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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

10:17 EDT 31st August 2016 | BioPortfolio

PubMed Articles [4244 Associated PubMed Articles listed on BioPortfolio]

Development and validation of a RP-UHPLC-ESI-MS/MS method for the chiral separation and determination of flavanone, naringenin and hesperetin enantiomers.

A quick and sensitive RP-UHPLC-ESI-MS/MS method for the separation of flavanone, naringenin and hesperetin enantiomers was developed. The separation of analytes was performed using a Chiralpak AD-3R c...

Modification biological activity of S and R forms of Proteus mirabilis and Burkholderia cepacia lipopolysaccharides by carrageenans.

The modification of biological features of S and R forms of Proteus mirabilis and Burkholderia cepacia LPS by kappa/iota and kappa/beta carrageenans was shown in Limulus activation test, ELISA, human ...

A novel encoding Lempel-Ziv complexity algorithm for quantifying the irregularity of physiological time series.

The Lempel-Ziv (LZ) complexity and its variants have been extensively used to analyze the irregularity of physiological time series. To date, these measures cannot explicitly discern between the irreg...

Neonatal Lupus: What We Have Learned and Current Approaches to Care.

Neonatal lupus results from the passive transfer of autoantibodies; however, this transfer is not sufficient to cause disease. This article reviews clinical presentation with a focus on autoimmune-med...

Progressive Supranuclear Palsy and Corticobasal Degeneration: Pathophysiology and Treatment Options.

There are currently no disease-modifying treatments for progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD), and no approved pharmacological or therapeutic treatments that are effe...

Autoimmune Myelofibrosis in Systemic Lupus Erythematosus Report of Two Cases and Review of the Literature.

Autoimmune myelofibrosis (AIMF) is a rare entity of steroid-responsive bone marrow fibrosis that accompanies a variety of autoimmune diseases, particularly systemic lupus erythematosus (SLE). Rarely i...

CLL: Common Leukemia; Uncommon Presentations.

We report here a series of ten patients with uncommon presentations and associations of chronic lymphocytic leukemia (CLL) not reported hitherto or occasionally reported in literature. The first two c...

Anosognosia in Dementia.

Progressive decline in memory (and other functions) is the defining feature of late-life dementia but affected individuals are often unaware of this impairment. This article reviews recent research on...

Informed Consent in the Changing Landscape of Research.

The history of informed consent dates back as early as the 16th century (Selek, 2010). The current tenets of informed consent pertaining to the ethical conduct of research on human participants predom...

Stability of extemporaneous erlotinib, lapatinib, and imatinib oral suspensions.

The stability of extemporaneously prepared erlotinib, lapatinib, and imatinib oral liquid dosage forms using two commercially available vehicles when stored at 4 and 25 °C was evaluated.

News Articles [1408 Associated News Articles listed on BioPortfolio]

A pathway-centric approach to rare variant association analysis

Zavante Therapeutics Forms Scientific Advisory Board And Appoints Infectious Disease Experts As Members

SAN DIEGO, Aug. 31, 2016 /PRNewswire/ -- Zavante Therapeutics, Inc., a privately-held, late clinical-stage biopharmaceutical company, today announced that it has formed a Scientific Advisory Boar...

Essential Source Changing Americans Bad Gut Health For Good

Essential Source has expanded its probiotics line to include patented “Microencapsulated Probiotic” blends, clinically proven to colonize/adhere five times better than typical or uncoated strains ...

One-time treatment rescues lethal metabolic liver disease in mice

To treat the liver disorder tyrosinaemia type I, one of the most severe forms of the disease, doctors typically use drug therapy. However the treatment is lifelong and a residual risk of liver cancer ...

Selena Gomez Takes Break From Her Career Because Of Lupus

Last year, Selena Gomez revealed that she has lupus. Now the 24-year old actress and singer is going to take a break from her career to deal with the disease. What exactly is lupus?

Study: Patients with SLE had frequent Staphylococcus aureus colonization

Recently published results showed patients with systemic lupus erythematosus frequently had Staphylococcus aureus colonization with a frequency similar to that of healthy patients.Researchers performe...

Zika virus — reigniting the TORCH

The placenta forms the foremost barrier that protects the developing fetus during pregnancy in eutherian organisms. However, diverse pathogens such as Toxoplasma gondii, ru...

Staurus Announces Issuance of U.S. Patent for Immunoglobulins and Variants Directed Against Pathogenic Microbes

JACKSON, Wyo., Aug. 30, 2016 /PRNewswire/ -- Staurus Pharma LLC, today announced that the United States Patent and Trademark Office has granted a key patent covering the composition of novel Fc v...

Rivaroxaban 'could be a safe treatment option for antiphospholipid syndrome'

The drug rivaroxaban could be an effective means of treating some patients with thrombotic antiphospholipid syndrome, according to a new study.Led by University College London and funded by Arthritis ...

Walgreens Forms Alliance With Prime Therapeutics

Walgreens Boots Alliance has struck a partnership with Prime Therapeutics to help it capture a greater share of the prescription-drug market and better compete with CVS Health.

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Companies [109 Associated Companies listed on BioPortfolio]

The Foundation for Mitochondrial Medicine

The Foundation for Mitochondrial Medicine is a 501(c) (3) non-profit organization dedicated to supporting the development of the most promising research and treatments of the many...

Ennis, Inc.

Ennis, Inc. (www.ennis.com) is primarily engaged in the production and sale of business forms, apparel and other business products. The Company is one of the largest privat...

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

Pinnacle Biologics

Founded in 2007 by former Abbott Laboratories executives Guillermo Herrera, James Miller, and Viren Grover, Pinnacle Biologics is a premier international company that excels in assisting pharmaceu...

HealthViewX

HealthViewX is a robust health IT platform designed for effective care coordination, communication and analytics to enhance patient treatment through meaningful health systems int...

Hereditary Neuropathy Foundation

Hereditary Neuropathy Foundation (HNF) is a non-profit 501(c)3 organization whose mission is to increase awareness and accurate diagnosis of Charcot-Marie-Tooth disease (CMT) and ...

North Carolina Council on Developmental Disabilities

The North Carolina Council on Developmental Disabilities (NCCDD) works to assure that people with intellectual and other developmental disabilities (I/DD) and their families parti...

OncoRx Pharmaceuticals Inc.

OncoRx Pharmaceuticals (www.oncorxpharmaceuticals.com) is an early-stage pharmaceutical company dedicated to the discovery and development of novel drugs that control tumor metast...

amcure GmbH

amcure GmbH is a spin-off from the Karlsruhe Institute of Technology established in 2011. The company develops peptide-based compounds for the treatment of highly metastatic forms...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

Clinical Trials [834 Associated Clinical Trials listed on BioPortfolio]

Childhood Influenza Immunisation Invitation Trial in Schools

This study will investigate whether influenza vaccine uptake by school-age children (in school-based clinics) can be increased by making behavioural-insight informed changes to the invitat...

Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms

Identification of genes involved in congenital atrioventricular block and progressive Cardiac Conduction Disease.

Belimumab Phase I Study in Chinese Subjects With Systemic Lupus Erythematosus

In China, Belimumab (GSK1550188) will be developed for a dosing regimen of once-monthly intravenous (IV) infusion for the treatment of SLE. This open-label, single dose study will evaluate...

Synovial Fluid Analysis of Intraarticular Elbow Fracture

The objective of this study is to obtain and compare bilateral elbow joint synovial fluid from patients with unilateral intraarticular elbow fracture and a contralateral healthy appearing ...

Acquisition of MI Competence Trough the Training Methods Used in the Swedish County Councils and Municipalities

In the Swedish county councils and municipalities, Motivational Interviewing (MI) training with different forms and content is taking place as part of the implementation of the method. The...

Effect of Green Tea on Treatment of Lupus

This randomized double blind clinical trial performed on 68 patients (32 in intervention and 36 in control group) diagnosed with SLE. The patients in intervention group were given daily do...

G6PD Assessment Before Primaquine for Radical Treatment of Vivax Malaria

This will be a single-arm observational cohort study. Malaria patients with Plasmodium vivax and meeting study inclusion criteria, who give consent to be enrolled in the study, will have t...

Computerized Psychoeducation for Anxiety Sensitivity

This investigation examines the efficacy of a 35 minute computerized psychoeducation protocol in the reduction of elevated anxiety sensitivity cognitive concerns, a risk factor for the dev...

Asia Study Group of Prostate Cancer (A-CaP Study)

This study will target patients who have received a histopathological diagnosis of prostate cancer and who are undergoing treatment in various forms, including active PSA surveillance, sur...

Compensation Mechanisms in Parkinson's Disease

Parkinson's disease onset is clinically defined as the appearance of motor symptoms including akinesia, tremor and hypertonia. Several studies have shown that motor symptoms occur when at ...

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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