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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

08:16 EST 21st January 2017 | BioPortfolio

PubMed Articles [4199 Associated PubMed Articles listed on BioPortfolio]

The genetic structure of hypoderatid mites (Actinotrichida: Astigmata) parasitizing great cormorant (Phalacrocorax carbo) during host post-breeding dispersal in Milicz, SW Poland.

The astigmatid family Hypoderatidae includes over 80 mite species exhibiting peculiar life cycle. Deutonymphs are parasitic instars inhabiting subcutaneous or visceral tissues of birds and rodents, wh...

Prochristianella clarkeae Beveridge, 1990 (Eutetrarhynchidae): a species complex or a species with intraspecific variation in the distribution of its tegumental microtriches?

The microthrix pattern of common forms of the trypanorhynch cestode Prochristianella clarkeae Beveridge, 1990 on which the microscopically visible microtriches almost extended to the posterior end of ...

Kinetics of the incorporation of the main phenolic compounds into the lignan macromolecule during flaxseed development.

The main flax lignan, secoisolariciresinol diglucoside, is stored in a macromolecule containing other ester-bound phenolic compounds. In this study, NMR and HPLC-UV analyses were performed on flaxseed...

Accumulation of guaiacol glycoconjugates in fruit, leaves and shoots of Vitis vinifera cv. Monastrell following foliar applications of guaiacol or oak extract to grapevines.

Previous studies have shown that volatile compounds present within a vineyard during the growing season can be absorbed by grapevines, assimilated within grapes, and then released during fermentation ...

Natural variation in folate levels among tomato (Solanum lycopersicum) accessions.

Folate content was estimated in tomato (Solanum lycopersicum) accessions using microbiological assay (MA) and by LC-MS. The MA revealed that in red-ripe fruits folate levels ranged from 4 to 60μg/100...

The Social Value of Health Research and the Worst Off.

In this article we argue that the social value of health research should be conceptualized as a function of both the expected benefits of the research and the priority that the beneficiaries deserve. ...

Reproductive modification in forest plantations: impacts on biodiversity and society.

1000 I. 1000 II. 1001 III. 1014 IV. 1015 V. 1016 1016 References 1016 SUMMARY: Genetic engineering (GE) can be used to improve forest plantation productivity and tolerance of biotic and abiotic stress...

Citrullinemia type I with recurrent liver failure in a child.

Citrullinemia type I is an autosomal recessive disorder caused by mutation of the gene expressing ASS1 argininosuccinate synthetase, limiting enzyme of the urea cycle. The classic variants are associa...

"They Can't Find Anything Wrong with Him, Yet": Mothers' experiences of parenting an infant with a prenatally diagnosed copy number variant (CNV).

Chromosome microarray (CMA) testing is used widely in prenatal settings. Some copy number variants (CNVs) detected using CMA are associated with variable or uncertain phenotype and/or possible neuroco...

First-principles study of thermal transport in nitrogenated holey graphene.

Nitrogenated holey graphene (NHG), a new two-dimensional graphene variant with a large fundamental direct band gap, has recently been successfully synthesized via a simple wet-chemical reaction. Motiv...

News Articles [1168 Associated News Articles listed on BioPortfolio]

Obesity is barely covered in medical students' licensing exam

Obesity is one of the most significant threats to health in the U.S. and is responsible for the development of multiple serious medical problems such as diabetes, heart disease and some forms of cance...

Medical students' licensing exam barely covers items related to obesity, study finds

Obesity is one of the most significant threats to health in the U.S. and is responsible for the development of multiple serious medical problems such as diabetes, heart disease and some forms of cance...

Systemic lupus erythematosus: New pathway blocks disease in lupus-prone mice

Aetiology and management of hereditary aortopathy

In this Review, the authors discuss the pathological mechanisms involved in thoracic aortic aneurysms (TAAs), including extracellular matrix homeostasis, transforming growth factor-β signalling, and ...

A novel sequence variant in SFRP4 causing Pyle disease

Tides Medical Forms And Collects First Placental Tissue Donation

  Life Sciences Jobs   ...

On the road: Manufacturers team up to produce portable facility for oral solid dosage forms

Pfizer, GEA and G-Con Manufacturing team up to produce a portable manufacturing facility for oral solid dosage forms.

UCB, Dermira plan psoriasis filing for Cimzia in Q3

UCB and Dermira are expecting to file anti-inflammatory Cimzia for psoriasis in the third quarter of this year, after the drug's strong performance in a late-stage trial involving patients with severe...

Infusion Express Opens Second Illinois Clinic in Schaumburg

SCHAUMBURG, Ill., Jan. 19, 2017 /PRNewswire/ -- Infusion Express, a patient-focused alternative to hospital infusion centers, today announced its second Illinois treatment centers as part of a nationa...

Aurinia Pharmaceuticals Inc AUP Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryAurinia Pharmaceuticals Inc Aurinia Pharmaceuticals focuses on the development and commercialization of therapies for the treatment of autoimmune diseases. The company's lead product candidate ...

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Companies [109 Associated Companies listed on BioPortfolio]

The Foundation for Mitochondrial Medicine

The Foundation for Mitochondrial Medicine is a 501(c) (3) non-profit organization dedicated to supporting the development of the most promising research and treatments of the many...

Ennis, Inc.

Ennis, Inc. (www.ennis.com) is primarily engaged in the production and sale of business forms, apparel and other business products. The Company is one of the largest privat...

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

Pinnacle Biologics

Founded in 2007 by former Abbott Laboratories executives Guillermo Herrera, James Miller, and Viren Grover, Pinnacle Biologics is a premier international company that excels in assisting pharmaceu...

HealthViewX

HealthViewX is a robust health IT platform designed for effective care coordination, communication and analytics to enhance patient treatment through meaningful health systems int...

Hereditary Neuropathy Foundation

Hereditary Neuropathy Foundation (HNF) is a non-profit 501(c)3 organization whose mission is to increase awareness and accurate diagnosis of Charcot-Marie-Tooth disease (CMT) and ...

North Carolina Council on Developmental Disabilities

The North Carolina Council on Developmental Disabilities (NCCDD) works to assure that people with intellectual and other developmental disabilities (I/DD) and their families parti...

OncoRx Pharmaceuticals Inc.

OncoRx Pharmaceuticals (www.oncorxpharmaceuticals.com) is an early-stage pharmaceutical company dedicated to the discovery and development of novel drugs that control tumor metast...

amcure GmbH

amcure GmbH is a spin-off from the Karlsruhe Institute of Technology established in 2011. The company develops peptide-based compounds for the treatment of highly metastatic forms...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

Clinical Trials [905 Associated Clinical Trials listed on BioPortfolio]

Photodynamic Therapy for Treatment of Cutaneous Squamous Cell Carcinoma in Situ

This pilot study will evaluate the effectiveness of using photodynamic therapy for treatment of cutaneous squamous cell in situ (SCCis). Our hypothesis is that PDT will be effective for tr...

Cohort Description of Younger With AV-block

Background: Disturbances of the heart's atrioventricular conduction - AV-block - may show by shortness of breath, fainting or sudden death. If AV-block is diagnosed in time pacemaker ther...

A Study of LY3202626 in Healthy Participants

The purposes of this study are to determine: - If there are any differences in the way LY3202626 is handled by the body when taken in two different forms - Whether a hig...

Prophylactic Foraminotomy and Its Impact on C5 Palsy

C5 palsy (C5P) is a well-known, although rare complication of cervical spine decompression surgery. In severe forms, C5P causes debilitating upper extremity weakness involving the deltoids...

Feasibility Study of Intermediate Doses of ARA-C With Autologous SCT as Consolidation of Low/Intermediate-risk AML

Create a network of institutions in developing countries that will perform AML diagnosis, risk classification, treatment, supportive care and follow-up evaluation according to a common pro...

Aurinia Renal Response in Active Lupus With Orelvo (Voclosporin)

The purpose of this study is to assess the efficacy of Orelvo (voclosporin) compared with placebo in achieving renal response after 24 weeks of therapy in subjects with active lupus nephri...

Cognitive-behavioral Therapy for Treatment of Post-traumatic Stress Disorder and Related Problems

The purpose of this study is to evaluate the efficacy of a form of cognitive behavioral therapy (CBT) in a population of individuals with PTSD and common related problems (depression, anxi...

Pharmacokinetic Interaction Between Trospium With an Inhibitor of OCT1 and of P-gp in Subjects Genotyped for OCT1

The purpose of the study is: - to determine absolute bioavailability, input rates, distribution volume, renal and intestinal excretion of trospium in subjects with wild-type of SL...

Transcranial Magnetic Stimulation (TMS) in Obesity

Obesity is a metabolic disease that has reached epidemic proportions. Insofar no long-term effective drug treatment was developed for obesity. Lyfe style modulation and bariatric surgery a...

PHASE III RANDOMISED TRIAL TO EVALUATE FOLFOX WITH OR WITHOUT DOCETAXEL (TFOX) AS 1st LINE CHEMOTHERAPY FOR LOCALLY ADVANCED OR METASTATIC OESOPHAGO-GASTRIC CARCINOMA

Gastric cancer is the fourth commonest cancer and the second largest cause of mortality from cancer. Surgical resection of localised forms of gastric cancer offers the only chance of a cur...

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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