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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

07:19 EST 26th February 2017 | BioPortfolio

PubMed Articles [4126 Associated PubMed Articles listed on BioPortfolio]

The genetic structure of hypoderatid mites (Actinotrichida: Astigmata) parasitizing great cormorant (Phalacrocorax carbo) during host post-breeding dispersal in Milicz, SW Poland.

The astigmatid family Hypoderatidae includes over 80 mite species exhibiting peculiar life cycle. Deutonymphs are parasitic instars inhabiting subcutaneous or visceral tissues of birds and rodents, wh...

Prochristianella clarkeae Beveridge, 1990 (Eutetrarhynchidae): a species complex or a species with intraspecific variation in the distribution of its tegumental microtriches?

The microthrix pattern of common forms of the trypanorhynch cestode Prochristianella clarkeae Beveridge, 1990 on which the microscopically visible microtriches almost extended to the posterior end of ...

ICNIRP Statement on Diagnostic Devices Using Non-ionizing Radiation: Existing Regulations and Potential Health Risks.

Use of non-ionizing radiation (NIR) for diagnostic purposes allows non-invasive assessment of the structure and function of the human body and is widely employed in medical care. ICNIRP has published ...

Homozygous mutation in PRUNE1 in an Oji-Cree male with a complex neurological phenotype.

The PRUNE1 gene encodes a member of the phosphoesterases (DHH) protein superfamily that is highly expressed in the human fetal brain and involved in the regulation of cell migration. Homozygous or com...

Timothy syndrome 1 genotype without syndactyly and major extracardiac manifestations.

Timothy syndrome 1 (TS1) is a rare genetic disorder characterized by multisystem abnormalities including QT prolongation, congenital heart defects, facial dysmorphism, episodic hypoglycemia, and neuro...

The recurrent PPP1CB mutation p.Pro49Arg in an additional Noonan-like syndrome individual: Broadening the clinical phenotype.

We report on a 12-year-old Brazilian boy with the p.Pro49Arg mutation in PPP1CB, a novel gene associated with RASopathies. This is the fifth individual described, and the fourth presenting the same va...

TSC2 c.1864C>T variant associated with mild cases of tuberous sclerosis complex.

Tuberous sclerosis complex (TSC) is an autosomal dominantly inherited disorder with variable expressivity associated with hamartomatous tumors, abnormalities of the skin, and neurologic problems inclu...

New Drugs and Dosage Forms.

Social Information on Fear and Food Drives Animal Grouping and Fitness.

Empirical studies in select systems suggest that social information-the incidental or deliberate information produced by animals and available to other animals-can fundamentally shape animal grouping ...

Utility of Neurological Imaging in Sensory Variant of Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report.

News Articles [1113 Associated News Articles listed on BioPortfolio]

Week in Review: BioSense Signs $68 Million China Deal with Neovacs For Therapeutic Vaccine

BioSense Global, a New Jersey-Suzhou biotech, signed a $68 million option agreement with France's Neovacs for China rights to a therapeutic vaccine aimed at lupus and dermatomyositis; Beijing's A...

Content Development Manager - 12994

Learn.Discover.Achieve_1000.png SpringerHealthcare_Logo.jpg Springer Healthcare is a leading full service medical communications agency, and forms part of Springer Nature, the world's largest acad...

WE tv's Braxton Family Values Reality Star Traci Braxton Teams with Pulmonary Hypertension Association (PHA) for a Cause Close to Her Heart

National recording artist Traci Braxton, who stars alongside her family on the hit WE tv reality show, Braxton Family Values, has three very personal reasons for supporting the Pulmonary Hypertension ...

Alzheimer's drug prescribed 'off-label' for mild cognitive impairment could pose risk for some

Donepezil, a medication that is approved to treat people with Alzheimer's disease, should not be prescribed for people with mild cognitive impairment without a genetic test. UCLA School of Nursing res...

Type 1 Diabetes Mellitus Heat Map and Analysis Prices from USD $2000

Type 1 Diabetes Mellitus Heat Map and AnalysisSummaryType I diabetes mellitus T1DM is a metabolic disease characterized by chronic hyperglycemia, and is caused by defective insulin secretion by pancr...

Alzheimer's drug prescribed off-label could pose risk for some

(University of California - Los Angeles Health Sciences) Donepezil, a medication that is approved to treat people with Alzheimer's disease, should not be prescribed for people with mild cognitive impa...

Hainan Pharmaceutical Co Ltd 000566 Financial and Strategic SWOT Analysis Review [Updated: 13012017] Prices from USD $300

SummaryHainan Pharmaceutical Co Ltd Hainan is a pharmaceutical company that offers antibiotic products. The company develops, manufactures and sells OTC, prescription products, antineoplastic, gastroi...

Sickle Cell Trait Confounds Blood Sugar Readings

Sickle cell trait (SCT) is a genetic hemoglobin variant found in 8% to 10% of African-Americans and it occurs in...

Infection Rates High in Kids with SLE (CME/CE)

(MedPage Today) -- Highest rates seen in those with lupus nephritis

OBERD collaborates with Oxford University Innovation to promote web-based best-in-class PROMs at AAOS 2017

COLUMBIA, Mo., Feb. 23, 2017 /PRNewswire/ -- OBERD will be promoting the best-in-class Patient Reported Outcome Measures (PROMs) licensed by Oxford University Innovation (OUI) at the American Aca...

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Companies [109 Associated Companies listed on BioPortfolio]

The Foundation for Mitochondrial Medicine

The Foundation for Mitochondrial Medicine is a 501(c) (3) non-profit organization dedicated to supporting the development of the most promising research and treatments of the many...

Ennis, Inc.

Ennis, Inc. (www.ennis.com) is primarily engaged in the production and sale of business forms, apparel and other business products. The Company is one of the largest privat...

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

Pinnacle Biologics

Founded in 2007 by former Abbott Laboratories executives Guillermo Herrera, James Miller, and Viren Grover, Pinnacle Biologics is a premier international company that excels in assisting pharmaceu...

HealthViewX

HealthViewX is a robust health IT platform designed for effective care coordination, communication and analytics to enhance patient treatment through meaningful health systems int...

Hereditary Neuropathy Foundation

Hereditary Neuropathy Foundation (HNF) is a non-profit 501(c)3 organization whose mission is to increase awareness and accurate diagnosis of Charcot-Marie-Tooth disease (CMT) and ...

North Carolina Council on Developmental Disabilities

The North Carolina Council on Developmental Disabilities (NCCDD) works to assure that people with intellectual and other developmental disabilities (I/DD) and their families parti...

OncoRx Pharmaceuticals Inc.

OncoRx Pharmaceuticals (www.oncorxpharmaceuticals.com) is an early-stage pharmaceutical company dedicated to the discovery and development of novel drugs that control tumor metast...

amcure GmbH

amcure GmbH is a spin-off from the Karlsruhe Institute of Technology established in 2011. The company develops peptide-based compounds for the treatment of highly metastatic forms...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

Clinical Trials [923 Associated Clinical Trials listed on BioPortfolio]

Anti-ficolin-2 Autoantibodies in Lupus Nephritis

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of multiple autoantibodies. The prevalence and significance of antibodies against Ficolin...

The Research on 89Zr-ABT806 PET Imaging in High Grade Glioma

The epidermal growth factor receptor variant Ⅲ(EGFR vⅢ) is commonly detected in high-grade gliomas, which is also an important epitope in EGFR-targeted therapies and correlated to poor...

Iguratimod as Treatment for Refractory Lupus Nephritis

This study is to evaluate the efficacy and safety of a novel chemical synthetic agent iguratimod as treatment of refractory lupus nephritis. All subjects should have at least one failed im...

Rituximab Objective Outcome Measures Trial in SLE

This is a feasibility study to test a new trial design for an important drug in Systemic Lupus Erythematosus (SLE or "lupus"). SLE is an autoimmune disease. The immune system attacks the ...

Stereotactic Body Radiation Therapy (SBRT) Combined With Avelumab (Anti-PD-L1) for Management of Early Stage Non-Small Cell Lung Cancer (NSCLC)

The purpose of the study is to determine whether avelumab has an effect on cancer and body in combination with SBRT, a standard treatment for early stage non-small cell lung cancer (NSCLC)...

Cabazitaxel in mCRPC Patients With AR-V7 Positive Circulating Tumor Cells (CTCs)

After failure on docetaxel, which has been the standard first line therapy for patients with metastatic castration-resistant prostate cancer (mCRPC), several treatment options are currentl...

Vascular Cell Activation, Cell-Derived Microparticles and In Vitro Fertilisation, and In Vitro Fertilisation

Introduction: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic phenomenon, poorly understood and difficult to predict, complicating intense ovarian stimulation cycle. The most sev...

Treatment of Incontinence Associated Dermatitis - Automated

Incontinence and the skin irritation (dermatitis) associated with it are common problems. Treatment of dermatitis is effective, but requires effective cleaning and application of a barrier...

AirSense 10 for Her RDI Validation Study

Detecting mild forms of obstructive sleep apnea (OSA) easily and efficiently might help to identify and improve care for patients suffering from wake reactions at night. The AirSense 10 fo...

Prophylactic Trimethoprim/Sulfamethoxazole to Prevent Severe Infections in Patients With Lupus Erythematous

The purpose of this study is to determine whether trimethoprim/sulfamethoxazole is effective in preventing serious infectious complications (those that require hospitalization or lead to d...

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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