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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

06:48 EDT 28th July 2017 | BioPortfolio

PubMed Articles [4238 Associated PubMed Articles listed on BioPortfolio]

Meso- or xeromorphic? Foliar characters of Asteraceae in a xeric scrub of Mexico.

The anatomical traits associated with water deficit are also observed in plants growing in poor soils. The species may resist water deficit through three main strategies: escape, avoid or tolerate. Th...

Association of CD58 gene polymorphisms with NMO spectrum disorders in a Han Chinese population.

This study aimed to perform a comprehensive assessment of the association between CD58 polymorphisms and the risk of neuromyelitis optica spectrum disorders (NMOSD) in a Han Chinese population. Nine s...

Morphological evaluation of clefts of the lip, palate, or both in dogs.

OBJECTIVE To systematically characterize the morphology of cleft lip, cleft palate, and cleft lip and palate in dogs. ANIMALS 32 client-owned dogs with clefts of the lip (n = 5), palate (23), or both ...

Variability of fluorescence spectra of coelenteramide-containing proteins as a basis for toxicity monitoring.

Nowadays, physicochemical approach to understanding toxic effects remains underdeveloped. A proper development of such mode would be concerned with simplest bioassay systems. Coelenteramide-Containing...

SPARC gene variants predict clinical outcome in locally advanced and metastatic pancreatic cancer patients.

Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein of the extracellular matrix whose expression can be altered in malignant pancreatic cells and in the adjacent stromal fibroblasts...

Multispecies Coexistence without Diffuse Competition; or, Why Phylogenetic Signal and Trait Clustering Weaken Coexistence.

Related and phenotypically similar species often compete more strongly than unrelated and dissimilar species. Much is unknown about the community-level implications of such complex interactions. Here,...

Pulmonary actinomycosis and tuberculosis. A comorbidity pediatric case.

Actinomycosis is a chronic suppurative infection, produced by anaerobic Gram-positive bacteria or microaerobic Actinomyces species. It is rare in children and adolescents and it is more common in immu...

Cytological Features of the Large Cell Variant of Small Cell Ovarian Carcinoma in Young Patients with Hypercalcemia: Histological Findings and Review of the Literature.

To present the cytological features of a very rare and lethal ovarian neoplasm occurring in the young.

Probabilistic Computations for Attention, Eye Movements, and Search.

The term visual attention immediately evokes the idea of limited resources, serial processing, or a zoom metaphor. But evidence has slowly accumulated that computations that take into account probabil...

Letter to the Editor: Reply to "Ultrasonography and cytology as predictors of noninvasive follicular thyroid (NIFTP) neoplasm with papillary-like nuclear features: importance of the differential diagnosis with the invasive encapsulated follicular variant of papillary thyroid cancer".

As Dr. Rosario pointed out, it might be more useful to differentiate NIFTP from invasive encapsulated follicular variant of papillary thyroid carcinoma (iE-FVPTC), not from infiltrative FVPTC (I-FVPTC...

News Articles [1184 Associated News Articles listed on BioPortfolio]

FDA clears Quantel for laser system to treat retinal diseases

The FDA has granted Quantel Medical 510(k) market clearance for the Easyret 577 nm yellow photocoagulator, which is used to treat certain forms of macular edema and peripheral retinal pathologies.The ...

Quantel Medical announces FDA approval for innovative Easyret photocoagulator

Quantel Medical today announced that it has received approval from the U.S. Food and Drug Administration on July 25, 2017 for the innovative new Easyret fully integrated 577nm yellow photocoagulator, ...

Five vascular diseases linked to one common genetic variant

Genome-wide association studies have implicated a common genetic variant in chromosome 6p24 in coronary artery disease, as well as four other vascular diseases: migraine headache, cervical artery diss...

Kellyanne Conway: Ethical disclosures discourage people from government service

Top White House adviser Kellyanne Conway said Thursday on “Fox & Friends” that having to complete financial disclosure forms demoralizes qualified people from serving in government.

EU OKs first-line use of AZ’ Faslodex

EU regulators are permitting the use of AstraZeneca’s breast cancer drug Faslodex at an earlier stage of the treatment pathway in patients with certain forms of the disease.

Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

Hundreds of thousands of human genomes are now being sequenced to characterize genetic variation and use this information to augment association mapping studies of complex disorders and other phenotyp...

Neptune Receives Nasdaq Notification Regarding Minimum Bid Requirements

LAVAL, QUEBEC -- (Marketwired) -- 07/27/17 -- Neptune Technologies & Bioressources Inc. ("Neptune" or the "Company") (NASDAQ: NEPT)(TSX: NEPT), announces that on July 21, 2017 it received notifi...

Supplementation of Nucleosides During Selection Can Reduce Sequence Variant Levels in CHO Cells Using GS/MSX Selection System

In the process of generating stable monoclonal antibody (mAb) producing cell lines, reagents such as Methotrexate (MTX) or Methionine Sulfoximine (MSX) are often used. However, using such selection re...

Retail Pharmacy to be the Largest End-user of Oral Solid Dosage Pharmaceutical Formulation: Future Market Insights

VALLEY COTTAGE, New York, July 26, 2017 /PRNewswire/ -- Instead of increasing pipeline productivity for biologics and patent cliff challenges, oral solid dosage forms hold substantial opportunity ...

World Medical Association Forms Strategic Partnership to Provide Continuing Medical Education Online

FERNEY-VOLTAIRE, France, July 26, 2017 /PRNewswire/ -- The WCEA is a leading global provider of specialist continuing education platforms that also works in partnership with the International Cou...

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Companies [114 Associated Companies listed on BioPortfolio]

Alpine Immune Sciences, Inc.

Alpine Immune Sciences, Inc. was founded in 2015 and is focused on developing novel protein‐based immunotherapies using its proprietary variant immunoglobulin domain (vIgD) p...

Samumed, LLC

Based in San Diego, CA, Samumed (www.samumed.com) is a pharmaceutical platform company focused on advancing regenerative medicine and oncology applications through research and in...

Halo Pharmaceutical

Halo Pharmaceutical, headquartered in Whippany, NJ, is a specialty pharmaceutical company engaged in pharmaceutical branded product lifecycle management. The company's strategy is to acquire products ...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

AgTech Accelerator

AgTech Accelerator, established in 2016 in Research Triangle Park, is a venture development organization focused on discovering and developing emerging agricultural technology and...

Fabric Genomics

Fabric GenomicsTM is a computational genomics company offering end-to-end genomic data analysis, annotation, curation, classification and reporting solutions ...

Puma Biotechnology, Inc.

Puma Biotechnology, Inc. is a development stage biopharmaceutical company that acquires and develops innovative products for the treatment of various forms of cancer. The Company ...

The Foundation for Mitochondrial Medicine

The Foundation for Mitochondrial Medicine is a 501(c) (3) non-profit organization dedicated to supporting the development of the most promising research and treatments of the many...

Ennis, Inc.

Ennis, Inc. (www.ennis.com) is primarily engaged in the production and sale of business forms, apparel and other business products. The Company is one of the largest privat...

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

Clinical Trials [1011 Associated Clinical Trials listed on BioPortfolio]

Prevalence and Characteristics of Fabry Disease (FD) in Patients With Stroke or Small Fiber Neuropathy

FD is pan-ethnic. Its reported annual incidence of 1 in 100,000 may underestimate the true prevalence of the disease. Indeed, recently, in addition with affected males FD developing a "cla...

Reposition of Second Line Treatment in Chronic Immune Thrombocytopenia

Hydroxychloroquine has been reported to have a clinically significant effect on the platelet count in systemic lupus thrombocytopenia. Its action may be due to its immune modulator effect....

ANti-Oxidant in Variant Angina (ANOVA) Trial

Purpose Objectives 1. To evaluate the anti-oxidant effect of long-term Vitamin C+E therapy on coronary vasospasm improvement. 2. To evaluate the anti-oxidant effect of lon...

Perioperative Music Listening on Anxiety, Analgesia Use and Patient Satisfaction

The capacity of music to relieve pain has been used in many forms of medicines and has been proven to reduce anxiety, pain and need for analgesia in perioperative setting. However, music l...

Natural History in Fabry Patients With IVS4+919G>A Mutation

Fabry disease is caused by the deficiency or absence of alpha-galactosidase A (α-Gal A) activity, leading to progressive deposition of glycosphingolipids, mainly globotriaosylceramide (Gb...

New Variants Involved in Taybi-Linder Syndrome

Taybi-Linder syndrome (TALS, OMIM 210710) is a rare autosomal recessive disorder belonging to the group of microcephalic osteodysplastic primordial dwarfisms (MOPD). This syndrome is chara...

Mind-body Awareness Training and Brain-computer Interface

Mind-Body Awareness Training (MBAT), in the forms of various yoga and meditative practices, has become increasingly prevalent due to an increase in awareness of the potential health benefi...

Thalidomide Versus Infliximab in New Onset Crohn's Disease With Poor Prognostic Factors

Crohn's disease (CD) is a life-long inflammatory bowel disease disease with an unknown pathogenesis. The ultimate goal of therapy is to modify the natural history of CD thus reducing compl...

Use of Social Media to Improve Medication Adherence in Adolescents and Young Adults With Systemic Lupus

The goal of this study was to examine the effect of an online educational program with and without a social media experience.The primary goal of this study was to determine whether medicat...

EMDR as a Treatment for Tinnitus

Tinnitus may be considered as a form of phantom auditory sensation and as such parallels may be drawn with other forms of phantom sensation, such as the sensation of pain in an amputated l...

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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