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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

13:13 EDT 30th July 2014 | BioPortfolio

PubMed Articles [4613 Associated PubMed Articles listed on BioPortfolio]

Role of the potassium channel KCa3.1 in diabetic nephropathy.

There is an urgent need to identify novel interventions for mitigating the progression of diabetic nephropathy. Diabetic nephropathy is characterized by progressive renal fibrosis, in which tubulointe...

Thermodynamic studies for adsorption of ionizable pharmaceuticals onto soil.

Although pharmaceutical compounds (PCs) are being used more and more widely, and studies have been carried out to assess their presence in the environment, knowledge of their fate and behavior, especi...

Soil-to-crop transfer factors of tellurium.

Stable tellurium (Te) concentrations in 148 sets of agricultural soil and associated crop samples were measured in this study to obtain soil-to-crop transfer factor (TF) of Te. We used a recently deve...

Effects of drying and comminution type on the quantification of Polycyclic Aromatic Hydrocarbons (PAH) in a homogenised gasworks soil and the implications for human health risk assessment.

This research investigates the effect of nine physical treatment types comprising a serial combination of three drying (air, freeze and oven) and two comminution (milling and sieving) methods on the q...

Speciation and bioavailability of selenium and antimony in non-flooded and wetland soils: A review.

Studies on the sorption behaviors of selenium (Se) and antimony (Sb) are reviewed. Both Se and Sb chemical speciation can be controlled by pH and redox potential, and both of them are likely to be sor...

Comparison of sewage sludge- and pig manure-derived biochars for hydrogen sulfide removal.

Biochars derived from pig manure and sewage sludge were evaluated for their abilities to remove hydrogen sulfide (H2S) from gas phase. The pig manure biochar had higher capacities for H2S sorption tha...

The impact of chromophoric dissolved organic matter on the photodegradation of 17α-ethinylestradiol (EE2) in natural waters.

17α-Ethinylestradiol (EE2), the potent estrogen which forms the basic constituent of the contraceptive pill, can undergo degradation in natural waters by sunlight and via secondary reactions initiate...

Malignant transformation of DNETs: a case report and literature review.

Dysembryoplastic neuroepithelial tumors (DNETs) have traditionally been thought of as lesions with a benign clinical course that generally do not undergo malignant transformation. However, cases are e...

Strategies to Enhance Adoption of Ventilator-Associated Pneumonia Prevention Interventions: A Systematic Literature Review.

Background. Ventilator-associated pneumonia (VAP) is among the most lethal of all healthcare-associated infections. Guidelines summarize interventions to prevent VAP, but translating recommendations...

American Brain Tumor Association Young Investigator Award 198 Circulating Tumor Cells in Patients With Glioblastoma.

Glioblastoma (GBM) is characterized by necrosis, angiogenesis, and inevitable recurrence. Despite its aggressiveness, GBM rarely forms extracranial metastases, suggesting impediments in vascular invas...

News Articles [1305 Associated News Articles listed on BioPortfolio]

Roche forms a pharma alliance with AmorChem

Roche and AmorChem announced they have entered into a pharma alliance to discover novel small molecule disease-modifying therapy for the treatment of myotonic muscular dystrophy 1, or Steinert’s dis...

Sunshine Biopharma forms Canadian subsidiary

Sunshine Biopharma, a pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, has announced that it has formed Sunshine...

EastGate expands pharmaceutical developments with sub-micron platform technology

EastGate Acquisitions, an emerging pharmaceutical company exploring drug delivery innovations in the development of improved novel formulations and alternative dosage forms of existing biologically ac...

Surgeon General Issues First Ever Warning About Tanning And Skin Cancer

redOrbit Staff & Wire Reports - Your Universe Online The US Surgeon General has issued a new warning against skin cancer, claiming that even though the condition is preventable in most cases, it...

Don't shake hands with patients during flu outbreak, study suggests

Nurses might want to consider avoiding shaking hands with patients during flu outbreaks or in other infection control situations, after a UK study found a handshake transferred more bacteria than simi...

HPV Vaccination Coverage Remains Unacceptably Low in the US

A New Report From the US Centers for Disease Control and Prevention Has Stated That HPV Vaccine Coverage in the US is Too Low Human Papillomavirus (HPV), the leading cause of cervical cancer, is the m...

New Protein Structure Could Help Treat Alzheimer’s

There is no cure for Alzheimer’s disease and other forms of dementia, but the research community is one step closer to finding treatment.  

Asia Pacific: World’s Epicenter for Hepatitis

With some 100 million people infected with forms of hepatitis, China is the world’s epicenter for the illness. Read more about Asia Pacific: World’s Epicenter for HepatitisComments

New protein structure could help treat Alzheimer’s, related diseases

There is no cure for Alzheimer’s disease and other forms […]

Total Pharmacy Supply to Seek GSA, Expand Sales to Federal Agencies, VA

DALLAS, July 29, 2014 /PRNewswire/ -- Total Pharmacy Supply (TPS), a leading Dallas-based wholesale distributor of pharmacy supplies announced plans today to expand sales of their Pharmacy Supply busi...

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Companies [86 Associated Companies listed on BioPortfolio]

Sunrise Senior Living, LLC

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of April 1, 2014, Sunrise operated 290 communities in the United States, Canada and the...

Sunrise Senior Living and Health Care REIT, Inc.

Sunrise Senior Living, a McLean, Va.-based company, employs approximately 29,000 people. As of January 1, 2014, Sunrise operated 290 communities in the United States, Canada and t...

DNAtrix Inc.

DNAtrix is a company developing modified oncolytic viruses for the treatment of the most aggressive forms of cancer. Since viruses are already efficient at killing cells, scientis...

GTS Medical Translation Services

GTS provides certified medical translation services to leading pharmaceutical companies, medical device companies and CROs. Customers include Astra Zeneca, GSK, Teva Pharmaceuticals, Siemens, Boston...

Eutropics Pharmaceuticals Inc.

Eutropics is addressing the need for improving the treatment of aggressive forms of leukemia, myeloma, lymphoma, and other cancers. The company is developing a novel diagnostic te...

Neos Therapeutics, Inc.

Neos Therapeutics Inc. is a specialty pharmaceutical company focused on the development, manufacture and sale of FDA approved drug products which utilize the Company’s propri...

Ignyta, Inc.

Ignyta, Inc., located in San Diego, California, is a personalized medicine company developing revolutionary new products and services to customize diagnosis and treatment of patie...

Refine Technology

Refine Technology was founded in 1999 with a vision to bring to the biopharmaceutical market cell separation systems that allow for increased productivity of cell derived biopharmaceuticals. Refine...

Puma Biotechnology, Inc.

Puma Biotechnology, Inc. is a development stage biopharmaceutical company that acquires and develops innovative products for the treatment of various forms of cancer. The Company...

Thrasos Innovation, Inc.

Thrasos is a private, clinical stage, bio-therapeutics Company focused on the discovery and development of targeted therapies for the prevention and treatment of severe organ fail...

Clinical Trials [529 Associated Clinical Trials listed on BioPortfolio]

Nutritional Counseling Associated With the Ingestion of Oat Bran in Hypercholesterolemic Subjects

Dyslipidemia is among the risk factors for cardiovascular diseases (CVD). Is's due to genetic and / or environmental factors such as inadequate dietary pattern. The occurrence of adverse e...

RSLV-132 Biologic Proof-of-Concept in Systemic Lupus Erythematosus

This one month multi-dose study will evaluate the ability of RSLV-132 to remove circulating immune complexes from the blood of lupus patients. Immune complexes are thought to trigger the...

Glucose Homeostasis Pre and Post Bariatric Surgery

The investigators wish to study the effects of two forms of bariatric surgery, gastric bypass and lap banding. The surgery is not part of the clinical trial. If your insurance does not co...

Copeptin for Risk Stratification in Non-traumatic Headache in the Emergency Setting - The CoHead Study

Headache is a common symptom, and patients often seek medical attention at emergency departments due to headaches. The aim of the CoHead Study is to find out if it is possible by measurin...

Evaluating the Safety and Immune Response to Two Doses of a Dengue Virus Vaccine Administered 12 Months Apart

Dengue viruses can cause dengue fever and other more severe forms of disease. This study will evaluate the safety and immune response to two doses of a dengue virus vaccine given 12 months...

Treatment of Social Phobia With Combined Cognitive Bias Modification and iCBT

The purpose of this study is to determine whether an internet-based treatment program, consisting of combined cognitive bias modification and cognitive behavioral therapy, reduces symptoms...

Safety, Tolerability and Pharmacokinetics of Iloperidone Depot in Schizophrenic Patients

This study is designed as a three-part trial to evaluate the safety of a novel depot formulation of iloperidone, compare two depot dosage forms, and perform dose ranging of one chosen form...

Lyme Disease Prevention Program

This is a large study of an educational program on Lyme disease prevention for passengers on ferry boats going to Nantucket Island during the period from Memorial Day until Labor Day. Some...

Safety of Estrogens in Lupus: Hormone Replacement Therapy

Safety of Estrogens in Lupus Erythematosus - National Assessment (SELENA) is a study to test whether postmenopausal women with systemic lupus erythematosus (SLE, or lupus) can safely use t...

Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients

This study compares three different therapies for treatment of refractory Pneumocystis carinii pneumonia (PCP) in patients with AIDS. "Refractory" means that the patient has failed to resp...

Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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