Vaginitis - Biotech, Pharma and Life Science Channel
Vaginitis is an inflammation of the vagina. It can result in discharge, itching and pain, and is often associated with an irritation or infection of the vulva. It is usually due to infection. Vulvovaginitis can affect women of all ages and is very common.
Specific forms of vaginitis are:
1. Infectious vaginitis, which accounts for 90% of all cases in reproductive age women and is represented by Candidiasis (caused by Candida albicans, a yeast), Bacterial vaginosis (caused by Gardnerella, a bacterium) or other less common infections by gonorrhea, chlamydia, mycoplasma, herpes, campylobacter, improper hygiene, and some parasites, notably Trichomonas vaginalis.
2. Hormonal vaginitis includes atrophic vaginitis usually found in postmenopausal or postpartum women. Sometimes it can occur in young girls before puberty. In these situations the estrogen support of the vagina is poor.
3. Irritant vaginitis can be caused by allergies to condoms, spermicides, soaps, perfumes, douches, lubricants and semen. It can also be caused by hot tubs, abrasion, tissue, tampons or topical medications.
4. In foreign body vaginitis, foreign bodies (most commonly retained tampons or condoms) cause extremely malodorous vaginal discharges. Treatment consists of removal, for which ring forceps may be useful. Further treatment is generally not necessary.
Women who have diabetes develop infectious vaginitis more often than women who do not.
Diagnosis is made with microscopy and culture of the discharge after a careful history and physical examination have been completed. The cause of the infection determines the appropriate treatment.
Source; Medical News
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PubMed Articles
To develop more effective antifungal microparticulate therapeutic systems for the treatment of Candida vaginitis, microparticles containing nystatin were elaborated by emulsification/internal gelation...
We sought to evaluate the evidence on the prevalence of aerobic vaginitis (AV) among symptomatic non-pregnant women, as well as the treatment administered for this clinical entity. The PubMed and Scop...
Aerobic vaginitis in pregnancy.
Please cite this paper as: Donders G, Bellen G, Rezeberga D. Aerobic vaginitis in pregnancy. BJOG 2011; DOI: 10.1111/j.1471-0528.2011.03020.x. Aerobic vaginitis (AV) is an alteration in vaginal bacter...
Vulvovaginal candidiasis (VVC), caused by Candida species, is a significant problem in women of childbearing age. Similar to clinical observations, a robust vaginal polymorphonuclear neutrophil (PMN)...
The triazole antifungal pramiconazole (Stiefel, a GSK company) was compared with itraconazole, miconazole and terbinafine in vitro and in vivo. A potent in vitro activity against Candida spp. (IC50 0....
Candida albicans forms Biofilms on the Vaginal Mucosa.
Current understanding of resistance and susceptibility to vulvovaginal candidiasis (VVC) challenges existing paradigms of host defense against fungal infection. While abiotic biofilm formation has a c...
BACKGROUND: Few population-based studies have investigated premalignant and malignant cervical abnormalities in Beijing. METHODS: A total of 6,385 randomly selected sexually active women were intervie...
To achieve better therapeutic efficacy and patient compliance in the treatment for Candida vaginitis, the antifungal agent amphotericin B (AmB) was formulated in a vaginal gel using Pluronic-based mul...
Prevalence and Related Factors of Urinary Incontinence among Hebei Women of China.
Background/Aims: The aim of this study was to assess the prevalence and related factors of different types of urinary incontinence (UI) among Hebei women in China. Methods: A total of 2,500 women aged...
In this study, we investigated the epidemiological characteristics of VVC among pregnant women. We conducted a prospective survey among 372 pregnant women to investigate the prevalence, clinical forms...
News Articles
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Izun Pharmaceuticals Initiates Additional Oral Mucositis Trial Sites
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Paladin Labs Announces the Canadian Launch of VagiSense(TM)
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Chronic vaginal infection, even the ones that do not respond to over-the-counter and prescription medicines, can be cured by boric acid suppositories according to leading health supplement website Roc...
Events
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Companies
Izun Pharmaceuticals Corporation
Izun Pharmaceuticals is a US based pharmaceutical company with a wholly owned R&D center in Israel. Izunâs technology platform allows it to develop botanical drugs by optimiz...
NanoBio® Corporation is a privately-held biopharmaceutical company focused on developing and commercializing dermatological products, anti-infective treatments and intranasal v...
Clinical Trials
Metronidazole for Pulmonary Tuberculosis (South Korea)
This study will evaluate the effect of adding metronidazole to standard second-line therapy for tuberculosis in patients who have multi-drug resistant tuberculosis (MDR-TB) of the lungs. I...
Study Comparing Premarin® Vaginal Cream Versus Premarin® Oral Tablets in Atrophic Vaginitis
The purpose of this study is to characterize the systemic exposure and bioavailability at steady state of Premarin® Vaginal Cream compared with Premarin® oral tablets in postmenopausal w...
Vagifem Low Dose for Postmenopausal Atrophic Vaginitis Symptoms
This trial is conducted in North America. The purpose of this study is to determine if Vagifem Low Dose is an effective and safe treatment for patients suffering from postmenopausal atroph...
Management of Vaginal Complaints
Many women present in primary care with vaginal complaints. The best way of managing these complaints is unclear. This trial will test two different methods of managing patients with vagi...
Use of Oral Probiotics as an Adjunctive Therapy to Fluconazole in the Treatment of Yeast Vaginitis
Yeast vaginitis is a very common ailment affecting premenopausal women in Nigeria. This condition is more prevalent in the age group between 21-30 years. More than 75% of premenopausal wom...
Endometrial Safety of Vagifem Low Dose in Postmenopausal Women With Atrophic Vaginitis
This trial is conducted in Europe. The purpose of this study is to evaluate endometrial safety of Vagifem Low dose in healthy postmenopausal women having atropic vaginitis.
Comparing the new Stainless Steel WaterWorks® douching device to a commercially available douching device using just water for safety and efficacy of odor abatement.
Atrophic vaginitis is a condition in which the skin lining of the vagina and labia becomes thin and symptoms develop including vaginal itching, vaginal discomfort and dyspareunia. These ca...
Atrophic vaginitis is a common problem that occurs in up to 40% of postmenopausal women. The main symptoms are dryness, itching and burning in and around the vagina. These symptoms in turn...
Accuracy and Acceptability of Self-Diagnostic Methods for Vaginitis in Adolescent Females
Symptoms of vaginitis are common among adolescent females, although studies have shown that neither experienced clinicians nor patients can accurately diagnose the cause of vaginitis based...
Videos
Medical and Biotech [MESH] Definitions
Trichomonas Vaginitis
Inflammation of the vagina, marked by a purulent discharge. This disease is caused by the protozoan TRICHOMONAS VAGINALIS.
Vaginitis
Inflammation of the vagina characterized by pain and a purulent discharge.
Vaginosis, Bacterial
Polymicrobial, nonspecific vaginitis associated with positive cultures of Gardnerella vaginalis and other anaerobic organisms and a decrease in lactobacilli. It remains unclear whether the initial pathogenic event is caused by the growth of anaerobes or a primary decrease in lactobacilli.
Metronidazole
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
