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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

15:21 EDT 1st May 2016 | BioPortfolio

PubMed Articles [4291 Associated PubMed Articles listed on BioPortfolio]

Constructing a short form of the hierarchical personality inventory for children (HiPIC): the HiPIC-30.

Children's personality traits are invaluable predictors of concurrent and later mental and physical health. Several validated longer inventories for assessing the widely recognized Five-Factor Model o...

Value of Pressure Measurements: Methods and Sources of Errors.

Tonometry is still an essential component of diagnostic testing in glaucoma. Functional and morphological investigations can provide very detailed information about the extent of glaucomatous damage. ...

Acute acalculous cholecystitis in systemic lupus erythematosus.

Resisting 'reason'. A Comparative Anthropological Study of Social Differences and Resistance Towards Health Promotion and Illness Prevention In Denmark.

Social differences in health and illness are well-documented in Denmark. However, very little is known about how health practices manifest in the everyday lives of different social classes. We propose...

Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients.

Three hundred and eight nanometer excimer light therapy has recently been reported to be effective against patchy alopecia areata (AA) in several clinical studies. However, these studies only included...

CD123 immunohistochemistry for plasmacytoid dendritic cells is useful in the diagnosis of scarring alopecia.

Distinguishing types of lymphocytic scarring alopecia is often difficult due to the overlapping features. Recently, the presence of plasmacytoid dendritic cells (PDCs) in cutaneous lupus erythematosus...

Imaging in Pediatric Demyelinating and Inflammatory Diseases of Brain- Part 2.

Imaging plays an important role in diagnosis, management, prognostication and follow up of pediatric demyelinating and inflammatory diseases of brain and forms an integral part of the diagnostic crite...

Spondylometaphyseal Dysplasia Corner Fracture (Sutcliffe) Type.

Spondylometaphyseal dysplasia corner fracture type (Sutcliffe) is an uncommon form of skeletal dysplasia which has some unique imaging features. The differential diagnoses include other forms of spond...

Heparin as a bundler in a self-assembled fibrous network of functionalized protein-based polymers.

Nature shows excellent control over the mechanics of fibrous hydrogels by assembling protein fibers into bundles of well-defined dimensions. Yet, obtaining artificial materials displaying controlled b...

HPV16 Sublineage Associations With Histology-Specific Cancer Risk Using HPV Whole-Genome Sequences in 3200 Women.

HPV16 is a common sexually transmitted infection although few infections lead to cervical precancer/cancer; we cannot distinguish nor mechanistically explain why only certain infections progress. HPV1...

News Articles [1251 Associated News Articles listed on BioPortfolio]

Mind of a murderer: Brain imaging helps scientists in search for ‘killer gene’

Body: Kent Kiehl, PhD, of the University of New Mexico, spends his days peering inside the brains of murderers, rapists, arsonists and other violent criminals using an fMRI scanner. To date, he...

Arkema Joins French Recycling Pact

Arkema has signed an agreement to participate in the French state-backed Reverplast project, alongside four other companies. Reverplast forms part of new measures launched by the French government to ...

Neovacs wins FDA approval to extend phase IIb clinical trial in Lupus to US

The US Food and Drug Administration (FDA) has approved Neovacs' investigational new drug application to extend its ongoing Phase IIb clinical trial of IFNα Kinoid to treat Lupus.

NEOVACS obtient l’accord de la FDA pour étendre aux États-Unis son étude de Phase IIb en Lupus

NEOVACS — Thursday, April 28th 2016 at 3:45pm UTC COMMUNIQUE DE PRESSE · COMMUNIQUE DE PRESSE · COMMUNIQUE DE PRESSE nEOVACS obtient l’accord de la FDA pour étendre aux États-Unis son ...

The genes behind non-identical twins

An international research collaboration has identified the gene variants that increase a woman’s chance of giving birth to non-identical (dizygotic) twins by almost a third. The study was conducted...

Neovacs obtains FDA approval to extend its Phase IIb clinical trial in Lupus to United States

  PRESS RELEASE· PRESS RELEASE· PRESS RELEASE Neovacs obtains FDA approval  to extend its Phase IIb clinical trial in Lupus to United States Paris and Boston, April 28th, 2016 ...

Experimental therapy has over 90% remission rate for advanced leukemia patients

Twenty-seven of 29 patients with an advanced type of leukemia that had proved resistant to multiple other forms of therapy went into remission after their T cells (disease-fighting immune cells) were ...

From retina to cortex: Unexpected division of labor

Neurons in our brain do a remarkable job of translating sensory information into reliable representations of our world that are critical to effectively guide our behavior. The parts of the brain that...

Immunotherapy Shows Impressive Results in Patients with Advanced Leukemia

Twenty-seven of 29 patients with an advanced type of leukemia that had proved resistant to multiple other forms of therapy went into remission after their T cells were genetically engineered to figh...

Immunotherapy Shows Impressive Results in Patients with Advanced Leukemia Study

Twenty-seven of 29 patients with an advanced type of leukemia that had proved resistant to multiple other forms of therapy went into remission after their T cells were genetically engineered to figh...

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Companies [109 Associated Companies listed on BioPortfolio]

The Foundation for Mitochondrial Medicine

The Foundation for Mitochondrial Medicine is a 501(c) (3) non-profit organization dedicated to supporting the development of the most promising research and treatments of the many...

Ennis, Inc.

Ennis, Inc. (www.ennis.com) is primarily engaged in the production and sale of business forms, apparel and other business products. The Company is one of the largest privat...

Vedanta Biosciences

Vedanta Biosciences, a privately held company, was co-founded by PureTech Ventures and a group of world renowned experts in immunology and microbiology. Vedanta Biosciences' mission is to develop a no...

Pinnacle Biologics

Founded in 2007 by former Abbott Laboratories executives Guillermo Herrera, James Miller, and Viren Grover, Pinnacle Biologics is a premier international company that excels in assisting pharmaceu...

HealthViewX

HealthViewX is a robust health IT platform designed for effective care coordination, communication and analytics to enhance patient treatment through meaningful health systems int...

Hereditary Neuropathy Foundation

Hereditary Neuropathy Foundation (HNF) is a non-profit 501(c)3 organization whose mission is to increase awareness and accurate diagnosis of Charcot-Marie-Tooth disease (CMT) and ...

North Carolina Council on Developmental Disabilities

The North Carolina Council on Developmental Disabilities (NCCDD) works to assure that people with intellectual and other developmental disabilities (I/DD) and their families parti...

OncoRx Pharmaceuticals Inc.

OncoRx Pharmaceuticals (www.oncorxpharmaceuticals.com) is an early-stage pharmaceutical company dedicated to the discovery and development of novel drugs that control tumor metast...

amcure GmbH

amcure GmbH is a spin-off from the Karlsruhe Institute of Technology established in 2011. The company develops peptide-based compounds for the treatment of highly metastatic forms...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

Clinical Trials [759 Associated Clinical Trials listed on BioPortfolio]

Health Burden of Hypophosphatasia

Hypophosphatasia (HPP) is a genetic disorder caused by mutation in the tissue-non-specific alkaline phosphatase gene (TNSALP). It causes impaired bone mineralisation, fractures, tooth loss...

Validation of a Clinical Screening Grid for Syndromic Schizophrenia

Background: Nowadays, despite a large number of studies about schizophrenia and genetics, clinical red flags for syndromic forms of schizophrenia remain poorly documented.

Analysis of B Cells From Autoimmune Individuals

This observational study aims at finding out if individual with autoimmunity exhibit increased numbers of B cells that express two types (instead of one type) of antibodies, and if B cells...

Cognitive Training for Fragile X Syndrome

Individuals with fragile X syndrome (FXS) demonstrate profound executive function deficits that interfere with learning, socialization and emotion regulation. Extensive research focused on...

Drug Transporter Interaction Study PHENTRA_2015_KPUK

The objective of the present study is to contribute to establishing in vivo phenotyping procedures for organic anionic transporter polypeptide 1B1 (OATP1B1), organic cation transporters 1 ...

The Effect of Metformin on Reducing Lupus Flares

This is a multicenter, randomised, double-blind placebo controlled trial on the efficacy and safety of add-on metformin to conventional immunosuppressants in systemic lupus erythematosus (...

Safety and Efficacy of Adult Adipose Derived Stem Cells in Refractory Rheumatoid Arthritis, Systemic Lupus Erythematosus or Sharp's Syndrome

This is a Phase I-II open- label single-dose study in subjects with significant refractory Rheumatoid Arthritis (RA), relapsing Systemic Lupus Erythematosus (SLE) or Sharp's Syndrome (SS)....

Study Evaluating the Optimal Dosage for Equivalence Between Lcr Regenerans® Capsules and Tablets (Lactobacillus Rhamnosus Lcr35®) on the Vaginal Flora Colonisation

The primary objective of this study is to study the vaginal flora colonisation equivalence between the tablet and capsule dosage forms of a treatment with Lcr Regenerans® between D0 (V1) ...

A Study of the Effect of XmAb®5871 in Patients With Systemic Lupus Erythematosus

The purpose of this study is to determine the ability of XmAb5871 to maintain Systemic Lupus Erythematosus (SLE) disease activity improvement achieved by a brief course of disease-suppress...

Defining the Physiological Mechanisms of Risk Genes for Hyperglycaemia, Insulin Resistance and Type 2 Diabetes

Recent genetic association studies have identified variants in the Peptidyl-Glycine alpha-amidating mono-oxygenase (PAM) gene that increase the risk of diabetes likely through a defect in ...

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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