Triggers - Biotech, Pharma and Life Science Channel

10:39 EDT 20th August 2014 | BioPortfolio

PubMed Articles [592 Associated PubMed Articles listed on BioPortfolio]

Specific Interaction with Cardiolipin Triggers Functional Activation of Dynamin-Related Protein 1.

Dynamin-Related Protein 1 (Drp1), a large GTPase of the dynamin superfamily, is required for mitochondrial fission in healthy and apoptotic cells. Drp1 activation is a complex process that involves tr...

Regulation of natural mRNAs by the nonsense-mediated mRNA decay pathway.

The nonsense-mediated mRNA decay (NMD) pathway is a specialized mRNA degradation pathway that degrades select mRNAs. This pathway is conserved in all eukaryotes examined so far and it triggers the deg...

Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization.

BACKGROUND. Patients with mutations that inactivate kisspeptin signaling are infertile. Kisspeptin-54, the major circulating isoform of kisspeptin in humans, potently stimulates reproductive hormone s...

Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage.

During brain ischemia, an excessive release of glutamate triggers neuronal death through the overactivation of NMDA receptors (NMDARs); however, the underlying pathways that alter glutamate homeostasi...

Dynamically-Driven Enhancement of the Catalytic Machinery of the SARS 3C-Like Protease by the S284-T285-I286/A Mutations on the Extra Domain.

Previously we revealed that the extra domain of SARS 3CLpro mediated the catalysis via different mechanisms. While the R298A mutation completely abolished the dimerization, thus resulting in the inact...

Ectopic trypsin in the myocardium promotes dilated cardiomyopathy after influenza A virus infection.

We previously reported ectopic trypsin in the myocardium triggers acute myocarditis after influenza A virus (IAV) infection. As myocarditis is a common precursor to dilated cardiomyopathy (DCM), the a...

Edaravone Protects against Methylglyoxal-Induced Barrier Damage in Human Brain Endothelial Cells.

Elevated level of reactive carbonyl species, such as methylglyoxal, triggers carbonyl stress and activates a series of inflammatory responses leading to accelerated vascular damage. Edaravone is the a...

Epigenetic regulation of tissue factor inducibility in endothelial cell senescence.

Cellular senescence, a programmed state induced by multiple deleterious triggers, is characterised by permanent cell-cycle exit and altered gene expression and cell morphology. In humans it is conside...

Stress: perspectives on its impact on cognition and pharmacological treatment.

Stress in life is unavoidable, affecting everyone on a daily basis. Psychological stress in mammals triggers a rapidly organized response for survival, but it may also cause a variety of behavioral di...

Cell death in human articular chondrocyte: a morpho-functional study in micromass model.

Chondrocyte death and loss of extracellular matrix are the central features in articular cartilage degeneration during osteoarthritis pathogenesis. Cartilage diseases and, in particular, osteoarthriti...

News Articles [244 Associated News Articles listed on BioPortfolio]

Md. Officials Vow To Have Marketplace Working In November

The online insurance website was plagued with problems during last year's enrollment season, but state officials say they are confident the $40 million reconstruction of the site will work. The Washin...

Worker bees 'know' when to invest in their reproductive future

(Springer) When a colony of honeybees grows to about 4,000 members, it triggers an important first stage in its reproductive cycle: the building of a special type of comb used for rearing male reprodu...

FDAnews Announces — Managing Risk for Clinical Trials: Incorporating Quality by Design and Risk Management Strategies Webinar, Sept. 9, 2014

With more than 50 years of combined experience, expert presenters Sherri Hubby and Brian Nugent will share insights that can be used to establish Risk Based Monitoring Plans, including triggers for re...

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

The polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types. However, loss-of-function mutations in PRC2 components occur in a subset of haematopoietic malignancies, suggest...

Cardioversion for New-Onset AF: Time to Hit the Pause Button?

A new study triggers memories of a patient who died following cardioversion, prompting Dr John Mandrola to question the safety of the 48-hour period after AF onset for cardioversion without antico...

Extremely high mold count triggers dangerous air quality alert

A dangerous air quality alert was called today due to the extremely high count for mold detected in the Gottlieb Allergy Count.

Cologuard gets green light from FDA, CMS

FDA approved Cologuard from Exact Sciences Corp. (NASDAQ:EXAS) as a non-invasive DNA screening test for colorectal cancer. Separately, CMS issued a proposed National Coverage Determination (NCD) for C...

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

Mammalian cells possess mechanisms to detect and defend themselves from invading viruses. In the cytosol, the RIG-I-like receptors (RLRs), RIG-I (retinoic acid-inducible gene I; encoded by DDX58) and...

Ragweed Detected For First Time In 2014 Gottlieb Allergy Count

Later summer triggers ragweed allergies in 10 to 20 percent of Americans and today spells misery for those with sensitive systems. Ragweed pollen was reported for the first time in the 2014 allergy re...

How to Record Data Quickly & Accurately With the Slam Stick X Data Logger

Mide Technology has launched a new configurable USB multifunction data logger to quickly and accurately record and analyze ±100g level tri-axial vibration, temperature, and pressure events at up...

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Companies [3 Associated Companies listed on BioPortfolio]

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

Clinical Trials [48 Associated Clinical Trials listed on BioPortfolio]

Environmental Triggers Of Cardiometabolic Disease

The investigators posit that a multi-national collaborative effort with focused investigations in environments with the highest levels of exposure (developing countries such as China and I...

A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant

The purpose of this study is to compare treatment with the new drug sirolimus (SRL) versus the standard treatment with cyclosporine (CsA) or tacrolimus in children who have received kidney...

Electrical Stimulation to Improve Hand Function in Patients With Chronic Stroke

This study will determine whether an electric shock to the forearm can improve hand function in patients with chronic stroke and, if so, whether the improvement is related to brain reorgan...

ABR-217620 in Patients With Advanced Non-Small Cell Lung Cancer, Renal Clear Cell Carcinoma or Pancreatic Cancer

The drug ABR-217620 is a combination of two proteins, one that recognizes tumor cells and one that triggers an attack on the tumor cells by activating some white blood cells belonging to t...

An Evaluation of the Efficacy and Safety of Tegaserod 6 mg Bid Given Orally to Chinese Patients With Chronic Constipation

Tegaserod is an aminoguanidine indole compound and a member of a new class of 5-hydroxytryptamine (5-HT) agonists. Activation of 5-HT4 receptors triggers the release of neurotransmitters f...

Teaching Children With Asthma and Who Live in a Rural Setting How to Self-Manage Their Asthma

To determine if teaching rural children with asthma and their parents about appropriate medication use, asthma triggers unique to a rural setting and increasing access to medical care will...

Three New Methods for Diagnosing Pancreas Cancer

The purpose of this project is to evaluate and compare three new methods for diagnosis, staging, operability evaluation and treatment control of pancreas cancer. The investigators use cont...

Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo

Our data indicate that the CFTR-molecule functions as a transporter for sphingosine-1-phosphate and sphingosine or regulates the uptake of these sphingolipids by epithelial cells. The dist...

The Immune Reactivity of Biofilms in Vaginal Mesh Erosion.

Aging, birth trauma and extensive pelvic surgery are the causes known to cause advanced pelvic organ prolaspe, fecal as well as urinary incontinence. Surgical treatment is the last resort...

A Randomized, Double-blind, Placebo-controlled Multicenter Study to Assess the Efficacy, Safety and Tolerability of Tegaserod 2 mg Bid vs Placebo in Patients With Chronic Constipation

Idiopathic or functional constipation is a common disorder, affecting up to 20% of the population depending on demographic factors, the sampling situation and the definitions used. Constip...

Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A technique that induces the processing of disturbing memories and experiences, by stimulating neural mechanisms that are similar to those activated during REM sleep. The technique consists of eye movements following side-to-side movements of the index and middle fingers, or the alternate tapping of the hands on the knees. This procedure triggers the processing of information, thus facilitating the connection of neural networks.

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