Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

01:52 EST 21st December 2014 | BioPortfolio

PubMed Articles [4578 Associated PubMed Articles listed on BioPortfolio]

Molecular Cloning, Sequence, and Phylogenetic Analysis of T Helper 1 Cytokines of Pashmina Goats.

Cytokines play an important role in regulation of immune responses either in health or disease. In the present study, the cDNAs encoding mature Interleukin (IL)-2, interferon gamma (IFN-γ), and IL-12...

Novel Polymorphisms in Porcine 3'UTR of the Leptin Gene, Including a Rare Variant within Target Sequence for MIR-9 Gene in Duroc Breed, not Associated with Production Traits.

The leptin gene (LEP) is considered as a functional candidate for production traits in livestock due to its crucial role in energy homeostasis. Because polymorphisms in regulatory sequences may affect...

Pound the alarm: danger signals in rheumatic diseases.

Damage-associated molecular patterns (DAMPs) are chemically heterogeneous endogenous host molecules rapidly released from damaged or dying cells that incite a sterile inflammatory response mediated vi...

Pentachlorophenol aerobic removal in a sequential reactor: start-up procedure and kinetic study.

This study has demonstrated the applicability of a simple technology such as the sequencing batch reactor (SBR), operated with suspended biomass, to the aerobic biodegradation of a highly toxic compou...

Impact of Anti-Peroxynitrite-Damaged-Thymidine- Monophosphate Antibodies on Disease Activity in Patients with Systemic Lupus Erythematosus.

Present study probes the role of peroxynitrite (ONOO(-))-modified thymidine-5'-monophosphate (TMP) in SLE patients with different disease activity scores according to the SLE Disease Activity Index (S...

Determination of α- and β-boldenone sulfate, glucuronide and free forms, and androstadienedione in bovine urine using immunoaffinity columns clean-up and liquid chromatography tandem mass spectrometry analysis.

The debate about the origins of boldenone in bovine urine is ongoing for two decades in Europe. Despite the fact that its use as a growth promoter has been banned in the European Union (EU) since 1981...

Metals in boat paint fragments from slipways, repair facilities and abandoned vessels: An evaluation using field portable XRF.

Paint flaking off abandoned vessels or generated during boat repair is hazardous to human health and wildlife. In this study, a means of screening paint fragments using a field portable-X-ray fluoresc...

Research on phosphorus loads and characteristics of adsorption and release in surface sediments of Nanyang Lake and Weishan Lake in China.

The characteristics of phosphate adsorption and the transformation of phosphorus forms in the release process of the sediments in Nanyang Lake and Weishan Lake are researched. Distribution of maximal ...

Prenatal Screening: An Ethical Agenda for the Near Future.

Prenatal screening for foetal abnormalities such as Down's syndrome differs from other forms of population screening in that the usual aim of achieving health gains through treatment or prevention doe...

Isolation and purification of versican and analysis of versican proteolysis.

Versican is a widely distributed chondroitin sulfate proteoglycan that forms large complexes with the glycosaminoglycan hyaluronan (HA). As a consequence of HA binding to its receptor CD44 and interac...

News Articles [1206 Associated News Articles listed on BioPortfolio]

Ethan Jostad Foundation Gives Gift of Childhood Cancer Research

Eagle Point, OR, December 20, 2014 --(PR.com)-- The Ethan Jostad Foundation for Childhood Cancer, a 501c3 non-profit charity dedicated to providing support to the children and families affected by ch...

Chiesi gets first-ever European stem cell nod

Chiesi has received the first approval for an advanced therapy medicinal product containing stem cells for use in Europe. The regulator described the Italian company’s treatment as an innovative the...

Tekmira says chief technical officer resigns

Tekmira Pharamceuticals (TSE:TKM) (NASDAQ:TKMR) said that its chief technical officer, Dr. Ian MacLachlan, will resign from the company at the end of the month.  Shares dropped 1.7 percent to C$1...

One common genetic variant and bacteria help dictate inflammation, antitumor activity

A common polymorphism - a variation in a person's DNA sequence that is found with regularity in the general population - can lead to a chain of events that dictates how a tumor will progress in certai...

Why Is This Woman Seeing Spots?

Are this woman's spots related to her systemic lupus erythematosus? Or is something else going on? Medscape Ophthalmology

Another Alzheimer's Antibody Goes Down

The clinical failure rate for disease-modifying Alzheimer's therapies remains perfect, unfortunately: a flat 100%. The latest news is from Roche. Their in-licensed amyloid-targeting antibody (gantener...

Padlock raises $23M series A

Padlock Therapeutics Inc. (Cambridge, Mass.) secured $23 million in a tranched series A round led by Atlas Venture. Johnson & Johnson Development Corp. (JJDC), MS Ventures, and Index Ventures also par...

Humira biosimilar released in India

Indian firm Zydus Cadila has launched the first biosimilar of AbbVie’s anti-inflammatory medicine Humira, the world’s biggest-selling drug. Used as a treatment in various forms of arthritis and an...

Padlock Therapeutics Secures $23 Million Series A Financing Led by Atlas Venture

Breakthroughs in the science of PAD enzymes leveraged to create treatments for Rheumatoid Arthritis, Systemic Lupus Erythematosus, and Multiple Sclerosis Padlock Therap...

Clinical trials of cannabis-based epilepsy medicine to start in the UK

Chuck Bednar for redOrbit.com - Your Universe Online UK health officials have given the go-ahead for doctors to test a new treatment derived from the cannabis plant in children suffering from certain...

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Companies [91 Associated Companies listed on BioPortfolio]

tesa Labtec GmbH

With more than 20 years of experience, tesa Labtec is one of the leading drug delivery companies for film-shaped dosage forms like patches and oral films. Based on its innovative ...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

Ansun BioPharma

Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. Ansun BioPharma has ...

TherapeuticsMD Inc.

TherapeuticsMD Inc. is an innovative healthcare company focused on developing and commercializing products exclusively for women. TherapeuticsMD is developing advanced hormone the...

BioFilm, Ltd.

Founded in 2003 as a subsidiary of Devro plc., BioFilm is the largest Thin Dissolving Film (TDF) producer in Europe, with their GMP certified manufacturing and packaging facility ...

Sunrise Senior Living, LLC

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of April 1, 2014, Sunrise operated 290 communities in the United States, Canada and the...

Sunrise Senior Living and Health Care REIT, Inc.

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of January 1, 2014, Sunrise operated 290 communities in the United States, Canada and t...

DNAtrix Inc.

DNAtrix is a company developing modified oncolytic viruses for the treatment of the most aggressive forms of cancer. Since viruses are already efficient at killing cells, scientis...

Alector LLC

Alector is combining state-of-the-art antibody technology and recent discoveries in neuroimmunology and human genetics to develop novel therapeutics for Alzheimer’s disease, ...

DataMotion

DataMotion enables organizations to dramatically reduce the cost and complexity of delivering electronic information to employees, customers and partners in a secure and compliant...

Clinical Trials [559 Associated Clinical Trials listed on BioPortfolio]

Establishment of Fibroid Tissue Bank

The purpose of this study is to collect information and tissue samples from women with uterine fibroids. The samples will be used to study genes, proteins and other substances in order to ...

Phenylbutyrate As a Treatment for Abnormal Accumulation of Brain Protein in Parkinson's Disease

This is a Phase I clinical trial of the FDA approved drug Glycerol Phenylbutyrate to see if phenylbutyrate can increase the removal of alpha-synuclein from the brain into the bloodstream. ...

Rituximab and Belimumab for Lupus Nephritis

Lupus nephritis is a severe form of systemic lupus erythematosus (SLE) with active disease in the kidneys. SLE is a complex disease in which the body's own immune system attacks some of th...

Collection of Blood From Patients With Prostate Cancer

Background: - It is not fully understood why prostate cancer in some men becomes androgen-independent (no longer responds to anti-androgen medication), but genetics likely plays a...

A SMART Design for Attendance-based Prize CM

The purpose of this study is to compare different forms of treatment for substance abuse. This study will involve a type of treatment called contingency management, in which patients recei...

Evaluation of Molecular Forms of PSA and Human Kallikrein 2 in a Cohort of Patients With Locally Resected Prostate Cancer But Biochemical Recurrence

The purpose of this study is to investigate if a new blood test looking at PSA and a group of PSA related proteins in a patient's blood can indicate which men after surgery with a rising P...

Implementation of Evidence-based Psychotherapy for PTSD

Approximately 9% of Canadians will have Posttraumatic Stress Disorder (PTSD) in their lifetime. In the military veteran population, the lifetime prevalence of PTSD has been estimated to be...

Psychoeducational and Behavioral Strategies in Reducing Distress and Anxiety in Patients With Multiple Myeloma and Their Family Caregivers

This pilot clinical trial studies how well psychoeducational and behavioral strategies work in reducing distress and anxiety in patients with multiple myeloma and their family caregivers. ...

Plegridy™ Observational Program

The primary objectives of the study are to determine the incidence of serious adverse events (SAEs) in patients with relapsing forms of multiple sclerosis (MS) in routine clinical practice...

Genetic Analysis of Immune Disorders

The purposes of this study are to 1) identify the genes responsible for certain immune disorders, 2) learn about the medical problems they cause, and 3) learn how to predict who is likely ...

Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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