Tissue Growth Factors BMP 2 - Biotech, Pharma and Life Science Channel
The classical tissue factors typically are proteins used for tissue repair and growth stimulation. Among the approved products are the growth factors PDGF, IGF, EGF, BMP and FGF. One of the commercially most successful growth factors is BMP-2 from Medtronic and Pfizer (ex Wyeth) with annual sales of nearly US$ 800 mln and prospect for further growth by use in additional indications. Growth factors are used for treatment of growth failure, skin wounds and ulcers, corneal damage, oral mucositis or to stimulate bone growth. Further growth factors such as HGF, VEGF, TGF, NGF, GDF and quite a number of neurotrophic factors are under development. Apart from proteins as the classical drugs, other classes of compounds are also under development such as small molecules to stimulate growth factor receptors or antibodies to block inhibitory pathways, thereby inducing functional recovery. Furthermore, engineered peptides mimicking growth factors, cells engineered to express growth factors or simply plasmids for growth factors are under development.
News Articles
Safeguard Scientifics Annual Meeting of Shareholders to Be Held on Thursday, May 23 at 8:00 A.M. EDT
Safeguard Scientifics, Inc. (NYSE:SFE), a holding company that builds value in growth-stage healthcare and technology companies, today announced that its annual meeting of...
St. Jude Medical to Present at the 38th Annual Deutsche Bank Health Care Conference
St. Jude Medical, Inc. (NYSE:STJ) will present at the 38th Annual Deutsche Bank Health Care Conference on Wednesday, May 29, in Boston. John Heinmiller, executive vice president,...
NORTH BRUNSWICK, N.J., May 21, 2013 /PRNewswire/ -- Hurel Corporation ("Hurel"), a world-leading provider of advanced artificial tissue constructs and microfluidic cell-based assay platforms, today an...
RBCC Opens Talks to Acquire Tech Innovators in $142 Billion Drug Delivery Market
As part of the company’s push to carve out a share of the $142 billion U.S. drug delivery market, Rainbow Coral Corp. (OTCBB: RBCC) opened talks this week to potentially partner...
BioRestorative Therapies, Inc. to Present at the Marcum MicroCap Conference
JUPITER, Fla., May 21, 2013 /PRNewswire/ -- BioRestorative Therapies, Inc. ("BRT" or the "Company") (OTC BB: BRTX), a life sciences company focused on developing stem cell based therapies for var...
LA JOLLA, Calif., May 21, 2013 (GLOBE NEWSWIRE) -- Innovus Pharmaceuticals, Inc., ("Innovus Pharma") www.innovuspharma.com (OTCBB:INNV), today announced that Dr. Bassam Damaj, Chief Executive Officer...
Medistem, Inc. Appoints Herm Rosenman to Board of Directors
SAN DIEGO, CA -- (Marketwired) -- 05/21/13 -- Medistem, Inc. (PINKSHEETS: MEDS), today announced that it has appointed Herm Rosenman to its Board of Directors and Chairman of the Audit Committee. Mr....
CHARLESTON, SC--(Marketwired - May 21, 2013) - Revolutions Medical Corporation ("Revolutions Medical" or the "Company") (OTCQB: RMCP) has received a 12 million unit contract of its RevVac™ auto-ret...
RTI Donor Services, a not-for-profit tissue recovery network, announced today the opening of a new Florida division working with hospitals and medical examiners in Florida to prov...
MiMedx Secures a $3.0 Million Revolving Line of Credit with Bank of America
KENNESAW, Ga., May 20, 2013 /PRNewswire/ -- MiMedx Group, Inc. (NASDAQ: MDXG), an integrated developer, manufacturer and marketer of patent protected regenerative biomaterials and bioimplants pro...
Events
Payer Strategies for Emerging Markets
Understand payer needs, build robust partnerships and drive profit growth.
Stem Cells & Cell Therapy Summit
Select Biosciences' Stem Cells & Cell Therapy Summit is focused on providing an up-to-date expansive view of the current marketplace
This conference will discuss the wide range of cutting edge research being conducted using Microarray technologies in various scientific fields.
Companies
Based in Princeton, N.J., and Paris, Stentys has developed a new generation of stents for the treatment of acute myocardial infarction. Founded by Jacques Séguin, M.D., Ph.D.,...
CSA Medical has advanced the proven science of cryotherapy. With the CryoSpray Ablation System, physicians have the ability to quickly and easily freeze, destroy and remove unwanted tissue, freeing pa...
Promedior has developed a novel drug discovery platform to regulate the monocyte-derived cell populations that play key roles in fibrotic, inflammatory and autoimmune diseases. By...
IRI Consulting provides strategic insights and actionable recommendations to leverage growth with support from IRIâs proprietary, granular data, analytics and technology asse...
BIO and ABFA and ABO and A4A and AFBF and Growth Energy and Pew Charitable Trusts
BIO represents more than 1,100 biotechnology companies, academic institutions, state biotechnology centers and related organizations across the United States and in more than 30 o...
Provectus Pharmaceuticals, Inc.
Provectus Pharmaceuticals specializes in developing oncology and dermatology therapies. Its lead oncology agent, PV-10, is designed to selectively target and destroy cancer cells...
RXi Pharmaceuticals Corporation
RXi Pharmaceuticals Corporation (OTC: RXII) is a biotechnology company focused on discovering, developing and commercializing innovative therapies based on its proprietary, next-generation RNAi plat...
BioNova - The Nova Scotia Biotechnology and Life Sciences Industry Association
BioNova was incorporated in 1993 in response to rapid growth in Nova Scotia’s biotechnology and life sciences sector. Since that time, we have advanced alongside our members to offer advocacy and de...
BSD Medical Corporation develops, manufactures, markets and services systems to treat cancer and benign diseases using heat therapy delivered using focused radio frequency (RF) an...
The GfK Group (GfK = Growth from Knowledge) is a well-respected member of the global market research industry. Established more than 70 years ago, originally as the non-profit "Association for Consume...
Clinical Trials
Pelvic Pain in Women With Endometriosis
This study will examine pelvic pain associated with endometriosis and explore better approaches to treatment. In women with endometriosis, uterine tissue grows outside the uterus. Standa...
Cell Lines From High-Risk Breast Tissue
Background: - Many risk factors for breast cancer have been identified, including family history, endocrine background, changes in breast tissue, cancer in one breast, radiation...
Immune Response to Hepatitis C Virus
This study will identify and characterize immune factors involved in hepatitis C infection and elimination of the virus. Individual responses to hepatitis C infection vary; some people ar...
Pamidronate to Treat Osteogenesis Imperfecta in Children
This study will evaluate the effect of pamidronate-a drug that decreases bone resorption (breakdown)-on osteogenesis imperfecta. This is a genetic disorder of collagen, the major protein...
Vorinostat and Gemcitabine in Treating Patients With Metastatic or Unresectable Solid Tumors
This phase I trial is studying the side effects and best dose of vorinostat and gemcitabine in treating patients with metastatic or unresectable solid tumors. Drugs used in chemotherapy, s...
This study will evaluate the safety and effectiveness of insulin-like growth factor-1 (IGF-1) to treat patients with X-linked severe combined immunodeficiency (XSCID). Those who have XSCID...
Tipifarnib may stop the growth of breast cancer by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as paclitax...
RATIONALE: Dutasteride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well dutasteride works in tr...
RATIONALE: Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well dasatinib works in treati...
Left Atrial Appendage Occlusion Study II
A pilot, multicentre randomized controlled study of surgical left atrial occlusion (LAA) in 50 patients with atrial fibrillation/flutter undergoing cardiac surgery requiring cardiopulmonar...
PubMed Articles
Antisense oligonucleotides (oligos) have been employed against prostate cancer models in both in vivo and in vitro systems. While most target growth factors or their receptors, other oligos are direct...
Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon.
Mucosa-associated lymphoid tissue (MALT)-type lymphomas most commonly occur in the stomach and have been associated with Helicobacter pylori infection. However, MALT-type lymphoma of the colon is a ra...
Prognostic value of proliferation markers expression in breast cancer.
In this study, immunohistochemical expression of five proliferation markers: Ki-67, aurora-A kinase, survivin, B-Myb and cyclin B1, was analyzed. Consecutive 215 tumor samples from breast cancer patie...
Hepatoma-derived growth factor (HDGF), a heparin-binding growth factor, has a wide range of biological functions, including mitogenic activity and vascular development. Recent studies demonstrated tha...
The human papillomavirus (HPV) vaccine helps to prevent cervical cancer. However, research indicates that public acceptance of the vaccine is suboptimal. Our aims were to evaluate the willingness of U...
PTPN4 negatively regulates CrkI in human cell lines.
PTPN4 is a widely expressed non-receptor protein tyrosine phosphatase. Although its overexpression inhibits cell growth, the proteins with which it interacts to regulate cell growth are unknown. In th...
Visualization of thermal ablation lesions using cumulative dynamic contrast enhancement MRI.
A novel robust and user friendly method for post-processing dynamic contrast enhanced (DCE) MRI data is presented, which provides reliable real-time delineation of the borders of thermal ablation lesi...
The conversion of absorbed dose-to-graphite in a graphite phantom to absorbed dose-to-water in a water phantom is performed by water to graphite stopping power ratios. If, however, the charged particl...
Microwave ablation is a technique used in treating hepatocellular carcinoma, especially in cases where surgical removal is impossible. In the present study we are investigating the effects of design c...
A simulative study was performed to measure the dielectric properties of anisotropic tissue using several in vivo and in vitro probes. COMSOL Multiphysics was selected to carry out the simulation. Fi...
Videos
USC Dentistry: International Periodontal & Implant Symposium 2011 (Aghaloo)
Tara Aghaloo presented a lecture titled "BMP-2 and Other Growth Factors for Craniofacial Reconstruction" as part of the 36th annual USC Periodontal and Impla...
Medical and Biotech [MESH] Definitions
Immunity, Herd
The non-susceptibility to infection of a large group of individuals in a population. A variety of factors can be responsible for herd immunity and this gives rise to the different definitions used in the literature. Most commonly, herd immunity refers to the case when, if most of the population is immune, infection of a single individual will not cause an epidemic. Also, in such immunized populations, susceptible individuals are not likely to become infected. Herd immunity can also refer to the case when unprotected individuals fail to contract a disease because the infecting organism has been banished from the population.
Directed Tissue Donation
Tissue, organ, or gamete donation intended for a designated recipient.
Duty To Recontact
The ethical and/or legal obligation of a health provider or researcher to communicate with a former patient or research subject about advances in research relevant to a treatment or to a genetic or other diagnostic test provided earlier, or about proposed new uses of blood or tissue samples taken in the past for another purpose.
Microscopy, Acoustic
A scientific tool based on ULTRASONOGRAPHY and used not only for the observation of microstructure in metalwork but also in living tissue. In biomedical application, the acoustic propagation speed in normal and abnormal tissues can be quantified to distinguish their tissue elasticity and other properties.
Ovulation Inhibition
Blocking the process leading to OVULATION. Various factors are known to inhibit ovulation, such as neuroendocrine, psychological, and pharmacological agents.
