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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

15:40 EDT 25th June 2016 | BioPortfolio

PubMed Articles [4282 Associated PubMed Articles listed on BioPortfolio]

Modification biological activity of S and R forms of Proteus mirabilis and Burkholderia cepacia lipopolysaccharides by carrageenans.

The modification of biological features of S and R forms of Proteus mirabilis and Burkholderia cepacia LPS by kappa/iota and kappa/beta carrageenans was shown in Limulus activation test, ELISA, human ...

Whiteness improvement of citric acid crosslinked cotton fabrics: H2O2 bleaching under alkaline condition.

Polycarboxylic acids have been employed as formaldehyde-free crosslinking agents in anti-wrinkle treatment for cotton fabrics. Cotton fabrics treated by citric acid (CA) catalyzed with effective catal...

Alien Hand Syndrome.

Alien hand syndrome (AHS) is a rare disorder of involuntary limb movement together with a sense of loss of limb ownership. It most commonly affects the hand, but can occur in the leg. The anterior (fr...

Beyond Tracheostomy: Noninvasive Ventilation and Potential Positive Implications for Speaking and Swallowing.

For more than a decade, there has been a trend toward increased use of noninvasive positive pressure ventilation (NPPV) via mask or mouthpiece as a means to provide ventilatory support without the nee...

Transient paralysis of diaphragm in Waldenstroms disease; a focal variant of Guillain-Barré syndrome?

TDP-43 in the hypoglossal nucleus identifies amyotrophic lateral sclerosis in behavioral variant frontotemporal dementia.

The hypoglossal nucleus was recently identified as a key brain region in which the presence of TDP-43 pathology could accurately discriminate TDP-43 proteinopathy cases with clinical amyotrophic later...

4,4'-Dichlorodiphenyltrichloroethane (DDT) and 4,4'-dichlorodiphenyldichloroethylene (DDE) promote adipogenesis in 3T3-L1 adipocyte cell culture.

4,4'-Dichlorodiphenyltrichloroethane (DDT), a chlorinated hydrocarbon insecticide, was extensively used in the 1940s and 1950s. DDT is mainly metabolically converted into 4,4'-dichlorodiphenyldichloro...

Loss of CDKN2A Promoter Methylation Coincides With the Epigenetic Transdifferentiation of Uterine Myosarcomatous Cells.

Leiomyosarcoma is the most common type of uterine sarcoma and usually displays typical morphology. Heterologous leiomyosarcoma is the rarest variant, in which the tumor contains liposarcomatous, osteo...

Measurement of labile copper in wine by medium exchange stripping potentiometry utilising screen printed carbon electrodes.

The presence of copper in wine is known to impact the reductive, oxidative and colloidal stability of wine, and techniques enabling measurement of different forms of copper in wine are of particular i...

Electrochemical DNA biosensor based on poly(2,6-pyridinedicarboxylic acid) modified glassy carbon electrode for the determination of anticancer drug gemcitabine.

In this study, a simple methodology was used to develop a new electrochemical DNA biosensor based on poly(2,6-pyridinedicarboxylic acid) (P(PDCA)) modified glassy carbon electrode (GCE). This modified...

News Articles [1318 Associated News Articles listed on BioPortfolio]

Aurinia grosses $7.1mm through private placement

Aurinia Pharmaceuticals Inc. raised $7.1mm through the private sale of 3mm units at $2.36 (a 17% discount). Each unit consisted of one common share and 0.35 of a two year common share purchase warrant...

Discovery of an epigenetic regulator of tumourigenesis suggests new strategies against

Scientists have identified a previously unknown mechanism by which a protein called CBX8 promotes tumour growth in the most lethal forms of breast cancer. The study, published today in the journal Ce...

BRIEF-Sichuan Languang Development forms strategic partnership with Sichuan University

* Says the co entered into strategic partnership agreement with Sichuan University, to jointly develop pharmaceuticals and medical apparatus

First detection of a chiral molecule in interstellar space

Chiral molecules have two forms that are identical in structure, but are mirror images of one another. They are important on Earth because most biomolecules found in living organisms are chiral. Now, ...

IBM Watson forms imaging coalition

Cognitive technology company IBM Watson has formed a new coalition to improve the way physicians use medical imaging data in their daily practice.

Propellon Therapeutics to Accelerate WDR5 Inhibitor Development for Cancers

FACIT forms biotechnology company for OICR-discovered first-in-class epigenetic modifiers  TORONTO, June 23, 2016 /PRNewswire/ - FACIT has announced the creation of a new Ontario biotechnolog...

Discovery of an epigenetic regulator of tumorigenesis suggests new strategies against lethal forms of breast cancer

Scientists have identified a previously unknown mechanism by which a protein called CBX8 promotes tumor growth in the most lethal forms of breast cancer. The study underscores the need for cancer rese...

Discovery of an epigenetic regulator of tumorigenesis suggests new strategies against breast cancer

Mount Sinai scientists have identified a previously unknown mechanism by which a protein called CBX8 promotes tumor growth in the most lethal forms of breast cancer. The study, published today in the ...

2016 Lupus Insight Prize Presented to Dr. Ann Marshak-Rothstein

BOSTON, June 23, 2016 /PRNewswire-USNewswire/ -- The 2016 Lupus Insight Prize was awarded today to Ann Marshak-Rothstein, PhD, University of Massachusetts Memorial Medical Center and Professor of...

West Nile Virus Sparks Synaptic Inflammation Leading to Memory Loss

Scientists at the University of Colorado Anschutz Medical Campus say they have discovered how the most severe forms of West Nile virus cause memory loss and mood disorders, opening the door to poten...

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Companies [109 Associated Companies listed on BioPortfolio]

The Foundation for Mitochondrial Medicine

The Foundation for Mitochondrial Medicine is a 501(c) (3) non-profit organization dedicated to supporting the development of the most promising research and treatments of the many...

Ennis, Inc.

Ennis, Inc. (www.ennis.com) is primarily engaged in the production and sale of business forms, apparel and other business products. The Company is one of the largest privat...

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

Pinnacle Biologics

Founded in 2007 by former Abbott Laboratories executives Guillermo Herrera, James Miller, and Viren Grover, Pinnacle Biologics is a premier international company that excels in assisting pharmaceu...

HealthViewX

HealthViewX is a robust health IT platform designed for effective care coordination, communication and analytics to enhance patient treatment through meaningful health systems int...

Hereditary Neuropathy Foundation

Hereditary Neuropathy Foundation (HNF) is a non-profit 501(c)3 organization whose mission is to increase awareness and accurate diagnosis of Charcot-Marie-Tooth disease (CMT) and ...

North Carolina Council on Developmental Disabilities

The North Carolina Council on Developmental Disabilities (NCCDD) works to assure that people with intellectual and other developmental disabilities (I/DD) and their families parti...

OncoRx Pharmaceuticals Inc.

OncoRx Pharmaceuticals (www.oncorxpharmaceuticals.com) is an early-stage pharmaceutical company dedicated to the discovery and development of novel drugs that control tumor metast...

amcure GmbH

amcure GmbH is a spin-off from the Karlsruhe Institute of Technology established in 2011. The company develops peptide-based compounds for the treatment of highly metastatic forms...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

Clinical Trials [791 Associated Clinical Trials listed on BioPortfolio]

LUMIER² Study : LUpus Molecular Immunomonitoring to Evaluate the Risk of Relapse

Systemic Lupus Erythematosus (SLE) is a chronic auto-immune disease evolving by flares, with possible organ damage, and periods of remission. Current biological markers of disease activity...

Default Mode Network in Multiple Sclerosis

The study will evaluate connectivity regardless whether patients present a clinical type that requires medical treatment. In this point, investigators will include patients with progressiv...

Role of Podocan and Wnt Pathway Regulatory Molecules in Coronary Artery Disease

The purpose of this study is to find an association between a protein named Podocan and WNT pathway regulatory molecules in patients with different forms of Coronary Artery Disease (Acute ...

A Clinical Trial Undertaken Around the World in Adult Patients With Lupus Erythematosus Currently Having Symptoms. These Patients Are Randomly (Like Flipping a Coin) Given a Drug (at 3 Different Doses) or an Inactive Drug in Addition to Their Usual Medica

A Phase 2b, randomized, double-blind, PBO-controlled, parallel-group, dose-ranging study followed by an observational period that will evaluate the efficacy of Dapirolizumab Pegol (DZP) in...

Studying Tailored Exercise Prescriptions in Breast Cancer Patients

Chemotherapy forms a significant part of many breast cancer patient's treatment and is associated with various common, known adverse effects. For the last few decades, physical activity ha...

New Approaches in MRI at 3T Dedicated to Targeting Subthalamic Nucleus on Parkinsonian Patients

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a validated procedure, used in many French and international centers for the treatment of severe forms of Parkinson's disea...

MRI Versus PSA in Prostate Cancer Screening

In this open randomized controlled trial, we seek to study whether prostate cancer screening using multiparametric prostate magnetic resonance imaging (mpMRI) improves the detection rate o...

Determination of the RANKL/Osteoprotegerin Ratio in Patients With Systemic Lupus Erythematosus. Role in Osteoporosis and Cardiovascular Calcification

Patients with Systemic lupus erythematosus (SLE) are known to present an increased risk of osteoporosis and cardiovascular calcification. It has also been suggested that bone remodelling a...

Combination Adenovirus + Pembrolizumab to Trigger Immune Virus Effects

Glioblastoma (GBM) and gliosarcoma (GS) are the most common and aggressive forms of malignant brain tumor in adults and can be resistant to conventional therapies. The purpose of this Phas...

Characterisation of Adult-Onset Hypophosphatasia

Hypophosphatasia (HPP) is an inherited condition which causes a defect in bone calcification, leading to weak bones. Early childhood forms are severe and easily recognised, and there is no...

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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