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Triggers - Biotech, Pharma and Life Science Channel

10:08 EDT 26th July 2016 | BioPortfolio

PubMed Articles [538 Associated PubMed Articles listed on BioPortfolio]

Priming Endothelial Cells With a Melanoma-Derived Extracellular Matrix Triggers the Activation of αvβ3/VEGFR2 Axis.

The unique composition of tumor-produced extracellular matrix (ECM) can be a determining factor in changing the profile of endothelial cells in the tumor microenvironment. As the main receptor for ECM...

Ageing is a process where the growth effect of neuronal noradrenaline changes progressively in favour of the flow mediated, neurodegenerative and inflammatory effect of plasma noradrenaline.

The noradrenaline stimulus has two components, one excitor, the other inhibitory. Neuronal noradrenaline is the excitor component and plasma noradrenaline is the inhibitory. The balance of effect betw...

Pragmatic randomised controlled trial of an allergy intervention for children aged 6 to 16 with asthma and rhinitis in general practice.

It is widely believed that for allergic rhinitis and asthma, avoidance of specific triggers can improve symptom control. Whilst many children with asthma or rhinitis are sensitised to airborne allerge...

A bactericidal calix4arene-based nanoconstruct with amplified NO photorelease.

A hydrophobic N-dodecyl-3-(trifluoromethyl)-4-nitrobenzenamine has been synthesized as a suitable NO photodonor and encapsulated in a nanocontainer based on a polycationic calix[4]arene derivative, le...

Revisiting the role of the Gcm transcription factor, from master regulator to Swiss army knife.

Master genes are known to induce the differentiation of a multipotent cell into a specific cell type. These molecules are often transcription factors that switch on the regulatory cascade that trigger...

Erratum: Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.

CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice.

CD95 ligand (CD95L) is expressed by immune cells and triggers apoptotic death. Metalloprotease-cleaved CD95L (cl-CD95L) is released into the bloodstream but does not trigger apoptotic signaling. Hence...

Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injury.

Type 1 interferons (IFNs) promote inflammation in the skin but the mechanisms responsible for inducing these cytokines are not well understood. We found that IFN-β was abundantly produced by epiderma...

The Human Immune Response to HIV and Its Impact in the Potential Development of an Inactivated HIV Vaccine.

There is evidence that the transmission and acute phase of HIV infection triggers an immune response capable of controlling HIV subverted by the process of virus integration, essential to the replicat...

Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet.

Oxidative damage triggers extensive repair in gametes and thereafter in the zygote but it results in clinically relevant damage when affecting the maturation of the gametes chromatin, i.e. padlocking ...

News Articles [257 Associated News Articles listed on BioPortfolio]

Report Finds Students Face Barriers to Quick, Reliable Access to Lifesaving Asthma Medication in Schools

While asthma is a manageable disease, it's also the third leading cause of hospitalization among children under the age of 15. Report from American Lung Association finds many kids may not have qu...

Alzheimer's disease in HIV-positive patient

The first case of Alzheimer's disease diagnosed in an HIV-positive individual has been documented. The finding in a 71-year-old man triggers a realization about HIV survivors now reaching the age when...

First diagnosed case of Alzheimer's disease in HIV-positive individual presented at AAIC

The first case of Alzheimer's disease diagnosed in an HIV-positive individual will be presented in a poster session at the Alzheimer's Association International Conference 2016 in Toronto July 27. The...

Researchers identify and successfully activate neurons that tell the brain to stop drinking.

In alcoholism and addictive drugs repeated exposure triggers glutamatergic and GABAergic plasticity in many neuronal populations. The dorsomedial striatum (DMS), a brain region critically involved in ...

Pennsylvania Department of Health Awarded $2.5 Million Housing and Urban Development Grant for Lead-Based Paint Hazard Control

HARRISBURG, Pa., July 22, 2016 /PRNewswire-USNewswire/ -- Department of Health Secretary Dr. Karen Murphy announced today that the Pennsylvania Department of Health will be awarded $2.5 million i...

FDA's oral Relistor approval triggers Progenics milestone

Progenics Pharmaceuticals Inc. (NASDAQ:PGNX) gained $1.20 (24%) to $6.14 on Wednesday after it and partner Valeant Pharmaceuticals International Inc. (TSX:VRX; NYSE:VRX) said FDA approved oral Relisto...

Non-Europeans 'at an increased genetic risk of lupus'

People of non-European descent are genetically predisposed to be more likely to develop lupus, according to a new study.Carried out by the National Institute for Health Research Biomedical Research Ce...

GSK Exercises Five Prime License Option

Triggers $1.5 million payment for respiratory target

Wise-Anderson Protocol -- and the Role of Chronic Nervous System Arousal in Pelvic Floor Dysfunction

SAN FRANCISCO, CA --(Marketwired - July 15, 2016) - One of the major insights of the Wise-Anderson Protocol for the treatment of pelvic pain in pelvic floor dysfunction is that chronic autonomic nervo...

CV Triggers Are in the Very Air We Breathe

Drs Brook and Black discuss the health effects of air pollution, the majority of which are cardiovascular events. Medscape Cardiology

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Companies [3 Associated Companies listed on BioPortfolio]

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

Clinical Trials [83 Associated Clinical Trials listed on BioPortfolio]

Molecular Hydrogen for Cognitive Function and Performance in Elderly

A variety of non-pharmacological interventions have been used in the management of Alzheimer's disease (AD) and similar cognitive disorders in elderly, yet no therapeutic modality has demo...

Short-Term Outcomes of Different Suture Materials for Sclerotomy Closure

Small-incision vitrectomy techniques have become increasingly popular, with a number of advantages over the older 20-gauge instrumentation. The beveled wounds created by the 23- and 25-gau...

The Effects of Dexmedetomidine on Intestine and Other Organ Damages After Cardiac Surgeries

Cardiac surgery with cardiopulmonary bypass (CPB) provokes a systemic inflammatory response that can often lead to dysfunction of major organs. Activation of the contact system, endotoxemi...

Benfotiamine Effect on Advanced Glycation End Products(AGEs) and Soluble Receptors for AGEs(sRAGE) in Type 2 Diabetes Mellitus.

Several mechanisms have been implicated in the pathophysiology of the complications of diabetes mellitus (DM), one of them is the formation and accumulation of a heterogeneous group of com...

Effectiveness of a Driving Intervention on Safe Community Mobility for Returning Combat Veterans

The main objective of this study is to discern if an Occupational Therapy Driving Intervention (OT-DI) improves fitness to drive abilities of Combat Veterans and also investigate if result...

Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD

The current study will modify an already existing therapy for individuals with substance use disorders to address Post Traumatic Stress Disorder (PTSD) in women enrolled in substance use d...

Protective HA Factors

This is a naturalistic study of 100 migraineurs and 75 post concussive headache patients who will be asked to record their headaches, medications, sleep and other behaviors in a smartphone...

Preventing Risky Drinking in Veterans Treated With Prescription Opioids

Veterans who are taking prescription opioids for chronic pain and are engaging in risky drinking are at heightened risk for drug interactions, including overdose and other negative effects...

Response to Social Rejection in Suicidal Behavior

Suicide is a major health problem that causes annually a million death worldwild. In the stress-vulnerability model, suicidal behavior (SB) results from the interaction between an individu...

Asthma and Pest Control Study: Demonstrating Return-on-Investment for In-Home Pest Control for Children With Persistent Asthma

The New York City Department of Health and Mental Hygiene and Montefiore Medical Center, with the Fund for Public Health of New York (FPHNY), DOHMH's fiscal agent, are partnering on a stud...

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Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A technique that induces the processing of disturbing memories and experiences, by stimulating neural mechanisms that are similar to those activated during REM sleep. The technique consists of eye movements following side-to-side movements of the index and middle fingers, or the alternate tapping of the hands on the knees. This procedure triggers the processing of information, thus facilitating the connection of neural networks.

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