Advertisement

Topics

Triggers - Biotech, Pharma and Life Science Channel

19:08 EDT 20th August 2017 | BioPortfolio

PubMed Articles [634 Associated PubMed Articles listed on BioPortfolio]

What is new in the pathophysiology of acne, an overview.

Acne is a chronic inflammatory disease of the pilosebaceous unit. Its pathophysiology includes hyperseborrhoea, abnormal follicular keratinization and Propionibacterium acnes proliferation in the pilo...

HDAC1 triggers the proliferation and migration of breast cancer cells via upregulation of interleukin-8.

Targeted inhibition of histone deacetylase (HDAC) is one of the potent anticancer therapy approaches. Our data showed that mRNA and protein levels of HDAC1 in breast cancer cells were greater than tha...

LPS-induced inflammatory response triggers cell cycle reactivation in murine neuronal cells through retinoblastoma proteins induction.

Cell cycle reactivation in adult neurons is an early hallmark of neurodegeneration. The lipopolysaccharide (LPS) is a well-known pro-inflammatory factor that provokes neuronal cell death via glial cel...

Nanomelatonin triggers superior anticancer functionality in a human malignant glioblastoma cell line.

Melatonin (MEL) has promising medicinal value as an anticancer agent in a variety of malignancies, but there are difficulties in achieving a therapeutic dose due to its short half-life, low bioavailab...

N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins.

Nearly one third of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N-glycosylated in the lumen of the endoplasmic reticulum. N-glycans fulfill multiple structur...

Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation.

The biogenesis of autophagosomes depends on the conjugation of Atg8-like proteins with phosphatidylethanolamine. Atg8 processing by the cysteine protease Atg4 is required for its covalent linkage to p...

Dasatinib reversibly disrupts endothelial vascular integrity by increasing non-muscle myosin II contractility in a ROCK-dependent manner.

Purpose: Dasatinib is a short-acting dual ABL/SRC family tyrosine kinase inhibitor (TKI), which is frequently used to treat chronic myeloid leukemia. Although very effective, dasatinib often displays ...

p53 non-genotoxic activation and mTORC1 inhibition lead to effective combination for neuroblastoma therapy.

mTORC1 inhibitors are promising agents for neuroblastoma therapy, however they have shown limited clinical activity as monotherapy, thus rational drug combinations need to be explored to improve effic...

Semaphorins and Their Roles in Airway Biology: Potential as Therapeutic Targets.

Semaphorins are a large family of proteins originally identified as axon guidance cues which play a crucial role in neural development. They are also ubiquitously expressed beyond the nervous system a...

Diflunisal inhibits prestin by chloride-dependent mechanism.

The motor protein prestin is a member of the SLC26 family of anion antiporters and is essential to the electromotility of cochlear outer hair cells and for hearing. The only direct inhibitor of electr...

News Articles [212 Associated News Articles listed on BioPortfolio]

CDK4/6 inhibition triggers anti-tumour immunity

Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initiation and progression of various malignancies. Pharmacological inhibitors of CDK4/6 ha...

[In Context] Flashing lights and poor funding: more than a headache

For many migraineurs, daily life can be a carefully choreographed routine of avoiding triggers. So to intentionally induce a migraine seems not only ill-advised, but also foolish. Yet, that is precise...

Trump's ObamaCare subsidy indecision triggers uncertainty over health care costs

Insurers’ final deadline to file rate requests or adjustments for 2018 in many states was pushed back to September as uncertainty over both health care policy and the future of key ObamaCare subsidy...

Death of baby dolphin triggers outrage in Spain

Spanish animal lovers reacted with fury on Wednesday after a baby dolphin approached a holiday beach, where it died as bathers played with it and took pictures.

Vectura Group to hook up with Dynavax to develop cancer treatment

Respiratory devices maker Vectura Group PLC (LON:VEC) has signed an exclusive global agreement with Dynavax Technologies Corporation (NASDAQ:DVAX), a clinical-stage immunotherapy company. The collab...

Key Factors Distinguish Transient Post-Stroke Symptoms

Investigators have identified key risk factors, triggers, and clinical features of transient post-stroke recrudescence in findings that may help clinicians distinguish this phenomenon from new stroke ...

From Thousands of Suspects, Scientists Ferret Out Cancer-causing Genes

NewsA Yale-led team of researchers has identified specific gene combinations that can cause the deadly brain cancer glioblastoma, using new technology that can also pinpoint triggers of other types ca...

Rooting out genes behind glioblastoma onset and development

A Yale-led team of researchers has identified specific gene combinations that can cause deadly brain cancer glioblastoma, using new technology that can also pinpoint triggers of other types cancers, t...

Researchers ID Genes in Mice That Cause Aggressive Brain Cancer

MONDAY, Aug. 14, 2017 -- Researchers say they've identified specific gene combinations that can cause the aggressive brain cancer glioblastoma in mice. Using new technology that can also identify gene...

From thousands of suspects, researchers ferret out cancer-causing genes

A Yale-led team of researchers has identified specific gene combinations that can cause deadly brain cancer glioblastoma, using new technology that can also pinpoint triggers of other types cancers, t...

Events [0 Results]

None

Companies [4 Associated Companies listed on BioPortfolio]

OsteoStrong

OsteoStrong leverages clinically researched osteogenic stimulation methodology to help people of all ages and fitness levels enhance bone health, balance, overall strength, and po...

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

Clinical Trials [113 Associated Clinical Trials listed on BioPortfolio]

Asthma Mobile Health Application 2.0

Mobile health applications (MHA) are increasingly being explored as tools to assist in management of chronic diseases. Little is known regarding which characteristics of MHAs are effective...

Pembrolizumab in Combination With Radiotherapy in Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

Lung cancer is the leading cause of cancer mortality worldwide and in the U.K alone; there are 38,000 new cases of non-small cell lung cancer (NSCLC) a year. The new treatment being teste...

Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas

Through this study, the investigators shall compare the effectiveness of atenolol with propranolol in the treatment of IH. In addition, the investigators shall try to elucidate the mechani...

GLOBAL LEADERS Adjudication Sub-Study

The GLOBAL LEADERS Adjudication Sub-StudY, GLASSY, is based on a re-assessment of all the events reported in the dataset of the parent trial (COMPARATIVE EFFECTIVENESS OF 1 MONTH OF TICAGR...

Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis

Sarcoidosis is a multi-system granulomatous disorder that is triggered and influenced by gene-environment interactions. Although sarcoidosis predominantly affects the lungs in most cases, ...

Pharmacologically Triggered Migraine Without Aura and Neuroimaging

Migraine is a highly disabling disorder affecting 14% of the general population Worldwide and ranked as the 6th most debilitating disease worldwide by the WHO. One of the most fundamental ...

Acute Effect of Axulin on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans

Blood sugar levels are controlled by insulin, a hormone made by cells in the pancreas. After a normal meal, carbohydrates are broken down into glucose (blood sugar) which is absorbed from ...

Impact of Diet on Functional Gastrointestinal Symptoms

This cross-sectional survey study is to determine the prevalence of functional gastrointestinal (GI) disorders in the general population and to describe common triggers for food-related GI...

Study of Durvalumab (MEDI4736) After Chemo-Radiation for Microsatellite Stable Stage II-IV Rectal Cancer

This study is being done to look at the safety and response to the investigational drug durvalumab (MEDI4736) following chemo-radiation therapy for patients with MSS stage II to IV rectal ...

Asthma Breath Biomarker Assessment

This study aims to assess the feasibility of capturing data on exhaled breath compounds during an acute asthma exacerbation. In addition to assessing the feasibility of such a study the in...

Videos

None available.

Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

System of psychological and/or therapeutic techniques used to control and or reduce the triggers, degrees, and effects of ANGER.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

Various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

Quick Search
Advertisement
 
review and buy Triggers market research data and corporate reports here

Channels Quicklinks