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Variant Forms of Lupus - Biotech, Pharma and Life Science Channel

05:24 EDT 23rd September 2017 | BioPortfolio

PubMed Articles [4278 Associated PubMed Articles listed on BioPortfolio]

Nonradioactive Isotopic Labeling and Tracing of Selenoproteins in Cultured Cell Lines.

Selenium (Se) is an essential component of genetically encoded selenoproteins, in the form of a rare amino acid, namely the selenocysteine (Sec). Radioactive (75)Se has been widely used to trace selen...

Preparation of Selenocysteine-Containing Forms of Human SELENOK and SELENOS.

Selenoprotein K (SELENOK) and Selenoprotein S (SELENOS) are the members of the endoplasmic-reticulum-associated degradation (ERAD) complex, which is responsible for translocating misfolded proteins fr...

Monitoring of Methionine Sulfoxide Content and Methionine Sulfoxide Reductase Activity.

The sulfur-containing amino acid methionine (Met) plays critical roles in protein synthesis, methylation, and sulfur metabolism. Both in its free form and in the form of an amino acid residue, it can ...

Perception of olive oils sensory defects using a potentiometric taste device.

The capability of perceiving olive oils sensory defects and intensities plays a key role on olive oils quality grade classification since olive oils can only be classified as extra-virgin if no defect...

LINE-1 as a therapeutic target for castration-resistant prostate cancer.

Prostate cancer is the third leading cause of death by cancer in men. Surgery or hormone deprivation usually contains the progression of the local forms of the disease. In metastatic situations, chemo...

Role of fibroblast growth factor receptor-2 splicing in normal and cancer cells.

Types 1-4 of fibroblast growth factor receptors (FGFR) are all expressed in various cancers. Because of its prominent role in carcinogenesis and cancer progression, FGFR-2, is being considered as a no...

Strategies for reducing inflammation and promoting bone repair in arthritis.

Chronic forms of arthritis encompass many joint inflammatory disorders, including rheumatoid arthritis (RA), an autoimmune inflammatory disease, and osteoarthritis (OA), typically a 'wear and tear' co...

Molecular mechanisms of disorders of lipid metabolism in chronic kidney disease.

Chronic kidney disease (CKD) is a progressive condition marked by protracted kidney damage which over time can lead to end stage renal disease (ESRD). CKD can be categorized into different stages base...

Purified umbilical cord derived mesenchymal stem cell treatment in a case of systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a multiple organ system autoimmune disorder for which there is no known cure.

Meso- or xeromorphic? Foliar characters of Asteraceae in a xeric scrub of Mexico.

The anatomical traits associated with water deficit are also observed in plants growing in poor soils. The species may resist water deficit through three main strategies: escape, avoid or tolerate. Th...

News Articles [1108 Associated News Articles listed on BioPortfolio]

Unither Pharmaceuticals Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 22082017] Prices from USD $250

SummaryUnither Pharmaceuticals Unither is a contract manufacturing organization which develops proprietary and generic pharmaceutical dosage forms. The organization's technologies include BlowFillSeal...

UPDATING and ADDING: Questcor Pharmaceuticals to Present at Upcoming Investor Conferences in September

ANAHEIM, Calif., Sept. 1, 2011 /PRNewswire/ -- Please replace the release dated August 24, 2011 with the following updated version.  First graph, second and third sentences added and should read:...

Internship Application Form: - Full Width

Full Width hbspt.forms.create({ portalId: '469813', formId: '62b287ff-32a0-4d73-a7e7-6e5e59144b76' });

Patient and Public Involvement (PPI) with the Haematology and Stem Cells theme

Patient and Public Involvement (PPI) takes many forms, but the objective is always the same. Only by carrying out our research with patients can we ever hope to do work that is meaningful and of high ...

FDA forms working group to increase generics competition

US Food and Drug Administration (FDA) Commissioner Dr Scott Gottlieb had announced the creation of a working group of senior staff focused on increasing generic drug competition.

New tissue-chip research aims to speed drug development for two genetic forms of epilepsy

An interdisciplinary team of Vanderbilt University researchers has received a two-year, $2-million federal grant to develop an "organ-on-chip" model for two genetic forms of epilepsy. These disorders ...

[Comment] Physical activity lowers mortality and heart disease risks

In The Lancet, Scott A Lear and colleagues1 report results from a large cohort of 130 843 participants from 17 countries (including four low-income countries and seven middle-income countries) inves...

Usher syndrome: Gene therapy restores hearing and balance

(Institut Pasteur) Scientists from the Institut Pasteur, Inserm, the CNRS, Collège de France, University Pierre et Marie Curie, and University Clermont Auvergne, have recently restored hearing and ba...

Multi-gene test predicts Alzheimer's better than APOE E4 alone

(University of California - San Francisco) A new test that combines the effects of more than two dozen genetic variants, most associated by themselves with only a small risk of Alzheimer's disease, do...

Lupus Community Prepares to Host Landmark Event to Drive Lupus Therapy Development

WASHINGTON, Sept. 21, 2017 /PRNewswire-USNewswire/ -- The Lupus and Allied Diseases Association, Inc., the Lupus Foundation of America and the Lupus Research Alliance are partnering to convene a day-l...

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Companies [116 Associated Companies listed on BioPortfolio]

Sun Pharmaceutical Industries Ltd.

Established in 1983, listed since 1994 and headquartered in India, Sun Pharmaceutical Industries Ltd. (Reuters: SUN.BO, Bloomberg: SUNP IN, NSE: SUNPHARMA, BSE: 524715) is an inte...

Bormioli Rocco Pharma

Bormioli Rocco Pharma exclusively serves the pharmaceutical and biopharmaceutical market with integrated glass and plastic containers, closures and accessories for packaging, usin...

Formstack

Formstack is a versatile online form solution that streamlines processes for capturing and managing information. With Formstack, businesses and teams of all types and sizes can ea...

Alpine Immune Sciences, Inc.

Alpine Immune Sciences, Inc. was founded in 2015 and is focused on developing novel protein‐based immunotherapies using its proprietary variant immunoglobulin domain (vIgD) p...

Samumed, LLC

Based in San Diego, CA, Samumed (www.samumed.com) is a pharmaceutical platform company focused on advancing regenerative medicine and oncology applications through research and in...

Halo Pharmaceutical

Halo Pharmaceutical, headquartered in Whippany, NJ, is a specialty pharmaceutical company engaged in pharmaceutical branded product lifecycle management. The company's strategy is to acquire products ...

Binary Fountain, Inc.

Binary Fountain is a leading social intelligence company that extracts operational feedback from online conversations and distills the results into actionable insights. The compan...

AgTech Accelerator

AgTech Accelerator, established in 2016 in Research Triangle Park, is a venture development organization focused on discovering and developing emerging agricultural technology and...

Fabric Genomics

Fabric GenomicsTM is a computational genomics company offering end-to-end genomic data analysis, annotation, curation, classification and reporting solutions ...

Puma Biotechnology, Inc.

Puma Biotechnology, Inc. is a development stage biopharmaceutical company that acquires and develops innovative products for the treatment of various forms of cancer. The Company ...

Clinical Trials [1045 Associated Clinical Trials listed on BioPortfolio]

Open-label Study of Tofacitinib for Moderate to Severe Skin Involvement in Young Adults With Lupus

This 76-week, 3-part Phase 1b/2 study is intended to evaluate the pharmacological properties (pharmacokinetics and pharmacodynamics), safety, tolerability and preliminary effectiveness of ...

Safety and Efficacy of Filgotinib and GS-9876 in Adults With Lupus Membranous Nephropathy (LMN)

The primary objective of this study is to evaluate the efficacy of filgotinib and GS-9876 in adults with Lupus Membranous Nephropathy (LMN).

Preschool Nap Study

The specific objective of the proposed research is to examine whether naps contribute to immediate and delayed benefits on multiple forms of learning in young children (3-5 yrs). By probin...

Phase 1 Study to Evaluate the Safety of ATA188 in Subjects With Progressive and Relapsing-Remitting Multiple Sclerosis

This is a multicenter, open-label, two-population, single-arm study with a sequential dose-escalation and dose-expansion in adult subjects with progressive forms of multiple sclerosis (MS)...

Intracerebral EGFR-vIII CAR-T Cells for Recurrent GBM

Malignant primary brain tumors account for more human deaths than melanoma or cancer of the bladder or kidney. The non-specific nature of conventional therapy for brain tumors often result...

A Study Comparing the Amounts of 2 Different Forms of Tafamidis (PF06291826), Both With and Without Food, In the Blood

2 different formulations of tafamidis will be compared under both fed and fasted conditions. Subjects will be fasted overnight or fed. After swallowing one of the tafamidis formulations, t...

Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System

Apathy can be defined as a quantitative reduction of voluntary or goal-directed behavior. So, the investigators propose a behavioral approach for assessing apathy, to obtain a quantifiabl...

Flash Open Trial With Therapists In Training

This study will test the EMDR-based Flash technique and a PC-based variant. EMDR-trained therapists will be trained in the standard Flash, and PC-trained therapists will be trained in PC F...

Effect of the Visual Information Change in Functional Dystonia

Cervical dystonia occurring only during the writing task is a rare form for which there is no established treatment. Many authors agree that alteration of sensory integration is associated...

PET Study of the Nicotinic System in Epilepsy

Mutations in neuronal nicotinic acetylcholine receptors (nAChRs) have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). Despite the demonstration of a gai...

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Medical and Biotech [MESH] Definitions

A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

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