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Triggers - Biotech, Pharma and Life Science Channel

23:59 EDT 23rd May 2017 | BioPortfolio

PubMed Articles [643 Associated PubMed Articles listed on BioPortfolio]

Platelet toll-like receptors in thromboinflammation.

Besides their undiscussed role in hemostasis and thrombosis, platelets are also key effector cells capable of assisting and modulating inflammatory reactions and immune responses. Platelets play a sen...

Nitric oxide signaling during meiotic cell cycle regulation in mammalian oocytes.

  Nitric oxide (NO) acts as a major signal molecules and modulate physiology of mammalian oocytes. Ovarian follicles generate large amount of NO through nitric oxide synthase (NOS) pathway to maintai...

AKT is indispensable for coordinating Par-4/JNK cross talk in p21 downmodulation during ER stress.

The double-edged role of p21 to command survival and apoptosis is emerging. The current investigation highlights ER stress-mediated JNK activation that plausibly triggers cell death by attenuating end...

The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer's Disease.

The role of interleukins (ILs) and oxidative stress (OS) in precipitating neurodegenerative diseases including sporadic Alzheimer's disease (AD), requires further clarification. In addition to neuropa...

Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substance.

HepaRG cells are widely used as an in vitro model to assess drug-induced hepatotoxicity. However, only few studies exist so far regarding their suitability to detect the effects of drugs requiring a p...

A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-β in mouse endometrium.

The TGF-β/Smad and the PI3K/AKT signaling pathways are important regulators of proliferation and apoptosis, and their alterations lead to cancer development. TGF-β acts as a tumor suppressor in prem...

Fingerprint of long non-coding RNA regulated by cyclic mechanical stretch in human aortic smooth muscle cells: implications for hypertension.

Emerging evidence suggests that long non-coding RNAs (lncRNAs) represent a cellular hub coordinating various cellular processes that are critical in health and disease. Mechanical stress triggers chan...

The Phenotypic Spectrum of Nephropathies Associated with Mutations in Diacylglycerol Kinase ε.

The recent discovery of mutations in the gene encoding diacylglycerol kinase ε (DGKE) identified a novel pathophysiologic mechanism leading to HUS and/or MPGN. We report ten new patients from eight u...

APC/C-Cdc20 mediates deprotection of centromeric cohesin at meiosis II in yeast.

Cells undergoing meiosis produce haploid gametes through one round of DNA replication followed by two rounds of chromosome segregation. This requires that cohesin complexes, which establish sister chr...

Diphenhydramine inhibits voltage-gated proton channels (Hv1) and induces acidification in leukemic Jurkat T cells- New insights into the pro-apoptotic effects of antihistaminic drugs.

An established characteristic of neoplastic cells is their metabolic reprogramming, known as the Warburg effect, with greater reliance on energetically less efficient pathways (such as glycolysis and ...

News Articles [233 Associated News Articles listed on BioPortfolio]

In Support of National Mental Health Awareness Month, New Survey by Therachat Explores Effects of Anxiety on Daily Life

According to Therachat's online survey, while the public views anxiety as a real health issue that can’t be resolved by oneself, few seek professional help or receive the support they require. S...

Sleep Easily Partners with The Last Mile to Rebrand Website

BOULDER, Colo., May 22, 2017 /PRNewswire/ -- Sleep Easily, a proven, natural sleep solution, announced the launch of its newly rebranded website today. The mobile-friendly, responsive site will h...

Thousands of cars banned from roads as Mexico City chokes in longest pollution alert for two decades

Authorities in Mexico City have ordered cars off the streets and warned people about exercising outdoors as sprawling metropolis chokes in its worst smog for nearly two decades. Hundreds of thousands...

Witchweed - Destructive by Nature

Scientists at Nagoya University, Japan, have designed a synthetic molecule that could aid the understanding of how the destructive weed Striga, or witchweed, is detecting its host crops. Striga is a p...

Tumors Hold Stiff Upper Lip Before Malignancy

While tumors alone can present a host of problems for the body, it’s the transition to malignancy that enables cancer cells to persist and wreak havoc on tissues and organs distant from the original...

T-cell signaling process central to immune response

The immune system cells known as T cells play a central role in the body's ability to fight infections and cancer. For decades, however, details of the molecular signaling process that leads to T cell...

Asthma's Multitude of Symptoms Hinders Patient Control of Disease, New Survey Reports

PHILADELPHIA, PA--(Marketwired - May 16, 2017) - Asthma patients suffer from a large number of symptoms that impact many aspects of their quality of life, according to Asthma In America 2017, a newly ...

IBM Researchers Uncover New Way to Stimulate The Body's Immune Response

ARMONK, N.Y., May 15, 2017 /PRNewswire/ -- IBM (NYSE: IBM) announced its researchers have identified a new way to trigger the body's immune response by using polymer-coated graphene sheets. ...

Researchers identify hormone that is key to brain development in fruit flies

University of Oregon researchers using Drosophila have identified a steroid hormone that triggers a vital transition in early brain development in which neural stem cells properly change gears to prod...

Discovery of steroid hormone in fruit flies may shed new light on maternal hypothyroidism

University of Oregon researchers using Drosophila have identified a steroid hormone that triggers a vital transition in early brain development in which neural stem cells properly change gears to prod...

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Companies [4 Associated Companies listed on BioPortfolio]

OsteoStrong

OsteoStrong leverages clinically researched osteogenic stimulation methodology to help people of all ages and fitness levels enhance bone health, balance, overall strength, and po...

BiondVax Pharmaceuticals Ltd

BiondVax is a publicly traded (TASE: BNDX), advanced clinical stage biotech company dedicated to improving protection against influenza, with its lead product a universal influenza (flu) vaccine cal...

MaxPoint Interactive

Using its unique Digital Zip technology, MaxPoint Interactive analyzes billions of data points consumed by neighborhoods across the U.S. such as: offline point of sale data...

Adaptimmune Limited

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy can...

Clinical Trials [109 Associated Clinical Trials listed on BioPortfolio]

Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis

Sarcoidosis is a multi-system granulomatous disorder that is triggered and influenced by gene-environment interactions. Although sarcoidosis predominantly affects the lungs in most cases, ...

Pharmacologically Triggered Migraine Without Aura and Neuroimaging

Migraine is a highly disabling disorder affecting 14% of the general population Worldwide and ranked as the 6th most debilitating disease worldwide by the WHO. One of the most fundamental ...

Acute Effect of Axulin on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans

Blood sugar levels are controlled by insulin, a hormone made by cells in the pancreas. After a normal meal, carbohydrates are broken down into glucose (blood sugar) which is absorbed from ...

Impact of Diet on Functional Gastrointestinal Symptoms

This cross-sectional survey study is to determine the prevalence of functional gastrointestinal (GI) disorders in the general population and to describe common triggers for food-related GI...

Study of Durvalumab (MEDI4736) After Chemo-Radiation for Microsatellite Stable Stage II-IV Rectal Cancer

This study is being done to look at the safety and response to the investigational drug durvalumab (MEDI4736) following chemo-radiation therapy for patients with MSS stage II to IV rectal ...

Asthma Breath Biomarker Assessment

This study aims to assess the feasibility of capturing data on exhaled breath compounds during an acute asthma exacerbation. In addition to assessing the feasibility of such a study the in...

Diabetes: Functional Medicine Approach vs. Usual Care

A Functional Medicine (FM) approach to diabetes care focuses on identifying and treating the etiologies for "imbalances in the core physiological systems."(1) If underlying triggers and im...

Personalized Dietary Intervention in Managing Bowel Dysfunction and Improving Quality of Life in Stage I-III Rectosigmoid Cancer Survivors

This pilot clinical trial studies how well personalized dietary intervention works in managing bowel dysfunction and improving quality of life in stage I-III rectosigmoid cancer survivors....

Internet Surveys and Their Impact on Adherence for Rosacea

An investigator-blinded, prospective, 6 month study of subjects with persistent erythema associated with active rosacea will be conducted in 20 subjects aged 18 years and older. All subjec...

Acute Effect of Salbutamol on Heart Rate and Blood Pressure During Exercise in Patients With Moderate or Severe Asthma and Healthy Subjects

Contextualization: Exercise is a common triggers of bronchospasm in patients with asthma and healthy subjects. To prevent these symptoms frequently they have to use Short-Acting Beta2-Agon...

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Medical and Biotech [MESH] Definitions

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

System of psychological and/or therapeutic techniques used to control and or reduce the triggers, degrees, and effects of ANGER.

A constellation of responses that occur when an organism is exposed to excessive cold. In humans, a fall in skin temperature triggers gasping, hypertension, and hyperventilation.

Various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

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