Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

16:47 EDT 18th April 2015 | BioPortfolio

PubMed Articles [4494 Associated PubMed Articles listed on BioPortfolio]

Potential changes in the allergenicity of three forms of peanut after thermal processing.

This study aimed to analyze the influence of thermal processing on the IgE binding properties of three forms of peanut, its effects in the content of individual allergens and IgE cross-linking capacit...

Extrapulmonary tuberculosis.

Up to 25% of tuberculosis cases present extrapulmonary involvement. This is produced by haematogenous and lymphatic spread of the M. tuberculosis bacillus to other organs. The most common locations ar...

Optimality and stability of symmetric evolutionary games with applications in genetic selection.

Symmetric evolutionary games, i.e., evolutionary games with symmetric fitness matrices, have important applications in population genetics, where they can be used to model for example the selection an...

Prediction of the hydrophilic antioxidant capacity of tomato pastes from the IR and fluorescence excitation-emission spectra of extracts and intact samples.

The performance of the recently proposed excitation-emission fluorescence method was compared to the method using infrared measurements for the evaluation of the antioxidant properties of intact sampl...

An enhanced chemiluminescence resonance energy transfer system based on target recycling G-guadruplexes/hemin DNAzyme catalysis and its application in ultrasensitive detection of DNA.

An enhanced chemiluminescence resonance energy transfer (CRET) system based on target recycling G-guadruplexes/hemin DNAzyme catalysis was developed for ultrasensitive detection of DNA. CRET system co...

Novel potentiometric application for the determination of pantoprazole sodium and itopride hydrochloride in their pure and combined dosage form.

Three sensitive and selective polyvinyl chloride (PVC) matrix membrane electrodes were developed and investigated. Sensor I was developed using tetraheptylammonium bromide (THB) as an anion exchanger ...

Salivary Duct Carcinoma: The Predominance of Apocrine Morphology, Prevalence of Histologic Variants, and Androgen Receptor Expression.

Salivary duct carcinoma (SDC) is a prototypic aggressive salivary gland carcinoma. Our aim is to determine the prevalence of histologic variants (micropapillary, basal-like) and androgen receptor (AR)...

Phagocyte NADPH oxidase and specific immunity.

The phagocyte NADPH oxidase NOX2 produces reactive oxygen species (ROS) and is a well-known player in host defence. However, there is also increasing evidence for a regulatory role of NOX2 in adaptiv...

Dynamics of the locomotor-respiratory coupling at different frequencies.

The locomotor-respiratory coupling (LRC) is a universal phenomenon reported for various forms of rhythmic exercise. In this study, we investigated the effect of movement and respiratory frequencies on...

Comparison of halogen bonds in M-X⋯N contacts (M=C, Si, Ge and X=Cl, Br).

The halogen bonds (XB) formed between some Si-X- and Ge-X- (X is Cl and Br) containing molecules and NCH (as a Lewis base) have been investigated and compared with C-X⋯N halogen bond. Although, in a...

News Articles [1075 Associated News Articles listed on BioPortfolio]

FDA Approves First Generic To Treat MS

The U.S. Food and Drug Administration today approved the first generic version of Copaxone (glatiramer acetate injection), used to treat patients with relapsing forms of multiple sclerosis (MS). Sand...

Microscopic Colitis -- Clinical and Pathologic Perspectives

How common is microscopic colitis, how does it develop, how does it differ histologically from other forms of colitis? Clinical Gastroenterology and Hepatology

FDA approves generic Copaxone for multiple sclerosis

The FDA has signed-off on the first generic version of Copaxone to treat people with relapsing forms of multiple sclerosis (MS). Glatopa (glatiramer acetate injection) was developed by Sandoz, Novarti...

FDA Approves Generic Version of Multiple Sclerosis Drug Copaxone

FDA approved the first generic version of Copaxone (glatiramer acetate), a widely prescribed drug to treat multiple sclerosis. The generic version of the medication, called Glatopa, will be marketed b...

Gene Variant Linked to Cancer

Smokers with a specific genetic variation are more likely to keep smoking longer than those who don’t have the gene variant, new research indicates. They’re also more likely to be diagnosed with l...

E-Cigarette Use Triples Among U.S. Teens in 1 Year

THURSDAY, April 16, 2015 -- E-cigarettes are booming among U.S. teens, with nearly 2.5 million middle and high school students now choosing to "vape" rather than smoke traditional cigarettes or indulg...

Vitruvias forms partnership with Sunny Pharmtech for high value generics

Taiwan-based Sunny Pharmtech, a developer of active pharmaceutical ingredients and finished-dose drugs,…

Vitamin D Tracks Systemic Lupus Erythematosus Activity (CME/CE)

(MedPage Today) -- Study first in Southern Hemisphere to examine role of vitamin D in SLE disease activity

FDA approves first generic Copaxone to treat multiple sclerosis

The U.S. Food and Drug Administration today approved the first generic version of Copaxone (glatiramer acetate injection), used to treat patients with relapsing forms of multiple sclerosis (MS).

Video: Octopuses have unique way to control their 'odd' forms

The body plan of octopuses is nothing if not unique, with a sophisticated brain in a soft, bilaterally symmetrical body, encircled by eight radially symmetrical and incredibly flexible arms. Now, rese...

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Companies [96 Associated Companies listed on BioPortfolio]

DermTech, Inc.

Headquartered in La Jolla, California, DermTech International (www.dermtech.com) is developing its proprietary EGIR(TM) (Epidermal Genetic Information Retrieval) technology for genomic-based, non-inva...

Burzynski Research Institute, Inc.

Burzynski Research Institute, Inc. (OTCBB: BZYR) is a biopharmaceutical company committed to developing treatment for cancer based on genomic and epigenomic principles. Research a...

The Feinstein Institute for Medical Research

Headquartered in Manhasset, NY, The Feinstein Institute for Medical Research is home to international scientific leaders in many areas including Parkinson's disease, Alzhei...

Rottendorf Pharmaceuticals

Rottendorf Pharmaceuticals is the U.S. subsidiary of Rottendorf Pharma GmbH, a German company that has manufactured pharmaceutical products for 85 years, with expertise in the for...

Aurinia Pharmaceuticals Inc.

Aurinia is a clinical stage pharmaceutical company focused on the global nephrology market. It is currently enrolling patients in its Phase 2b clinical trial to evaluate the effic...

tesa Labtec GmbH

With more than 20 years of experience, tesa Labtec is one of the leading drug delivery companies for film-shaped dosage forms like patches and oral films. Based on its innovative ...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

Ansun BioPharma

Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. Ansun BioPharma has ...

TherapeuticsMD Inc.

TherapeuticsMD Inc. is an innovative healthcare company focused on developing and commercializing products exclusively for women. TherapeuticsMD is developing advanced hormone the...

BioFilm, Ltd.

Founded in 2003 as a subsidiary of Devro plc., BioFilm is the largest Thin Dissolving Film (TDF) producer in Europe, with their GMP certified manufacturing and packaging facility ...

Clinical Trials [586 Associated Clinical Trials listed on BioPortfolio]

Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults

Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older pro...

Proton Beam Therapy (PBT) Versus Intensity-Modulated Radiation Therapy (IMRT) Trial

The goal of this clinical research study is to learn how safe and effective proton-beam therapy (PBT) may be in comparison to intensity modulated radiation therapy (IMRT) in combination wi...

Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias

Human induced pluripotent stem cells (hiPSCs) have driven a paradigm shift in the modeling of human disease; the ability to reprogram patient-specific cells holds the promise of an enhance...

Impact of Local Biopsy to the Endometrium Prior to Controlled Ovarian Stimulation on Clinical Pregnancy

In vitro fertilization (IVF) is the only available solution for many couples with various forms of infertility. The embryo implantation step in the IVF procedure is a complex multistage pr...

Exploratory Study of MT-1303 in Systemic Lupus Erythematosus Patients

The purpose of this study is to evaluate the safety/tolerability and to explore the efficacy of MT-1303 in subjects with systemic lupus erythematosus

Evaluation of Efficacy of Different Methods of Tobacco Cessation Interventions Among BEST Employees in Mumbai

Tobacco use is the single most preventable cause of premature adult death globally. It is one of the major causes of death and disease in India, accounting for nearly 0.9 million deaths ev...

Continuous Lidocaine Infusion for Management of Perioperative Burn Pain

Thermal injury results in one of the most intense and prolonged forms of pain the body can experience. Opioid narcotics are the most powerful drugs for acute and chronic pain, and their us...

Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus

The purpose of this study is to determine if three functional Magnetic Resonance brain imaging techniques: Magnetic Resonance Spectroscopy(MRS),Magnetic Resonance perfusion, and Diffusion ...

Safety Study of AMG 557 in Subjects With Lupus Arthritis

This is a multicenter, randomized, double-blind, parallel, placebo-controlled, multiple dose study that will enroll approximately 40 systemic lupus erythematosus subjects with active lupus...

Prediction of Outcome of Lupus Nephritis

The purpose of this study is to clarify the mechanisms involved in the formation and glomerular deposition of immune complexes in lupus nephritis. The determination of an antibody pattern...

Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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