Triggers - Biotech, Pharma and Life Science Channel

19:42 EST 30th January 2015 | BioPortfolio

PubMed Articles [588 Associated PubMed Articles listed on BioPortfolio]

The pupillary light response reflects eye-movement preparation.

When the eyes are exposed to an increased influx of light, the pupils constrict. The pupillary light response (PLR) is traditionally believed to be purely reflexive and not susceptible to cognitive in...

Programmable nanomedicine: synergistic and sequential drug delivery systems.

Recent developments in nanomedicine for the cancer therapy have enabled programmable delivery of therapeutics by exploiting the stimuli-responsive properties of nanocarriers. These therapeutic systems...

Pseudomonas syringae effector AvrPphB suppresses AvrB-induced activation of RPM1, but not AvrRpm1-induced activation.

The Pseudomonas syringae effector AvrB triggers a hypersensitive resistance response in Arabidopsis and soybean plants expressing the disease resistance (R) proteins RPM1 and Rpg1b respectively. In Ar...

Hydrogen peroxide modulates the proliferation/quiescence switch in the liver during embryonic development and post-hepatectomy regeneration.

Aims: The liver undergoes marked changes in the rate of proliferation during normal development and regeneration through the coordinated activity of numerous signaling pathways. Little is known, howev...

Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection.

Aspergillus fumigatus forms ubiquitous airborne conidia that humans inhale on a daily basis. Although respiratory fungal infection activates the adaptor proteins CARD9 and MyD88 via C-type lectin, Tol...

Autophagy and Ubiquitination in Cardiovascular Diseases.

A main function of the heart is to pump blood to the tissues and organs of the body. Although formed by different types of cells, the cardiomyocytes are the ones responsible for the coordinated and sy...

The role of lamin B1 for the maintenance of nuclear structure and function.

Abstract Lamins constitute an integral structural component of the nuclear lamina. However, their impact on the structure and stability of chromosome territories, and on the regulation of gene express...

RIP140 triggers foam-cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor.

Receptor-interacting protein 140 (RIP140) is a multifunctional coregulator of lipid metabolism and inflammation. However, the potential role of RIP140 in atherosclerosis remains unknown. The present s...

Palmitate Activation by Fatty Acid Transport Protein 4 as a Model System for Hepatocellular Apoptosis and Steatosis.

Fatty acid transport protein (FATP) 4 is a minor FATP in the liver but it some activity towards palmitate 16:0 (Pal). We here chose FATP4 as a representative model enzyme for acyl-CoA synthetases (ACS...

Diethyldithiocarbamate-mediated zinc ion chelation reveals role of Cav2.3 channels in glucagon secretion.

Peptide-hormone secretion is partially triggered by Ca(2+) influx through voltage-gated Ca(2+) channels (VGCCs) and gene inactivation of Zn(2+)-sensitive Cav2.3-type VGCCs is associated with disturbed...

News Articles [211 Associated News Articles listed on BioPortfolio]

A call for beautiful prose in papers

A blog post urging scientists to write elegantly triggers online discussion.

Lupus Foundation of America Accepting Applications to Fund Critical Lupus Research

WASHINGTON, DC--(Marketwired - January 29, 2015) - The Lupus Foundation of America (Foundation) is accepting applications from lupus investigators to provide critical funding for lupus scientific rese...

Ebola Vaccine Appears Safe, Triggers Immune Response, U.K. Study Finds

WEDNESDAY, Jan. 28, 2015 -- Early results suggest an experimental Ebola vaccine triggers an immune response and is safe to use. However, larger clinical trials in West Africa are needed to determine i...

Trust in Cervical Cancer Screening is Strong - Extending Time Between Tests Triggers Concern

WASHINGTON, D.C., Jan. 28, 2015 /PRNewswire/ -- A newly released survey, Cervical Cancer Today: A National Survey of Attitudes and Behaviors, paints a picture of women and their healthcare provid...

Prima BioMed to Receive Financial Milestone Payment From GSK

SYDNEY, AUSTRALIA -- (Marketwired) -- 01/28/15 -- Prima BioMed Ltd (ASX: PRR) (NASDAQ: PBMD) ("Prima," the "Company") announces the first dosing of a subject by GSK in a Phase 1, first-in-human clini...

Lakeview Health combines surfing with clinical therapy in the latest unexpected and innovative move to treat drug and alcohol addiction

Surfing may offer new ways to help fight addiction and help patients in their recovery. Jacksonville, FL (PRWEB) January 27, 2015 Addiction treatment center Lakeview Health has announced a new and un...

New Survey Reveals Deficiencies in Care for Patients with Severe Allergic Reactions, says Asthma and Allergy Foundation of America

WASHINGTON, Jan. 27, 2015 /PRNewswire-USNewswire/ -- A novel study by the Asthma and Allergy Foundation of America (AAFA) finds significant differences among physician groups in knowledge and attitude...

Prima BioMed in for seven-figure payday

GSK has dosed the first subject for a first-in-human trial of the technology, which was licensed to GSK from Immutep in 2010.Prima BioMed arranged to acquire Immutep last year in a deal worth up to US...

Disneyland Measles Outbreak Triggers Discussion, Criticism Of Anti-Vaccination Movement

The measles outbreak originated in California at Disneyland and has since been tracked to include 70 infected people in six states.

Medical News Today: Exhaled carbon dioxide alerts malaria mosquito to human presence

While human odor guides malaria mosquitoes to human homes, once they take up residence, it is exhaled carbon dioxide that triggers them to land on skin for their next blood meal.

Events [0 Results]

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Companies [3 Associated Companies listed on BioPortfolio]

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

Clinical Trials [51 Associated Clinical Trials listed on BioPortfolio]

FAST Mapping During Atrial Fibrillation

Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide with a prevalence of 8% in the elderly. AF is responsible for frequent hospitalizations, stroke, heart failure and ...

Effects of Frailty, Sarcopenia and Muscle Wasting on Outcomes of Patients in the Surgical Intensive Care Unit

The primary aim of the study is to evaluate consequences of frailty in critically ill patients. We hypothesize that a higher frailty index (based on published questionnaires) predicts a lo...

Aerosol IL-2 for Pulmonary Metastases

The goal of this clinical research study is find the highest tolerable dose of interleukin-2 (IL-2) that can be given as an inhaled mist to patients with lung metastases. The safety of thi...

Environmental Triggers Of Cardiometabolic Disease

The investigators posit that a multi-national collaborative effort with focused investigations in environments with the highest levels of exposure (developing countries such as China and I...

A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant

The purpose of this study is to compare treatment with the new drug sirolimus (SRL) versus the standard treatment with cyclosporine (CsA) or tacrolimus in children who have received kidney...

Triggers of Ventricular Arrhythmias (TOVA) Study

To investigate factors which trigger the discharge of implantable cardioverter-defibrillators (ICDs).

Electrical Stimulation to Improve Hand Function in Patients With Chronic Stroke

This study will determine whether an electric shock to the forearm can improve hand function in patients with chronic stroke and, if so, whether the improvement is related to brain reorgan...

ABR-217620 in Patients With Advanced Non-Small Cell Lung Cancer, Renal Clear Cell Carcinoma or Pancreatic Cancer

The drug ABR-217620 is a combination of two proteins, one that recognizes tumor cells and one that triggers an attack on the tumor cells by activating some white blood cells belonging to t...

Early Rehabilitation After Hip Fracture

The aim of this study is to compare a low versus high intensity physiotherapy early rehabilitation program combined with a low versus high dose vitamin D early rehabilitation program in a ...

An Evaluation of the Efficacy and Safety of Tegaserod 6 mg Bid Given Orally to Chinese Patients With Chronic Constipation

Tegaserod is an aminoguanidine indole compound and a member of a new class of 5-hydroxytryptamine (5-HT) agonists. Activation of 5-HT4 receptors triggers the release of neurotransmitters f...

Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A technique that induces the processing of disturbing memories and experiences, by stimulating neural mechanisms that are similar to those activated during REM sleep. The technique consists of eye movements following side-to-side movements of the index and middle fingers, or the alternate tapping of the hands on the knees. This procedure triggers the processing of information, thus facilitating the connection of neural networks.

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