Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

19:15 EST 4th March 2015 | BioPortfolio

PubMed Articles [4507 Associated PubMed Articles listed on BioPortfolio]

Novel Polymorphisms in Porcine 3'UTR of the Leptin Gene, Including a Rare Variant within Target Sequence for MIR-9 Gene in Duroc Breed, not Associated with Production Traits.

The leptin gene (LEP) is considered as a functional candidate for production traits in livestock due to its crucial role in energy homeostasis. Because polymorphisms in regulatory sequences may affect...

Molecular Cloning, Sequence, and Phylogenetic Analysis of T Helper 1 Cytokines of Pashmina Goats.

Cytokines play an important role in regulation of immune responses either in health or disease. In the present study, the cDNAs encoding mature Interleukin (IL)-2, interferon gamma (IFN-γ), and IL-12...

Collagen matrix as a tool in studying fibroblastic cell behavior.

Type I collagen is a fibrillar protein, a member of a large family of collagen proteins. It is present in most body tissues, usually in combination with other collagens and other components of extrace...

Carbonic Anhydrase-8 Regulates Inflammatory Pain by Inhibiting the ITPR1-Cytosolic Free Calcium Pathway.

Calcium dysregulation is causally linked with various forms of neuropathology including seizure disorders, multiple sclerosis, Huntington's disease, Alzheimer's, spinal cerebellar ataxia (SCA) and chr...

Potential electron mediators to extract electron energies of RBC glycolysis for prolonged in vivo functional lifetime of hemoglobin-vesicles.

Developing a functional blood substitute as an alternative to donated blood for clinical use is believed to relieve present and future blood shortage, and to reduce the risks of infection and blood ty...

Redox Potential Tuning Through Differential Quninone Binding in the Photosynthetic Reaction Center of Rhodobacter sphaeroides.

Ubiquinone forms an integral part of the electron transport chain in cellular respiration and photosynthesis across a vast number of organisms. Prior experimental results have shown that the photosynt...

Dispersion Behavior and Aqueous Foams in Mixtures of a Vesicle-Forming Surfactant and Edible Nanoparticles.

In an attempt to prepare ultrastable aqueous foams composed entirely of food-grade ingredients, we describe the foamability and foam stability of aqueous phases containing either calcium carbonate par...

Evidence of nanotubular self-organization in solution and solid states of heterochiral cyclo 1:1 alpha/alpha-N(alpha)-Bn-hydrazinomers series.

The cyclization of heterochiral 1:1 [α/α-Nα-Bn-hydrazino]mers leads to the corresponding cyclotetramer and cyclohexamer 3 and 4. X-ray crystallographic analysis of 3 unveils its ability to self-ass...

Conditional Deletion of Kit in Melanocytes: White Spotting Phenotype is Cell-Autonomous.

It is well established that cell-intrinsic signaling through the receptor tyrosine kinase KIT is critical for the development of neural crest-derived melanocytes. Nevertheless, it is not entirely clea...

Partial and Generalized Lipodystrophy: Comparison of Baseline Characteristics and Response to Metreleptin.

Context: Lipodystrophies are extreme forms of metabolic syndrome. Metreleptin was approved in the US for generalized lipodystrophy (GLD), but not partial lipodystrophy (PLD). Objective: To test metrel...

News Articles [1118 Associated News Articles listed on BioPortfolio]

Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB

Matrin3 is an RNA- and DNA-binding nuclear matrix protein found to be associated with neural and muscular degenerative diseases. A number of possible functions of Matrin3 have been suggested, but no w...

Baxter’s BioScience Business Acquires Biopharmaceutical Company SuppreMol

Acquisition Includes SuppreMol’s Early-Stage Pipeline of Protein Therapeutics for Autoimmune and Allergic Diseases Baxter International Inc. (NYSE:BAX) and SuppreMol GmbH to...

France faulted by rights body over failure on child-smacking

PARIS (Reuters) - Europe's leading human right's body, the Council of Europe, faulted France on Wednesday for failing to impose a clear ban on slapping and all other forms of corporal punishment of ch...

Coronado Biosciences Forms New Subsidiary, Checkpoint Therapeutics, to Develop Novel Immuno-Oncology Antibodies

Checkpoint licenses rights to 3 novel immuno-oncology targeted antibodies, including Anti-PD-L1, Anti-GITR and Anti-CAIX Dr. Wayne Marasco to chair Checkpoint's Scientific Advisory Board Checkp...

Strong genetic risk factor for MS discovered in family of five affected siblings

(University of Illinois at Chicago) Researchers at the University of Illinois at Chicago have identified a genetic variation that in women significantly increases their risk of developing multiple scl...

Chylomicronaemia—current diagnosis and future therapies

Chylomicronaemia is a challenging metabolic disorder that presents in two distinct primary forms: rare monogenic early-onset chylomicronaemia and polygenic late-onset chylomicronaemia. In this Review,...

Why seashells’ mineral forms differently in seawater

Read more about Why seashells’ mineral forms differently in seawaterComments

ASHA Applauds Launch of New WHO Campaign

Association Served as Advisor to WHO on Campaign’s Development, Will Promote Campaign Messages and Resources Throughout the Year Rockville, MD (PRWEB) March 03, 2015 Today is International Ear Care...

The origins of polarized nervous systems

(Phys.org)—There is no mistaking the first action potential you ever fired. It was the one that blocked all the other sperm from stealing your egg. After that, your spikes only got more interesting....

RPT-Harvard prevention trial studies tau, Alzheimer's other protein

CHICAGO, March 3 (Reuters) - Alzheimer's researchers at Harvard for the first time are scanning the brains of healthy patients for the presence of a hallmark protein called tau, which forms toxic tang...

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Companies [92 Associated Companies listed on BioPortfolio]

Aurinia Pharmaceuticals Inc.

Aurinia is a clinical stage pharmaceutical company focused on the global nephrology market. It is currently enrolling patients in its Phase 2b clinical trial to evaluate the effic...

tesa Labtec GmbH

With more than 20 years of experience, tesa Labtec is one of the leading drug delivery companies for film-shaped dosage forms like patches and oral films. Based on its innovative ...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

Ansun BioPharma

Ansun BioPharma is a clinical stage biopharmaceutical company focused on the development of unique host-directed anti-viral therapies for respiratory viruses. Ansun BioPharma has ...

TherapeuticsMD Inc.

TherapeuticsMD Inc. is an innovative healthcare company focused on developing and commercializing products exclusively for women. TherapeuticsMD is developing advanced hormone the...

BioFilm, Ltd.

Founded in 2003 as a subsidiary of Devro plc., BioFilm is the largest Thin Dissolving Film (TDF) producer in Europe, with their GMP certified manufacturing and packaging facility ...

Sunrise Senior Living, LLC

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of April 1, 2014, Sunrise operated 290 communities in the United States, Canada and the...

Sunrise Senior Living and Health Care REIT, Inc.

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of January 1, 2014, Sunrise operated 290 communities in the United States, Canada and t...

DNAtrix Inc.

DNAtrix is a company developing modified oncolytic viruses for the treatment of the most aggressive forms of cancer. Since viruses are already efficient at killing cells, scientis...

Alector LLC

Alector is combining state-of-the-art antibody technology and recent discoveries in neuroimmunology and human genetics to develop novel therapeutics for Alzheimer’s disease, ...

Clinical Trials [568 Associated Clinical Trials listed on BioPortfolio]

Study of Epratuzumab Versus Placebo in Subjects With Moderate to Severe General Systemic Lupus Erythematosus

The primary objective of the study is to confirm the clinical efficacy of epratuzumab in the treatment of subjects with Systemic Lupus Erythematosus (SLE)

Pediatric Lupus Trial of Belimumab Plus Background Standard Therapy

This is a multi-center study to evaluate the safety, pharmacokinetics, and efficacy of belimumab intravenous (IV) in pediatric patients 5 to 17 years of age with active systemic lupus eryt...

A Study to Assess the Relative Bioavailability of Process Variants of Selumetinib in Healthy Male Volunteers

A Study to assess, against a reference selumetinib capsule, if the drug levels of a variant of selumetinib capsule are comparable, and to assess how drug levels differed in another variant...

Pharmacokinetics of Rosuvastatin and Atorvastatin in Pediatric Dyslipidemia Patients

This will be a single center, open label, randomized, cross-over study in patients with dyslipidemia comparing the pharmacokinetics of rosuvastatin and atorvastatin in patients with greate...

Prospective Study of Rapamycin for the Treatment of SLE

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin. It involves multiple organs including the joints, skin, kidneys and central nervous system. The disease proce...

Duke Lupus Registry

Lupus is a systemic autoimmune disease that can present with many varied symptoms, including joint pain, fevers, kidney disease, and rashes. Lupus can affect anyone, but it is most common...

Characterization of the Metabolic Fate of an Oral Arginine Form

The purpose of this study is to compare the metabolic fate of two oral forms of L-Arginine in healthy subjects featuring metabolic syndrome related risk factors

Cediranib Maleate in Treating Patients With Recurrent or Persistent Endometrial Cancer

This phase II trial studies the side effects and how well cediranib maleate works in treating patients with endometrial cancer that has failed to respond to initial chemotherapy or has com...

Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse Treatment

The initial phase of substance abuse treatment is a vulnerable period for relapse. Cognitive impairments are common during this phase and may reduce the ability to benefit from other forms...

Establishment of Fibroid Tissue Bank

The purpose of this study is to collect information and tissue samples from women with uterine fibroids. The samples will be used to study genes, proteins and other substances in order to ...

Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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