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Triggers - Biotech, Pharma and Life Science Channel

05:03 EDT 25th September 2016 | BioPortfolio

PubMed Articles [545 Associated PubMed Articles listed on BioPortfolio]

Priming Endothelial Cells With a Melanoma-Derived Extracellular Matrix Triggers the Activation of αvβ3/VEGFR2 Axis.

The unique composition of tumor-produced extracellular matrix (ECM) can be a determining factor in changing the profile of endothelial cells in the tumor microenvironment. As the main receptor for ECM...

Role of Cyclic Nucleotide Phosphodiesterases During Meiotic Resumption from Diplotene Arrest in Mammalian Oocytes.

Cyclic nucleotide phosphodiesterases (PDEs) are group of enzymes that hydrolyze cyclic nucleotides in wide variety of cell types including encircling granulosa cells as well as associated oocytes. One...

Increased Pain Communication following Multiple Group Memberships Salience Leads to a Relative Reduction in Pain-Related Brain Activity.

Pain is a fundamental human experience that triggers a range of social and psychological responses. In this study, we present behavioral and fMRI data to examine the effect of multiple group membershi...

A Systematic Review of Factors That Contribute to Nocebo Effects.

Medication side effects are common, often leading to reduced quality of life, nonadherence, and financial costs for health services. Many side effects are the result of a psychologically mediated "noc...

To Be Connected or Not To Be Connected? Mobile Messenger Overload, Fatigue, and Mobile Shunning.

With the increased adoption of mobile devices, mobile communication is all around us and we are connected anywhere, anytime. Mobile communication in general and mobile messenger service in particular ...

Hypertension and the eye.

Hypertension is the primary risk factor for cardiovascular disease and mortality that consists a major public health issue worldwide. Hypertension triggers a series of pathophysiological ocular modifi...

Why doesn't conventional IVF work in the horse?

In contrast to man and many other mammalian species, conventional in vitro fertilization (IVF) with horse gametes is not reliably successful. The apparent inability of stallion spermatozoa to penetrat...

Analysis of calcium transients and uni-axial contraction force in single human embryonic stem cell derived-cardiomyocytes on microstructured elastic substrate with spatially controlled surface chemistries.

The mechanical activity of cardiomyocytes is the result of a process called excitation contraction coupling (ECC). A membrane depolarization wave induces a transient cytosolic calcium concentration in...

Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors.

High rates of APOBEC-signature mutations are found in many tumors, but factors affecting this mutation pattern are not well understood. Here we explored the contribution of two common germline variant...

Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses.

The RNA interference (RNAi)-based therapeutic ARC-520 for chronic hepatitis B virus (HBV) infection consists of a melittin-derived peptide conjugated to N-acetylgalactosamine for hepatocyte targeting ...

News Articles [268 Associated News Articles listed on BioPortfolio]

Frontal Fibrosing Alopecia

Why are clinicians seeing an apparent increase in the incidence of frontal fibrosing alopecia? Might there be environmental triggers for this clinical variant of lichen planopilaris? Skin Therapy Le...

Sleep Easily to Exhibit at the 2nd Annual Sleep Technology Summit & Expo

BOULDER, Colo., Sept. 23, 2016 /PRNewswire/ -- Sleep Easily, Boulder, Colorado based sleep solution, is pleased to join The National Sleep Foundation (NSF) as exhibitor at  the 2nd Annual Sleep T...

Amount of gluten triggers genetic risk of celiac disease, research shows

The amount of gluten could be a more important clue than breast-feeding or the timing of the introduction of gluten for continued research into the causes of celiac disease (gluten intolerance).

PharmaMar submits Aplidin MAA

PharmaMar S.A. (Madrid:PHM) submitted an MAA to EMA for Aplidin plitidepsin in combination with dexamethasone to treat relapsed or refractory multiple myeloma (MM). In March, the company said the cand...

Cellular Mechanism Provides Explanation Model for Declining Memory Performance in Alzheimer's Disease

Alzheimer’s disease triggers memory and learning disorders. To date, the causes are poorly understood. Now, researchers of the German Center for Neurodegenerative Diseases (DZNE) are shedding light...

Allergan Targets Liver Disease Drugs with Tobira Acquisition

Botox-maker Allergan is bulking up its drug pipeline by acquiring Tobira Therapeutics Inc. and two potential liver disease treatments in a deal that could be worth almost $1.7 billion. Tobira is...

Unique Gut Microbiome Triggers AS, Research Hints

The differences in gut bacteria between carriers of the spondyloarthritis-linked HLA-B27 gene and noncarriers suggest a possible causative role in ankylosing spondylitis (AS), investigators report. ...

Corbus Pharmaceuticals to Present at the Jefferies Cystic Fibrosis Summit

NORWOOD, MA--(Marketwired - September 19, 2016) - Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) ("Corbus" or the "Company"), a clinical stage drug development company targeting rare, chronic, ...

Light causes drosophila to take longer midday nap

Fruit flies' activity peaks in the morning and late afternoon. The insects extend their midday siesta on long summer days. Researchers from the University of Würzburg have now discovered what trigger...

A blue-light photoreceptor mediates the feedback regulation of photosynthesis

In plants and algae, light serves both as the energy source for photosynthesis and a biological signal that triggers cellular responses via specific sensory photoreceptors. Red light is perceived by b...

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Companies [3 Associated Companies listed on BioPortfolio]

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

Clinical Trials [88 Associated Clinical Trials listed on BioPortfolio]

Evaluation and Characterization of Motion Sickness on Passengers Sailing on the Astrolabe

Sea sickness syndrome is present for 80% of persons on board when the boat rotation missions Astrolabe, sometimes there is a risk of very significant dehydration. A special unit specialize...

Impact of Neutrophil Extracellular Traps on Tissue Plasminogen Activator Induced Thrombolysis in Acute Ischemic Stroke Patients

Acute Ischemic stroke (AIS) remains a leading cause of adult disability, cognitive impairment and mortality worldwide despite the development of revascularization therapies (intravenous Ti...

Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With Pediatric Acute-Onset Neuropsychiatric Syndrome

This study is an investigation of the neurologic, immunologic, and rheumatologic markers of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS). PANS is a condition characterized by the...

EoE Food Desensitization

This is a single-center, prospective, pilot clinical trial in which children ages 5-17 years with eosinophilic esophagitis (EoE) who have a known food that triggers EoE flares receive oral...

Genetic Susceptibility and Influence of the Microbiome in Bullous Pemphigoid

Autoimmune bullous dermatoses include pemphigus, bullous pemphigoid, pemphigoid gestationis, linear IgA dermatosis, mucous membrane, lichen pemphigoid, anti-p200 pemphigoid, epidermolysis ...

Molecular Hydrogen for Cognitive Function and Performance in Elderly

A variety of non-pharmacological interventions have been used in the management of Alzheimer's disease (AD) and similar cognitive disorders in elderly, yet no therapeutic modality has demo...

Short-Term Outcomes of Different Suture Materials for Sclerotomy Closure

Small-incision vitrectomy techniques have become increasingly popular, with a number of advantages over the older 20-gauge instrumentation. The beveled wounds created by the 23- and 25-gau...

The Effects of Dexmedetomidine on Intestine and Other Organ Damages After Cardiac Surgeries

Cardiac surgery with cardiopulmonary bypass (CPB) provokes a systemic inflammatory response that can often lead to dysfunction of major organs. Activation of the contact system, endotoxemi...

Benfotiamine Effect on Advanced Glycation End Products(AGEs) and Soluble Receptors for AGEs(sRAGE) in Type 2 Diabetes Mellitus.

Several mechanisms have been implicated in the pathophysiology of the complications of diabetes mellitus (DM), one of them is the formation and accumulation of a heterogeneous group of com...

Effectiveness of a Driving Intervention on Safe Community Mobility for Returning Combat Veterans

The main objective of this study is to discern if an Occupational Therapy Driving Intervention (OT-DI) improves fitness to drive abilities of Combat Veterans and also investigate if result...

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Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A technique that induces the processing of disturbing memories and experiences, by stimulating neural mechanisms that are similar to those activated during REM sleep. The technique consists of eye movements following side-to-side movements of the index and middle fingers, or the alternate tapping of the hands on the knees. This procedure triggers the processing of information, thus facilitating the connection of neural networks.

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