Triggers - Biotech, Pharma and Life Science Channel

23:34 EDT 26th March 2015 | BioPortfolio

PubMed Articles [599 Associated PubMed Articles listed on BioPortfolio]

Microfabricated microporous membranes reduce the host immune response and prolong the functional lifetime of a closed-loop insulin delivery implant in a type 1 diabetic rat model.

Implantation of a medical implant within the body inevitably triggers a host inflammatory response that negatively impacts its function and longevity. Nevertheless, the degree and severity of this res...

Ectopic Expression of a Neospora caninum Kazal Type Inhibitor Triggers Developmental Defects in Toxoplasma and Plasmodium.

Regulated proteolysis is known to control a variety of vital processes in apicomplexan parasites including invasion and egress of host cells. Serine proteases have been proposed as targets for drug de...

Splice Variants of Activation Induced Deaminase (AID) Do Not Affect the Efficiency of Class Switch Recombination in Murine CH12F3 Cells.

Activation Induced Deaminase (AID) triggers the antigen-driven antibody diversification processes through its ability to edit DNA. AID dependent DNA damage is also the cause of genetic alterations oft...

Imbalance in Fatty-Acid-Chain Length of Gangliosides Triggers Alzheimer Amyloid Deposition in the Precuneus.

Amyloid deposition, a crucial event of Alzheimer's disease (AD), emerges in distinct brain regions. A key question is what triggers the assembly of the monomeric amyloid ß-protein (Aß) into fibrils ...

Trastuzumab Triggers Phagocytic Killing of High HER2 Cancer Cells In Vitro and In Vivo by Interaction with Fcγ Receptors on Macrophages.

Trastuzumab has been used for the treatment of HER2-overexpressing breast cancer for more than a decade, but the mechanisms of action for the therapy are still being actively investigated. Ab-dependen...

Single Amino Acid Change in STING Leads to Constitutive Active Signaling.

The production of cytokines by the immune system in response to cytosolic DNA plays an important role in host defense, autoimmune disease, and cancer immunogenicity. Recently a cytosolic DNA signaling...

The GerW Protein Is Not Involved in the Germination of Spores of Bacillus Species.

Germination of dormant spores of Bacillus species is initiated when nutrient germinants bind to germinant receptors in spores' inner membrane and this interaction triggers the release of dipicolinic a...

Impacts of aqueous Mn(II) on the sorption of Zn(II) by hexagonal birnessite.

We used a combination of batch studies and spectroscopic analyses to assess the impacts of aqueous Mn(II) on the solubility and speciation of Zn(II) in anoxic suspensions of hexagonal birnessite at pH...

Gender related differences in clinical profile and outcome of patients with heart failure. Results of the RICA Registry.

To analyze the differential clinical characteristics according to gender of patients with heart failure in terms of etiology, comorbidity, triggers, treatment, hospital stay and overall mortality at o...

Calcium-homeostasis and Ionic Mechanisms in Pulmonary Fibroblasts.

Fibroblasts are key mediators of many lung diseases, including pulmonary fibrosis, chronic obstructive pulmonary disorder, scleroderma and asthma. A great deal of effort has been expended to understan...

News Articles [195 Associated News Articles listed on BioPortfolio]

Loss of Drosophila pseudouridine synthase triggers apoptosis-induced proliferation and promotes cell-nonautonomous EMT

Dermatology Specialist Dr. Romeo Morales Explains Causes of Melasma and Offers Tips on Treatment and Prevention

According to Dr. Romeo Morales with Advanced Dermatology PC, melasma is a common, patchy brown, tan or blue-gray skin discoloration due to overproduction of pigment on the skin. Albertson, NY (PRWEB) ...

The Paf1 complex represses small-RNA-mediated epigenetic gene silencing

RNA interference (RNAi) refers to the ability of exogenously introduced double-stranded RNA to silence expression of homologous sequences. Silencing is initiated when the enzyme Dicer processes the do...

Emergent's anthrax treatment gets FDA nod

FDA approved a BLA for Anthrasil anthrax immune globulin IV (AIGIV) from Emergent BioSolutions Inc. (NYSE:EBS) to treat inhaled anthrax. The drug, developed using plasma collected from healthy donors ...

Emergent BioSolutions Receives FDA Approval for Anthrasil

Emergent BioSolutions has announced that the U.S. Food and Drug Administration (FDA) has approved Anthrasil™ [Anthrax Immune Globulin Intravenous (Human)], also known as AIGIV, for treatment of inha...

Iatrogenic urological triggers of autonomic dysreflexia: a systematic review

FDA Approves Emergent BioSolutions Anthrasil

Triggers $7 million BARDA milestone

Mylan Specialty to Present Poster Presentations about an Individual's Risk of Anaphylaxis at Upcoming Medical Meeting

PITTSBURGH, March 1, 2014 /PRNewswire/ -- Mylan Specialty will present initial data from The Anaphylaxis Risk Assessment (TARA) study at the 2014 Annual Meeting of the American Academy of Allergy, Ast...

Mylan Applauds New Federal Legislation to Increase Anaphylaxis Preparedness in Schools

PITTSBURGH, Nov. 14, 2013 /PRNewswire/ -- Mylan Inc. (NASDAQ: MYL) commends federal legislation signed by President Barack Obama yesterday aimed at protecting people living with potentially life-...

Mylan Kicks Off Second Year of Providing Free EpiPen® (epinephrine) Auto-Injectors to U.S. Schools

BASKING RIDGE, N.J., Aug. 14, 2013 /PRNewswire/ -- Mylan Specialty L.P., the fully integrated specialty pharmaceutical business of Mylan Inc. (NASDAQ: MYL), today announced it is continuing the E...

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Companies [3 Associated Companies listed on BioPortfolio]

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

Clinical Trials [53 Associated Clinical Trials listed on BioPortfolio]

Partners and Alerts: A Study of Social Forces in Medication Adherence

The overall objectives of this study are to improve medication adherence of patients and subsequent health outcomes. This study is designed to examine the existence of strong associations...

Evolution of Molecular Biomarkers in Acute Heart Failure Induced by Shock

The relationship between shock, ischemia and reperfusion (I/R) injury, hemodynamic instability, systemic inflammatory response syndrome and multiorgan failure has been extensively investig...

FAST Mapping During Atrial Fibrillation

Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide with a prevalence of 8% in the elderly. AF is responsible for frequent hospitalizations, stroke, heart failure and ...

Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit

The primary aim of the study is to evaluate consequences of frailty in critically ill patients. We hypothesize that a higher frailty index (based on published questionnaires) predicts a lo...

Aerosol IL-2 for Pulmonary Metastases

The goal of this clinical research study is find the highest tolerable dose of interleukin-2 (IL-2) that can be given as an inhaled mist to patients with lung metastases. The safety of thi...

Environmental Triggers Of Cardiometabolic Disease

The investigators posit that a multi-national collaborative effort with focused investigations in environments with the highest levels of exposure (developing countries such as China and I...

A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant

The purpose of this study is to compare treatment with the new drug sirolimus (SRL) versus the standard treatment with cyclosporine (CsA) or tacrolimus in children who have received kidney...

Triggers of Ventricular Arrhythmias (TOVA) Study

To investigate factors which trigger the discharge of implantable cardioverter-defibrillators (ICDs).

Electrical Stimulation to Improve Hand Function in Patients With Chronic Stroke

This study will determine whether an electric shock to the forearm can improve hand function in patients with chronic stroke and, if so, whether the improvement is related to brain reorgan...

ABR-217620 in Patients With Advanced Non-Small Cell Lung Cancer, Renal Clear Cell Carcinoma or Pancreatic Cancer

The drug ABR-217620 is a combination of two proteins, one that recognizes tumor cells and one that triggers an attack on the tumor cells by activating some white blood cells belonging to t...

Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A technique that induces the processing of disturbing memories and experiences, by stimulating neural mechanisms that are similar to those activated during REM sleep. The technique consists of eye movements following side-to-side movements of the index and middle fingers, or the alternate tapping of the hands on the knees. This procedure triggers the processing of information, thus facilitating the connection of neural networks.

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