Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

00:20 EDT 23rd September 2014 | BioPortfolio

PubMed Articles [4610 Associated PubMed Articles listed on BioPortfolio]

Genetic heterogeneity in Alzheimer disease and implications for treatment strategies.

Since the original publication describing the illness in 1907, the genetic understanding of Alzheimer's disease (AD) has advanced such that it is now clear that it is a genetically heterogeneous condi...

Role of the potassium channel KCa3.1 in diabetic nephropathy.

There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointe...

Urologic Pathology: CBS25-1 UROTHELIAL CARCINOMA WITH VILLOGLANDULAR DIFFERENTIATION.

The patient is a 72-year-old man who presented with hematuria. On cystoscopy, a large friable mass was identified involving the left bladder wall. A transurethral resection of the bladder tumor was pe...

Urologic Pathology: CBS25-1 PLEOMORPHIC GIANT CELL CARCINOMA OF THE URINARY BLADDER.

Pleomorphic giant cell carcinoma is a rare aggressive variant of urothelial carcinoma characterized by the presence of highly pleomorphic bizarre tumor giant cells similar to giant cell carcinoma of t...

Urologic Pathology: CBS25-1 CLEAR CELL PAPILLARY RENAL CELL CARCINOMA.

Clear cell papillary renal cell carcinoma is a newly described variant of renal cell carcinoma (RCC). The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplas...

Renal Pathology: SY23-1 CURRENT APPROACH TO CLASSIFICATION OF MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS.

Membranoproliferative glomerulonephritis (MPGN) is a pattern of injury, which historically has been classified using light and electron microscopic morphologic features. Primary (idiopathic) MPGN was ...

Renal Pathology: SY23-1 CLASSIFICATION OF LUPUS GLOMERULONEPHRITIS: AN UPDATE.

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease commonly affecting the kidneys, mostly mediated by immune complexes, resulting in a spectrum of glomerular lesions. They range ...

Renal Pathology: SC23-3 LUPUS TUBULOINTERSTITIAL AND VASCULAR DISEASE.

Since its inception over 40 years ago, the classification of lupus nephritis has focused entirely on glomerular alterations. Existing data indicate that tubulointerstitial and possibly vascular altera...

Renal Pathology: SC23-2 RENAL TRANSPLANT PATHOLOGY: REVIEW AND UPDATE.

Renal transplant pathology forms an integral part of medical kidney diseases requiring a biopsy for diagnosis, prognosis and/or appropriate therapy. Often, multiple transplant biopsies are performed t...

Pulmonary Pathology: LC22-1 RESPIRATORY BRONCHIOLITIS WITH FIBROSIS: A FORM OF SMOKING-RELATED DISEASE.

A new smoking-associated lesion has been described in the pathology literature over the last few years by various names including RBILD with fibrosis, smoking-related interstitial fibrosis, and airspa...

News Articles [1252 Associated News Articles listed on BioPortfolio]

Natural GMOs Part 208. Conventional Wisdom wrong.Breeders incorporating unknown’ DNA into food crops for centuries

Curtis Hannah calls out the Conventional Wisdom Trap at GLP:When transgenic plants (the so-cal

Japan approves Eylea for myopic CMV

Regeneron Pharmaceuticals Inc. (NASDAQ:REGN) said Japan's Ministry of Health approved Eylea aflibercept to treat myopic choroidal neovascularization (myopic CNV), the second leading cause of blindness...

How Gene Expression Affects Facial Expressions

A person’s face is the first thing that others see, and much remains unknown about how it forms — or malforms — during early development. Recently, Chong Pyo Choe, a senior postdoctoral fellow w...

MIT Engineers are Battling Superbugs

In recent years, new strains of bacteria have emerged that resist even the most powerful antibiotics. Each year, these superbugs, including drug-resistant forms of tuberculosis and staphylococcus, inf...

Mycophenolate Mofetil Cuts Relapse in MS Variant NMO

MMF reduced the frequency of relapse while stabilizing or improving disability in patients with neuromyelitis optica spectrum disorder, a new study shows. Medscape Medical News

Plant variants point the way to improved biofuel production

Manufacturing biofuels from food crop by-products such as straw could be made quicker and cheaper thanks to the work of scientists in the UK and France. Researchers funded by the Biotechnology an...

Hollywood Supports Walk to End Lupus Now in Los Angeles

LOS ANGELES, Sept. 22, 2014 /PRNewswire-USNewswire/ -- Hollywood stars of television turned out to shed light on the cruel mystery that is lupus and raise critically needed funds for research and educ...

TauRx hits milestone in mild Alzheimer's trial

Singapore-based TauRx has completed enrolment in a second pivotal trial of its Alzheimer's disease (AD) candidate LMTX, setting it on course for a data read-out in early 2016.TauRx is bucking the tren...

TauRx Therapeutics Achieves Enrolment Target for Second Phase III Clinical Trial of LMTX™ in Alzheimer's Disease

ABERDEEN, Scotland and SINGAPORE, Sept. 22, 2014 /PRNewswire/ -- TauRx Therapeutics Ltd has achieved its target enrolment of 700 subjects with mild Alzheimer's disease into the second of its...

Study reveals how gene expression affects facial expressions

A person's face is the first thing that others see, and much remains unknown about how it forms—or malforms—during early development. Recently, Chong Pyo Choe, a senior postdoctoral fellow working...

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Companies [89 Associated Companies listed on BioPortfolio]

Ansun BioPharma

Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. Ansun BioPharma has ...

TherapeuticsMD Inc.

TherapeuticsMD Inc. is an innovative healthcare company focused on developing and commercializing products exclusively for women. TherapeuticsMD is developing advanced hormone the...

BioFilm, Ltd.

Founded in 2003 as a subsidiary of Devro plc., BioFilm is the largest Thin Dissolving Film (TDF) producer in Europe, with their GMP certified manufacturing and packaging facility ...

Sunrise Senior Living, LLC

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of April 1, 2014, Sunrise operated 290 communities in the United States, Canada and the...

Sunrise Senior Living and Health Care REIT, Inc.

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of January 1, 2014, Sunrise operated 290 communities in the United States, Canada and t...

DNAtrix Inc.

DNAtrix is a company developing modified oncolytic viruses for the treatment of the most aggressive forms of cancer. Since viruses are already efficient at killing cells, scientis...

Alector LLC

Alector is combining state-of-the-art antibody technology and recent discoveries in neuroimmunology and human genetics to develop novel therapeutics for Alzheimer’s disease, ...

DataMotion

DataMotion enables organizations to dramatically reduce the cost and complexity of delivering electronic information to employees, customers and partners in a secure and compliant...

University of Iowa Pharmaceuticals

The University of Iowa Pharmaceuticals (UIP) is the largest and most experienced university-affiliated FDA-registered pharmaceutical manufacturing facility in the United States fo...

Noble Biomaterials, Inc.

X-STATIC® is a registered trademark of Noble Fiber Technologies, LLC. Headquartered in Scranton, PA, Noble Biomaterials, Inc. is a global leader in bacterial management solutio...

Clinical Trials [532 Associated Clinical Trials listed on BioPortfolio]

A Study of Belimumab Administered Subcutaneously in Subjects With Systemic Lupus Erythematosus (SLE)

The purpose of this study is to evaluate the efficacy, safety and tolerability of belimumab administered subcutaneously (SC) to adult subjects with Systemic Lupus Erythematosus (SLE).

Positron Emission Tomography in Extrapulmonary Tuberculosis

Tuberculosis (TB) remains a major public health problem. In extra-pulmonary forms, evidence of bacteriological cure is difficult to be obtained raising the need for other therapeutic asses...

Evaluating the Safety and Immune Response to Two Doses of a Dengue Virus Vaccine Administered 12 Months Apart

Dengue viruses can cause dengue fever and other more severe forms of disease. This study will evaluate the safety and immune response to two doses of a dengue virus vaccine given 12 months...

Massage for Chemotherapy Induced Peripheral Neuropathy (CIPN)

The goal of this research study is to test two forms of massage for neuropathy from your cancer treatment. Researchers also want to study how participants may respond to massage treatment...

Nutritional Counseling Associated With the Ingestion of Oat Bran in Hypercholesterolemic Subjects

Dyslipidemia is among the risk factors for cardiovascular diseases (CVD). Is's due to genetic and / or environmental factors such as inadequate dietary pattern. The occurrence of adverse e...

RSLV-132 Biologic Proof-of-Concept in Systemic Lupus Erythematosus

This one month multi-dose study will evaluate the ability of RSLV-132 to remove circulating immune complexes from the blood of lupus patients. Immune complexes are thought to trigger the ...

Copeptin for Risk Stratification in Non-traumatic Headache in the Emergency Setting - The CoHead Study

Headache is a common symptom, and patients often seek medical attention at emergency departments due to headaches. The aim of the CoHead Study is to find out if it is possible by measurin...

Treatment of Social Phobia With Combined Cognitive Bias Modification and iCBT

The purpose of this study is to determine whether an internet-based treatment program, consisting of combined cognitive bias modification and cognitive behavioral therapy, reduces symptoms...

Safety, Tolerability and Pharmacokinetics of Iloperidone Depot in Schizophrenic Patients

This study is designed as a three-part trial to evaluate the safety of a novel depot formulation of iloperidone, compare two depot dosage forms, and perform dose ranging of one chosen form...

Blocking Tumor Necrosis Factor in Ankylosing Spondylitis

The Division of Rheumatology at University of California San Francisco is conducting a research study on the treatment of ankylosing spondylitis (AS) with a new therapy currently used for ...

Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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