions. It is thought that chemokines attract or recruit white blood cells from the blood stre...

Mercury Levels in Premature and LBW Infants Receiving Thimerosal-containing Vaccines

The goal of the study is to find out how much mercury is in the blood, urine, and stools of premature and low birth weight infants who have received standard childhood vaccines that are gi...

Medical and Biotech [MESH] Definitions

An ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate.

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A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe, its toxins or one...

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