Vascular - Biotech, Pharma and Life Science Channel
'Vascular' relates to blood vessels (Oxford Medical Dictionary) and can be used to describe the supply of blood, a disease affecting the blood vessels or molecules associated with these structures. For example, atherosclerosis is a vascular disease. The vascular nature of cancers can determine their ability to survive, and new vascular growth is stimulated in part by Vascular Growth Factors.
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PubMed Articles
BACKGROUND: Current rates of survival for gastric cancer patients are much improved compared with those of the past. The purpose of our study was to analyze the survival of gastric cancer patients acc...
Integrin β4 and its Y-1494 phosphorylation play an important role in cell signaling. We found a small molecule, ethyl1-(3-(4-chlorophenoxy)-2-hydroxypropyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carboxyla...
OBJECTIVES: To evaluate the efficacy and long term safety of transulnar approach in complex coronary interventions. BACKGROUND: The success rate of transulnar approach in complex coronary intervention...
PURPOSE: The αvβ3 integrin is expressed in angiogenic vessels and is a potential target for molecular imaging of evolving pathological processes. Its expression is upregulated in cancer lesions and...
Essential oil components from turmeric (Curcuma longa L.) are documented for neuroprotective, anti-cancer, anti-thrombotic and antioxidant effects. The present study aimed to investigate the disease-m...
Abstract The kinin-kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of kininogen...
Palmoplantar contractures in childhood: a rare complication of vascular Ehlers-Danlos syndrome.
Although catastrophic vascular complications in vascular Ehlers-Danlos Syndrome (EDS) are well recognized, other complications such as flexion contractures and tendon nodules are rarely reported and p...
Cilostazol prevents foot ulcers in diabetic patients with peripheral vascular disease.
Diabetic patients are at the high risk of foot ulcerations that may lead to limb amputations with important socio economic impact. Peripheral vascular disease may be frequently associated in diabetes...
BACKGROUND: Proton pump inhibitors (PPIs) are a class of drugs that is extensively used for common gastrointestinal disorders and often prescribed long-term for years. Long-term PPI treatment is assoc...
Therapeutic angiogenesis for critical limb ischaemia.
Peripheral arterial disease (PAD) is caused by occlusive atherosclerosis in a vascular bed other than the heart. The lower extremity is the most-common location for PAD. Critical limb ischaemia (CLI)...
News Articles
Study: VEGF inhibitor appears to improve glaucoma surgical outcomes
The most common cause of failure after glaucoma surgery is scarring at the surgical site, so researchers are actively looking for ways to minimize or prevent scar formation. Previous work had suggeste...
CDC Protocols Cut Dialysis Bloodstream Infections in Half
ATLANTA—Today, the Centers for Disease Control and Prevention (CDC) released results of its Dialysis Bloodstream Infection Prevention Collaborative showing a 32 percent decrease in overall bloodstre...
Lab Notes: Cell Therapy May Rescue Veins in CKD
(MedPage Today) -- An intravenous infusion of endothelial cells improved vascular function in a mouse model of chronic kidney disease, researchers said. Also this week: another reason not to tailgate...
New Study Recommends Using Active Videogaming (“Exergaming”) to Improve Children’s Health
SOURCE: Elsevier DESCRIPTION:Cincinnati, OH, May 17, 2013 /3BL Media/ – Levels of physical inactivity and obesity are very high in children, with fewer than 50% of primary school-aged boys and fewer...
New study pinpoints biochemical mechanism underlying fibrosis following glaucoma surgery
(Elsevier Health Sciences) The most common cause of glaucoma surgery failure is scarring at the surgical site.Previous work had suggested that vascular endothelial growth factor (VEGF) inhibition resu...
How can computer technology help patients manage their own diabetes? The British Journal of Diabetes and Vascular Disease
Vascular Positioning System Offers Alternative PICC Placement
A novel vascular positioning system device helps reduce complications and exposure to radiation during the placement of a peripherally inserted...
Research sheds new light on occupation-specific rehabilitation
After cardiac surgery, should a farmer and an attorney take the same physical test to be found fit for work? They do now. But new research from Jenny Adams, PhD, at Baylor Health Care System's Baylor...
Vascular Solutions, Inc. (VASC) Bank of America Merrill Lynch Health Care Conference Call May 15, 2013 8:00 pm ET Executives James Hennen – Senior Vice President-Finance, Secretary and Chief...
PLC Systems Demonstrating RenalGuard(R) at EuroPCR 2013
MILFORD, MA--(Marketwired - May 16, 2013) - PLC Systems Inc. (OTCBB: PLCSF), a company focused on innovative medical device technologies, today announced it will demonstrate its product, RenalGuard®...
Events
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Companies
BIOTRONIK® is a leading European company in the field of biomedical technology. Our main focus is on the business sectors of electrotherapy of the heart and vascular intervention. Our products help p...
Navix Diagnostix is a full-service outsource provider of cardiovascular diagnostic services to hospitals and multi-speciality, cardiology and vascular surgery physician practices....
DecImmune Therapeutics was founded by Michael Carroll PhD (The Immune Disease Institute, Harvard Medical School), and Francis Moore Jr. MD (Brigham and Womenâs Hospital, Harv...
St. Joseph Hospital and St. Joseph Health System
Founded in 1929, St. Joseph Hospital in Orange, California is a nationally recognized, 525-bed, not-for-profit Catholic hospital dedicated to extending the healing ministry of the...
Corgenix is a leader in the development and manufacturing of specialized diagnostic kits for immunology disorders, vascular diseases and bone and joint disorders, including the wo...
Cappella Medical Devices, Ltd.
Cappella, Inc. is a medical device company, developing novel solutions for the treatment of complex Coronary Artery Disease (CAD) and specifically bifurcation vascular disease. Ca...
The Gore Medical Products Division has provided creative therapeutic solutions to complex medical problems for more than 35 years. During that time, more than 30 million innovativ...
MyoPowers Medical Technologies SA was founded by Dr Piergiorgio Tozzi, MD, of the University Hospital of Lausanne (CHUV), Switzerland and Professor Daniel Hayoz of the Cantonal Ho...
DJO Global is a leading global developer, manufacturer and distributor of high-quality medical devices that provide solutions for musculoskeletal health, vascular health and pain...
Christie Medical Innovations is a global company based in Memphis, Tenn., that discovers, develops and commercializes medical technologies. The companyâs market-leading produ...
Clinical Trials
Can Tadalafil Maintain Erectile Function In Patients Treated With Radiotherapy For Prostate Cancer?
Because of the high incidence of post-radiation erectile dysfunction (ED), up to 72% after external-beam radiotherapy, this patient category represents a most difficult therapeutic challen...
Effects of Anemia Correction on Vascular and Monocyte Function in Renal Transplant Recipients
Correction of anaemia in renal transplant recipients by parenteral application of recombinant erythropoietin and if necessary iron will improve large artery function (endothelial function...
Chronic transplant nephropathy and cardiovascular death are the main reasons for loss of transplanted organs after kidney transplantation. Vascular changes, induced by hypertension and/or...
Glitazones and Endothelial Function (GATE)
The purpose of the study is to determine if the addition of rosiglitazone to subjects with fair glucose control on other oral agents improves endothelial function, a surrogate marker of va...
This feasibility study is designed to examine modulation of the relative activities of ACE and ACE2 in diabetic patients following treatment with the angiotensin type 1 receptor (AT1R) ant...
The purpose of this study is to evaluate the effect of DHEA on endothelial dysfunction in patients with systemic lupus by measuring: 1. changes in brachial artery flow-mediated dilatati...
Adenosine Receptors Influence Ischemia-Reperfusion Injury
Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size. Thi...
This is a prospective randomized study to compare the influence of area under the curve (AUC)-monitored dual treatment with steroids in combination with either a calcineurin inhibitor (CNI...
Double Blind Atorvastatin Amlodipine Study
To evaluate and compare the safety and efficacy of amlodipine, atorvastatin and the combination in patients with symptomatic myocardial ischemia. Amlodipine's use in angina has been well...
One emerging concept is that some form of injury or inflammation is a prerequisite for the success of circulating-cell participation in differentiated tissue structure and function. Once r...
Videos
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Medical and Biotech [MESH] Definitions
Hepatophyta
A plant division. They are simple plants that lack vascular tissue and possess rudimentary rootlike organs (rhizoids). Like MOSSES, liverworts have alternation of generations between haploid gamete-bearing forms (gametophytes) and diploid spore-bearing forms (sporophytes).
Integrin Alphavbeta3
An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
Neuropilins
Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.
Neuropilin-2
Transmembrane receptor for CLASS 3 SEMAPHORINS and several vascular endothelial growth factor isoforms. Neuropilin-2 functions either as a homodimer or as a heterodimer with NEUROPILIN-1. The binding affinity of neuropilin-2 varies for different class 3 semaphorin isoforms and is dependent on the composition of the dimer. The protein also forms receptor complexes with plexins and with VEGF RECEPTORS, which alters the binding characteristics of the receptor.
Receptors, Vascular Endothelial Growth Factor
A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular Ig-like domains which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.
