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Triggers - Biotech, Pharma and Life Science Channel

13:31 EDT 28th June 2017 | BioPortfolio

PubMed Articles [653 Associated PubMed Articles listed on BioPortfolio]

Expression of TLR2, NOD1, and NOD2 and the NLRP3 Inflammasome in Renal Tubular Epithelial Cells of Male versus Female Mice.

Gender-biased outcomes are associated with acute kidney injury (AKI) and human and animal studies have shown that females are preferentially protected from renal ischemia. However, the reason for this...

p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes.

To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombinatio...

Synthesis of functionalised azepanes and piperidines from bicyclic halogenated aminocyclopropane derivatives.

A series of 6,6-dihalo-2-azabicyclo[3.1.0]hexane and 7,7-dihalo-2-azabicyclo[4.1.0]heptane compounds were prepared by the reaction of dihalocarbene species with N-Boc-2,3-dihydro-1H-pyrroles or -1,2,3...

Salt Triggers the Simple Coacervation of an Underwater Adhesive When Cations Meet Aromatic π Electrons in Seawater.

Adhesive systems in many marine organisms are postulated to form complex coacervates (liquid-liquid phase separation) through a process involving oppositely charged polyelectrolytes. Despite this ubiq...

Development of a Trigger Tool to Identify Adverse Drug Events in Elderly Patients With Multimorbidity.

Elderly patients with multimorbidity are especially vulnerable to adverse drug events (ADEs) and had high prevalence rates. Identifying ADEs is essential for enabling timely interventions that can mit...

Endothelial nitric oxide synthase inhibition triggers inflammatory responses in the brain of male rats exposed to ischemia-reperfusion injury.

Nitric oxide (NO) derived from endothelial NO synthase (eNOS) plays a role in preserving and maintaining the brain's microcirculation, inhibiting platelet aggregation, leukocyte adhesion, and migratio...

Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections.

The innate immune system is the first line of defense against virus infection that triggers the expression of type I interferon (IFN) and proinflammatory cytokines. Pattern recognition receptors (PRRs...

Antenatal dexamethasone exposure differentially affects distinct cortical neural progenitor cells and triggers long-term changes in murine cerebral architecture and behavior.

Antenatal administration of synthetic glucocorticoids (sGC) is the standard of care for women at risk for preterm labor before 34 gestational weeks. Despite their widespread use, the type of sGC used ...

MerTK as a therapeutic target in glioblastoma.

Glioma-associated macrophages and microglia (GAMs) are components of the glioblastoma (GBM) microenvironment that express MerTK, a receptor tyrosine kinase that triggers efferocytosis and can suppress...

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

Intrahepatic cholangiocarcinoma (ICC) is a highly malignant, heterogeneous cancer with poor treatment options. We found that mitochondrial dysfunction and oxidative stress trigger a niche favoring cho...

News Articles [225 Associated News Articles listed on BioPortfolio]

Sleep Easily Announces Fourth of July Price Reduction on all Products

BOULDER, Colo., June 28, 2017 /PRNewswire/ -- Sleep Easily (sleepeasily.com), a proven, natural sleep solution, announced a special for 50% off its All-in-One Sleep Kit. Sleep Easily is a prov...

London apartment tower fire triggers emergency inspections, evacuations

The deaths of 79 people in a London apartment tower have triggered emergency inspections, evacuations and soul searching among British officials who failed to prevent the tragedy.

Mechanism Shown to Reverse Disease in Arteries

NEW YORK, June 27, 2017 /PRNewswire-USNewswire/ -- A certain immune reaction is the key, not to slowing atherosclerosis like cholesterol-lowering drugs do, but instead to reversing a disease that grad...

Three-Time Gold Medalist Misty May-Treanor Teams Up with Abreva to Knock Out Cold Sores this Cold and Flu Season

PARSIPPANY, N.J., Dec. 6, 2012 /PRNewswire/ -- GlaxoSmithKline Consumer Healthcare today announced it is teaming up with Misty May-Treanor, three-time Olympic gold medalist in beach volleyball, in a c...

Medical News Today: Contact dermatitis: Triggers and treatment

The unpleasant itching of contact dermatitis may be experienced by everyone once in their lifetime, but what is it? How can it be treated?

Corbus Pharmaceuticals Announces Inclusion in Russell 3000(R) Index

NORWOOD, MA--(Marketwired - June 26, 2017) - Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) ("Corbus" or the "Company"), a clinical stage drug development company targeting rare, chronic, serio...

Risky Behavior Triggers Vicious Cycle for Vets With PTSD

FRIDAY, June 23, 2017 -- Reckless behavior could worsen post-traumatic stress disorder (PTSD) in veterans, a new report suggests. The study of more than 200 U.S. veterans with PTSD found that risky be...

European Hematology Association: Beziehung zwischen verspäteter Exposition mit üblichen ...

     (Logo: http://mma.prnewswire.com/media/524821/EHA_Logo.jpg) Referentin: Dr. Julia Hauer Beschäftigt bei: Klinik für Kinder-Onkologie, -Hämatologie und klinische Immunologie, Düss...

European Hematology Association: Delayed Exposure to Common Infections Causes Acute Leukemia of ...

     (Logo: http://mma.prnewswire.com/media/524821/EHA_Logo.jpg)     Presenter: Dr Julia Hauer Affiliation: Clinic for Pediatric Oncology, Haematology and Clinical Immunology, Düsseldo...

Parkinson?s Is Partly An Autoimmune Disease, Study Finds

First direct evidence that abnormal protein in Parkinson’s disease triggers immune response

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Companies [4 Associated Companies listed on BioPortfolio]

OsteoStrong

OsteoStrong leverages clinically researched osteogenic stimulation methodology to help people of all ages and fitness levels enhance bone health, balance, overall strength, and po...

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

Clinical Trials [109 Associated Clinical Trials listed on BioPortfolio]

Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis

Sarcoidosis is a multi-system granulomatous disorder that is triggered and influenced by gene-environment interactions. Although sarcoidosis predominantly affects the lungs in most cases, ...

Pharmacologically Triggered Migraine Without Aura and Neuroimaging

Migraine is a highly disabling disorder affecting 14% of the general population Worldwide and ranked as the 6th most debilitating disease worldwide by the WHO. One of the most fundamental ...

Acute Effect of Axulin on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans

Blood sugar levels are controlled by insulin, a hormone made by cells in the pancreas. After a normal meal, carbohydrates are broken down into glucose (blood sugar) which is absorbed from ...

Impact of Diet on Functional Gastrointestinal Symptoms

This cross-sectional survey study is to determine the prevalence of functional gastrointestinal (GI) disorders in the general population and to describe common triggers for food-related GI...

Study of Durvalumab (MEDI4736) After Chemo-Radiation for Microsatellite Stable Stage II-IV Rectal Cancer

This study is being done to look at the safety and response to the investigational drug durvalumab (MEDI4736) following chemo-radiation therapy for patients with MSS stage II to IV rectal ...

Asthma Breath Biomarker Assessment

This study aims to assess the feasibility of capturing data on exhaled breath compounds during an acute asthma exacerbation. In addition to assessing the feasibility of such a study the in...

Diabetes: Functional Medicine Approach vs. Usual Care

A Functional Medicine (FM) approach to diabetes care focuses on identifying and treating the etiologies for "imbalances in the core physiological systems."(1) If underlying triggers and im...

Personalized Dietary Intervention in Managing Bowel Dysfunction and Improving Quality of Life in Stage I-III Rectosigmoid Cancer Survivors

This pilot clinical trial studies how well personalized dietary intervention works in managing bowel dysfunction and improving quality of life in stage I-III rectosigmoid cancer survivors....

Internet Surveys and Their Impact on Adherence for Rosacea

An investigator-blinded, prospective, 6 month study of subjects with persistent erythema associated with active rosacea will be conducted in 20 subjects aged 18 years and older. All subjec...

Acute Effect of Salbutamol on Heart Rate and Blood Pressure During Exercise in Patients With Moderate or Severe Asthma and Healthy Subjects

Contextualization: Exercise is a common triggers of bronchospasm in patients with asthma and healthy subjects. To prevent these symptoms frequently they have to use Short-Acting Beta2-Agon...

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Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

System of psychological and/or therapeutic techniques used to control and or reduce the triggers, degrees, and effects of ANGER.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

Various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

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