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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

22:44 EDT 24th April 2017 | BioPortfolio

PubMed Articles [4188 Associated PubMed Articles listed on BioPortfolio]

Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart.

Mitochondrial connexin 43 (Cx43) plays a key role in cardiac cytoprotection caused by repeated exposure to short periods of non-lethal ischemia/reperfusion, a condition known as ischemic preconditioni...

Key Parameters for the Use of AbobotulinumtoxinA in Aesthetics: Onset and Duration.

Time to onset of response and duration of response are key measures of botulinum toxin efficacy that have a considerable influence on patient satisfaction with aesthetic treatment. However, there is n...

S100P as a Marker for Urothelial Histogenesis: A Critical Review and Comparison With Novel and Traditional Urothelial Immunohistochemical Markers.

S100P, or placental S100, is a member of a large family of S100 proteins and considered to be a promising immunohistochemical marker to support urothelial differentiation. This review synthesizes publ...

Frontotemporal Dementia.

Frontotemporal dementia (FTD) is a heterogeneous disorder with distinct clinical phenotypes associated with multiple neuropathologic entities. Presently, the term FTD encompasses clinical disorders th...

Psychocutaneous disease: Pharmacotherapy and psychotherapy.

Building a strong therapeutic alliance with the patient is of utmost importance in the management of psychocutaneous disease. Optimal management of psychocutaneous disease includes both pharmacotherap...

ALK Expression is a Rare Finding in Mycosis Fungoides.

Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Although indolent in its early stages, MF is more aggressive in advanced stages, particularly if large cell transformation ...

Repeated evolution of digital adhesion in geckos, a reply to Harrington and Reeder.

We published a phylogenetic comparative analysis that found geckos had gained and lost adhesive toepads multiple times over their long evolutionary history (Gamble et al. 2012). This was consistent w...

A rare variant in TOR1A exon 5 associated with isolated dystonia in southwestern Chinese.

TOR1A has been proposed as an important genetic factor in early-onset isolated dystonia. Variants located in the 3' untranslated region of TOR1A are of particular importance because they may influence...

NMDAR-Independent Hippocampal Long-Term Depression Impairment after Status Epilepticus in a Lithium-Pilocarpine Model of Temporal Lobe Epilepsy.

Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits. Despite numerous existing studies on various animal models, the mechanisms of these deficits remain largely unc...

Structure of Fam20A reveals a pseudokinase featuring unique disulfide pattern and inverted ATP-binding.

Mutations in FAM20A cause tooth enamel defects known as Amelogenesis Imperfecta (AI) and renal calcification. We previously showed that Fam20A is a secretory pathway pseudokinase and allosterically ac...

News Articles [1105 Associated News Articles listed on BioPortfolio]

R. Swamy Venuturupalli, M.D. Launches Attune Health in Beverly Hills, CA

Dr. R. Swamy Venuturupalli, M.D., one of the nation’s leading rheumatologists, has launched his new practice, Attune Health (www.attunehealth.com). To better serve patients who ...

MolecularMatch Introduces MMPower Knowledge Base - Providing One of the Industry's Most Dynamic Molecular Search Engines

MolecularMatch has announced their new knowledge platform, MMPower. The Platform covers over 400 million alterations with the ability to process whole exomes in seconds. ...

Recipharm Opens GMP Suite for Clinical Trial Materials

$750k investment will focus on non-sterile dosage forms including metered dose inhalers and semi-solid topical products

Visualisation in network psychometrics is effective

How do you map out psychological phenomena in a way that makes their relationships and interactions clear? Sacha Epskamp conducted research in this area known as 'network psychometrics', which explain...

AWARE for All: CISCRP’s Clinical Research Education Event Returning to Houston this May

The Center for Information and Study on Clinical Research Participation (CISCRP) is holding an AWARE for All - Clinical Research Education and Health Screening event on Friday, May 12 from 11 am-2 pm ...

Penn team identifies genetic target for growing hardier plants under stress

(University of Pennsylvania) In a new investigation, researchers from the University of Pennsylvania identified two proteins that regulate whether a cell in plant roots forms a hair cell, which increa...

Lupus Patients at Risk for Stroke (CME/CE)

(MedPage Today) -- Risks high for women, the young, and during the year after diagnosis

Report: Anti-Semitism rises, but violence against Jews falls

TEL AVIV, Israel (AP) — Violent attacks on Jews dropped for a second straight year in 2016, but other forms of anti-Semitism are on the rise worldwide, particularly on U.S. university campuses, acco...

Medical News Today: Are you a chocaholic? Your genes could be to blame

Researchers have uncovered a number of genetic variants that affect what foods we choose to eat, including one variant linked to higher chocolate intake.

DPP4 truncated GM-CSF and IL-3 manifest distinct receptor-binding and regulatory functions compared with their full-length forms

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Companies [111 Associated Companies listed on BioPortfolio]

AgTech Accelerator

AgTech Accelerator, established in 2016 in Research Triangle Park, is a venture development organization focused on discovering and developing emerging agricultural technology and...

Fabric Genomics

Fabric GenomicsTM is a computational genomics company offering end-to-end genomic data analysis, annotation, curation, classification and reporting solutions ...

Puma Biotechnology, Inc.

Puma Biotechnology, Inc. is a development stage biopharmaceutical company that acquires and develops innovative products for the treatment of various forms of cancer. The Company ...

The Foundation for Mitochondrial Medicine

The Foundation for Mitochondrial Medicine is a 501(c) (3) non-profit organization dedicated to supporting the development of the most promising research and treatments of the many...

Ennis, Inc.

Ennis, Inc. (www.ennis.com) is primarily engaged in the production and sale of business forms, apparel and other business products. The Company is one of the largest privat...

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

Pinnacle Biologics

Founded in 2007 by former Abbott Laboratories executives Guillermo Herrera, James Miller, and Viren Grover, Pinnacle Biologics is a premier international company that excels in assisting pharmaceu...

HealthViewX

HealthViewX is a robust health IT platform designed for effective care coordination, communication and analytics to enhance patient treatment through meaningful health systems int...

Hereditary Neuropathy Foundation

Hereditary Neuropathy Foundation (HNF) is a non-profit 501(c)3 organization whose mission is to increase awareness and accurate diagnosis of Charcot-Marie-Tooth disease (CMT) and ...

North Carolina Council on Developmental Disabilities

The North Carolina Council on Developmental Disabilities (NCCDD) works to assure that people with intellectual and other developmental disabilities (I/DD) and their families parti...

Clinical Trials [945 Associated Clinical Trials listed on BioPortfolio]

Relevance of Monitoring Blood and Salivar Levels of Drugs Used in Rheumatic Autoimmune Diseases

No drug treatment is completely free of risk and lack of response, adverse events and poor adherence may affect its effectiveness. Within this context, this project aims to evaluate the im...

Descriptive Study of the Evolution in Proportion of Regulatory B Lymphocytes in Patients Hospitalized in Intensive Care for Severe Sepsis

Severe sepsis and septic shock are the most severe forms of sepsis (which associates a systemic inflammatory response with infection). These are serious pathologies with a lethality estima...

Astrocytoma / Desmoplastic Gamliogliomes (DIA / DIG) - Study of the French Cohort of the Last 20 Years : Clinical, Anatomopathological, Molecular and Radiological Charactersics

Astrocytomas / infantile desmoplastic gangliogliomas (DIA / DIG) are rare brain tumors usually affecting infants. They represent about 0.5% of all pediatric brain tumors. DIA / DIG occurs ...

Compare the Performance of Targeted Biopsy Versus Aspiration Biopsy With a Pipette for the Diagnosis of Endometrial Cancer

Endometrial cancer is the most common pelvic gynecological cancer in so-called developed countries, with 320,000 new cases annually, including more than 1,500 in Belgium. It preferentially...

Autologous Antigen-activated Dendritic Cells in the Treatment of Patients With Breast Cancer

The purpose of this work: to assess the tolerability and effectiveness of the autogemotherapy method on the basis of autologous antigen-activated dendritic cells in the treatment of patien...

Evaluation of Readability of Consent Forms on the Understanding of the Information Received by Volunteers

Prior to the completion of biomedical research, any person undergoing it must receive a readable and intelligible information about this research, in order to give free and informed consen...

Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Hypertonic Saline

The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Hypertonic Saline (HS) in individuals with cough variant as...

Pilot Study to Investigate Contemplative Intervention in Lupus Patients

The study tests whether contemplative-based intervention can modify pathogenic processes in participants with Lupus. Techniques such as meditation, mindfulness and yoga may have an impact ...

Evaluating Raised Intracranial Pressure Using MR Elastography

Investigators will compare magnetic resonance (MR) elastography measurements to other forms of noninvasive methods of detecting raised intracranial pressure, including optical coherence to...

JBT-101 in Systemic Lupus Erythematosus (SLE)

One hundred adults with active joint disease and at least moderate pain will be enrolled in this study to evaluate JBT-101, a synthetic endocannabinoid receptor type 2 (CB2) agonist and an...

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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