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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

10:50 EST 9th February 2016 | BioPortfolio

PubMed Articles [4309 Associated PubMed Articles listed on BioPortfolio]

Neonatal multiorgan failure due to ACAD9 mutation and complex I deficiency with mitochondrial hyperplasia in liver, cardiac myocytes, skeletal muscle, and renal tubules.

Complex I deficiency causes Leigh syndrome, fatal infant lactic acidosis, and neonatal cardiomyopathy. Mutations in more than 100 nuclear DNA and mitochondrial DNA genes miscode for complex I subunits...

Importance of universal mismatch repair protein immunohistochemistry in patients with sebaceous neoplasia as an initial screening tool for Muir-Torre syndrome.

Muir-Torre syndrome, a Lynch syndrome variant, is characterized by sebaceous neoplasia plus one or more malignancies, typically colon cancer. The significance of DNA mismatch repair (MMR) deficiency d...

Expression of BAFF and BR3 in patients with systemic lupus erythematosus.

The objective of this study was to examine the relationship between the expression of B cell activating factor (BAFF) and BAFF receptor in patients with disease activity of systemic lupus erythematosu...

Specialized Laboratory Information Systems.

Some laboratories or laboratory sections have unique needs that traditional anatomic and clinical pathology systems may not address. A specialized laboratory information system (LIS), which is designe...

Characterization of cetuximab Fc/2 dimers by off-line CZE-MS.

Monoclonal antibody (mAb) therapeutics attract the largest concern due to their strong therapeutic potency and specificity. The Fc region of mAbs is common to many new biotherapeutics as biosimilar, a...

epiGBS: reference-free reduced representation bisulfite sequencing.

We describe epiGBS, a reduced representation bisulfite sequencing method for cost-effective exploration and comparative analysis of DNA methylation and genetic variation in hundreds of samples de novo...

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer.

The tremendous pandemic potential of coronaviruses was demonstrated twice in the past few decades by two global outbreaks of deadly pneumonia. Entry of coronaviruses into cells is mediated by the tran...

Non-destructive state detection for quantum logic spectroscopy of molecular ions.

Precision laser spectroscopy of cold and trapped molecular ions is a powerful tool in fundamental physics-used, for example, in determining fundamental constants, testing for their possible variation ...

Estimating Causal Effects With Propensity Score Models: An Evaluation of the Touch Condom Media Campaign in Pakistan.

Rapid population growth in Pakistan poses major risks, including those pertinent to public health. In the context of family planning in Pakistan, the current study evaluates the Touch condom media cam...

Critical analysis of fragment-orbital DFT schemes for the calculation of electronic coupling values.

We present a critical analysis of the popular fragment-orbital density-functional theory (FO-DFT) scheme for the calculation of electronic coupling values. We discuss the characteristics of different ...

News Articles [1165 Associated News Articles listed on BioPortfolio]

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

The tremendous pandemic potential of coronaviruses was demonstrated twice in the past few decades by two global outbreaks of deadly pneumonia. Entry of coronaviruses into cells is mediated by the tran...

Non-destructive state detection for quantum logic spectroscopy of molecular ions

Precision laser spectroscopy of cold and trapped molecular ions is a powerful tool in fundamental physics—used, for example, in determining fundamental constants, testing for their possible variatio...

Cirrus, a Kemwell Company, Ready to Launch Clinical Trial Manufacturing at Raleigh-Durham Site

Cirrus Pharmaceuticals, a Kemwell company, which is a global CDMO, announces that it is ready to launch its services for manufacturing cGMP materials for early phase clinical tria...

You can train your body into thinking it's had medicine

Marette Flies was 11 when her immune system turned against her. A cheerful student from Minneapolis, Minnesota, she had curly brown hair and a pale, moon-shaped face, and she loved playing trumpet in ...

Evidence of a lipid link in the inherited form of Alzheimer's disease

Australian researchers have found biochemical changes occurring in the blood, in the rare inherited form of Alzheimer's disease. Changes in these fat-like substances, may suggest a method to diagnose ...

Domain-swap polymerization drives the self-assembly of the bacterial flagellar motor

A combination of evolutionary covariance, biochemistry and SAXS analyses reveal that Escherichia coli FliG exists as a monomer in solution but forms domain-swapped polymers in assembled flagellar moto...

epiGBS: reference-free reduced representation bisulfite sequencing

We describe epiGBS, a reduced representation bisulfite sequencing method for cost-effective exploration and comparative analysis of DNA methylation and genetic variation in hundreds of samples de novo...

Variants in MBOAT7 locus show link to NAFLD

Researchers found the membrane bound O-acyltransferase domain-containing 7 gene rs641738 variant was linked to severe nonalcoholic fatty liver disease in people of European descent, according to publi...

Smoking linked to chronic damage in patients with SLE

Patients with systemic lupus erythematosus with previous or current smoking status were likely to have more accumulated damage compared with patients who never smoked or were never exposed to secondha...

A new role for vitamin B6 in plants

Vitamin B6, which exists in different natural forms called vitamers, is essential for all living organisms, as it participates in numerous aspects of cells' everyday life. Researchers from the Univers...

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Companies [106 Associated Companies listed on BioPortfolio]

Hereditary Neuropathy Foundation

Hereditary Neuropathy Foundation (HNF) is a non-profit 501(c)3 organization whose mission is to increase awareness and accurate diagnosis of Charcot-Marie-Tooth disease (CMT) and ...

North Carolina Council on Developmental Disabilities

The North Carolina Council on Developmental Disabilities (NCCDD) works to assure that people with intellectual and other developmental disabilities (I/DD) and their families parti...

OncoRx Pharmaceuticals Inc.

OncoRx Pharmaceuticals (www.oncorxpharmaceuticals.com) is an early-stage pharmaceutical company dedicated to the discovery and development of novel drugs that control tumor metast...

amcure GmbH

amcure GmbH is a spin-off from the Karlsruhe Institute of Technology established in 2011. The company develops peptide-based compounds for the treatment of highly metastatic forms...

Pinnacle Biologics

Founded in 2007 by former Abbott Laboratories executives Guillermo Herrera, James Miller, and Viren Grover, Pinnacle Biologics is a premier international company that excels in assisting pharmaceu...

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

ICON Eyecare

ICON Eyecare is a leading surgical and medical eye care provider, based out of Denver, CO. Since 1999, ICON has been building a Center of Ophthalmology Excellence empowered by an ...

OncoRx Pharmaceuticals, Inc.

OncoRx Pharmaceuticals (www.oncorxpharmaceuticals.com) is a pharmaceutical company dedicated to the discovery and development of novel drugs that control tumor metastasis; disrupt...

Neos Therapeutics, Inc.

Neos Therapeutics Inc. is a specialty pharmaceutical company focused on the development, manufacture and sale of FDA approved drug products which utilize the Company’s propri...

Clinical Trials [727 Associated Clinical Trials listed on BioPortfolio]

Amniotic Biomarkers in the Prediction of Postpartum Renal Function.

The discovery of antenatal bilateral renal anomaly poses an essential question: can we predict postnatal renal function in short, medium and long term? Ultrasound appears sufficient in sev...

Outpatient Hematopoietic Grafting in Multiple Sclerosis Employing Autologous Peripheral Blood Stem Cells

Multiple sclerosis (MS) is a chronic, inflammatory, debilitating disease that causes destruction of central nervous system (CNS) myelin, with varying degrees of axonal damage. It mainly af...

Agent-Enhanced Document Explanation

Both the main and sub-studies will investigate how consent forms and other health care documents are explained to patients. The findings will be used to create a computer program that can ...

EGFRvIII CAR T Cells for Newly-Diagnosed GBM

Newly diagnosed glioblastoma subjects who are eligible will be enrolled following surgery to remove the brain tumor. They will then undergo a leukapheresis to harvest cells for the generat...

Study of IFN-K in Systemic Lupus Erythematosus

The safety and immunogenicity of the IFN-Kinoid (IFN-K) have been evaluated in a phase I clinical study conducted in subjects with SLE. Preliminary results were promising. The principal a...

Effect of Standing, Lying and Stockings on Blood Bio-markers (v.1)

Venous disease effects 25% of the population and most healthy people experience venous symptoms after standing for too long. The prime function of leg veins is drainage. Failure leads to a...

Oral Hygiene Regimen in Patients on HCT

Oral mucositis is one of the most common debilitating forms of mucositis that arise from high dose chemotherapy and radiotherapy. It is reported that almost 75% patients undergoing hematop...

A Phase 2a, Double-blind, Placebo-Controlled Study of RSLV-132 in Subjects With Systemic Lupus Erythematosus (SLE)

This study evaluates the impact of 13 bi-weekly intravenous infusions of RSLV-132 on the cutaneous manifestations in subjects with systemic lupus erythematosus.

Anisakis Blastocystis Cryptosporidium Fish Prevalence

Anisakidae frequently infect fish species that are commonly eaten by humans. Some of them are recognized as zoonotic agents, and have a high impact on human health. Infestation results fr...

The Impact of Illness Perceptions on Health Related Outcomes in Patients With Lupus and Systemic Sclerosis

This research project has the overall objective to investigate the direction of the associations between illness perceptions, their influencing factors and health-related outcomes. Moreove...

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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