Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

11:36 EST 1st February 2015 | BioPortfolio

PubMed Articles [4580 Associated PubMed Articles listed on BioPortfolio]

Molecular Cloning, Sequence, and Phylogenetic Analysis of T Helper 1 Cytokines of Pashmina Goats.

Cytokines play an important role in regulation of immune responses either in health or disease. In the present study, the cDNAs encoding mature Interleukin (IL)-2, interferon gamma (IFN-γ), and IL-12...

Novel Polymorphisms in Porcine 3'UTR of the Leptin Gene, Including a Rare Variant within Target Sequence for MIR-9 Gene in Duroc Breed, not Associated with Production Traits.

The leptin gene (LEP) is considered as a functional candidate for production traits in livestock due to its crucial role in energy homeostasis. Because polymorphisms in regulatory sequences may affect...

Pediatric lupus: varied haematological picture and presentation.

Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease characterized by periods of increased disease activity caused by inflammation of blood vessels and connective tissue. P...

Pound the alarm: danger signals in rheumatic diseases.

Damage-associated molecular patterns (DAMPs) are chemically heterogeneous endogenous host molecules rapidly released from damaged or dying cells that incite a sterile inflammatory response mediated vi...

HPLC in characterization of hemoglobin profile in thalassemia syndromes and hemoglobinopathies: a clinicohematological correlation.

High-performance liquid chromatography (HPLC) is a technique introduced for the accurate diagnosis of hemoglobinopathies and thalassemias. The advantage of the HPLC system is the excellent resolution,...

Analysis of AGG interspersion of the FMR1 gene in fragile X syndrome.

OBJECTIVE To analyze (CGG)n repeats sequence and AGG interspersion correlated with unstable expansion of FMR1 gene in a general Chinese population. METHODS AmplideX FMR1 PCR Kit was used to amplify 38...

Identification of a novel T421C mutation of α-1,3-N-acetylgalactosaminyltransferase allele responsible for an A variant.

OBJECTIVE To investigate the molecular basis of an individual featuring weak A phenotype of ABO blood group system. METHODS Serologic investigations, serum transferases activity assay and absorption-e...

Pentachlorophenol aerobic removal in a sequential reactor: start-up procedure and kinetic study.

This study has demonstrated the applicability of a simple technology such as the sequencing batch reactor (SBR), operated with suspended biomass, to the aerobic biodegradation of a highly toxic compou...

Is IGSF1 involved in human pituitary tumor formation?

IGSF1 is a membrane glycoprotein highly expressed in the anterior pituitary. Pathogenic mutations in the IGSF1 gene (on Xq26.2) are associated with X-linked central hypothyroidism and testicular enlar...

Mental simulation and meaning in life.

Mental simulation, the process of self-projection into alternate temporal, spatial, social, or hypothetical realities is a distinctively human capacity. Numerous lines of research also suggest that th...

News Articles [1228 Associated News Articles listed on BioPortfolio]

Winter Is the Season of Nosebleeds

SATURDAY, Jan. 31, 2015 -- Nosebleeds are a common during the winter and shouldn't be cause for concern, an expert says. "Cold winter air can be drying and irritating to the nose, and so can forms of ...

Gender identity is innate in transgender children, study finds

Chuck Bednar for redOrbit.com - Your Universe Online In contrast to the commonly-held belief that transgender children are confused or subject to peer pressure, a new University of Washington study i...

From Negligence to Intimidation, what Constitutes Child Abuse? A Series of NoBullying Articles in the Spotlight Today

From Negligence to Intimidation, what Constitutes Child Abuse? A Series of NoBullying Articles in the Spotlight Today http://nobullying.com/negligence/ London, UK (PRWEB) January 30, 2015 In a world ...

Researchers reveal how pancreatic cancer cells sidestep chemotherapy

Pancreatic cancer is one of the deadliest forms of the disease. The American Cancer Society's most recent estimates for 2014 show that over 46,000 people will be diagnosed with pancreatic cancer and m...

Study links deficiency of cellular housekeeping gene with aggressive forms of breast cancer

UT Southwestern Medical Center scientists have identified a strong link between the most aggressive type of breast cancer and a gene that regulates the body's natural cellular recycling process, calle...

UTSW study links deficiency of cellular housekeeping gene with aggressive forms of breast cancer

(UT Southwestern Medical Center) UT Southwestern Medical Center scientists have identified a strong link between the most aggressive type of breast cancer and a gene that regulates the body's natural ...

New £5m consortium aims to improve lupus treatment

A new £5.1 million consortium of UK universities and industry partners aims to improve treatment of lupus.The project will be lead by the University of Manchester and hopes to eliminate what it ...

Aurinia Pharmaceuticals to Present at the BIO CEO Investor Conference

Aurinia Pharmaceuticals, Inc., (NASDAQ: AUPH / TSX: AUP) today announced that its President and Chief Executive Officer Stephen Zaruby will present a corporate overview of the com...

Gut bacteria created by red meat and dairy linked to chronic kidney disease

Researchers have linked trimethylamine N-oxide (TMAO) - a gut metabolite formed during the digestion of eggs, red meat or dairy-derived nutrients choline and carnitine - to chronic kidney disease. TM...

Researchers Devise Novel Way to Generate Corneal Stem Cells for Treating Corneal Blindness

(News-Medical) – Researchers in the Cedars-Sinai Board of Governors Regenerative Medicine Institute have devised a novel way to generate transplantable corneal stem cells that may eventually ben...

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Companies [91 Associated Companies listed on BioPortfolio]

tesa Labtec GmbH

With more than 20 years of experience, tesa Labtec is one of the leading drug delivery companies for film-shaped dosage forms like patches and oral films. Based on its innovative ...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

Ansun BioPharma

Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. Ansun BioPharma has ...

TherapeuticsMD Inc.

TherapeuticsMD Inc. is an innovative healthcare company focused on developing and commercializing products exclusively for women. TherapeuticsMD is developing advanced hormone the...

BioFilm, Ltd.

Founded in 2003 as a subsidiary of Devro plc., BioFilm is the largest Thin Dissolving Film (TDF) producer in Europe, with their GMP certified manufacturing and packaging facility ...

Sunrise Senior Living, LLC

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of April 1, 2014, Sunrise operated 290 communities in the United States, Canada and the...

Sunrise Senior Living and Health Care REIT, Inc.

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of January 1, 2014, Sunrise operated 290 communities in the United States, Canada and t...

DNAtrix Inc.

DNAtrix is a company developing modified oncolytic viruses for the treatment of the most aggressive forms of cancer. Since viruses are already efficient at killing cells, scientis...

Alector LLC

Alector is combining state-of-the-art antibody technology and recent discoveries in neuroimmunology and human genetics to develop novel therapeutics for Alzheimer’s disease, ...

DataMotion

DataMotion enables organizations to dramatically reduce the cost and complexity of delivering electronic information to employees, customers and partners in a secure and compliant...

Clinical Trials [559 Associated Clinical Trials listed on BioPortfolio]

Establishment of Fibroid Tissue Bank

The purpose of this study is to collect information and tissue samples from women with uterine fibroids. The samples will be used to study genes, proteins and other substances in order to ...

Phenylbutyrate As a Treatment for Abnormal Accumulation of Brain Protein in Parkinson's Disease

This is a Phase I clinical trial of the FDA approved drug Glycerol Phenylbutyrate to see if phenylbutyrate can increase the removal of alpha-synuclein from the brain into the bloodstream. ...

Rituximab and Belimumab for Lupus Nephritis

Lupus nephritis is a severe form of systemic lupus erythematosus (SLE) with active disease in the kidneys. SLE is a complex disease in which the body's own immune system attacks some of th...

Collection of Blood From Patients With Prostate Cancer

Background: - It is not fully understood why prostate cancer in some men becomes androgen-independent (no longer responds to anti-androgen medication), but genetics likely plays a...

A SMART Design for Attendance-based Prize CM

The purpose of this study is to compare different forms of treatment for substance abuse. This study will involve a type of treatment called contingency management, in which patients recei...

Evaluation of Molecular Forms of PSA and Human Kallikrein 2 in a Cohort of Patients With Locally Resected Prostate Cancer But Biochemical Recurrence

The purpose of this study is to investigate if a new blood test looking at PSA and a group of PSA related proteins in a patient's blood can indicate which men after surgery with a rising P...

Implementation of Evidence-based Psychotherapy for PTSD

Approximately 9% of Canadians will have Posttraumatic Stress Disorder (PTSD) in their lifetime. In the military veteran population, the lifetime prevalence of PTSD has been estimated to be...

Psychoeducational and Behavioral Strategies in Reducing Distress and Anxiety in Patients With Multiple Myeloma and Their Family Caregivers

This pilot clinical trial studies how well psychoeducational and behavioral strategies work in reducing distress and anxiety in patients with multiple myeloma and their family caregivers. ...

Plegridy™ Observational Program

The primary objectives of the study are to determine the incidence of serious adverse events (SAEs) in patients with relapsing forms of multiple sclerosis (MS) in routine clinical practice...

Genetic Analysis of Immune Disorders

The purposes of this study are to 1) identify the genes responsible for certain immune disorders, 2) learn about the medical problems they cause, and 3) learn how to predict who is likely ...

Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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