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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

20:56 EDT 27th May 2017 | BioPortfolio

PubMed Articles [4268 Associated PubMed Articles listed on BioPortfolio]

Meso- or xeromorphic? Foliar characters of Asteraceae in a xeric scrub of Mexico.

The anatomical traits associated with water deficit are also observed in plants growing in poor soils. The species may resist water deficit through three main strategies: escape, avoid or tolerate. Th...

Variability of fluorescence spectra of coelenteramide-containing proteins as a basis for toxicity monitoring.

Nowadays, physicochemical approach to understanding toxic effects remains underdeveloped. A proper development of such mode would be concerned with simplest bioassay systems. Coelenteramide-Containing...

Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry IX: Clinical Features and Survival of Childhood-Onset Systemic Lupus Erythematosus in China.

Approximately 15-20% cases of systemic lupus erythematosus (SLE) are diagnosed in children. There have been a few studies reporting the epidemiological data of pediatric-onset SLE (cSLE) in China, nei...

Genetic Structure and Phylogeography of the Leopard Cat (Prionailurus bengalensis) Inferred from Mitochondrial Genomes.

The Leopard cat Prionailurus bengalensis is a habitat generalist that is widely distributed across Southeast Asia. Based on morphological traits, this species has been subdivided into 12 subspecies. T...

Population Differentiation in Common Walnut (Juglans regia L.) across Major Parts of Its Native Range-Insights from Molecular and Morphometric Data.

Juglans regia is an economically highly important species for fruit and wood production in the warm temperate and subtropical zones of the Northern Hemisphere. Besides the natural influence of climati...

Case 242: Radiation-induced Angiosarcoma.

History In 2004, this woman received a diagnosis of invasive mammillary carcinoma, tubular variant, strongly positive for estrogen and progesterone receptors. Her lesion was found at screening mammogr...

Why Have Multiple Plastic Responses? Interactions between Color Change and Heat Avoidance Behavior in Battus philenor Larvae.

Having multiple plastic responses to a change in the environment, such as increased temperature, can be adaptive for two major reasons: synergy (the plastic responses perform better when expressed sim...

The Interlenticulostriate Approach to Very High-Riding Distal Basilar Trunk Aneurysms.

Most high-riding distal basilar trunk aneurysms can be surgically approached via the transsylvian route and its orbitozygomatic variant. However, on rare occasions, the basilar bifurcation may be unus...

Association of polymorphic variants of PTPN22, TNF and VDR genes in children with lupus nephritis: A study in Colombian family triads.

Systemic lupus erythematosus is an autoimmune disease in which the severity varies according to race, sex and age of onset. This variation is also observed in the genetic markers associated with the d...

The contemporary refugee crisis: an overview of mental health challenges.

There has been an unprecedented upsurge in the number of refugees worldwide, the majority being located in low-income countries with limited resources in mental health care. This paper considers conte...

News Articles [1122 Associated News Articles listed on BioPortfolio]

Immupharma Plc IMM Pharmaceuticals Healthcare Deals and Alliances Profile [Updated: 10052017] Prices from USD $250

SummaryImmuPharma Plc ImmuPharma develops novel drugs for the treatment of serious medical conditions with unmet medical need. ImmuPharma has five drugs in development stage towards the treatment of l...

Natco Pharma Ltd NATCOPHARM Pharmaceuticals Healthcare Deals and Alliances Profile [Updated: 17052017] Prices from USD $250

SummaryNatco Pharma Ltd Natco Pharma focuses on the research, development, manufacture and commercialization of pharmaceutical substances and finished dosage forms. The company offers finished dosage ...

Heart disease preventing gene identified in Greeks – Business Standard

Laboratory EquipmentHeart disease preventing gene identified in GreeksBusiness StandardScientists have discovered a genetic variant that protects the heart against cardiovascular diseases and is uniqu...

Nanolek Pharmaceuticals Healthcare Deals and Alliances Profile [Updated: 10052017] Prices from USD $250

SummaryNanolek specializes in the production of importsubstituting and novel pharmaceuticals. The company's product portfolio includes vaccines; drugs for treatment of leukemias, brain cancer, breast ...

Health Ministry launches Pneumococcal Conjugate Vaccine under Universal Immunization Programme

The Union Health Ministry has launched Pneumococcal Conjugate Vaccine (PCV) under Universal Immunization Programme (UIP) of the country which will protects children against severe forms of

Antinuclear antibody testing — misunderstood or misbegotten?

The presence of antinuclear antibodies (ANAs) is an important criterion for the classification of autoimmune diseases such as systemic lupus erythematosus, but the specificity of ANA tests is controve...

Dr. Xinping Song's 3D Prostate Treatment & New Research Cancer Cell Specific Treatment Options

CHANGSHA, China and XIANGTAN, China, May 26, 2017 /PRNewswire/ -- Cancer levels in China are noted to be below many western nations, however there is a growing incidence rate. One of the most pro...

Isolated Greek villages reveal genetic secrets that protect against heart disease

A genetic variant that protects the heart against cardiovascular disease has been discovered by researchers at the Wellcome Trust Sanger Institute and their collaborators. Reported today in Nature Com...

Analysis of hospital discharges: Pulmonary embolism linked with systemic lupus erythematosus

Pulmonary embolism was associated with lupus, according to results of a recently published retrospective study. Srinadh Annangi, MBBS, from the Morehouse School of Medicine in Atlanta, and collea...

Hypoactive delirium

What you need to knowHypoactive presentations of delirium are more common than the classically agitated, hyperactive forms and may be overlookedA collateral history can distinguish hypoactive...

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Companies [112 Associated Companies listed on BioPortfolio]

Halo Pharmaceutical

Halo Pharmaceutical, headquartered in Whippany, NJ, is a specialty pharmaceutical company engaged in pharmaceutical branded product lifecycle management. The company's strategy is to acquire products ...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

AgTech Accelerator

AgTech Accelerator, established in 2016 in Research Triangle Park, is a venture development organization focused on discovering and developing emerging agricultural technology and...

Fabric Genomics

Fabric GenomicsTM is a computational genomics company offering end-to-end genomic data analysis, annotation, curation, classification and reporting solutions ...

Puma Biotechnology, Inc.

Puma Biotechnology, Inc. is a development stage biopharmaceutical company that acquires and develops innovative products for the treatment of various forms of cancer. The Company ...

The Foundation for Mitochondrial Medicine

The Foundation for Mitochondrial Medicine is a 501(c) (3) non-profit organization dedicated to supporting the development of the most promising research and treatments of the many...

Ennis, Inc.

Ennis, Inc. (www.ennis.com) is primarily engaged in the production and sale of business forms, apparel and other business products. The Company is one of the largest privat...

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

Pinnacle Biologics

Founded in 2007 by former Abbott Laboratories executives Guillermo Herrera, James Miller, and Viren Grover, Pinnacle Biologics is a premier international company that excels in assisting pharmaceu...

HealthViewX

HealthViewX is a robust health IT platform designed for effective care coordination, communication and analytics to enhance patient treatment through meaningful health systems int...

Clinical Trials [975 Associated Clinical Trials listed on BioPortfolio]

Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia

Preeclampsia is commonly viewed as one of the hypertensive pregnancy disorders, which cover a spectrum of clinical presentations from chronic hypertension ( hypertension occurring prior to...

Lipoic Acid for Progressive Multiple Sclerosis (MS)

The purpose of the study is to determine if lipoic acid, a natural dietary supplement, can preserve mobility and protect the brain in progressive forms of multiple sclerosis.

A Study to Evaluate the Efficacy and Safety of CC-220 in Subjects With Active Systemic Lupus Erythematosus

The purpose of this Phase 2, multicenter, randomized, placebo-controlled, double-blind study to evaluate the efficacy and safety of an oral treatment regimen of CC-220 versus placebo in ad...

Review of Charts From Amish/Mennonite Variant PA Patients

The natural history of patients with PA-AMV has not been systematically studied before and there is no published data in the literature about this condition since 1980. There is no evidenc...

The BARCODE 1 Study

BARCODE 1 is a screening study designed to investigate the role of genetic profiling for targeting population prostate cancer screening. This study forms a pilot of 300 men, with the view ...

Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks

This study attempts to identify two types of AD by using clinical and cognitive tasks and brain imaging. The subtypes of AD are separated into a "typical" group (memory loss) and a "varian...

Transcranial Magnetic Stimulation in Nonfluent/Agrammatic Variant Primary Progressive Aphasia

Nonfluent/agrammatic variant primary progressive aphasia (nf/avPPA) is a fatal neurodegenerative disease that begins with isolated language deficits. There is currently no cure or treatmen...

Connecticut Child STEPs

Connecticut Child STEPS is a randomized controlled trail investigating the effectiveness of MATCH-ADTC in treating anxiety, depression, trauma, and/or behavioral problems in children seeki...

Pilot Evaluation of the Effect of Riboflavin Supplementation on Blood Pressure and Possible Effect Modification by the MTHFR C677T Genotype

Hypertension, which results from a combination of multiple lifestyle and genetic factors, is a global public health problem affecting 1 billion people worldwide. The identification of chea...

IMPACT Study: IMProve Pregnancy in APS With Certolizumab Therapy

This treatment trial evaluates the addition of an anti-tumor necrosis factor-alpha drug, certolizumab, to usual treatment (a heparin agent and low-dose aspirin) in pregnant women with anti...

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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