Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

19:08 EST 21st November 2014 | BioPortfolio

PubMed Articles [4566 Associated PubMed Articles listed on BioPortfolio]

Molecular Cloning, Sequence, and Phylogenetic Analysis of T Helper 1 Cytokines of Pashmina Goats.

Cytokines play an important role in regulation of immune responses either in health or disease. In the present study, the cDNAs encoding mature Interleukin (IL)-2, interferon gamma (IFN-γ), and IL-12...

Novel Polymorphisms in Porcine 3'UTR of the Leptin Gene, Including a Rare Variant within Target Sequence for MIR-9 Gene in Duroc Breed, not Associated with Production Traits.

The leptin gene (LEP) is considered as a functional candidate for production traits in livestock due to its crucial role in energy homeostasis. Because polymorphisms in regulatory sequences may affect...

Pound the alarm: danger signals in rheumatic diseases.

Damage-associated molecular patterns (DAMPs) are chemically heterogeneous endogenous host molecules rapidly released from damaged or dying cells that incite a sterile inflammatory response mediated vi...

Determination of α- and β-boldenone sulfate, glucuronide and free forms, and androstadienedione in bovine urine using immunoaffinity columns clean-up and liquid chromatography tandem mass spectrometry analysis.

The debate about the origins of boldenone in bovine urine is ongoing for two decades in Europe. Despite the fact that its use as a growth promoter has been banned in the European Union (EU) since 1981...

Metals in boat paint fragments from slipways, repair facilities and abandoned vessels: An evaluation using field portable XRF.

Paint flaking off abandoned vessels or generated during boat repair is hazardous to human health and wildlife. In this study, a means of screening paint fragments using a field portable-X-ray fluoresc...

Research on phosphorus loads and characteristics of adsorption and release in surface sediments of Nanyang Lake and Weishan Lake in China.

The characteristics of phosphate adsorption and the transformation of phosphorus forms in the release process of the sediments in Nanyang Lake and Weishan Lake are researched. Distribution of maximal ...

Isolation and purification of versican and analysis of versican proteolysis.

Versican is a widely distributed chondroitin sulfate proteoglycan that forms large complexes with the glycosaminoglycan hyaluronan (HA). As a consequence of HA binding to its receptor CD44 and interac...

The detection of glycosaminoglycans in pancreatic islets and lymphoid tissues.

In this chapter, we describe the detection of the glycosaminoglycans hyaluronan and heparan sulfate in pancreatic islets and lymphoid tissues. The identification of hyaluronan in tissues is achieved b...

Glycosaminoglycan-protein interaction studies using fluorescence spectroscopy.

Fluorescence spectroscopy is a quantitative analytical tool that has been extensively used to provide structural and dynamical information on GAG-protein complexes. It possesses major advantages inclu...

Efficacy of supplementation of selected medicinal mushrooms with inorganic selenium salts.

The aim of the study was to evaluate the possibility of supplementation with inorganic forms of selenium (Na2SeO4 and Na2SeO3) in concentrations of 0, 0.1, 0.2, 0.4, 0.6, 0.8, 1.0 and 1.5 mM of three...

News Articles [1225 Associated News Articles listed on BioPortfolio]

National Comprehensive Cancer Network’s Patient Guidelines for Mesothelioma®, Sponsored By Mesothelioma Law Firm Baron and Budd, Now Available on Amazon.com

Guidelines Also Available on Website Covering Several Other Forms of Cancer The National Comprehensive Cancer Network® (NCCN), comprised of several of the world’s le...

Archaea May Be an Untapped Source of Antibacterial Drugs

One of the most mysterious forms of life may turn out to be a rich and untapped source of antibacterial drugs. The mysterious life form is Archaea, a family of single-celled organisms that thrive in e...

Key factor discovered in the progression of liver cancer

One of the most aggressive and common forms of liver cancer is hepatocellular carcinoma. A team of researchers from the Institute of Cancer Research at the MedUni Vienna has identified the crucial ke...

Discovery could lead to new drugs to stop many solid-tumor cancers

In a step forward in the battle against cancer, researchers have identified promising compounds to inhibit a key driver of many forms of the disease, including lung, prostate, colon, bladder and pancr...

Dead Sea Moringa® Promotes Holiday Health Through Unique Supplement

All-natural supplement from Israel packs impressive punch of vitamins and nutrients Boca Raton, FL (PRWEB) November 21, 2014 With holiday travelers preparing to encounter a wide variety of coughs, co...

Scientists develop 3-D model of regulator protein bax

Scientists at Freie Universität Berlin, the University of Tubingen, and the Swiss Federal Institute of Technology in Zurich (ETH) provide a new 3D model of the protein Bax, a key regulator of cell de...

Key protein decrypted: Scientists develop 3D model of regulator protein bax

A new 3D model of the protein Bax, a key regulator of cell death, has been developed and released by researchers. When active, Bax forms pores in the membranes of mitochondria, causing the release of ...

George Tsokos, M.D., honored by Lupus Foundation and American College of Rheumatology

(Beth Israel Deaconess Medical Center) Tsokos, Chief of Rheumatology at Beth Israel Deaconess Medical Center, is honored for investigations into the origins of lupus which have led to the discovery of...

Eczema May Hike Lupus Risk in Kids

(MedPage Today) -- SLE incidence rate tied to severity of atopic dermatitis.

BP Still High With Lupus Nephritis in Remission

(MedPage Today) -- Aggressive treatment important to achieve complete remission, prevent relapses.

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Companies [91 Associated Companies listed on BioPortfolio]

tesa Labtec GmbH

With more than 20 years of experience, tesa Labtec is one of the leading drug delivery companies for film-shaped dosage forms like patches and oral films. Based on its innovative ...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

Ansun BioPharma

Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. Ansun BioPharma has ...

TherapeuticsMD Inc.

TherapeuticsMD Inc. is an innovative healthcare company focused on developing and commercializing products exclusively for women. TherapeuticsMD is developing advanced hormone the...

BioFilm, Ltd.

Founded in 2003 as a subsidiary of Devro plc., BioFilm is the largest Thin Dissolving Film (TDF) producer in Europe, with their GMP certified manufacturing and packaging facility ...

Sunrise Senior Living, LLC

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of April 1, 2014, Sunrise operated 290 communities in the United States, Canada and the...

Sunrise Senior Living and Health Care REIT, Inc.

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of January 1, 2014, Sunrise operated 290 communities in the United States, Canada and t...

DNAtrix Inc.

DNAtrix is a company developing modified oncolytic viruses for the treatment of the most aggressive forms of cancer. Since viruses are already efficient at killing cells, scientis...

Alector LLC

Alector is combining state-of-the-art antibody technology and recent discoveries in neuroimmunology and human genetics to develop novel therapeutics for Alzheimer’s disease, ...

DataMotion

DataMotion enables organizations to dramatically reduce the cost and complexity of delivering electronic information to employees, customers and partners in a secure and compliant...

Clinical Trials [556 Associated Clinical Trials listed on BioPortfolio]

Implementation of Evidence-based Psychotherapy for PTSD

Approximately 9% of Canadians will have Posttraumatic Stress Disorder (PTSD) in their lifetime. In the military veteran population, the lifetime prevalence of PTSD has been estimated to be...

Psychoeducational and Behavioral Strategies in Reducing Distress and Anxiety in Patients With Multiple Myeloma and Their Family Caregivers

This pilot clinical trial studies how well psychoeducational and behavioral strategies work in reducing distress and anxiety in patients with multiple myeloma and their family caregivers. ...

Plegridy™ Observational Program

The primary objectives of the study are to determine the incidence of serious adverse events (SAEs) in patients with relapsing forms of multiple sclerosis (MS) in routine clinical practice...

Genetic Analysis of Immune Disorders

The purposes of this study are to 1) identify the genes responsible for certain immune disorders, 2) learn about the medical problems they cause, and 3) learn how to predict who is likely ...

A Biomarker Study to Identify Predictive Signatures of Response to LDE225 (Hedgehog Inhibitor) In Patients With Resectable Pancreatic Cancer

Pancreatic cancer is considered a rare form of cancer with about 277,000 new cases diagnosed in 2008 world-wide, which is about 2.5% of all forms of cancer. However, pancreatic cancer is m...

A Study to Compare the Efficacy and Safety of Tacrolimus Capsules With Leflunomide Tablets in Lupus Nephritis Patients

The purpose of this study is to compare the efficacy and safety of tacrolimus capsules with leflunomide tablets in the treatment of lupus nephritis.

Influence of Selenium on Prostate Cancer Related Biomarkers

Penn State Milton S. Hershey Medical Center researchers are trying to compare the effects of two different forms of selenium (selenium yeast and selenomethionine) on blood selenium levels ...

Evaluation of Molecular Forms of PSA and Human Kallikrein 2 in a Cohort of Patients With Locally Resected Prostate Cancer But Biochemical Recurrence

The purpose of this study is to investigate if a new blood test looking at PSA and a group of PSA related proteins in a patient's blood can indicate which men after surgery with a rising P...

Language Proficiency and Quality of Life After Receiving Cochlear Implantation as a Child

Treatment with cochlear implantation is now offered to proximately 95 % of children with deafness in Norway. More than 500 children have been operated at Oslo University Hospital. The stud...

An Adaptive Phase II Study to Evaluate the Efficacy, Pharmacodynamics, Safety and Tolerability of GSK2586184

This is an adaptive, dose ranging, Phase II study to investigate the relationship between repeat doses of GSK2586184 and the pharmacodynamic effect and clinical efficacy in patients with a...

Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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