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Triggers - Biotech, Pharma and Life Science Channel

23:46 EDT 23rd April 2014 | BioPortfolio

PubMed Articles [395 Associated PubMed Articles listed on BioPortfolio]

Chemotherapy and QT Prolongation: Overview With Clinical Perspective.

Cardiotoxic adverse events are of concern to physicians treating cancer patients; they are encountered with a variety of agents. Cardiac events may delay the approval of new drugs or impose burdensome...

cGAS, innate immune responses and viral hepatitis.

The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors. Recent screening s...

Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization.

EAAT2 is a predominantly astroglial glutamate transporter responsible for the majority of synaptic glutamate clearance in the mammalian central nervous system (CNS). Its dysfunction has been linked wi...

The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity.

Since xenobiotics enter the organism via the liver, hepatocytes must cope with numerous perturbations, including modifications of proteins leading to endoplasmic reticulum stress (ER-stress). This tri...

TLR2/TLR4 heterodimer mediates Inflammatory Injury in Intracerebral hemorrhage.

Objective: Inflammatory injury plays a critical role in intracerebral hemorrhage (ICH)-induced secondary brain injury. However, the upstream events that initiate inflammatory responses following ICH r...

Genetics in PBC: What Do the "Risk Genes" Teach Us?

Primary biliary cirrhosis is characterised by a progressive and destructive lymphocytic cholangitis, targeting small intra-hepatic bile ducts. In association with the histologic liver injury, patients...

Δ9-Tetrahydrocannabinol-induced anti-inflammatory responses in adolescent mice switch to proinflammatory in adulthood.

Marijuana abuse is prominent among adolescents. Although Δ(9)-THC, one of its main components, has been demonstrated to modulate immunity in adults, little is known about its impact during adolescenc...

A Neural Code for Looming and Receding Motion Is Distributed over a Population of Electrosensory ON and OFF Contrast Cells.

Object saliency is based on the relative local-to-background contrast in the physical signals that underlie perceptual experience. As such, contrast-detecting neurons (ON/OFF cells) are found in many...

Valproate-Induced Liver Injury: Modulation by the Omega-3 Fatty Acid DHA Proposes a Novel Anticonvulsant Regimen.

The polyunsaturated, ω-3 fatty acid, docosahexaenoic acid (DHA), claims diverse cytoprotective potentials, although via largely undefined triggers. Thus, we currently first tested the ability of DHA...

Oxygen diffusion limitation triggers ventilatory movements during spiracle closure when insects breathe discontinuously.

During discontinuous gas exchange cycles in insects, spiracular opening follows a typical prolonged period of spiracle closure. Gas exchange with the environment occurs mostly during the period of ful...

News Articles [227 Associated News Articles listed on BioPortfolio]

Rosacea Awareness Month Provides Opportunities for Learning about Common Skin Condition

San Diego dermatologist Dr. William Groff of Cosmetic Laser Dermatology discusses key takeaways from April’s Rosacea Awareness Month. San Diego, CA (PRWEB) April 23, 2014 April was designated Rosac...

Fibrosis—a lethal component of systemic sclerosis

Fibrosis is characterized by excessive accumulation of connective tissue components in organs or tissues and is a critical, and potentially lethal, component of systemic sclerosis (SSc). Here, the aut...

Enanta Pharmaceuticals Announces New Drug Application Submission to the U.S. FDA for All-Oral, Interferon-Free Hepatitis C Regimen

Filing Triggers Milestone Payment to Enanta AbbVie’s submission to FDA triggers $20 million milestone payment to Enanta Regimen include...

The Indoor Allergen That Might Surprise You

WASHINGTON, April 22, 2014 /PRNewswire/ -- (NU) -- While many welcome the arrival of warmer temperatures with open arms, people with seasonal allergies and asthma may be bracing themselves with b...

Sublytic C5b-9 triggers glomerular mesangial cell apoptosis via XAF1 gene activation mediated by p300-dependent IRF-1 acetylation

AutismOne: The Cutting-Edge Autism Conference Announces One in Two Advocacy Debut in Chicago

Advocacy organizations including AutismOne and the Brighton Institute collaborate to protect our children and our future Chicago, IL (PRWEB) April 17, 2014 Today, more than ONE IN TWO children suffer...

Synaptic vesicle recycling: steps and principles

Synaptic vesicle recycling is one of the best-studied cellular pathways. Many of the proteins involved are known, and their interactions are becoming increasingly clear. However, as for many other pat...

FDA approves Ragwitek

FDA approved a BLA from Merck & Co. Inc. (NYSE:MRK) for Ragwitek, a ragweed sublingual allergy immunotherapy tablet (AIT), to treat ragweed pollen-induced allergic rhinitis, with or without conjunctiv...

Dangerously Stressful Work Environments Force Workers to Seek New Employment

International Poll Reveals 42% of US Respondents Have Purposely Switched Jobs Due to a Stressful Work Environment; US Survey Finds That Workplace Stress has Caused Illness for 61%...

Clues to Type 2 Diabetes Discovered on Mount Everest

MONDAY, April 14, 2014 -- Research conducted on climbers atop Mount Everest offers new insight into the biological triggers for type 2 diabetes. Specifically, the British investigators learned more ab...

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Companies [3 Associated Companies listed on BioPortfolio]

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

Clinical Trials [48 Associated Clinical Trials listed on BioPortfolio]

Evaluation of an ICU Hyperglycemia Protocol Using Insulin Aspart

In response to the evidence supporting “tight” glucose control (70 – 110) in the critical care setting, the MMH ICU developed a protocol utilizing regular intravenous insulin. This p...

Early Rehabilitation After Hip Fracture

The aim of this study is to compare a low versus high intensity physiotherapy early rehabilitation program combined with a low versus high dose vitamin D early rehabilitation program in a...

Electrical Stimulation to Improve Hand Function in Patients With Chronic Stroke

This study will determine whether an electric shock to the forearm can improve hand function in patients with chronic stroke and, if so, whether the improvement is related to brain reorgan...

A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant

The purpose of this study is to compare treatment with the new drug sirolimus (SRL) versus the standard treatment with cyclosporine (CsA) or tacrolimus in children who have received kidney...

Hepcidin in Anemic Chronic Heart Failure (CHF) Patients

Background: Anemia in chronic heart failure (CHF) is directly linked to increased mortality and reduced exercise capacity. The pathomechanism for the development of anemia in CHF is not...

Manipulation of Visceral Sensitivity and Immune System in IBS

Irritable bowel syndrome (IBS) is a common condition. At least 20% of the population suffer from IBS. The symptoms of abdominal pain, diarrhoea, constipation, bloating and difficulty with...

STAR-AF:Substrate Versus Trigger Ablation for Reduction of Atrial Fibrillation Trial

Patient Population: Patients with AF that is symptomatic and refractory to at least one antiarrhythmic medication. Patients must have AF that is paroxysmal (>4 episodes within 6 months, t...

Stem Cell Mobilization and VEGF Gene Transfer for Heart Failure

The purpose of this study is to evaluate the safety and bioactivity of intramyocardial gene transfer using VEGF (vascular endothelial growth factor) in patients with ischemic heart failure...

Interleukin-4 (IL-4) as a Marker of Atherosclerosis

In recent years, medical research into the cause and progression of heart disease due to narrowing and blockage of blood vessels to the heart muscle has improved the understanding of ische...

An Evaluation of the Efficacy and Safety of Tegaserod 6 mg Bid Given Orally to Chinese Patients With Chronic Constipation

Tegaserod is an aminoguanidine indole compound and a member of a new class of 5-hydroxytryptamine (5-HT) agonists. Activation of 5-HT4 receptors triggers the release of neurotransmitters f...

Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A technique that induces the processing of disturbing memories and experiences, by stimulating neural mechanisms that are similar to those activated during REM sleep. The technique consists of eye movements following side-to-side movements of the index and middle fingers, or the alternate tapping of the hands on the knees. This procedure triggers the processing of information, thus facilitating the connection of neural networks.

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