Tumor Growth and Metastasis - Biotech, Pharma and Life Science Channel
PubMed Articles
Tumor lysis syndrome and malignant melanoma.
Tumor lysis syndrome (TLS) is an oncological emergency that results from massive cytolysis of malignant cells with a sudden release of their contents into the systemic circulation. TLS was rarely desc...
Antisense oligonucleotides (oligos) have been employed against prostate cancer models in both in vivo and in vitro systems. While most target growth factors or their receptors, other oligos are direct...
Giant cell tumor (GCT) of bone is a benign but locally aggressive neoplasm of bone. However, molecular mechanisms underlying osteolysis in GCT have not been deeply understood. The aim of this study wa...
PR (PRDI-BF1 and RIZ) domain containing proteins (PRDM) have been indicated to play important roles in several human cancers. The objectives of this study were to determine the frequency and prognosti...
Expression of synuclein gamma indicates poor prognosis of triple-negative breast cancer.
Synuclein gamma (SNCG), previously identified as breast cancer-specific gene 1, is highly expressed in malignant cells but not in normal epithelium. Studies have demonstrated that the expression of SN...
Adrenomedullin (ADM) is a potent, long-lasting angiogenic peptide that was originally isolated from human pheochromocytoma. ADM signaling is of particular significance in endothelial cell biology beca...
Protein tyrosine phosphatase nonreceptor type 12 (PTPN12) has been recognized as a tumor suppressor gene that may inhibit tumor growth. However, PTPN12 expression in oral squamous carcinoma (OSCC) has...
Effects of legumain as a potential prognostic factor on gastric cancers.
Although legumain has been found to be a prognostic factor in both breast cancer and colorectal cancer, its effects on gastric cancer are unknown. In this study, we investigated effects of legumain on...
Preferential loss of heterozygosity at the rs1042522 locus of the tumor protein 53 gene (TP53) (Arg72Pro) is observed in several tumors. Genetic association studies in oncology often use tumor tissue...
Objective-To evaluate risk factors for outcome for dogs with adrenal gland tumors with or without invasion of the caudal vena cava treated via adrenalectomy. Design-Retrospective study. Animals-86 dog...
News Articles
Defect pair separation as the controlling step in homogeneous ice melting
On being heated, ice melts into liquid water. Although in practice this process tends to be heterogeneous, it can occur homogeneously inside bulk ice. The thermally induced homogeneous melting of soli...
The Long Case For WellCare Health
ByUnbigoted Research:WellCare Health Plans (WCG) has posted some extremely positive financials of late - with anticipation of continuing to do so throughout 2013 and beyond. This Tampa, Florida, based...
Report: U.S. healthcare cost growth slowing down
U.S. healthcare inflation is projected to drop to 6.5 percent next year despite millions more newly insured Americans added to the system, consultants say. (UPI)
Recipients of microRNA Research Grant Announced by Firefly BioWorks
The Firefly Frontiers Grant is a $10,000 award towards Firefly BioWorks products for scientists engaged in cutting-edge microRNA research. The awards encourage large-scale...
Sanofi, Curie-Cancer enter ovarian cancer collaboration
Sanofi and the Curie Institute, through its Curie-Cancer partnership, have announced the establishment of a three-year research collaboration to identify new therapeutic targets for the development of...
Intraoperative MRI and angiography confirms retinoblastoma chemotherapy treatment MINNEAPOLIS, MN, June 19, 2013 /PRNewswire/ - IMRIS Inc. (NASDAQ: IMRS; TSX: IM) ("IMRIS" or the "Company") toda...
American Brain Tumor Association Conference Advances Holistic Approach to Living with a Brain Tumor
Sessions to focus on scientific, medical and rehabilitative therapies that reflect needs of both patients and caregivers. Chicago, IL (PRWEB) June 19, 2013 A brain tumor diagnosis is not only life-ch...
Perfectus Biomed seals £100k growth funding
A fledging medical testing company has secured £100,000 investment to expand its research team and make other strategic investments.Perfectus Biomed, based at Sci-Tech Daresbury, Cheshire, rec...
New blood test finds cancer-related microRNA in blood before tumor development
A new blood test developed in the Gastrointestinal Cancer Research Lab at Baylor Research Institute is showing very promising results for finding cancer-related microRNA in the blood before a tumor de...
Signaling pathway correlates with EGFR status and poor survival in breast cancer patients
Researchers have discovered and mapped the signaling network between two previously unconnected proteins, exposing a link that, if broken, could cut off cancer cell growth at its starting point.
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Companies
ADC Therapeutics sarl (ADCT) is a Swiss-based oncology drug development company that specializes in the development of proprietary Antibody Drug Conjugates (ADCs) targeting major...
Houston-based Mattress Firm (NASDAQ: MFRM) is a high growth specialty retailer, recognized as one of the nationâs largest specialty bedding companies, offering a broad select...
Verastem, Inc. (NASDAQ: VSTM) is a clinical-stage biopharmaceutical company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells. Cancer stem cell...
Next Wave Health provides start-up healthcare technology companies with initial funding, experienced industry advisors and operational services that support growth. For more infor...
MiMedx® delivers innovative bioactive healing products for tissue regeneration MiMedx® is the global premier processor, marketer, and distributor of human amniotic tissue. MiMedx® has...
OncoMed is a clinical development-stage biopharmaceutical company focused on discovering and developing first-in-class monoclonal antibody therapeutics targeting cancer stem cells, or CSCs. Our appr...
Delaware Sustainable Chemistry Alliance (DESCA)
DESCA is a not-for-profit, public-private partnership formed in 2010 to build on Delawareâs strong, existing foundation in chemicals and bio-based materials. DESCA's mission...
Provision Center for Proton Therapy
Opening in early 2014, the Provision Center for Proton Therapy will be the first of its kind in Tennessee and only the second in the Southeast. Proton therapy, the most advanced...
Philadelphia Alliance for Capital and Technologies (PACT)
Greater Philadelphia Alliance for Capital and Technologies (PACT)'s vision is to be a premier resource for emerging growth companies in the technology, clean technology, and life...
Based in Princeton, N.J., and Paris, Stentys has developed a new generation of stents for the treatment of acute myocardial infarction. Founded by Jacques Séguin, M.D., Ph.D.,...
Clinical Trials
This phase II trial is studying how well giving erlotinib together with celecoxib works in treating patients with recurrent stage IIIB or stage IV non-small cell lung cancer. Erlotinib and...
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells....
SU5416 in Treating Patients With Metastatic or Locally Recurrent Colorectal Cancer
Phase II trial to study the effectiveness of SU5416 in treating patients who have metastatic or locally recurrent colorectal cancer. SU5416 may stop the growth of colorectal cancer by stop...
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may...
CCI-779 and EKB-569 in Treating Patients With Advanced Solid Tumors
This phase I trial is studying the side effects, best way to give, and best dose of CCI-779 and EKB-569 in treating patients with advanced solid tumors. Drugs used in chemotherapy, such as...
RATIONALE: PKC412 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. It may also increase the effectiveness of daunorubicin and cytarabine by making ca...
This randomized phase III trial is studying giving tamoxifen citrate or letrozole together with bevacizumab to see how well it works compared with tamoxifen citrate or letrozole alone in t...
Safety and Efficacy Phase 2 Study of Long-acting hGH (MOD-4023) in Growth Hormone Deficient Children
This is a phase II, open label, active-controlled, randomized safety and dose finding study of different MOD-4023 dose levels compared to daily r-hGH therapy in pre-pubertal growth hormone...
This phase I trial studies the side effects and best dose of PI3K inhibitor BKM120 when given together with carboplatin and pemetrexed disodium in treating patients with stage IV non-small...
Akt Inhibitor MK2206 in Treating Patients With Advanced Gastric or Gastroesophageal Junction Cancer
This phase II clinical trial is studying how well Akt inhibitor MK2206 works in treating patients with advanced gastric or gastroesophageal junction cancer. Akt Inhibitor MK2206 may stop t...
Videos
Tumor growth and Metastasis in Breast cancer
Tumor growth is the common denominator of all cancer epidemiological functions. It drives them and shape their manifestations. I described it in other presen...
Medical and Biotech [MESH] Definitions
Taxodium
A plant genus of the family TAXODIACEAE. Members contain taxodione and taxodone, which are diterpenoid quinone methide tumor inhibitors.
Mastocytoma
A solid tumor consisting of a dense infiltration of MAST CELLS. It is generally benign.
Factor For Inversion Stimulation Protein
A highly abundant DNA binding protein whose expression is strongly correlated with the growth phase of bacteria. The protein plays a role in regulating DNA topology and activation of RIBOSOMAL RNA transcription. It was originally identified as a factor required for inversion stimulation by the Hin recombinase of SALMONELLA and Gin site-specific recombinase of BACTERIOPHAGE MU.
Receptor, Epha1
The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.
Ephrin-a1
An ephrin that was originally identified as the product of an early response gene induced by TUMOR NECROSIS FACTORS. It is linked to the CELL MEMBRANE via a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR and binds EPHA2 RECEPTOR with high affinity. During embryogenesis high levels of ephrin-A1 are expressed in LUNG; KIDNEY; SALIVARY GLANDS; and INTESTINE.
