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Triggers - Biotech, Pharma and Life Science Channel

13:13 EDT 30th July 2014 | BioPortfolio

PubMed Articles [592 Associated PubMed Articles listed on BioPortfolio]

Specific Interaction with Cardiolipin Triggers Functional Activation of Dynamin-Related Protein 1.

Dynamin-Related Protein 1 (Drp1), a large GTPase of the dynamin superfamily, is required for mitochondrial fission in healthy and apoptotic cells. Drp1 activation is a complex process that involves tr...

Regulation of natural mRNAs by the nonsense-mediated mRNA decay pathway.

The nonsense-mediated mRNA decay (NMD) pathway is a specialized mRNA degradation pathway that degrades select mRNAs. This pathway is conserved in all eukaryotes examined so far and it triggers the deg...

Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization.

BACKGROUND. Patients with mutations that inactivate kisspeptin signaling are infertile. Kisspeptin-54, the major circulating isoform of kisspeptin in humans, potently stimulates reproductive hormone s...

Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage.

During brain ischemia, an excessive release of glutamate triggers neuronal death through the overactivation of NMDA receptors (NMDARs); however, the underlying pathways that alter glutamate homeostasi...

Dynamically-Driven Enhancement of the Catalytic Machinery of the SARS 3C-Like Protease by the S284-T285-I286/A Mutations on the Extra Domain.

Previously we revealed that the extra domain of SARS 3CLpro mediated the catalysis via different mechanisms. While the R298A mutation completely abolished the dimerization, thus resulting in the inact...

Ectopic trypsin in the myocardium promotes dilated cardiomyopathy after influenza A virus infection.

We previously reported ectopic trypsin in the myocardium triggers acute myocarditis after influenza A virus (IAV) infection. As myocarditis is a common precursor to dilated cardiomyopathy (DCM), the a...

Edaravone Protects against Methylglyoxal-Induced Barrier Damage in Human Brain Endothelial Cells.

Elevated level of reactive carbonyl species, such as methylglyoxal, triggers carbonyl stress and activates a series of inflammatory responses leading to accelerated vascular damage. Edaravone is the a...

Epigenetic regulation of tissue factor inducibility in endothelial cell senescence.

Cellular senescence, a programmed state induced by multiple deleterious triggers, is characterised by permanent cell-cycle exit and altered gene expression and cell morphology. In humans it is conside...

Stress: perspectives on its impact on cognition and pharmacological treatment.

Stress in life is unavoidable, affecting everyone on a daily basis. Psychological stress in mammals triggers a rapidly organized response for survival, but it may also cause a variety of behavioral di...

Cell death in human articular chondrocyte: a morpho-functional study in micromass model.

Chondrocyte death and loss of extracellular matrix are the central features in articular cartilage degeneration during osteoarthritis pathogenesis. Cartilage diseases and, in particular, osteoarthriti...

News Articles [250 Associated News Articles listed on BioPortfolio]

House dust mites may be the primary trigger for allergy-associated respiratory problems in tropical urban environments

City life can be an assault on the senses—quite literally, in the case of allergies. The steady increase in global urbanization is mirrored by a growing prevalence of allergy-associated respiratory...

It takes two to court: Pheromone that triggers mating found in mice

The functions of two classes of pheromone receptors have been identified by researchers, who have also found pheromones crucial to triggering the mating process in mice. "Interestingly, the pheromone...

RxNetwork Brings the Next Generation Customer Care Connectivity to Pharmacies, Providers, and Patients

RxNetwork is showcasing their solution to the vexing problem of prescription non-adherence at Cardinal Health RBC 2014 in Washington, DC on July 23 – 26th. Utilizing familiar and user-friendly Mobil...

FDA approves Eagle's Ryanodex for malignant hyperthermia

FDA approved an NDA from Eagle Pharmaceuticals Inc. (NASDAQ:EGRX) for Ryanodex dantrolene to treat malignant hyperthermia. The company said it plans to launch the drug next month at a wholesale acquis...

Mislabeling Triggers Tablet Recall by American Health Packaging

American Health Packaging announced a voluntary nationwide recall of ibuprofen and oxcarbazepine tablets due to mislabeling on the inner unit dose blister packaging.

Genetic Mapping Triggers Hope for Schizophrenia

This 2013 file photo provided by Cardiff University shows Dr.Read more about Genetic Mapping Triggers Hope for Schizophrenia

Infertility: Novel Egg Maturation Method Shows Promise

A single injection of kisspeptin-54 triggers egg maturation sufficient to result in fertilization, embryo implantation, and successful live birth. Medscape Medical News

Genetic mapping triggers new hope on schizophrenia

New Link Between Obesity, Inflammation And Insulin Resistance

Sanford-Burnham Medical Research Institute Study finds that the NBR1 protein plays a critical role in regulating obesity-induced inflammation that leads to metabolic disease A new study by researche...

Insulators recruit histone methyltransferase dMes4 to regulate chromatin of flanking genes

Chromosomal domains in Drosophila are marked by the insulator-binding proteins (IBPs) dCTCF/Beaf32 and cofactors that participate in regulating long-range interactions. Chromosomal borders are further...

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Companies [3 Associated Companies listed on BioPortfolio]

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

Clinical Trials [48 Associated Clinical Trials listed on BioPortfolio]

Environmental Triggers Of Cardiometabolic Disease

The investigators posit that a multi-national collaborative effort with focused investigations in environments with the highest levels of exposure (developing countries such as China and I...

A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant

The purpose of this study is to compare treatment with the new drug sirolimus (SRL) versus the standard treatment with cyclosporine (CsA) or tacrolimus in children who have received kidney...

Electrical Stimulation to Improve Hand Function in Patients With Chronic Stroke

This study will determine whether an electric shock to the forearm can improve hand function in patients with chronic stroke and, if so, whether the improvement is related to brain reorgan...

ABR-217620 in Patients With Advanced Non-Small Cell Lung Cancer, Renal Clear Cell Carcinoma or Pancreatic Cancer

The drug ABR-217620 is a combination of two proteins, one that recognizes tumor cells and one that triggers an attack on the tumor cells by activating some white blood cells belonging to t...

An Evaluation of the Efficacy and Safety of Tegaserod 6 mg Bid Given Orally to Chinese Patients With Chronic Constipation

Tegaserod is an aminoguanidine indole compound and a member of a new class of 5-hydroxytryptamine (5-HT) agonists. Activation of 5-HT4 receptors triggers the release of neurotransmitters f...

Teaching Children With Asthma and Who Live in a Rural Setting How to Self-Manage Their Asthma

To determine if teaching rural children with asthma and their parents about appropriate medication use, asthma triggers unique to a rural setting and increasing access to medical care will...

Three New Methods for Diagnosing Pancreas Cancer

The purpose of this project is to evaluate and compare three new methods for diagnosis, staging, operability evaluation and treatment control of pancreas cancer. The investigators use cont...

Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo

Our data indicate that the CFTR-molecule functions as a transporter for sphingosine-1-phosphate and sphingosine or regulates the uptake of these sphingolipids by epithelial cells. The dist...

The Immune Reactivity of Biofilms in Vaginal Mesh Erosion.

Aging, birth trauma and extensive pelvic surgery are the causes known to cause advanced pelvic organ prolaspe, fecal as well as urinary incontinence. Surgical treatment is the last resort...

A Randomized, Double-blind, Placebo-controlled Multicenter Study to Assess the Efficacy, Safety and Tolerability of Tegaserod 2 mg Bid vs Placebo in Patients With Chronic Constipation

Idiopathic or functional constipation is a common disorder, affecting up to 20% of the population depending on demographic factors, the sampling situation and the definitions used. Constip...

Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A technique that induces the processing of disturbing memories and experiences, by stimulating neural mechanisms that are similar to those activated during REM sleep. The technique consists of eye movements following side-to-side movements of the index and middle fingers, or the alternate tapping of the hands on the knees. This procedure triggers the processing of information, thus facilitating the connection of neural networks.

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