Advertisement

Topics

Virulence Factors - Biotech, Pharma and Life Science Channel

10:25 EDT 3rd May 2016 | BioPortfolio

Virulence factors are molecules expressed and secreted by pathogens (bacteria, viruses, fungi and protozoa) that enable them to achieve the following:

* colonization of a niche in the host (this includes adhesion to cells)
* Immunoevasion, evasion of the host's immune response
* Immunosuppression, inhibition of the host's immune response
* entry into and exit out of cells (if the pathogen is an intracellular one)
* obtain nutrition from the host.

Virulence factors are very often responsible for causing disease in the host as they inhibit certain host functions.

Adherence Factors: Many pathogenic bacteria colonize mucosal sites by using pili (fimbriae) to adhere to cells.

Invasion Factors: Surface components that allow the bacterium to invade host cells can be encoded on plasmids, but more often are on the chromosome.

Capsules: Many bacteria are surrounded by capsules that protect them from opsonization and phagocytosis.

Endotoxins: The lipopolysaccharide endotoxins on Gram-negative bacteria cause fever, changes in blood pressure, inflammation, lethal shock, and many other toxic events.

Exotoxins: Exotoxins include several types of protein toxins and enzymes produced and/or secreted from pathogenic bacteria. Major categories include cytotoxins, neurotoxins, and enterotoxins.

Siderophores: Siderophores are iron-binding factors that allow some bacteria to compete with the host for iron, which is bound to hemoglobin, transferrin, and lactoferrin.

Source; NCBI

PubMed Articles [10580 Associated PubMed Articles listed on BioPortfolio]

The roles of the zinc finger transcription factors XlnR, ClrA and ClrB in the breakdown of lignocellulose by Aspergillus niger.

Genes encoding the key transcription factors (TF) XlnR, ClrA and ClrB were deleted from Aspergillus niger and the resulting strains were assessed for growth on glucose and wheat straw, transcription o...

Microbiological profiles of fungal keratitis: a 10-year study at a tertiary referral center.

Given the rise in cases of fungal keratitis in recent years, this study was performed to better elucidate the microbiological profile, risk factors, and surgical intervention rates of fungal keratitis...

Gradient Distribution of Martensite Phase in Melt-Spun Ribbons of a Fe-Ni-Ti-Al Alloy.

Metallographic, X-ray diffraction and magnetometric analysis were used to study the regularities of martensitic transformation in melt-spun ribbons of a Fe - 28 wt. % Ni - 2.1 wt. % Ti - 2 wt. % Al - ...

Early life exposure to obesogenic diets and learning and memory dysfunction.

Obesogenic dietary factors, such as simple sugars and saturated fatty acids, have been linked to memory impairments and hippocampal dysfunction. Recent evidence suggests that the brain may be particul...

Prevalence of colorectal adenomas in asymptomatic young adults: a window to early intervention?

Objective The prevalence of colorectal adenoma is increasing in the average-risk population. However, little research is available on colorectal adenoma in young adults under age 40. The aim of this s...

Hypertension Is a Key Feature of the Metabolic Syndrome in Subjects Aging with HIV.

With widespread and effective antiretroviral therapy, the life expectancy in the HIV population has dramatically improved over the last two decades. Consequently, as patients are aging with HIV, other...

Change Factors in Group Therapy: Development and Validation of a Questionnaire.

While the efficacy of group therapy is sufficiently confirmed, there is a research gap concerning relevant therapeutic processes. Particularly, there is a dearth of integrative instruments that assess...

Walking beyond preferred transition speed increases muscle activations with a shift from inverted pendulum to spring mass model in lower extremity.

The triggers for the transition of gait from walking to running during increasing speed locomotion have been attributed to an energy conservation strategy or a relief of excessive muscle activation. W...

Role of myosin 1H gene polymorphisms in mandibular retrognathism.

Mandibular retrognathism may be the result of a developmental abnormality or the unfavorable positional relationship of developing jaws. Several lines of evidence suggest that muscles are known to hav...

The prevalence of celiac disease in patients with geographic tongue.

Geographic tongue (GT) is a benign inflammatory condition usually involving the dorsal surface and lateral borders of the tongue. Numerous etiological factors of GT have been suggested, including immu...

News Articles [1916 Associated News Articles listed on BioPortfolio]

Scientists double number of known genetic risk factors for endometrial cancer

An international collaboration of researchers has identified five new gene regions that increase a woman's risk of developing endometrial cancer, one of the most common cancers to affect women, taking...

BRÛLURE: Pourquoi et comment elle mène à la sepsis - mSphere

On sait que les exsudats favorisent globalement la prolifération bactérienne, cette étude de l'Université de Genève (Unige) montre que les brûlures stimulent l...

Allergan launches Crestor generic in the US

Allergan has received FDA approval on the generic version of AstraZeneca’s high cholesterol drug, Crestor (rosuvastatin), and has become the first company to launch a generic of the drug in the US. ...

CORRECTED-Swiss stocks - Factors to watch on May 3

ZURICH, May 3 (Reuters) - The Swiss blue-chip SMI was seen opening flat at 7,976 points on Tuesday, according to premarket indications by bank Julius Baer.

NORDIC STOCKS - Factors to watch on May 3

The following stocks may be affected by newspaper reports and other factors on Tuesday:

Swiss stocks - Factors to watch on May 3

ZURICH, May 3 (Reuters) - The following are some of the main factors expected to affect Swiss stocks on Tuesday:

German stocks - Factors to watch on May 3

BERLIN/FRANKFURT, May 3 (Reuters) - The following are some of the factors that may move German stocks on Tuesday:

PharmaRoth Labs Announces Integration of HSBC Credit Facilities

LAS VEGAS, NV -- (Marketwired) -- 05/03/16 -- PharmaRoth Labs, Inc. (OTC PINK: ROTH), the exclusive producer, marketer, and distributor of Sucanon®, an oral Type-II Diabetes treatment, today announc...

Global RNA recognition patterns of post-transcriptional regulators Hfq and CsrA revealed by UV crosslinking in vivo

The molecular roles of many RNA-binding proteins in bacterial post-transcriptional gene regulation are not well understood. Approaches combining in vivo UV crosslinking with RNA deep sequencing (...

Elucidating the DDK-dependent step in replication initiation

By phosphorylating specific replication factors, cell cycle kinases ensure that eukaryotic DNA replication is initiated once and only once per mitotic cell division. New work in The EMBO Journal now r...

Events [0 Results]

None

Companies [45 Associated Companies listed on BioPortfolio]

Telephus Medical LLC

Telephus Medical, located in San Diego, California, is developing a suite of monoclonal antibody products designed to neutralize key staphylococcal enzymes used to attach to host ...

Design SHIFT

Design SHIFT is a Menlo Park-based product design firm founded in 2009 with the simple idea that with passion and focus, small teams can deliver breakthrough products on a global ...

Integra ServiceConnect®, LLC

Integra ServiceConnect® connects people to services they need to improve their health. With the recognition that 80% of health outcomes are driven by non-clinical social factor...

Conceivable

Conceivable is the first modern fertility program that radically improves a woman’s natural ability to get and stay pregnant. The Conceivable program helps women identify, un...

Tenet Healthcare Corporation and Health Net, Inc.

This release contains “forward-looking statements” – that is, statements that relate to future, not past, events. In this context, forward-looking statements often ...

N of One: Autism Research Foundation

N of One: Autism Research Foundation was founded in 2014, with a mission to facilitate and sponsor breakthrough autism medical research. N of One emphasizes research that treats t...

Stemedica Cell Technologies, Inc.

Stemedica Cell Technologies, Inc. (www.stemedica.com) is a specialty biopharmaceutical company that is committed to the development and manufacturing of best-in-class adult stem cells and stem cell fa...

Stemedica International S.A.

Founded in Epalinges, Switzerland, in 2008, Stemedica International S.A. is a global biotechnology company that develops therapeutic applications for the treatment and prevention ...

Angiocrine Bioscience, Inc.

Angiocrine Bioscience is a privately held biotech company focused on applying vascular biology to new therapeutic applications. Angiocrine’s VeraVecTM technology platform is ...

Ocugen, Inc.

Ocugen is advancing novel biologicals discovered based on endogenous proteins with well understood biology at the molecular, cellular, and whole animal level to treat eye diseases...

Clinical Trials [1467 Associated Clinical Trials listed on BioPortfolio]

Early Detection of Lung Cancer With Low-dose Multislice Computed Tomography

Lung cancer is one of the leading causes of cancer-related death in Taiwan. Early diagnosis of lung cancer may improve cancer survival. Low-dose computed tomography (LDCT) was thought to b...

Impact of Maternal Stress on Infant Stunting

This study takes place in rural Mam-Mayan communities of Guatemala characterized by high rates of childhood stunting. It aims to characterize women's exposure to nutrition, infection and p...

Severe Male Factor Infertility Management

This study is the first to evaluate the effect of oral supplementation with antioxidants combined with lifestyle modification for severe male factor partners of couples undergoing ICSI.

Personalized Indications for CBT and Antidepressants in Treating Depression

Depression currently affects close to 2 million Canadians and is the leading cause of disability worldwide. Pharmacological treatments (antidepressant medication) and psychological treatme...

A Study on the Effects of Interventional Therapy in Patients With Lower Extremity Arterial Occlusive Disease and Its Risk Factors(EILRF)

Along with the improvement of living standard, the prevalence of Lower extremity arterial occlusive disease (LEAOD) is also increasing, which has become an important cause of lower extremi...

Predicting Severe Toxicity of Targeted Therapies in Elderly Patients With Cancer

In order to assess the important issue of the safety of antiangiogenic TKI in geriatric population we set up this project which aims to identify, among clinical, biological, pharmacokineti...

Persistent Pain After Cystectomy for Bladder Cancer

This single-center, cross-sectional survey and sensory examination is conducted to determine the prevalence, sensory characteristics and risk factors of PPSP in patients who underwent cyst...

The Effect of Vitamin D Supplementation on Cardiovascular Risk Factors

Six-hundred subjects with vitamin D deficiency will be randomized to vitamin D 3000 IU per day versus placebo for 4 months, with effects on cardiovascular risk factors as main endpoint

Protective HA Factors

This is a naturalistic study of 100 migraineurs and 75 post concussive headache patients who will be asked to record their headaches, medications, sleep and other behaviors in a smartphone...

Risk Factors Related to Metabolic Syndrome in School-aged Children Who Were Born Preterm

This is a follow-up cohort study of 8 years old children born preterm at Seoul National University Children's Hospital in Korea from 2008-2009. The children will visit outpatient clinics ...

Videos

None available.

Medical and Biotech [MESH] Definitions

The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.

One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.

One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLATE CYCLASE and hemolysin components.

Infections resulting from the use of catheters. Proper aseptic technique, site of catheter placement, material composition, and virulence of the organism are all factors that can influence possible infection.

Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)

Quick Search
Advertisement
 

Relevant Topics

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Bioinformatics
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

review and buy Virulence Factors market research data and corporate reports here

Channels Quicklinks