Toll Like Receptor TLR - Biotech, Pharma and Life Science Channel
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. TLRs have become attractive targets for activation or antagonism in pharmaceutical research. TLR agonists find use either alone or as adjuvants in combination with vaccine antigens. TLR antagonists are also under development for diseases with overwhelming immune response. Special attention has focused on the role of TLR agonists as novel adjuvants in prophylactic and therapeutic vaccines. They enhance dendritic cell function and their ability to prime T cells. Agonists that target toll-like receptors are being used clinically either alone or in combination with tumor antigens and showing initial success both in terms of enhancing immune responses and eliciting antitumor activity. TLR agonists and adjuvants are being investigated in a number of other therapeutic areas, such as in allergy, skin or infectious diseases.
News Articles
Patheon Announces Date of Fiscal 2013 Second Quarter Financial Results
TORONTO, May 20, 2013 /PRNewswire/ - Patheon Inc. (TSX: PTI), a leading provider of contract development and commercial manufacturing services to the global pharmaceutical industry, announced today...
Nexus Legal Cash Announces Sponsorship of TVT-NO! Foundation
YONKERS, N.Y., May 20, 2013 /PRNewswire/ -- Nexus Legal Cash, the legal funding company, is delighted to announce a landmark sponsorship of TVTNO.org, a not for profit organization that was creat...
UnitedHealth Group Acts to Support Texans Affected by Tornadoes
Assistance for UnitedHealthcare plan participants whose access to care may have been affected Free emotional-support help line from Optum...
Merck Prices $ 6.5 Billion Debt Offering
Merck & Co., Inc. priced today a $6.5 billion public offering of senior unsecured notes. The notes include: $1,000 million of 0.70% notes due May 2016$500 million of...
Tenet Healthcare Corporation (NYSE: THC) announced today that it commenced a tender offer to purchase for cash (the “Tender Offer”) any and all of the $925 million aggregate p...
Idera Pharmaceuticals Reports First Quarter 2013 Financial Results
Idera Pharmaceuticals, Inc. (NASDAQ: IDRA) today reported financial results for the quarter ended March 31, 2013. “Our next objective in Idera’s autoimmune dis...
Tokai Pharmaceuticals Announces $35.5 Million Series E Financing
Financing Reflects Encouraging Clinical Progress with Galeterone in Prostate Cancer Tokai Pharmaceuticals, Inc., a biopharmaceutical company focused on developin...
ATLANTA, May 15, 2013 /PRNewswire/ -- Galectin Therapeutics (NASDAQ: GALT) will host a conference call at 9:30 A.M. Eastern Time on Thursday, May 23, 2013, to provide an update following the Comp...
The U.S. Food and Drug Administration today approved the cobas EGFR Mutation Test, a companion diagnostic for the cancer drug Tarceva (erlotinib). This is the first FDA-approved companion diagnostic t...
VWR to Hold First Quarter 2013 Financial Results Conference Call
RADNOR, Pa., May 14, 2013 /PRNewswire/ -- VWR Funding, Inc., the parent company of VWR International, LLC, a global provider of laboratory supplies, equipment and services, will hold a conference...
Events
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Companies
Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The companyâs lead drug candidate, TOK-001, is the first i...
Izun Pharmaceuticals Corporation
Izun Pharmaceuticals is a US based pharmaceutical company with a wholly owned R&D center in Israel. Izunâs technology platform allows it to develop botanical drugs by optimiz...
Opsona is a leading immunology drug development company, focused on novel therapeutic approaches to key targets of the innate immune system associated with a wide range of majo...
WorkflowOne provides print production and document management, billing and customer communication, marketing solutions and promotional strategies, and fulfillment and distribution...
Therapy Source, a premier therapy staffing provider, offers highly qualified speech, occupational, physical, psychological and related therapy services to educational and healthca...
Founded in 1998, HealthWyse, LLC provides integrated clinical and financial information software and services to home health, hospice and private duty agencies nationwide. The Hea...
First 5 Commission of San Diego
The first five years of life are critical to a childâs development. These years shape a childâs success in school and in life. First 5 San Diego helps parents and others...
Andover Wellness Group is a community-based organization that focuses on health and wellness by deploying the concept of preventive healthcare as its mantra. We passionately belie...
The first five years of life are critical to a child's development. These years shape a child's success in school and in life. First 5 San Diego helps parents and others help chil...
SilverTree Health is the premier provider of medical insurance reimbursement and practice management resources. Our powerful service for providers combines proprietary Web-based p...
Clinical Trials
RATIONALE: Aromatase inhibitors, such as letrozole, prevent the formation of estradiol, a female hormone. Giving letrozole together with goserelin, leuprolide, or surgery may be an effecti...
Usefulness of Myocardial Deformation Imaging for Trastuzumab-induced Cardiotoxicity
Trastuzumab prolongs survival in patients with human epidermal growth factor receptor type 2-positive breast cancer. Sequential left ventricular (LV) ejection fraction (EF) assessment has...
D-Serine Monotherapy for Schizophrenia
N-methyl-D-aspartate receptor (NMDAR) agonist, added to classical or atypical antipsychotic medication, has reduced negative, depressive, and cognitive symptomatology. We will be investiga...
D-Serine Adjuvant Treatment for Parkinson's Disease
The proposed experiment will evaluate the effects of the NMDA receptor full agonist D-serine (~2g/day) on persistent symptoms of Parkinson's Disease and on antiparkinsonian drugs-induced d...
The Use of Kineret (Anakinra) in the Treatment of Familial Cold Urticaria
An open labelled trial of Kineret (anakinra) induction therapy (100mg./day) in over a four week period in the treatment of Familial Cold Urticaria. Familial Cold Urticaria (FCU) is a rare...
Adenoscan® (adenosine) is an approved pharmacological stress agent indicated as an adjunct to thallium-201 myocardial perfusion scintigraphy in patients unable to exercise adequately. Th...
This feasibility study is designed to examine modulation of the relative activities of ACE and ACE2 in diabetic patients following treatment with the angiotensin type 1 receptor (AT1R) ant...
Cisplatin and ZD1839 + Re-Irradiation in Recurrent Squamous Cell Cancer of the Head and Neck
To determine safety profile of the epidermal growth factor receptor (EGFR) antagonist, ZD1839 in combination with cisplatin and radiation therapy in patients with local-regional recurrent...
The Effect of Caffeine on Ischemic Preconditioning
Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia render the (myocardial) muscle more resistant to a subsequent more prolonged period of ischaemia and...
Nicotinic Acid - Pharmacokinetics, Pharmacodynamics, Receptor Expression
The study will be a double-blind, randomized, placebo-controlled, single-center, 2 treatment, 3-way crossover. Subjects will be randomly allocated to a treatment sequence – AAB, ABA or...
PubMed Articles
p73 gene shares structural and functional similarities to p53 and plays an important role in modulating cell cycle arrest and apoptosis. A common non-coding polymorphism of p73 G4C14-to-A4T14 (rs22739...
P2Y12 receptor inhibition augments cytotoxic effects of cisplatin in breast cancer.
Expression of P2Y12 receptors has been documented in some cancer cell lines like C6 glioma, renal carcinoma and colon carcinoma. However, its direct role in altering response to chemotherapeutics has...
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies in men and the second leading cause of male cancer mortality. MAZ (Myc-associated zinc-finger protein) is a transcription facto...
Tristetraprolin suppresses AHRR expression through mRNA destabilization.
The aryl hydrocarbon receptor repressor (AHRR) inhibits the transcription of the aryl hydrocarbon receptor (AHR) by binding to XRE. We report that AHRR expression is inhibited by tristetraprolin (TTP)...
Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds.
Diabetes mellitus, characterised by hyperglycemia and altered β-cell function, is an increasingly common disorder affecting millions of individuals world-wide. While therapeutic regimens exist to man...
The steroid and xenobiotic receptor (SXR) regulates the transcription of its target genes by interacting with various nuclear receptor cofactors. We have previously shown that silencing mediator for r...
The deposition of β-amyloid (Aβ) in neurons and vascular cells of the brain has been characterized in Alzheimer's disease. Ginsenoside Rg1 (Rg1) is an active components in Panax ginseng, a famous tr...
δGABAA receptors promote memory and neurogenesis in the dentate gyrus.
Objective: Extrasynaptic γ-aminobutyric acid type A receptors that contain the δ subunit (δGABAA receptors) are highly expressed in the dentate gyrus (DG) subfield of the hippocampus, where they ge...
Estrogen receptor α (ERα) has been reported to play a critical role in promoting the growth of breast tumor cells. In the present study, we explored the effect of Huaier extract on estrogen recepto...
ADAM12-cleaved ephrin-A1 contributes to lung metastasis.
Eph receptor tyrosine kinases and their ephrin ligands have been implicated in neuronal development and neovascularization. Overexpression of ephrin-A1 has been implicated in tumor progression and poo...
Videos
Immune Response, Toll Like Receptors (TLR) Pathway - IMGENEX
Watch The second Video in the TLR Series!!!! - Don't for get to Like and Follow! http://youtu.be/d0fgMaQfAQw http://www.imgenex.com Toll Like Receptors: The ...
Medical and Biotech [MESH] Definitions
Transferrin-binding Protein A
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN B.
Transferrin-binding Protein B
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN A.
Bacterial Transferrin Receptor Complex
A complex of proteins that forms a receptor for TRANSFERRIN in BACTERIA. Many pathogenic bacteria utilize the transferrin-binding complex to acquire their supply of iron from serum.
Receptors, Eph Family
A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this family of proteins derives from original protein Eph (now called the EPHA1 RECEPTOR), which was named after the cell line it was first discovered in: Erythropoietin-Producing human Hepatocellular carcinoma cell line. Members of this family have been implicated in regulation of cell-cell interactions involved in nervous system patterning and development.
Receptor, Epha1
The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.
