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Triggers - Biotech, Pharma and Life Science Channel

23:00 EDT 26th August 2016 | BioPortfolio

PubMed Articles [544 Associated PubMed Articles listed on BioPortfolio]

Priming Endothelial Cells With a Melanoma-Derived Extracellular Matrix Triggers the Activation of αvβ3/VEGFR2 Axis.

The unique composition of tumor-produced extracellular matrix (ECM) can be a determining factor in changing the profile of endothelial cells in the tumor microenvironment. As the main receptor for ECM...

Preparation of supramolecular hydrogel-enzyme hybrids exhibiting biomolecule-responsive gel degradation.

Hydrogelators are small, self-assembling molecules that form supramolecular nanofiber networks that exhibit unique dynamic properties. Development of supramolecular hydrogels that degrade in response ...

Granuloma annulare: Pathogenesis, disease associations and triggers, and therapeutic options.

Granuloma annulare (GA) represents a cutaneous reaction pattern of unknown cause with a variety of previously described potential disease associations and triggers. This review attempts to synthesize ...

In-Depth Review of Symptoms, Triggers, and Surgical Deactivation of Frontal Migraine Headaches (Site I).

This study reports details of the technique and assesses efficacy of surgical deactivation of frontal migraine headaches. In addition, this study examines the effect of surgical deactivation of fronta...

The Helminth-Derived Immunomodulator AvCystatin Reduces Virus Enhanced Inflammation by Induction of Regulatory IL-10+ T Cells.

Respiratory Syncytial Virus (RSV) is a major pathogen causing low respiratory tract disease (bronchiolitis), primarily in infants. Helminthic infections may alter host immune responses to both helmint...

Aliskiren Regulates Neonatal Fc Receptor and IgG Metabolism with Attenuation of Anti-GBM Glomerulonephritis in Mice.

Renin, in addition to its activation of the renin-angiotensin system, binds to the (pro)renin receptor (PRR) and triggers inflammatory and fibrogenic signaling in tissue. In addition, aliskiren, a dir...

Insights into the in vitro Anticancer Effects of Diruthenium-1.

The in vitro anticancer activity of the dinuclear trithiolato-bridged arene ruthenium complex diruthenium-1 (DiRu-1) was evaluated against a panel of human cancer cell lines used as in vitro model...

New Methods for the Site-Selective Placement of Peptides on a Microelectrode Array: Probing VEGF - v107 Binding as Proof of Concept.

Cu(I)-catalyzed "click"-reactions cannot be performed on a borate ester derived polymer coating on a microelectrode array because the Cu(II)-precursor for the catalyst triggers background reactions be...

Ligand Binding at the 4-4 Agonist-Binding Site of the 42 nAChR Triggers Receptor Activation through a Pre-Activated Conformational State.

The α4β2 nicotinic acetylcholine receptor (nAChR) is the most abundant subtype in the brain and exists in two functional stoichiometries: (α4)3(β2)2 and (α4)2(β2)3. A distinct feature of the (α...

Label-Free Photonic Crystal-Based β-lactamase Biosensor for β-lactam Antibiotic and β-lactamase Inhibitor.

A simple, label-free and visual photonic crystal-based β-lactamase biosensor was developed for β-lactam antibiotic and β-lactamase inhibitor in which the penicillinase (a β-lactamase) was immobili...

News Articles [268 Associated News Articles listed on BioPortfolio]

Mechanical force triggers gene expression by stretching chromatin

How genes in our DNA are expressed into traits within a cell is a complicated mystery with many players, the main suspects being chemical. However, a new study has demonstrated that external mechanica...

Innovative Partnership Helps Veterans with PTSD

JACKSONVILLE, Fla., Aug. 26, 2016 /PRNewswire-USNewswire/ -- There was a time when Bill Geiger overreacted far too often – and he's the first to admit it. "I exploded when the anger got t...

Force triggers gene expression by stretching chromatin

(University of Illinois at Urbana-Champaign) How genes in our DNA are expressed into traits within a cell is a complicated mystery with many players, the main suspects being chemical. However, a new s...

Study identifies previously unknown mechanism of the immune system.

Generally, researchers divide the human immune system into two parts. One part, called the innate immune system, allows for immediate and direct recognition of invading bacteria. It prompts immune cel...

Researchers pinpoint enzyme that triggers cell demise in ALS

Scientists from Harvard Medical School (HMS) have identified a key instigator of nerve cell damage in people with amyotrophic lateral sclerosis, or ALS, a progressive and incurable neurodegenera...

Is CT Angio Sufficient Without Functional Data? (CME/CE)

(MedPage Today) -- Adding FFR into the mix triggers different clinical decisions

Season of Conception May Affect Fetal Brain Growth

WEDNESDAY, Aug. 24, 2016 -- Children conceived during the winter are more likely to have learning disabilities, and a mother's exposure to sunlight may play a role, a new study suggests. Sunlight trig...

Getting Buy-in For Including Cost in Decision-making is Uphill Battle

Any talk of considering costs in treatment decisions usually triggers an immediate outcry against “rationing” of care, experts say.

What You Need to Know About Allergy Testing

Allergy Partners offers skin testing and blood based allergy testing and treatment at all of their locations. Finding out what you are allergic to is an important first step to effective allergy treat...

Scientists identify spark plug that ignites nerve cell demise in ALS

(Harvard Medical School) Harvard Medical School scientists have pinpointed an enzyme that triggers rapid demise of nerve cells in people with ALS. The research team describes a molecular chain of even...

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Companies [3 Associated Companies listed on BioPortfolio]

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

Clinical Trials [84 Associated Clinical Trials listed on BioPortfolio]

Genetic Susceptibility and Influence of the Microbiome in Bullous Pemphigoid

Autoimmune bullous dermatoses include pemphigus, bullous pemphigoid, pemphigoid gestationis, linear IgA dermatosis, mucous membrane, lichen pemphigoid, anti-p200 pemphigoid, epidermolysis ...

Molecular Hydrogen for Cognitive Function and Performance in Elderly

A variety of non-pharmacological interventions have been used in the management of Alzheimer's disease (AD) and similar cognitive disorders in elderly, yet no therapeutic modality has demo...

Short-Term Outcomes of Different Suture Materials for Sclerotomy Closure

Small-incision vitrectomy techniques have become increasingly popular, with a number of advantages over the older 20-gauge instrumentation. The beveled wounds created by the 23- and 25-gau...

The Effects of Dexmedetomidine on Intestine and Other Organ Damages After Cardiac Surgeries

Cardiac surgery with cardiopulmonary bypass (CPB) provokes a systemic inflammatory response that can often lead to dysfunction of major organs. Activation of the contact system, endotoxemi...

Benfotiamine Effect on Advanced Glycation End Products(AGEs) and Soluble Receptors for AGEs(sRAGE) in Type 2 Diabetes Mellitus.

Several mechanisms have been implicated in the pathophysiology of the complications of diabetes mellitus (DM), one of them is the formation and accumulation of a heterogeneous group of com...

Effectiveness of a Driving Intervention on Safe Community Mobility for Returning Combat Veterans

The main objective of this study is to discern if an Occupational Therapy Driving Intervention (OT-DI) improves fitness to drive abilities of Combat Veterans and also investigate if result...

Mindfulness Meditation for the Treatment of Women With Comorbid PTSD and SUD

The current study will modify an already existing therapy for individuals with substance use disorders to address Post Traumatic Stress Disorder (PTSD) in women enrolled in substance use d...

Protective HA Factors

This is a naturalistic study of 100 migraineurs and 75 post concussive headache patients who will be asked to record their headaches, medications, sleep and other behaviors in a smartphone...

Preventing Risky Drinking in Veterans Treated With Prescription Opioids

Veterans who are taking prescription opioids for chronic pain and are engaging in risky drinking are at heightened risk for drug interactions, including overdose and other negative effects...

Response to Social Rejection in Suicidal Behavior

Suicide is a major health problem that causes annually a million death worldwild. In the stress-vulnerability model, suicidal behavior (SB) results from the interaction between an individu...

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Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A technique that induces the processing of disturbing memories and experiences, by stimulating neural mechanisms that are similar to those activated during REM sleep. The technique consists of eye movements following side-to-side movements of the index and middle fingers, or the alternate tapping of the hands on the knees. This procedure triggers the processing of information, thus facilitating the connection of neural networks.

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