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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

03:19 EST 6th December 2016 | BioPortfolio

PubMed Articles [4213 Associated PubMed Articles listed on BioPortfolio]

Kinetics of the incorporation of the main phenolic compounds into the lignan macromolecule during flaxseed development.

The main flax lignan, secoisolariciresinol diglucoside, is stored in a macromolecule containing other ester-bound phenolic compounds. In this study, NMR and HPLC-UV analyses were performed on flaxseed...

Accumulation of guaiacol glycoconjugates in fruit, leaves and shoots of Vitis vinifera cv. Monastrell following foliar applications of guaiacol or oak extract to grapevines.

Previous studies have shown that volatile compounds present within a vineyard during the growing season can be absorbed by grapevines, assimilated within grapes, and then released during fermentation ...

Natural variation in folate levels among tomato (Solanum lycopersicum) accessions.

Folate content was estimated in tomato (Solanum lycopersicum) accessions using microbiological assay (MA) and by LC-MS. The MA revealed that in red-ripe fruits folate levels ranged from 4 to 60μg/100...

Preparing an Adjuvanted Thermoresponsive Gel Formulation for Sublingual Vaccination.

Thermoresponsive gels have unique physicochemical properties that may enable more effective mucosal delivery of active compounds. The thermoresponsive gel (TRG) formulation developed by our group for ...

Analysis of DNA Hydroxymethylation Using Colorimetric Assay.

Hydroxymethylcytosine (hmC or 5-hmC) is a nitrogen base occurring as a result of cytosine methylation followed by replacing a methyl group with a hydroxyl group through active oxidation. 5-hmC is cons...

Cytochrome c Stabilization and Immobilization in Aerogels.

Sol-gel-derived aerogels are three-dimensional, nanoscale materials that combine large surface area with high porosity. These traits make them useful for any rate-critical chemical process, particular...

Whole-Genome Characterization and Strain Comparison of VT2f-Producing Escherichia coli Causing Hemolytic Uremic Syndrome.

Verotoxigenic Escherichia coli infections in humans cause disease ranging from uncomplicated intestinal illnesses to bloody diarrhea and systemic sequelae, such as hemolytic uremic syndrome (HUS). Pre...

Roles of 1,25(OH)2D3 and Vitamin D Receptor in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus by Regulating the Activation of CD4+ T Cells and the PKCδ/ERK Signaling Pathway.

The study aims to elucidate the roles of 1,25(OH)2D3 and vitamin D receptor (VDR) in the pathogenesis of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) by regulating the activation o...

Mechanism of Sex Determination in Humans: Insights from Disorders of Sex Development.

In this review we will consider the gene mutations responsible for the non-syndromic forms of disorders of sex development (DSD) and how recent genetic findings are providing insights into the mechani...

Touch-contingent visual motion perception: tactile events drive visual motion perception.

It has recently been demonstrated that the brain rapidly forms an association between concurrently presented sound sequences and visual motion. Once this association has been formed, the associated so...

News Articles [1299 Associated News Articles listed on BioPortfolio]

JHL Forms $257 Million Partnership with Sanofi for Rituximab Biosimilar

JHL Biotech, a Taiwan-China biologics company, signed a $257 million partnership agreement that gives Sanofi  rights to market a JHL clinical-stage rituximab biosimilar, initially for China. Sano...

Pubic Grooming Tied to Higher STD Rates

MONDAY, Dec. 5, 2016 -- Brazilian bikini waxing and similar forms of personal grooming may be all the rage, but they come with a heightened risk of acquiring a sexually transmitted disease, new resear...

Gene that 'limits desire for alcohol'

A newly discovered gene variant seems to reduce an individual's fondness for alcohol, a study has found...

Researchers uncover possible source of genetic error causing multiple diseases

Tufts University researchers have discovered a possible explanation for the occurrence of a genetic error that causes over a dozen neuromuscular and neurodegenerative disorders, including Huntington's...

FDA allows cardiovascular death reduction claim for Jardiance

In a huge boon for Lilly and Boehringer Ingelheim, US regulators have expanded the scope of diabetes drug Jardiance to include a reduction in the risk of cardiovascular death patients with type II for...

Acetylon forms Regenacy ahead of Celgene takeover

Boston biotech Acetylon revealed it was being acquired by Celgene and rolled out a new business to continue production of gene expression drugs. 

Strategic Partnerships and Joint Ventures Crucial to Unlock Growth Opportunities Created by Digital Health

SANTA CLARA, Calif., Dec. 5, 2016 /PRNewswire/ -- Digital technologies and the massive flows of all forms of data fuelled by the Internet of Things (IoT) are driving vertical integration within h...

Immunotherapy agent yields full and partial remissions in aggressive non-Hodgkin lymphomas

(Dana-Farber Cancer Institute) An immunotherapy drug able to induce lasting remissions in classical Hodgkin lymphoma may be equally effective in patients with either of two rare, aggressive forms of n...

New day for nephrons

Aurinia's voclosporin could increase lupus nephritis remissions while reducing reliance on toxic standards of care.

Corbus Pharmaceuticals Announces NASDAQ Closing Bell Ceremony

NORWOOD, MA--(Marketwired - December 05, 2016) - Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) ("Corbus" or the "Company"), a clinical stage drug development company targeting rare, chronic, s...

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Companies [109 Associated Companies listed on BioPortfolio]

The Foundation for Mitochondrial Medicine

The Foundation for Mitochondrial Medicine is a 501(c) (3) non-profit organization dedicated to supporting the development of the most promising research and treatments of the many...

Ennis, Inc.

Ennis, Inc. (www.ennis.com) is primarily engaged in the production and sale of business forms, apparel and other business products. The Company is one of the largest privat...

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

Pinnacle Biologics

Founded in 2007 by former Abbott Laboratories executives Guillermo Herrera, James Miller, and Viren Grover, Pinnacle Biologics is a premier international company that excels in assisting pharmaceu...

HealthViewX

HealthViewX is a robust health IT platform designed for effective care coordination, communication and analytics to enhance patient treatment through meaningful health systems int...

Hereditary Neuropathy Foundation

Hereditary Neuropathy Foundation (HNF) is a non-profit 501(c)3 organization whose mission is to increase awareness and accurate diagnosis of Charcot-Marie-Tooth disease (CMT) and ...

North Carolina Council on Developmental Disabilities

The North Carolina Council on Developmental Disabilities (NCCDD) works to assure that people with intellectual and other developmental disabilities (I/DD) and their families parti...

OncoRx Pharmaceuticals Inc.

OncoRx Pharmaceuticals (www.oncorxpharmaceuticals.com) is an early-stage pharmaceutical company dedicated to the discovery and development of novel drugs that control tumor metast...

amcure GmbH

amcure GmbH is a spin-off from the Karlsruhe Institute of Technology established in 2011. The company develops peptide-based compounds for the treatment of highly metastatic forms...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

Clinical Trials [885 Associated Clinical Trials listed on BioPortfolio]

Tolerability and Safety of Switching From Rituximab to Ocrelizumab in Patients With Relapsing Forms of Multiple Sclerosis

This is a prospective between and within group observational study to determine differences in tolerability, immunogenicity and safety related outcomes for 100 multiple sclerosis (MS) pati...

Pulmonary Vascular Disease Phenomics Program PVDOMICS

It is recognized that patients with various forms of heart and lung disease exhibit varying degrees of pulmonary hypertension, pulmonary vascular remodeling, and right ventricular dysfunct...

Oxidation Rates of the Different Substrates During Exercise in Children and Adolescents With Juvenile Idiopathic Arthritis. Case-control Study and Cases Treated / Cases Not Treated With Anti-TNFα

During exercise, energy comes mainly from carbohydrates and lipids. The relative contribution of lipids and glucose as energy substrates to exercise depends on the parameters of the exerci...

Histopathological Techniques and PCR on Tissues Included in Paraffin for the Diagnosis of Tuberculosis

Tuberculosis (TB) remains a major public health problem nowadays. About 30% of the world population is infected with Mycobacterium tuberculosis. There is an increase in the number of cases...

Pembrolizumab and Lenvatinib in Treating Metastatic or Recurrent Differentiated Thyroid Cancer That Cannot Be Removed by Surgery

This phase II trial studies how well pembrolizumab and lenvatinib work in treating patients with differentiated thyroid cancer that has spread to other places in the body or has come back ...

Amendment of rTSST-1 Variant Vaccine Phase 1 First-in-man Trail

Toxic Shock Syndrome (TSS) a severe condition with high morbidity and mortality results from the hosts overwhelming inflammatory response and cytokine storm. Staphylococcal superantigen to...

Detection of High Grade Prostate Cancer With Subharmonic Ultrasound Imaging, A Pilot Study

This is a phase II single center study using contrast-enhanced ultrasound to identify aggressive forms of prostate cancer with subharmonic imaging. The following are the study objectives:...

A Multi-center Study to Evaluate Performance of an Automated Device for the Detection of Diabetic Retinopathy

Diabetes affects 29.1 million people or 9.3% of the population of the United States. Results of a study by the Eye Diseases Prevalence Research Group reveal that 40% of diabetes patients h...

A Study to Characterize the Pharmacokinetics, Pharmacodynamics, and Safety of Anifrolumab in Adult Type I Interferon Test High Systemic Lupus Erythematosus Subject With Active Skin Manifestations

This study will be conducted to characterize pharmacokinetics, pharmacodynamics, safety, and tolerability of anifrolumab given via the subcutaneous (SC) route of administration in adult Sy...

Trial With Mesenchymal Stromal Cells (MSCs) vs Standard of Care in New Onset Cardiomyopathy

The goal of this clinical research study is to learn if adding mesenchymal stem cells (MSCs) to standard of care drugs can help control heart failure that may have been caused by anthracyc...

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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