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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

00:47 EDT 21st April 2014 | BioPortfolio

PubMed Articles [3206 Associated PubMed Articles listed on BioPortfolio]

Bifunctional Gd(III) and Tb(III) chelates based on a pyridine-bis(iminodiacetate) platform, suitable optical probes and contrast agents for magnetic resonance imaging.

To study the physicochemical properties of lanthanide complexes derived from a bifunctional chelating agent based on a PMN-tetraacetic acid moiety {PMN-tetraacetic acid (1): [2,6-pyridinediylbis(methy...

Nonallergic rhinitis.

Rhinitis is normally defined by the symptoms of nasal congestion, postnasal drainage, rhinorrhea, and sneezing. It has been associated with various pathologic changes, but can occur in the absence of...

Informed consent for phase I oncology trials: form, substance and signature.

Federal regulations state consent information should be understandable to participants; concerns have been voiced about the quality of informed consent forms (ICFs) in oncology trials.

Metabolomics approach in allergic and rheumatic diseases.

Metabolomics is the analysis of the concentration profiles of low molecular weight compounds present in biological fluids. Metabolites are nonpeptide molecules representing the end products of cellula...

Development of an analytical protocol for the estimation of vitamin D2 in fortified toned milk.

A simple and rapid method has been developed for the isolation and determination of vitamin D2 in fortified milk samples by HPLC. The advantage of the proposed method is that sample preparation time i...

LC MS/MS identification of large structural proteins from bull muscle and their degradation products during post mortem storage.

Large proteins (>100kDa) in bovine M. longissimus dorsi and their degradation products during post mortem ageing were investigated by gel electrophoresis and LC-MS/MS analysis. Seventeen protein bands...

(1)H NMR spectroscopy for profiling complex carbohydrate mixtures in non-fractionated beer.

A plethora of biological and biotechnological processes involve the enzymatic remodelling of carbohydrates in complex mixtures whose compositions affect both the processes and products. In the current...

Comparison of near and medium infrared spectroscopy to predict fatty acid composition on fresh and thawed milk.

Near (NIR) and medium (MIR) infrared reflectance spectroscopy (IR) predictions of fatty acid (FA) composition, expressed as g/kg of milk or g/100g of FA, on fresh and thawed milk were compared. Two-hu...

The taste of D- and L-amino acids: In vitro binding assays with cloned human bitter (TAS2Rs) and sweet (TAS1R2/TAS1R3) receptors.

The taste of different enantiomeric forms of amino acids has been deeply investigated because it represents the most impressive case of correlation between stereochemistry and flavour. Herein, we aime...

High frequency of rare variants with a moderate-to-high predicted biological effect in protocadherin genes of extremely obese.

Relatively rare variants with a moderate-to-high biological effect may contribute to the genetic predisposition of common disorders. To investigate this for obesity, we performed exome sequencing for...

News Articles [1246 Associated News Articles listed on BioPortfolio]

Nick Cannon Leads Thousands of DC Residents in the Walk to End Lupus Now®

WASHINGTON, April 19, 2014 /PRNewswire-USNewswire/ -- More than 4,000 people with lupus, their friends and families converged in the nation's capital on Saturday to shed light on the cruel mystery tha...

Terry Gaasterland to Speak at Bioinformatics Conference Jun 19-20 2014, San Diego, CA

San Diego, CA, April 19, 2014 --(PR.com)-- Terry Gaasterland, Professor of Computational Biology and Genomics at University of California, San Diego will give a presentation on “Integrating exo...

Treat-to-Target the New Goal in Lupus

(MedPage Today) -- An international task force has taken the first steps toward formulating a "treat to target" approach for the treatment of systemic lupus erythematosus (SLE), focusing on remission,...

New gene variant ups risk of cancer from processed meat

A common genetic variant that affects one in three people […]

Moxibustion

There are many forms of Traditional Chinese Medicine (TCM), and many have the same underlying theory: they stimulate non-existent acupuncture points to alter the flow of non-existent qi. For each form...

A Reader Asks: How Do We Prove We Have Insurance?

Q. How will we prove to the government that we have health insurance? A. Until the income tax forms for next year are available, exactly what people will be required to report is unclear. Howe...

How do we prove we have insurance?

Q. How will we prove to the government that we have health insurance? A. Until the income tax forms for next year are available, exactly what people will be required...

Amphotericin forms an extramembranous and fungicidal sterol sponge

Fred Hutchinson Cancer Center researchers find a new gene variant that increases the risk of colorectal cancer from eating processed meat

A common genetic variant that affects one in three people appears to significantly increase the risk of colorectal cancer from the consumption of processed meat.

Medical News Today: Gene variant makes eaters of processed meat 'more likely to get colorectal cancer'

Researchers have found that a common gene variant - carried by 1 in 3 people - may increase risk of colorectal cancer in individuals who eat processed meat.

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Companies [84 Associated Companies listed on BioPortfolio]

Patheon Inc.

Patheon is a leading provider of contract development and commercial manufacturing (CDMO) services to the global pharmaceutical industry for a full array of solid and sterile dosa...

700 for Science

700 for Science is an elite group of professionals involved in the research, development and commercialization of biotech and clean technologies. Members are invited to join the g...

DNAtrix Inc.

DNAtrix is a company developing modified oncolytic viruses for the treatment of the most aggressive forms of cancer. Since viruses are already efficient at killing cells, scientis...

Mapi Pharma Ltd.

Mapi Pharma Ltd. (“Mapi” or the “Company”) is a developer of high-barrier to entry and high value-added generic drugs that include complex active pharmaceutica...

Sunrise Senior Living and Health Care REIT, Inc.

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of January 1, 2014, Sunrise operated 290 communities in the United States, Canada and t...

Ignyta, Inc.

Ignyta, Inc., located in San Diego, California, is a personalized medicine company developing revolutionary new products and services to customize diagnosis and treatment of patie...

Colorcon, Inc

Colorcon, Inc. is a global company that develops, manufactures and supplies specialty chemicals and excipients for the pharmaceutical industry. Our core business is the design and technical support of...

Sunrise Senior Living, Inc.

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of January 1, 2014, Sunrise operated 290 communities in the United States, Canada and t...

Vensun Pharmaceuticals, Inc.

Vensun Pharmaceuticals, Inc., based in Yardley, Pennsylvania, is a generic pharmaceutical company, established in July 2011. The company is developing a unique portfolio of comple...

Rebecca Wang

Rebecca Wang is an entrepreneur, executive film producer and former psychotherapist who is passionate about all forms of artistic expression. She is also keen in her desire to bri...

Clinical Trials [527 Associated Clinical Trials listed on BioPortfolio]

Trial of Dasatinib (Sprycel®) in Subjects With Hormone-refractory Prostate Cancer

The purpose of this research study is to find out if a new anti-cancer drug, dasatinib (Sprycel®), previously approved for treatment of some forms of leukemia, will be safe and helpful in...

Evaluating the Safety and Immune Response to Two Doses of a Dengue Virus Vaccine Administered 12 Months Apart

Dengue viruses can cause dengue fever and other more severe forms of disease. This study will evaluate the safety and immune response to two doses of a dengue virus vaccine given 12 months...

A Phase II Trial of Induction Chemotherapy With ND-420, Cisplatin and Fluorouracil Followed by Surgery in the Treatment of Patients With Localized Squamous Cell Carcinoma of the Esophagus

Investigator will assign 53 patients who had been histologically proven localized squamous cell carcinoma of esophagus to receive the induction chemotherapy regimen of ND-420 50 mg/m2 on d...

Glucose Homeostasis Pre and Post Bariatric Surgery

The investigators wish to study the effects of two forms of bariatric surgery, gastric bypass and lap banding. The surgery is not part of the clinical trial. If your insurance does not co...

Autoimmunity in Sisters of Lupus Patients

This study enrolled over 400 unaffected sisters of young women diagnosed with SLE. These unaffected sisters are being followed with an annual health questionnaire (CSQ) and blood sample.

A Pilot Study Comparing the Efficacy of Group Versus Individual Anger Management in Subjects With IED

The purpose of this study is to see how different forms of "Anger Management" compare in reducing anger and impulsive aggressive symptoms in people. "Anger Management" is a common form of...

Copeptin for Risk Stratification in Non-traumatic Headache in the Emergency Setting - The CoHead Study

Headache is a common symptom, and patients often seek medical attention at emergency departments due to headaches. The aim of the CoHead Study is to find out if it is possible by measurin...

myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory Myopathies

The diagnosis of the different forms of inflammatory myopathies (polymyositis, dermatomyositis, inclusion-body myositis...) remains difficult which may lead to unappropriate patient care....

Resynchronization Therapy in Young Patients With and Without CHD

Pacemakers can be attached to one or more than one of the heart chambers. After watching pacemakers work over time, doctors have found that the pacemakers that stimulate only one chamber o...

A Study to Evaluate the Safety and Immunogenicity of GSK Biologicals' Candidate Vaccines RTS,S/AS02D (0.5 mL Dose) and RTS,S/AS02A (0.25 mL Dose) Administered IM According to a 0, 1, 2 Month Vaccination Schedule in Children Aged 3 to 5 Years Living in a M

GSK Biologicals is developing in partnership with the Malaria Vaccine Initiative at PATH a candidate malaria vaccine RTS,S/AS02 for the routine immunization of infants and children living...

Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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