Thrombocytosis - Biotech, Pharma and Life Science Channel
PubMed Articles
Colorectal cancer and hypercoagulability.
Since the first report of the spontaneous appearance of venous thrombophlebitis as a sign of visceral cancer by Trousseau in 1865, many other studies have documented the existence of cancer-associated...
The present report describes two chronic myelogenous leukemia (CML) patients with the JAK2-V617F mutation who were in complete hematologic and cytogenetic remission and subsequently developed clinical...
Reproducibility and clinical usefulness of the WHO-classification of chronic myeloproliferative neoplasm (MPN) persist to be a controversial issue . Major arguments are focused on the critical impact...
Backgrounds/Aims: Thrombocytosis had been found to be associated with tumor metastasis and poor prognosis in malignant tumors including colorectal cancer (CRC). In the present study, we investigated t...
Paraneoplastic thrombocytosis in ovarian cancer.
Germline JAK2 mutation in a family with hereditary thrombocytosis.
Miliaria rubra and thrombocytosis in pseudohypoaldosteronism: Case report.
Pseudohypoaldosteronism type 1 (PHA1) is a disease involving a state of renal tubular unresponsiveness to the action of aldosterone and characterized by excessive salt loss in the urine, hyperkalemia,...
Impact of Preoperative Thrombocytosis on the Survival of Patients with Primary Colorectal Cancer.
BACKGROUND: Although thrombocytosis has been reported in patients with various types of cancer, the association between thrombocytosis and the clinicopathological features of pat...
POEMS syndrome : An interdisciplinary clinical challenge.
POEMS syndrome is a rare paraneoplastic syndrome due to a plasma cell dyscrasia, which includes peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasma cell proliferation and skin chang...
News Articles
Bristols-Myers Squibb filed a public knowledge-based application Nov. 26 for an additional indication of their oncology product Hydrea for treatment of essential thrombocytosis and polycythemia vera....
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Clinical Trials
Pegasys® in Patients With Myeloproliferative Diseases
The goal of this clinical research study is to see if Pegasys (IFN-alpha2a) can help to control the disease in patients with essential thrombocytosis (ET), polycythemia vera (PV), agnogeni...
Molecular Biology of Polycythemia and Thrombocytosis
Our study is designed to characterize the clinical picture and genetic pattern of Polycythemia and Thrombocytosis. The purpose of this project is to find a gene and its mutation that caus...
This is an 18-week open-label, multicenter study to evaluate the efficacy and tolerability of CEP-701 (lestaurtinib) treatment in patients with Polycythemia Vera (PV) and patients with Ess...
Pomalidomide in Patients With Myeloproliferative Neoplasms in Fibrotic Stage
This is a phase II, multi-center study of pomalidomide in adult patients with PMF, SMF, and unclassifiable MPN showing at least grade 1 bone marrow fibrosis and requiring therapy. All pati...
Ferinject® in Patient With Thrombocytosis Secondary to Inflammatory Bowel Disease (IBD)
The aim of this study is to show the benefits for patients, with a high platelet count, iron deficiency and IBD, receiving intravenous iron therapy.
Videos
Essential Thrombocythemia-Mayo Clinic
Hematologist Ruben Mesa, M.D., of Mayo Clinic in Arizona, provides a comprehensive overview of Essential Thrombocythemia, also known as ET. Dr. Mesa describe...
Medical and Biotech [MESH] Definitions
Thrombocytosis
Increased numbers of platelets in the peripheral blood. (Dorland, 27th ed)
Vitamin E Deficiency
A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181)
Poems Syndrome
A multisystemic disorder characterized by a sensorimotor polyneuropathy (POLYNEUROPATHIES), organomegaly, endocrinopathy, monoclonal gammopathy, and pigmentary skin changes. Other clinical features which may be present include EDEMA; CACHEXIA; microangiopathic glomerulopathy; pulmonary hypertension (HYPERTENSION, PULMONARY); cutaneous necrosis; THROMBOCYTOSIS; and POLYCYTHEMIA. This disorder is frequently associated with osteosclerotic myeloma. (From Adams et al., Principles of Neurology, 6th ed, p1335; Rev Med Interne 1997;18(7):553-62)
Anemia, Diamond-blackfan
A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94)
