Urokinase Abbott - Biotech, Pharma and Life Science Channel
PubMed Articles
Diagnostic and prognostic significance of CA IX and suPAR in gastric cancer.
This study was intended to evaluate the prognostic and diagnostic significance of carbonic anhydrase IX (CA IX) and soluble urokinase plasminogen activator receptor (suPAR) levels in gastric cancer pa...
Haemarthrosis stimulates the synovial fibrinolytic system in haemophilic mice.
Recurrent joint bleeding is the most common manifestation of haemophilia resulting in haemophilic arthropathy (HA). The exact pathophysiology is unknown, but it is suggested that arthropathy is stimul...
Opposite modulation of cell migration by distinct subregions of urokinase connecting Peptide.
Functional analysis of isolated protein domains may uncover cryptic activities otherwise missed. The serine protease urokinase (uPA) has a clear-cut motogen activity that is catalytically independent...
BACKGROUND: Semaphorin 5A, a member of the semaphorin family, was originally identified as an axonal guidance factor functioning during neuronal development. Previously, we showed that the expression...
Abstract 1. Human chimeric mice (h-PXB mice) having humanized liver, constructed by transplantation of human hepatocytes, were evaluated as an experimental model for predicting human drug metabolism....
Patients with lung adenocarcinoma are often diagnosed with metastasizing symptoms and die of early and distal metastasis. Metastasis is made up of a cascade of interrelated and sequential steps, inclu...
Activation requirements for metabotropic glutamate receptors.
It has been common experimentally to use high frequency, tetanic, stimulation to activate metabotropic glutamate receptors (mGluRs) in cortex and thalamus. To determine what type of stimulation is act...
Ovarian carcinoma is a common gynecological malignancy and a great threat to health as a result of metastasis. The chemokine stromal-derived factor (SDF-1) plays multiple roles in tumor pathogenesis....
Fibrinolysis (plasmin-mediated cleavage of fibrin structures) is a process in which fibrin clots can be removed from blood vessels, allowing the return of normal vascular function. Although several me...
News Articles
Allegheny General Hospital (AGH) in Pittsburgh has been selected to join the ABSORB III clinical trial, a multi-center international study exploring a unique bioresorbable vascular scaffold (BVS), a s...
Goldman Sachs stuft Abbott Labs von Neutral auf Buy hoch
Goldman Sachs stuft Abbott Labs von Neutral auf Buy hoch (© BörseGo AG 2013 - Autor: Thomas Gansneder, Redakteur)...
Blood Banking Market Trends and Opportunities for Suppliers
DALLAS, May 17, 2013 /PRNewswire-iReach/ -- ReportsnReports.com offers new blood banking market research reports for UK, France, Germany, Italy, Spain, US and Japan covering information on industry ou...
[AbbVie] pays for option to acquire [Alvine] equity or its celiac disease compound
In an effort to strengthen its existing gastroenterology pipeline, [Abbott]’s spin off [AbbVie Inc.] has paid $70mm up front for the exclusive option to acquire either equity in [Alvine Pharmaceutic...
AbbVie Inc. (NYSE:ABBV) disclosed in an SEC filing that SVP and CSO John Leonard will retire in the "next few months." AbbVie said Leonard will be involved in the transition process for naming his suc...
Dietitians, nurses, hospitalists and other physicians and clinicians join to address the impact of hospital malnutrition on patient outcomes in the United States...
Abbott receives CE Mark for Architect clinical chemistry Hemoglobin A1c test
Abbott has received CE Mark for its Architect clinical chemistry Hemoglobin A1c (HbA1c) test, which may assist physicians in diagnosing and monitoring diabetes as well as identifying patients at risk...
Perdue Kidd & Vickery Wins First Humira Trial - Abbott Laboratories To Pay $2.24 Million
CHICAGO, May 9, 2013 /PRNewswire/ -- Today, a Cook County jury entered a verdict finding Abbott Laboratories negligent and ordering it to pay $2,244,063.20 to Plaintiff Milton Tietz on behalf of...
Sucampo's Stock Could Reach $12, Says Maxim's Senior Vice President
By Ben Yoffe:Sucampo Pharmaceuticals (SCMP) is a global pharmaceutical company focuses on the research, development, and commercialization of proprietary drugs based on prostones. Prostones are a clas...
Abbott receives CE Mark for ARCHITECT HbA1c test
Abbott today announced CE Marking (Conformité Européenne) for the ARCHITECT clinical chemistry Hemoglobin A1c test, which may aid physicians in diagnosing and monitoring diabetes as well as identify...
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Companies
Abbott science-based offerings in diagnostics, medical devices, nutrition and pharmaceuticals are addressing important health needs of people in more than 150 countries. Abbott's diversity&mdash...
The Alliance to Advance Patient Nutrition
The Alliance to Advance Patient Nutrition is an interdisciplinary partnership dedicated to raising awareness about malnutrition and championing for early nutrition screening, asse...
Biogen Idec uses cutting-edge science to discover, develop, manufacture and market therapies for serious diseases with a focus on neurology, immunology and hemophilia. Founded in...
Research Park at the University of Illinois
The Research Park at the University of Illinois at Urbana-Champaign provides an environment where technology-based businesses can work with faculty and students at Illinois to tak...
RMi, headquartered in Des Moines, Iowa and with offices in New York City and Thousand Oaks, Calif., is a multi-channel marketing consultancy focused on the pharmaceutical and biot...
Bionest Partners Inc. provides strategy consulting services exclusively for the life science industries to help pharmaceutical, biopharmaceutical, diagnostics, biotechnology, and...
Celera is a healthcare business focusing on the integration of genetic testing into routine clinical care through a combination of products and services incorporating proprietary...
The BioRN Cluster Management GmbH is a public-private partnership between the Rhine-Neckar BioRegion, the Heidelberg Technology Park, the Rhine-Neckar Chamber of Com...
Sucampo Pharmaceuticals, Inc. and Abbott
Sucampo Pharmaceuticals, Inc., an international biopharmaceutical company based in Bethesda, Maryland, focuses on the development and commercialization of medicines based on prost...
1535 Abbott Drive
Clinical Trials
A growing body of evidence links Chlamydia pneumoniae to the progression of coronary heart disease. The purpose of this study is to determine the positive and negative effect of 14 days tr...
Treatment for Blood Clots in the Veins of the Legs
Acute deep venous thrombosis (ADVT) of the lower extremity is a common disorder. Traditional treatment with anticoagulation therapy is effective in reducing the associated risk of pulmonar...
Effect of the Fat Content of the Bedtime Snack on Overnight Hypoglycemia
Low blood sugar at night (called nocturnal hypoglycemia), can often happen without symptoms and can last for a long time. Doctors often suggest that patients take a bedtime snack to try t...
Use of OraQuick for Screening HIV in Children Less Than Eighteen Months Old
Blood is the most commonly used specimen to test for HIV. In the past 20 years, use of saliva as an alternative specimen for HIV testing has been explored. Today, very sensitive tests have...
Single Dose Intravenous Inositol Pharmacokinetics in Preterm Infants
This pilot study was a randomized, placebo-controlled, clinical trial to measure changes in blood and urine levels of inositol in premature infants at high risk for retinopathy of prematur...
Double-Blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
Double-Blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression Previously Diagnosed and Treated as Recurrent Major Depression: This study recruits males and fe...
Prospective, randomized, controlled, single-blinded, parallel two-arm, multicenter trial. Test arm: XIENCE V® Everolimus Eluting Coronary Stent System(stent length: 18mm, diameter: 3.0mm...
Urokinase Versus Primary Video-Assisted Thorascopic Surgery for Empyema
This study will compare VATS versus chest drain insertion and urokinase in the treatment of childhood empema by a randomised prospective study.
The purpose of this study is to determine the safety, tolerability, maximum tolerated dose (MTD), pharmacokinetics, and pharmacodynamics of the combination of WX-UK1 and capecitabine in pa...
The Groshong and Groshong PICC catheters are popular venous access devices because they are maintained with only weekly saline flushes. In a recent study, however, we found an apparent de...
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Tissue Plasminogen Activator (TPA)
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Medical and Biotech [MESH] Definitions
Receptors, Urokinase Plasminogen Activator
An extracellular receptor specific for UROKINASE-TYPE PLASMINOGEN ACTIVATOR. It is attached to the cell membrane via a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE and plays a role in the co-localization of urokinase-type plasminogen activator with PLASMINOGEN.
Serpin E2
A protease nexin and serpin subtype that is specific for several SERINE PROTEASES including UROKINASE; THROMBIN; TRYPSIN; and PLASMINOGEN ACTIVATORS.
Urokinase-type Plasminogen Activator
A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.
Plasminogen Inactivators
Important modulators of the activity of plasminogen activators. Four inhibitors, all belonging to the serpin family of proteins, have been implicated in plasminogen activation inhibition. They are PAI-1; PAI-2; protease-nexin; and PROTEIN C INHIBITOR; (PAI-3). All inhibit both the tissue-type and urokinase-type plasminogen activators.
Anistreplase
An acylated inactive complex of streptokinase and human lysine-plasminogen. After injection, the acyl group is slowly hydrolyzed, producing an activator that converts plasminogen to plasmin, thereby initiating fibrinolysis. Its half-life is about 90 minutes compared to 5 minutes for TPA; (TISSUE PLASMINOGEN ACTIVATOR); 16 minutes for UROKINASE-TYPE PLASMINOGEN ACTIVATOR and 23 minutes for STREPTOKINASE. If treatment is initiated within 3 hours of onset of symptoms for acute myocardial infarction, the drug preserves myocardial tissue and left ventricular function and increases coronary artery patency. Bleeding complications are similar to other thrombolytic agents.
