Tuberculosis Vaccines and Therapeutics - Biotech, Pharma and Life Science Channel
The WHO estimates that the largest number of new tuberculosis (TB) cases in 2008 occurred in the South-East Asia Region, which accounted for 34% of incident cases globally. However, the estimated incidence rate in sub-Saharan Africa is nearly twice that of the South-East Asia Region with over 350 cases per 100 000 population. An estimated 1.3 million people died from TB in 2008. The highest number of deaths was in the South-East Asia Region, while the highest mortality per capita was in the Africa Region. Until 50 years ago, there were no medicines to cure TB. Now, strains that are resistant to a single drug have been documented in every country surveyed; what is more, strains of TB resistant to all major anti-TB drugs have emerged. Drug-resistant TB is caused by inconsistent or partial treatment. A particularly dangerous form of drug-resistant TB is multidrug-resistant TB (MDR-TB), which is defined as the disease caused by TB bacilli resistant to at least isoniazid and rifampicin, the two most powerful anti-TB drugs.
Private-public partnerships have considerably contributed to establish a tuberculosis vaccine and drug pipeline. So far, there is no approved vaccine for tuberculosis. Now, several vaccines are in clinical development and further in preclinical stages. Small molecule therapeutics are also in clinical and preclinical development and significant research efforts are being undertaken to discover novel small molecule therapeutics with a mechanism of action different from currently used treatments.
News Articles
Study Finds Vitamin C Can Kill Drug-Resistant TB
NEW YORK, May 21, 2013 /PRNewswire-USNewswire/ -- In a striking, unexpected discovery, researchers at Albert Einstein College of Medicine of Yeshiva University have determined that vitamin C kill...
Company’s Virtual Conjugate Vaccine Program Shows Promise Liquidia Technologies today announced that its collaborative agreement with PATH, a global health nonprofit organiz...
OAKLAND, Calif., May 20, 2013 /PRNewswire/ -- Whole-cell pertussis vaccines were more effective at protecting against pertussis than acellular pertussis vaccines during a large recent outb...
A New 5-year Guarantee Has the Potential to Unlock Immense Private Sector Financing, Accelerating Efforts to Achieve MDGs Today, leading global health and development experts...
Sinovac to Host Conference Call to Report First Quarter 2013 Unaudited Financial Results
BEIJING, May 17, 2013 /PRNewswire/ -- Sinovac Biotech Ltd. (Nasdaq: SVA), a leading provider of vaccines in China, today announced that it will release its unaudited financial results for the...
Pennsylvania Physicians Urge State Legislators to Support Immunization Expansion Bill
HARRISBURG, Pa., May 16, 2013 /PRNewswire/ -- The Pennsylvania Pharmacists Association announced today that numerous physicians throughout the Commonwealth are urging state legislators to support Hous...
The World Small Animal Veterinary Association Recommends Canine VacciCheck
KIBBUTZ GALED, Israel, May 16, 2013 /PRNewswire/ -- The World Small Animal Veterinary Association (WSAVA) Vaccination Guidelines Group has recently published the "Vaccination Guidelines for New Puppy...
Immunovaccine Announces Financial Results for the Quarter Ended March 31, 2013
HALIFAX, NOVA SCOTIA -- (Marketwired) -- 05/16/13 -- Immunovaccine Inc. ("Immunovaccine" or "IMV") (TSX VENTURE: IMV), a clinical stage vaccine company, today released its financial and operational...
Research Team Publishes New Methods for Synthetic Generation of Influenza Vaccines
LA JOLLA, Calif. and ROCKVILLE, Md., May 15, 2013 /PRNewswire/ -- A team of international researchers from the J. Craig Venter Institute (JCVI), Synthetic Genomics Inc. (SGI), Novartis Vaccines a...
Sinovac Appoints Ernst & Young Hua Ming Llp China as External Auditor
BEIJING, May 15, 2013 /PRNewswire/ -- Sinovac Biotech Ltd. (NASDAQ: SVA), a leading provider of biopharmaceutical products in China, has appointed China-based Ernst & Young Hua Ming LLP as...
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Companies
We have a challenging and inspiring mission: to improve the quality of human life by enabling people to do more, feel better and live longer. This mission gives us the purpose to develop innovative me...
Merck is a global healthcare leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, a...
Xenetic is a leading UK-based biopharmaceutical company providing leading-edge expertise in the development of a whole new generation of drugs and vaccines. Working with some of the largest pharma...
VGTI Florida is the Florida-funded expansion of Oregon Health & Science University's highly successful Vaccine and Gene Therapy Institute. Research at the facility will focus on v...
Etubics Corporation, based in Seattle, Wash., is a clinical stage bio-pharmaceutical company, which has developed a proprietary platform technology consisting of a next generation...
Fraunhofer USA CMB, a division of Fraunhofer USA, Inc., is a not-for-profit research organization whose mission is to develop safe and effective vaccines targeting infectious dise...
Profectus BioSciences, Inc. is a technology based vaccine company devoted to the treatment and prevention of chronic viral diseases with a goal of reducing morbidity and mo...
Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell response helps confer protect...
Advaxis is a biotechnology company developing proprietary, live but attenuated Listeria monocytogenes (Listeria) vaccines that deliver engineered tumor antigens, which stimulate...
Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell responses help confer protect...
Clinical Trials
RATIONALE: Vaccines made from a person's white blood cells may help the body build an effective immune response. PURPOSE: This phase I trial is studying the side effects of vaccine therap...
Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had Chemotherapy
Background: - Drugs given to treat cancer (chemotherapy) can weaken the human immune system. But it can also become weaker because of aging. Interleukin (IL)-7, a molecule produced natura...
Can Screening People Registering With Primary Care Improve the Detection of Tuberculosis?
This randomised controlled trial tests whether screening people registering with general practices cost-effectively increases the detection of tuberculosis. The study objectives are to:...
Effect of Public Sector Antiretroviral Treatment Programme on Tuberculosis and Immunization Care
A scale-up of public sector antiretroviral treatment (ART) programmes may divert scarce resources from other priority primary care programmes like tuberculosis and childhood immunization....
Efficacy of Anti-Tubercular Vaccination in Multiple Sclerosis
The frequency of auto-immune diseases (including multiple sclerosis) is increasing in industrialised countries. According to an hypothesis which is receiving a wide international credit,...
GSK Biologicals is developing in partnership with the Malaria Vaccine Initiative at PATH a candidate malaria vaccine RTS,S/AS02 for the routine immunization of infants and children living...
A Study to Assess the Safety of Live Intranasal Sendai Virus Vaccine in Children and Toddlers
Croup is an illness of young children that is caused by a virus. With this illness, the child has fever, cough, and hoarseness. Although the illness usually gets better in 2 to 4 days, so...
TB Nutrition, Immunology and Epidemiology
The purpose of this study is to see whether people who take vitamins along with the standard medicine for tuberculosis (TB) recover better and quicker than people who take only the standar...
Randomized Clinical Trial of 4RIF Vs. 9INH for the Treatment of Latent TB
Although effective medications to treat and even prevent Tuberculosis (TB) have been available for over 40 years, TB remains the most important infectious cause of mortality among adults i...
Vitamin A Supplementation With Routine Childhood Vaccines and Mortality and Morbidity
Vitamin A supplementation (VAS) is important for the immune system and may interact with different childhood vaccinations. We have hypothesized that the improved survival after VAS may dep...
PubMed Articles
Icotinib hydrochloride is the third single target EGFR-TKI used in clinical treatment of advanced non-small cell lung cancer (NSCLC). Clinical research reports on its efficacy and survival in patients...
Granulocyte-macrophage colony-stimulating factor (GM-CSF) secreting cellular tumor vaccines contribute to the induction of potent antitumor immune responses in murine models and patients suffering fro...
Structural comparison of biological networks based on dominant vertices.
It is a current practice to organize biological data in a network structure where vertices represent biological components and arrows represent their interactions. A great diversity of graph theoretic...
Serum resistin levels are elevated in schoolchildren with atopic asthma.
OBJECTIVES: There are limited data on the role of adipokines in atopic asthma. DESIGN AND SETTING: To determine serum levels of resistin in asthmatic children in relation to body weight, asthma severi...
Management of tuberculosis and latent tuberculosis infection in HIV-infected persons.
The syndemic of human immunodeficiency virus (HIV) / tuberculosis (TB) co-infection has grown as a result of the considerable socio-geographic overlaps between the two epidemics. The situation is part...
Genetic Diversity in Mycobacterium tuberculosis.
Recent years have witnessed an increased appreciation of the extent and relevance of strain-to-strain variation in Mycobacterium tuberculosis. This paradigm shift can largely be attributed to an impro...
Pediatric tuberculosis (TB) often goes undiagnosed because of the lack of reliable diagnostic methods. With the aim of assessing biomarker(s) that can aid in the diagnosis of TB infection and disease,...
SUMMARY Understanding how seasonality shapes the dynamics of tuberculosis (TB) is essential in determining risks of transmission and drug resistance in (sub)tropical regions. We developed a relative f...
Nanoelectrospray ionisation mass spectrometry (nanoESI MS) of intact protein complexes was used to study CYP121, one of the twenty cytochrome P450s in Mycobacterium tuberculosis (Mtb) and an enzyme th...
Using a capillary isoelectric focusing-whole column imaging detection (CIEF-WCID) method the isoelectric points (pI) of complete intact polioviruses were determined. The polio viruses that were analyz...
Videos
Nanotechnology-based therapeutic platforms / Dr Pere Santamaria - Parvus Therapeutics -World Vaccine
Subscribe: http://www.youtube.com/user/vaccinenation Dr Pere Santamaria - Parvus Therapeutics joined us at the World Vaccine Congress to present on his compa...
Medical and Biotech [MESH] Definitions
Tuberculosis Vaccines
Vaccines or candidate vaccines used to prevent or treat TUBERCULOSIS.
Ebola Vaccines
Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.
Dengue Vaccines
Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.
West Nile Virus Vaccines
Vaccines or candidate vaccines used to prevent infection with WEST NILE VIRUS.
Electrochemotherapy
A treatment modality that uses pulsed electrical currents to permeabilize cell membranes (ELECTROPORATION) and thereby enhance the uptake of chemotherapeutic agents, vaccines, or genes into the body's cells.
