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Triggers - Biotech, Pharma and Life Science Channel

04:53 EDT 30th March 2017 | BioPortfolio

PubMed Articles [606 Associated PubMed Articles listed on BioPortfolio]

Loss of predator species, not intermediate consumers, triggers rapid and dramatic extinction cascades.

Ecological networks are tightly interconnected, such that loss of a single species can trigger additional species extinctions. Theory predicts that such secondary extinctions are driven primarily by l...

Factor XII Contact Activation.

Contact activation is the surface-induced conversion of factor XII (FXII) zymogen to the serine protease FXIIa. Blood-circulating FXII binds to negatively charged surfaces and this contact to surfaces...

Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus.

Understanding the mechanisms regulating cell cycle, proliferation and potency of pluripotent stem cells guarantees their safe use in the clinic. Embryonic stem cells (ESCs) present a fast cell cycle w...

Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation.

Epigenetic mechanisms regulate the formation, consolidation and reconsolidation of memories. However, the signaling path from neuronal activation to epigenetic modifications within the memory-related ...

Evaluation of Hydraulic Properties of Aquitards Using Earthquake-Triggered Groundwater Variation.

The hydraulic properties of aquitards are not easily obtained because monitoring wells are usually installed in aquifers for groundwater resources management. Earthquake-induced crust stress (strain) ...

GnRH-mediated olfactory and visual inputs promote mating-like behaviors in male zebrafish.

The engagement of sexual behaviors is regulated by a number of factors which include gene expression, hormone circulation, and multi-sensory information integration. In zebrafish, when a male and a fe...

PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner.

B55α is a regulatory subunit of the PP2A phosphatase. We have recently found that B55α-associated PP2A promotes partial deactivation of the HIF-prolyl-hydroxylase enzyme PHD2. Here, we show that, in...

RECONsidering Sensing of Cyclic Dinucleotides.

Detection of cyclic dinucleotides (cdNs) by the STING pathway potently triggers the antiviral response. McFarland et al. now show that the mouse oxidoreductase RECON acts as a sensor for some bacteri...

RCN1 suppresses ER stress-induced apoptosis via calcium homeostasis and PERK-CHOP signaling.

Endoplasmic reticulum (ER) stress is caused by the disturbance of ER homeostasis and leads to the activation of the unfolded protein response (UPR), which alleviates stress at an early stage and trigg...

Trypanocidal Effect of Isotretinoin through the Inhibition of Polyamine and Amino Acid Transporters in Trypanosoma cruzi.

Polyamines are essential compounds to all living organisms and in the specific case of Trypanosoma cruzi, the causative agent of Chagas disease, they are exclusively obtained through transport process...

News Articles [239 Associated News Articles listed on BioPortfolio]

Pharma facing uncertainty as May triggers Brexit

The UK government will shortly trigger Brexit under Article 50, opening up negotiations which are expected to see the country leave the European Union by March 2019. Prime Minister Theresa May has d...

Study explores new immunotherapy combinations to treat prostate cancer

Prostate cancer, notoriously resistant to immunotherapy due to its immunologically cool nature, triggers two pathways to chill an immune attack after one immunotherapy drug fires up the immune system,...

The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity

‘Crown-like’ structures composed of apoptotic adipocytes surrounded by adipose tissue macrophages (ATMs) are a characteristic of obesity. Liu and colleagues show that engulfment of apoptotic adipo...

Tony Robbins Partners with OsteoStrong®

Celebrated Coach and Strategist Teams with Wellness Brand to Catalyze International Growth Tony Robbins, long revered for his contagious passion, has found something ne...

Wounded Warrior Project Identifies 4 Benefits of Telephonic Emotional Support

JACKSONVILLE, Fla., March 28, 2017 /PRNewswire-USNewswire/ -- With more than 2.4 million service members having deployed as part of the Global War on Terrorism, the number of warriors returning home w...

A molecular on/off switch for CRISPR

Picture bacteria and viruses locked in an arms race. For many bacteria, one line of defense against viral infection is a sophisticated RNA-guided "immune system" called CRISPR-Cas. At the center of th...

Fly to Israel Now and Find your Sobriety in a Unique Therapeutic Community

NEW ROCHELLE, N.Y., March 28, 2017 /PRNewswire/ -- Tekuma Recovery Group (http://www.tekumarecovery.com), a renowned leader in treating alcohol and drug addiction, gambling addiction, and eating disor...

Study provides path for new immunotherapy approaches to prostate cancer

Prostate cancer, notoriously resistant to immunotherapy due to its immunologically cool nature, triggers two pathways to chill an immune attack after one immunotherapy drug fires up the immune system,...

Medical News Today: Common skin rashes: Pictures, causes, and treatments

In this article, we look at a variety of skin rashes including eczema, hives, and psoriasis. Learn about possible triggers and when to see a doctor.

Medical News Today: How do alcohol and caffeine affect A-fib?

Learn how caffeine and alcohol may affect the heart and if they are triggers for A-fib. Is it safe to consume alcohol and caffeine with A-fib?

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Companies [4 Associated Companies listed on BioPortfolio]

OsteoStrong

OsteoStrong leverages clinically researched osteogenic stimulation methodology to help people of all ages and fitness levels enhance bone health, balance, overall strength, and po...

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

Clinical Trials [104 Associated Clinical Trials listed on BioPortfolio]

Asthma Breath Biomarker Assessment

This study aims to assess the feasibility of capturing data on exhaled breath compounds during an acute asthma exacerbation. In addition to assessing the feasibility of such a study the in...

Diabetes: Functional Medicine Approach vs. Usual Care

A Functional Medicine (FM) approach to diabetes care focuses on identifying and treating the etiologies for "imbalances in the core physiological systems."(1) If underlying triggers and im...

Personalized Dietary Intervention in Managing Bowel Dysfunction and Improving Quality of Life in Stage I-III Rectosigmoid Cancer Survivors

This pilot clinical trial studies how well personalized dietary intervention works in managing bowel dysfunction and improving quality of life in stage I-III rectosigmoid cancer survivors....

Internet Surveys and Their Impact on Adherence for Rosacea

An investigator-blinded, prospective, 6 month study of subjects with persistent erythema associated with active rosacea will be conducted in 20 subjects aged 18 years and older. All subjec...

Acute Effect of Salbutamol on Heart Rate and Blood Pressure During Exercise in Patients With Moderate or Severe Asthma and Healthy Subjects

Contextualization: Exercise is a common triggers of bronchospasm in patients with asthma and healthy subjects. To prevent these symptoms frequently they have to use Short-Acting Beta2-Agon...

Micronutrient Supplement Effects on Cognitive Outcomes in Post-Acute TBI

Traumatic brain injury (TBI) refers to neuronal damage occurring as the result of an external force being applied to brain tissue. In the United Kingdom annual figures (2013-2014) show 449...

Attention Training for Underserved Youth With Anxiety

This study aims to test the efficacy and feasibility of administering a computerized attention training program targeting clinical levels of anxiety in Latino youth between the ages of 8-1...

Mindfulness Meditation or Survivorship Education in Improving Behavioral Symptoms in Younger Stage 0-III Breast Cancer Survivors (Pathways to Wellness)

This randomized phase III trial studies how well mindfulness meditation or survivorship education work in improving behavioral symptoms in younger stage 0-III breast cancer survivors. Beha...

Multimodality Monitoring Directed Management of Aneurysmal Subarachnoid Haemorrhage

Aneurysmal subarachnoid haemorrhage (aSAH) affects up to 10,000 individuals per year in the UK. It accounts for ~5% of strokes, but is responsible for about 25% quality-adjusted life years...

Low-Intensity Extracorporeal Shock Wave Treatment for Erectile Dysfunction: A Randomized, Controlled, Double Blind Trial

The proposed mechanism of action for LI-ESWT in ED is that it improves endothelial function and triggers angiogenesis through induction of local growth factors and endothelial nitric oxide...

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Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A technique that induces the processing of disturbing memories and experiences, by stimulating neural mechanisms that are similar to those activated during REM sleep. The technique consists of eye movements following side-to-side movements of the index and middle fingers, or the alternate tapping of the hands on the knees. This procedure triggers the processing of information, thus facilitating the connection of neural networks.

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