Tricuspid Regurgitation - Biotech, Pharma and Life Science Channel
Tricuspid regurgitation (tricuspid incompetence, tricuspid insufficiency) is leakage of blood backward through the tricuspid valve each time the right ventricle contracts.Tricuspid regurgitation is caused by disorders that enlarge the right ventricle. Symptoms are vague, such as weakness and fatigue. Doctors suspect the diagnosis because of physical examination findings, and they use echocardiography to confirm the diagnosis. The underlying disorder needs to be treated.
As the right ventricle contracts to pump blood forward to the lungs, some blood leaks backward into the right atrium, increasing the volume of blood there and resulting in less blood being pumped through the heart and to the body. As a result, the right atrium enlarges, and blood pressure increases in the right atrium and the large veins that enter it from the body. The liver may swell because of this increased pressure. Enlargement of the right atrium also can result in atrial fibrillation, a rapid, irregular heartbeat. Eventually, heart failure develops.
Tricuspid regurgitation usually results when the right ventricle enlarges and resistance to blood flow from the right ventricle to the lungs is increased. Resistance may be increased by a severe, long-standing lung disorder, such as emphysema or pulmonary hypertension, by disorders involving the left side of the heart, or rarely by narrowing of the pulmonary valve (pulmonic stenosis). To compensate, the right ventricle enlarges, stretching the tricuspid valve and causing regurgitation. Other, less common causes are infection of the heart valves (infective endocarditis most often due to intravenous injection of illicit drugs), use of fenfluramine (no longer available), birth defects of the tricuspid valve, injury, and myxomatous degeneration (a hereditary disorder in which the valve gradually becomes floppy).
Tricuspid regurgitation can cause vague symptoms, such as weakness and fatigue. They develop because the heart is pumping a smaller amount of blood. Usually, the only other symptoms are pulsations in the neck from the elevated right atrial pressure and discomfort in the right upper part of the abdomen due to an enlarged liver. Heart failure results in accumulation of fluid in the body, mainly in the legs.
The diagnosis is based on the person's medical history and results of a physical examination, electrocardiography (ECG), and chest x-ray. Usually, mild tricuspid regurgitation requires little or no treatment. However, the underlying disorder, such as emphysema, pulmonary hypertension, pulmonic stenosis, or abnormalities of the left side of the heart, is likely to require treatment. Treatment of atrial fibrillation and heart failure is also necessary, but surgery to repair the tricuspid valve is rarely done unless surgery on another heart valve (for example, mitral valve replacement) is also needed.
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PubMed Articles
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Videos
Tricuspid Regurgitation Health Byte
Tricuspid regurgitation is a heart condition wherein the tricuspid valve fails in systole. Learn about the different causes, symptoms, and treatments for Tri...
Medical and Biotech [MESH] Definitions
Endocardial Cushions
A fetal heart structure that is the bulging areas in the cardiac septum between the HEART ATRIA and the HEART VENTRICLES. During development, growth and fusion of endocardial cushions at midline forms the two atrioventricular canals, the sites for future TRICUSPID VALVE and BICUSPID VALVE.
Systolic Murmurs
Heart murmurs which are systolic in timing. They occur between the first and the second HEART SOUNDS, between the closure of MITRAL VALVE and TRICUSPID VALVE and the closure of semilunar aortic and pulmonary valves. Systolic murmurs include ejection murmurs and regurgitant murmurs.
Regurgitation, Gastric
GASTROESOPHAGEAL REFLUX wherein the retrograde flow passes through the UPPER ESOPHAGEAL SPHINCTER
Tricuspid Valve
The valve consisting of three cusps situated between the right atrium and right ventricle of the heart.
Tricuspid Valve Insufficiency
Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.
