Vascular endothelial growth factor VEGF VEGF R - Biotech, Pharma and Life Science Channel
The importance of tumor angiogenesis in tumor biology is now widely accepted and has emerged as a valid therapeutic target in oncology. Vascular endothelial growth factor (VEGF) represents a key mediator of tumor-initiated angiogenesis and the first target of antiangiogenesis agents introduced in clinical practice. VEGF and VEGF receptor antagonists have revolutionized therapy of cancer which is reflected by their outstanding commercial success: 2008 sales of US$ 6.4 bln only in oncology. VEGF blockers found further use in inhibiting or even reversing angiogenesis in neovascular (wet) age-related macular degeneration (AMD). This market already reached US$ 1.8 bln in 2008.
The total market size of US$ 8.2 bln for VEGF and VEGF receptor (VEGF-R) antagonists has attracted many companies to invest in follow-up and next generation molecules targeting VEGF and VEGF-R. The clinically validated target provides a low risk opportunity for new technologies with proteins, RNA, antibodies and vaccines for validation of the technologies. Multi-target receptor tyrosine kinase (RTK) inhibitors are another possibility to further increase the efficacy of VEGF-R antagonists by adding anti-proliferative or anti-migration effects. In contrast to antagonism of angiogenesis, the growth factor activity of VEGF has created a high level of interest for neuroprotection and several approaches are in clinical evaluation.
Source; PipeLineReview
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Medical and Biotech [MESH] Definitions
Thrombopoiesis
The process of generating thrombocytes (BLOOD PLATELETS) from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via the MEGAKARYOCYTES. The humoral factor with thrombopoiesis-stimulating activity is designated THROMBOPOIETIN.
Host Factor 1 Protein
An integration host factor that was originally identified as a bacterial protein required for the integration of bacteriophage Q beta (ALLOLEVIVIRUS). Its cellular function may be to regulate mRNA stability and processing in that it binds tightly to poly(A) RNA and interferes with ribosome binding.
Factor For Inversion Stimulation Protein
A highly abundant DNA binding protein whose expression is strongly correlated with the growth phase of bacteria. The protein plays a role in regulating DNA topology and activation of RIBOSOMAL RNA transcription. It was originally identified as a factor required for inversion stimulation by the Hin recombinase of SALMONELLA and Gin site-specific recombinase of BACTERIOPHAGE MU.
Tata-box Binding Protein
A general transcription factor that plays a major role in the activation of eukaryotic genes transcribed by RNA POLYMERASES. It binds specifically to the TATA BOX promoter element, which lies close to the position of transcription initiation in RNA transcribed by RNA POLYMERASE II. Although considered a principal component of TRANSCRIPTION FACTOR TFIID it also takes part in general transcription factor complexes involved in RNA POLYMERASE I and RNA POLYMERASE III transcription.
Transcription Factor Tfiiib
One of several general transcription factors that are specific for RNA POLYMERASE III. TFIIIB recruits and positions pol III over the initiation site and remains stably bound to the DNA through multiple rounds of re-initiation by RNA POLYMERASE III.
