Triggers - Biotech, Pharma and Life Science Channel

17:04 EST 22nd December 2014 | BioPortfolio

PubMed Articles [604 Associated PubMed Articles listed on BioPortfolio]

The G Protein-Coupled Receptor-Transient Receptor Potential Channel Axis: Molecular Insights for Targeting Disorders of Sensation and Inflammation.

Sensory nerves are equipped with receptors and ion channels that allow them to detect and respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins include G protein-coupled...

Redox-linked effects of green tea on DNA damage and repair, and influence of microsatellite polymorphism in HMOX-1: results of a human intervention trial.

Green tea has many reported health benefits, including genoprotective and antioxidant effects, but green tea has pro-oxidant activity in vitro. A tea-induced pro-oxidant shift that triggers cytoprotec...

Validation of triggers and development of a pediatric trigger tool to identify adverse events.

BackgroundLittle is known about adverse events (AEs) in pediatric patients. Record review is a common methodology for identifying AEs, but in pediatrics the record review tools generally have limited ...

Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil.

Alpha-lipoic acid (LA), which plays a pivotal role in mitochondrial energy metabolism, is an endogenous dithiol compound with an array of antioxidative functions. It has been shown that LA triggers ce...

In situ Amplification of Intracellular MicroRNA with MNAzyme Nanodevices for Multiplexed Imaging, Logic Operation, and Controlled Drug Release.

MicroRNAs (miRNAs), as key regulators in gene expression networks, have participated in many biological processes, including cancer initiation, progression, and metastasis, indicative of potential dia...

Optical Behavior of Substituted 4-(2'-Hydroxyphenyl)imidazoles.

A set of tetraarylimidazoles bearing 2-hydroxyphenyl substituent at position 4, as well as their models lacking intramolecular hydrogen bonds, was efficiently synthesized. Structural investigations pr...

Satellite DNA as a driver of population divergence in the red flour beetle Tribolium castaneum.

Tandemly repeated satellite DNAs are among most rapidly evolving sequences in eukaryotic genome, usually differing significantly among closely related species. By inducing changes in heterochromatin a...

Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice.

Machado-Joseph disease is a neurodegenerative disease without effective treatment. Patients with Machado-Joseph disease exhibit significant motor impairments such as gait ataxia, associated with multi...

Inhibition of the GTPase Rac1 mediates the anti-migratory effects of metformin in prostate cancer cells.

Cell migration is a critical step in the progression of prostate cancer to the metastatic state, the lethal form of the disease. The anti-diabetic drug metformin has been shown to display anti-tumoral...

The Central Role of cAMP in Regulating Plasmodium falciparum Merozoite Invasion of Human Erythrocytes.

All pathogenesis and death associated with Plasmodium falciparum malaria is due to parasite-infected erythrocytes. Invasion of erythrocytes by P. falciparum merozoites requires specific interactions b...

News Articles [218 Associated News Articles listed on BioPortfolio]

Winter-Specific Dry Skin Treatment: Cold Weather Skincare – Presented by Skincare-News.com

Dry skin is a common condition, especially in the winter. The latest article by Skincare-News discusses the symptoms and treatment options so that it is possible to enjoy the colder weather without ir...

Holiday Trimmings Can Trigger Allergies

SATURDAY, Dec. 20, 2014 (HealthDay News) -- The holidays can be anything but joyous for people with allergies when they contend with fresh trees, scented candles and other allergy triggers. "The dust...

Roche down on Phase III setbacks

Roche (SIX:ROG; OTCQX:RHHBY) fell CHF18.30 to CHF270.40 on Friday after reporting disappointing data from a Phase III trial of breast cancer drug Kadcyla ado-trastuzumab emtansine and discontinuing a ...

Altruistic behavior may be governed more by relationships than instincts, psychologist finds

Ever since the concept of altruism was proposed in the 19th century, psychologists have debated whether or not people are born into the world preprogrammed to be nice to others. Now, a pair of Stanfor...

Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma

Sarasota, FL (PRWEB) December 19, 2014 If you have ever been unable to breathe, or witnessed someone having difficulty breathing, you probably wished you had an arsenal of treatments to battle this...

An activated unfolded protein response promotes retinal degeneration and triggers an inflammatory response in the mouse retina

Orexo gets £5 million milestone for Abstral in Europe; Zubsolv continues strong growth in the USA

The annual sales in Europe of Abstral, a rapidly-disintegrating, sublingual formulation of fentanyl, have passed 60 million euros ($74.4 million) during 2014, which triggers a milestone payment of mil...

Report: Clearing rainforests distorts wind and water, packs climate wallop beyond carbon

(Burness Communications) A new study released today presents powerful evidence that clearing trees not only spews carbon into the atmosphere, but also triggers major shifts in rainfall and increased t...

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis

Intracellular recognition of non-self and also self-nucleic acids can result in the initiation of potent pro-inflammatory and antiviral cytokine responses. Most recently, cGAS was shown to be critical...

BIONOVA asks: Men Skincare is a necessity or a treat?

NEW YORK, Dec. 17, 2014 /PRNewswire/ -- The simple act of shaving causes constant stress and visible skin irritation: triggers non-inflammatory skin inflammation, a chronicle process undergoing in dee...

Events [0 Results]

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Companies [3 Associated Companies listed on BioPortfolio]

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

Clinical Trials [51 Associated Clinical Trials listed on BioPortfolio]

FAST Mapping During Atrial Fibrillation

Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide with a prevalence of 8% in the elderly. AF is responsible for frequent hospitalizations, stroke, heart failure and ...

Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit

The primary aim of the study is to evaluate consequences of frailty in critically ill patients. We hypothesize that a higher frailty index (based on published questionnaires) predicts a lo...

Aerosol IL-2 for Pulmonary Metastases

The goal of this clinical research study is find the highest tolerable dose of interleukin-2 (IL-2) that can be given as an inhaled mist to patients with lung metastases. The safety of thi...

Environmental Triggers Of Cardiometabolic Disease

The investigators posit that a multi-national collaborative effort with focused investigations in environments with the highest levels of exposure (developing countries such as China and I...

A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant

The purpose of this study is to compare treatment with the new drug sirolimus (SRL) versus the standard treatment with cyclosporine (CsA) or tacrolimus in children who have received kidney...

Triggers of Ventricular Arrhythmias (TOVA) Study

To investigate factors which trigger the discharge of implantable cardioverter-defibrillators (ICDs).

Electrical Stimulation to Improve Hand Function in Patients With Chronic Stroke

This study will determine whether an electric shock to the forearm can improve hand function in patients with chronic stroke and, if so, whether the improvement is related to brain reorgan...

ABR-217620 in Patients With Advanced Non-Small Cell Lung Cancer, Renal Clear Cell Carcinoma or Pancreatic Cancer

The drug ABR-217620 is a combination of two proteins, one that recognizes tumor cells and one that triggers an attack on the tumor cells by activating some white blood cells belonging to t...

Early Rehabilitation After Hip Fracture

The aim of this study is to compare a low versus high intensity physiotherapy early rehabilitation program combined with a low versus high dose vitamin D early rehabilitation program in a ...

An Evaluation of the Efficacy and Safety of Tegaserod 6 mg Bid Given Orally to Chinese Patients With Chronic Constipation

Tegaserod is an aminoguanidine indole compound and a member of a new class of 5-hydroxytryptamine (5-HT) agonists. Activation of 5-HT4 receptors triggers the release of neurotransmitters f...

Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A technique that induces the processing of disturbing memories and experiences, by stimulating neural mechanisms that are similar to those activated during REM sleep. The technique consists of eye movements following side-to-side movements of the index and middle fingers, or the alternate tapping of the hands on the knees. This procedure triggers the processing of information, thus facilitating the connection of neural networks.

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