Thimerosal Preservative - Biotech, Pharma and Life Science Channel

23:12 EDT 21st October 2014 | BioPortfolio

Thimerosal is a mercury-based preservative that has been used for decades in the United States in multi-dose vials (vials containing more than one dose) of some vaccines to prevent the growth of germs, bacteria and fungi, that can contaminate them.

What are preservatives and why are they sometimes used in vaccines?

Preservatives have been used in vaccines for more than 70 years and are added to vaccines to prevent the growth of bacteria or fungi that could possibly make the vaccine in multi-dose vials unsafe. This may occur when a syringe needle enters a vial as a vaccine is being prepared for administration. Contamination by germs in a vaccine could cause serious infections.

Source: CDC

PubMed Articles [8 Associated PubMed Articles listed on BioPortfolio]

Effects of Contact Lens Solution Disinfectants against Filamentous Fungi.

To assess and compare the antifungal activity of polyhexamethylene biguanide (PHMB), thimerosal, cetylpyridinium chloride, and chlorhexidine, which are disinfectants used in multipurpose disinfectant ...

Determination of thimerosal in pharmaceutical industry effluents and river waters by HPLC coupled to atomic fluorescence spectrometry through post-column UV-assisted vapor generation.

A high performance liquid chromatography coupled with atomic fluorescence spectrometry method for the determination of thimerosal (sodium ethylmercury thiosalicylate, C9H9HgNaO2S), ethylmercury, and i...

A systematic study of the disposition and metabolism of mercury species in mice after exposure to low levels of thimerosal (ethylmercury).

Thimerosal (TM) is an ethylmercury (etHg)-containing preservative used in some vaccines despite very limited knowledge on the kinetics and direct interaction/effects in mammals׳ tissues after exposur...

Thimerosal compromises human dendritic cell maturation, IL-12 production, chemokine release, and T-helper polarization.

Thimerosal is a preservative used in multidose vials of vaccine formulations to prevent bacterial and fungal contamination. We recently reported that nanomolar concentrations of thimerosal induce cell...

A meta-analysis of the evidence on the impact of prenatal and early infancy exposures to mercury on autism and attention deficit/hyperactivity disorder in the childhood.

Although a measurable number of epidemiological studies have been conducted to clarify the associations between mercury exposure during embryo or early infancy and later incidences of autism spectrum ...

On-line species-unspecific isotope dilution analysis in the picomolar range reveals the time- and species-depending mercury uptake in human astrocytes.

In order to reveal the time-depending mercury species uptake by human astrocytes, a novel approach for total mercury analysis is presented, which uses an accelerated sample introduction system combine...

Cloning, expression, purification and preliminary X-ray crystallographic analysis of mouse protein arginine methyltransferase 7.

Protein arginine methyltransferase 7 (PRMT7) is a unique but less characterized member of the family of protein arginine methyltransferases (PRMTs) that plays a role in male germline gene imprinting. ...

Mitochondrial dysfunction, impaired oxidative-reduction activity, degeneration, and death in human neuronal and fetal cells induced by low-level exposure to thimerosal and other metal compounds.

Thimerosal (ethylmercurithiosalicylic acid), an ethylmercury (EtHg)-releasing compound (49.55% mercury (Hg)), was used in a range of medical products for more than 70 years. Of particular recent conce...

News Articles [19 Associated News Articles listed on BioPortfolio]

Flublok® Influenza Vaccine Now Available for the 2014/2015 Influenza Season

MERIDEN, Conn., Sept. 29, 2014 /PRNewswire/ -- Protein Sciences Corporation, manufacturer of the revolutionary Flublok influenza vaccine, announced today that doses of the vaccine have been relea...

CDC vaccine scientist admits wrongdoing.

ATLANTA, Sept. 2, 2014 /PRNewswire-USNewswire/ -- For over a decade SafeMinds has claimed that the CDC manipulated data to show no link between vaccines and autism. But at least for one study, th...

Flublok® Influenza Vaccine Will Be Available At Over 230 Passport Health Locations Nationwide

MERIDEN, Conn. and SCOTTSDALE, Ariz., Aug. 19, 2014 /PRNewswire/ -- Protein Sciences Corporation and Passport Health announced today that Flublok® influenza vaccine will be available this fa...

Protein Sciences and Liomont Announce Licensing of Proprietary Influenza Vaccines for the Mexico Market

MERIDEN, Conn. and MEXICO CITY, Aug. 12, 2014 /PRNewswire/ -- Protein Sciences Corporation and Laboratorios Liomont, S.A. de C.V. (Liomont), a leading Mexican pharmaceutical company, announced to...

New Kennedy Book Calls for Thimerosal-Free Vaccines

A new book about the safety of thimerosal in vaccines attempts to reopen a question that public health authorities consider settled. Robert Kennedy Jr. is the editor. But who are the authors? Medsca...

bioCSL Inc. Launches AFLURIA® Shipping Campaign for 2014-2015 Seasonal Influenza

bioCSL Inc. to supply U.S. Market with 16.5 Million Doses Historical reliability, coupled with dedicated commercial and production efforts, drive strong...

Kennedy Rebuts Critics on Thimerosal

(MedPage Today) -- On July 24, MedPage Today published a blog post on Robert F. Kennedy Jr.'s upcoming book on thimerosal in vaccines. Kennedy responded in an interview Tuesday.

Pay and Practice: Kennedy Stirs Thimerosal Debate

(MedPage Today) -- Robert F. Kennedy Jr. is putting out a book on the dangers of thimerosal in vaccines, raising an issue that many in the medical and scientific communities hoped was long settled.

Robert Kennedy’s Dangerous Anti-Vaccine Activism

Robert F. Kennedy Jr. is coming out with a new book that claims thimerosal in vaccines causes autism. This claim has been thoroughly discredited, but RFK Jr. believes that it's all a big conspiracy an...

Protein Sciences and Partners Launch Health-At-Work to Bring Flublok® and Other Vaccines to the Workplace

MERIDEN, Conn., July 17, 2014 /PRNewswire/ -- Protein Sciences Corporation announced today that they have partnered with physicians from Velocity Urgent Care and launched a new initiative called ...

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Clinical Trials [3 Associated Clinical Trials listed on BioPortfolio]

Research in Skin Inflammation

This study will examine the production of proteins called chemokines in inflammatory skin reactions. It is thought that chemokines attract or recruit white blood cells from the blood stre...

Mercury Levels in Premature and LBW Infants Receiving Thimerosal-containing Vaccines

The goal of the study is to find out how much mercury is in the blood, urine, and stools of premature and low birth weight infants who have received standard childhood vaccines that are gi...

Clinical Evaluation of T.R.U.E. TEST® Fragrance Mix and Thimerosal Allergens:Bioequivalence of PVP Formulations

An open, prospective, multi-center study to evaluate the bioequivalence of polyvinylpyrrolidone formulations of T.R.U.E. TEST fragrance mix and thimerosal allergens.

Medical and Biotech [MESH] Definitions

An ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate.

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