Thimerosal Preservative - Biotech, Pharma and Life Science Channel

00:14 EDT 25th April 2015 | BioPortfolio

Thimerosal is a mercury-based preservative that has been used for decades in the United States in multi-dose vials (vials containing more than one dose) of some vaccines to prevent the growth of germs, bacteria and fungi, that can contaminate them.

What are preservatives and why are they sometimes used in vaccines?

Preservatives have been used in vaccines for more than 70 years and are added to vaccines to prevent the growth of bacteria or fungi that could possibly make the vaccine in multi-dose vials unsafe. This may occur when a syringe needle enters a vial as a vaccine is being prepared for administration. Contamination by germs in a vaccine could cause serious infections.

Source: CDC

PubMed Articles [7 Associated PubMed Articles listed on BioPortfolio]

Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder.

This case-control study investigated the relationship between the risk of Autism Spectrum Disorder (ASD) onset, and early exposure to the combined Measles-Mumps-Rubella (MMR) vaccine and thimerosal co...

Effects of Contact Lens Solution Disinfectants against Filamentous Fungi.

To assess and compare the antifungal activity of polyhexamethylene biguanide (PHMB), thimerosal, cetylpyridinium chloride, and chlorhexidine, which are disinfectants used in multipurpose disinfectant ...

Determination of thimerosal in pharmaceutical industry effluents and river waters by HPLC coupled to atomic fluorescence spectrometry through post-column UV-assisted vapor generation.

A high performance liquid chromatography coupled with atomic fluorescence spectrometry method for the determination of thimerosal (sodium ethylmercury thiosalicylate, C9H9HgNaO2S), ethylmercury, and i...

A systematic study of the disposition and metabolism of mercury species in mice after exposure to low levels of thimerosal (ethylmercury).

Thimerosal (TM) is an ethylmercury (etHg)-containing preservative used in some vaccines despite very limited knowledge on the kinetics and direct interaction/effects in mammals׳ tissues after exposur...

Thimerosal compromises human dendritic cell maturation, IL-12 production, chemokine release, and T-helper polarization.

Thimerosal is a preservative used in multidose vials of vaccine formulations to prevent bacterial and fungal contamination. We recently reported that nanomolar concentrations of thimerosal induce cell...

A meta-analysis of the evidence on the impact of prenatal and early infancy exposures to mercury on autism and attention deficit/hyperactivity disorder in the childhood.

Although a measurable number of epidemiological studies have been conducted to clarify the associations between mercury exposure during embryo or early infancy and later incidences of autism spectrum ...

Exposure to Mercury and Aluminum in Early Life: Developmental Vulnerability as a Modifying Factor in Neurologic and Immunologic Effects.

Currently, ethylmercury (EtHg) and adjuvant-Al are the dominating interventional exposures encountered by fetuses, newborns, and infants due to immunization with Thimerosal-containing vaccines (TCVs)....

News Articles [7 Associated News Articles listed on BioPortfolio]

Glaxo Recalls Flu Vaccine Due to Potency Issue

GlaxoSmithKline is recalling the FluLaval Quadrivalent Thimerosal-Free vaccine because it may offer suboptimal protection against some influenza strains. News Alerts

GSK Recalls Flu Vaccine

GSK notifies CDC and FDA that it is recalling the remaining doses of its 2014–2015 flu vaccine, Flulaval Quadrivalent Thimerosal-free Pre-Filled Syringes, due to decreased potency. Date: ...

Glaxo Recalls Flu Vaccine Due to Potency Problem

GlaxoSmithKline is recalling a popular four-in-one flu vaccine because its effectiveness can decline over time.   The company alerted U.S. customers Tuesday that the vaccine can lose potency and fa...

Pre-Booking for Flublok® Influenza Vaccine Now Available from Cardinal Health and McKesson

MERIDEN, Conn., Feb. 24, 2015 /PRNewswire/ -- Protein Sciences Corporation  announced today it has expanded distribution options for its revolutionary Flublok influenza vaccine and that pre-...

Clinical Efficacy Study of Flublok® Quadrivalent Compares Flublok to a Traditional Egg-based Flu Vaccine

MERIDEN, Conn., Jan. 29, 2015 /PRNewswire/ -- Protein Sciences Corporation announced today that results from a double-blinded comparative efficacy study of Flublok Quadrivalent in adults over 50 ...

Flublok® Technology Could Solve the Problem of Ineffective Flu Vaccines

MERIDEN, Conn., Dec. 15, 2014 /PRNewswire/ -- The Centers for Disease Control and Prevention (CDC) recently warned that flu vaccines may be ineffective this season because a new strain of H3N2 influen...

Flublok® Influenza Vaccine Now Approved for Adults Ages 18 and Older

MERIDEN, Conn., Oct. 29, 2014 /PRNewswire/ -- Protein Sciences Corporation announced today that the U.S. FDA has approved Flublok influenza vaccine for all adults aged 18 years and older, granting app...

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Clinical Trials [3 Associated Clinical Trials listed on BioPortfolio]

Research in Skin Inflammation

This study will examine the production of proteins called chemokines in inflammatory skin reactions. It is thought that chemokines attract or recruit white blood cells from the blood stre...

Mercury Levels in Premature and LBW Infants Receiving Thimerosal-containing Vaccines

The goal of the study is to find out how much mercury is in the blood, urine, and stools of premature and low birth weight infants who have received standard childhood vaccines that are gi...

Clinical Evaluation of T.R.U.E. TEST® Fragrance Mix and Thimerosal Allergens:Bioequivalence of PVP Formulations

An open, prospective, multi-center study to evaluate the bioequivalence of polyvinylpyrrolidone formulations of T.R.U.E. TEST fragrance mix and thimerosal allergens.

Medical and Biotech [MESH] Definitions

An ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate.

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