Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

08:42 EDT 30th June 2015 | BioPortfolio

PubMed Articles [4532 Associated PubMed Articles listed on BioPortfolio]

Bone tissue engineering using silica-based mesoporous nanobiomaterials:Recent progress.

Bone disorders are of significant concern due to increase in the median age of our population. It is in this context that tissue engineering has been emerging as a valid approach to the current therap...

Potential changes in the allergenicity of three forms of peanut after thermal processing.

This study aimed to analyze the influence of thermal processing on the IgE binding properties of three forms of peanut, its effects in the content of individual allergens and IgE cross-linking capacit...

Chemical characteristics and anti-proliferation activities of Ganoderma tsugae polysaccharides.

Polysaccharides were extracted by hot-water and hot-alkali from four forms of Ganoderma tsugae including mature and baby Ling chih, mycelium and filtrate. Different profiles of proximate composition a...

A categorical review on electroanalytical determination of non-narcotic over-the-counter abused antitussive drugs.

Dextromethorphan (DXM) and diphenhydramine (DPH) are two commonly used over-the-counter non-narcotic antitussive drugs. Recent reports reveal the widespread abuse of DXM and DPH due to their euphoric ...

Modification of xylan in alkaline treated bleached hardwood kraft pulps as classified by attenuated total-internal-reflection (ATR) FTIR spectroscopy.

The glucuronoxylan composition of a pulp affects the bonding between cellulosic fibres, and thus correlates with such network properties as tensile strength. Here, we demonstrate the promise of attenu...

Evaluation of ionic liquids as alternative solvents for aldolase activity: Use of a new automated SIA methodology.

An automated methodology is proposed for the evaluation of a set of ionic liquids (ILs) as alternative reaction media for aldolase based synthetic processes. For that, the effect of traditionally used...

Do selenium hyperaccumulators affect selenium speciation in neighboring plants and soil? An X-Ray Microprobe Analysis.

Neighbors of Se hyperaccumulators Stanleya pinnata and Astragalus bisulcatus were found earlier to have elevated Se levels. Here we investigate whether Se hyperaccumulators affect Se localization and ...

Ball-milled solid dispersions of BCS Class IV drugs: Impact on the dissolution rate and intestinal permeability of acyclovir.

Acyclovir, an analog of 2'-deoxyguanosine, is one of the most important drugs in the current approved antiviral treatment. However, it's biopharmaceutical properties, contribute to acyclovir's poor or...

Treatment of Vascular Cognitive Impairment.

Cerebrovascular disease (CVD) is an important cause of cognitive dysfunction and dementia. The term vascular cognitive impairment (VCI) is used to describe the entire spectrum of cognitive dysfunction...

Histone variants as emerging regulators of embryonic stem cell identity.

Dynamic regulation of chromatin structure is an important mechanism for balancing the pluripotency and cell fate decision in embryonic stem cells (ESCs). Indeed ESCs are characterized by unusual chrom...

News Articles [1083 Associated News Articles listed on BioPortfolio]

Xarelto Lawsuit News: New Xarelto Lawsuit Filings to Be Expedited

Attorneys representing clients nationwide in Xarelto lawsuits for allegations of internal bleeding and hemorrhagic stroke announce developments in the national Xarelto lawsuit multidistrict litigation...

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

The clinical course of autoimmune and infectious disease varies greatly, even between individuals with the same condition. An understanding of the molecular basis for this heterogeneity could lead to ...

Genentech’s ocrelizumab Significantly Reduced Both Relapses and Disability Progression versus interferon beta-1a (Rebif®) in Two Phase III Studies in Multiple Sclerosis

Studies showed superiority on primary and major secondary endpoints in people with relapsing forms of multiple sclerosis Genentech will submit data to t...

Rare A2ML1 variants confer susceptibility to otitis media

Regie Lyn Santos-Cortez and colleagues identify a duplication variant within A2ML1 that cosegregates with otitis media in an indigenous Filipino pedigree. They also identify seven additional A2ML1 var...

Assembly and diploid architecture of an individual human genome via single-molecule technologies

A combination of single-molecule long-read sequencing, single-molecule genome mapping and short-read sequencing provides reference-quality de novo assemblies and also shows improved phasing and varian...

Severe asthma fails to respond to mainstay treatment

The immune response that occurs in patients with severe asthma is markedly different than what occurs in milder forms of the lung condition, according to researchers from the University of Pittsburgh ...

Is the World Running out of Food?

In this article, The Economist delves into the question of whether the world is running out of food. In the short term, the article states, we are not running out of food. But, it adds, international ...

Mount Sinai Scientists Develop New Approach for More Accurate and Comprehensive Whole Genome Assembly, Variant Discovery and Interpretation

A new strategy for uncovering difficult-to-detect, complex forms of genomic variation associated with human disease New York, NY (PRWEB) June 29, 2015 Scientists from the Icahn School of Medicine at ...

New strategies against rare, fatal lung syndrome

Hermansky-Pudlak syndrome (HPS) patients suffer symptoms including albinism, visual impairment, and slow blood clotting, but what makes some versions of the genetic condition fatal is that patients wi...

Stem-Like Cell Exclusively Forms Heart Muscle

Future therapies for failing hearts are likely to include stem-like cells and associated growth factors that regenerate heart muscle.Re

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Companies [98 Associated Companies listed on BioPortfolio]

Anova Cancer Care

Anova Cancer Care serves Denver and the Rocky Mountain region with the world’s only robotic radiosurgery system designed to treat tumors anywhere in the body. Used by the nat...

CreakyJoints

CreakyJoints, part of the not-for-profit Global Healthy Living Foundation, is a dynamic education, support, advocacy and patient-centered research organization for people with all...

Riverbed Technology, Inc.

Riverbed, at more than $1 billion in annual revenue, is the leader in Application Performance Infrastructure, delivering the most complete platform for the hybrid enterprise to...

The Feinstein Institute for Medical Research

Headquartered in Manhasset, NY, The Feinstein Institute for Medical Research is home to international scientific leaders in many areas including Parkinson's disease, Alzhei...

DermTech, Inc.

Headquartered in La Jolla, California, DermTech International (www.dermtech.com) is developing its proprietary EGIR(TM) (Epidermal Genetic Information Retrieval) technology for genomic-based, non-inva...

Burzynski Research Institute, Inc.

Burzynski Research Institute, Inc. (OTCBB: BZYR) is a biopharmaceutical company committed to developing treatment for cancer based on genomic and epigenomic principles. Research a...

Rottendorf Pharmaceuticals

Rottendorf Pharmaceuticals is the U.S. subsidiary of Rottendorf Pharma GmbH, a German company that has manufactured pharmaceutical products for 85 years, with expertise in the for...

Aurinia Pharmaceuticals Inc.

Aurinia is a clinical stage pharmaceutical company focused on the global nephrology market. It is currently enrolling patients in its Phase 2b clinical trial to evaluate the effic...

tesa Labtec GmbH

With more than 20 years of experience, tesa Labtec is one of the leading drug delivery companies for film-shaped dosage forms like patches and oral films. Based on its innovative ...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

Clinical Trials [619 Associated Clinical Trials listed on BioPortfolio]

3,3'-Diindolylmethane in Patients With Systemic Lupus Erythematosus

This is a single center study of patients with inactive or mild SLE being performed to determine the safety, tolerability, and pharmacodynamics of DIM.

Using Ultrasound Elastography to Predict Development of SOS

Sinusoidal obstruction syndrome (SOS) is a potentially fatal hepatic veno-occlusive disease-affecting children following bone marrow transplantation (BMT). SOS most likely develops seconda...

Hemodialysis Blood Flow and Urea Clearance

The study purpose is to determine whether two different hemodialysis blood flow rates each meet national dialysis standards for urea clearance. Urea is used as the primary marker of dialys...

Impact of Labour Kinesiotherapy in the Quality Life of Auxiliary Nursing in the Surgery Center

The quality of life and daily activities can be affected by muscleskeletal pain and one of the forms of assessment is through the SF-36 questionnaire. The investigators know that the worki...

Long-term Immunogenicity of a HPV Vaccine in SLE

To study the 5-year immunogenicity against a quadrivalent HPV vaccine in patients with SLE and healthy controls.

Safety and Immunogenicity of a Zoster Vaccine in SLE

To study the safety and immunogenicity of a herpes zoster vaccine in patients with SLE.

Effect of the Interleukin-6 Receptor Antagonist Tocilizumab in Patients With Hand Osteoarthritis

Hand osteoarthritis (HOA) which affects the interphalangeal joints and the metacarpophalangeal of the thumb is a common disease, the prevalence of which being about 30 % of the population ...

Clinical Trial to Evaluate the PK, PD, Biological Activity and Safety of ACT-334441 in SLE

International trial to evaluate the biological activity and safety of ACT-334441 in lupus patients.

Heart Rate Variability (HRV) Analysis in Patients With Nocturnal Epileptic Seizures

Epilepsy is disabling and costly to patients and the health service. Nearly 400,000 people in England suffer from epilepsy. About 40% of these patients are known to have seizures predomina...

Opel Label Cross Over Study Pharmacokinetics (PK) Study in Healthy Volunteers Recieving Various Forms of Fentanyl

A partially randomized, open-label, 3-way crossover, single-center, systemic and CSF PK and bioavailability study in healthy volunteers.

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.


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