Advertisement

Topics

Virulence Factors - Biotech, Pharma and Life Science Channel

10:04 EDT 28th June 2017 | BioPortfolio

Virulence factors are molecules expressed and secreted by pathogens (bacteria, viruses, fungi and protozoa) that enable them to achieve the following:

* colonization of a niche in the host (this includes adhesion to cells)
* Immunoevasion, evasion of the host's immune response
* Immunosuppression, inhibition of the host's immune response
* entry into and exit out of cells (if the pathogen is an intracellular one)
* obtain nutrition from the host.

Virulence factors are very often responsible for causing disease in the host as they inhibit certain host functions.

Adherence Factors: Many pathogenic bacteria colonize mucosal sites by using pili (fimbriae) to adhere to cells.

Invasion Factors: Surface components that allow the bacterium to invade host cells can be encoded on plasmids, but more often are on the chromosome.

Capsules: Many bacteria are surrounded by capsules that protect them from opsonization and phagocytosis.

Endotoxins: The lipopolysaccharide endotoxins on Gram-negative bacteria cause fever, changes in blood pressure, inflammation, lethal shock, and many other toxic events.

Exotoxins: Exotoxins include several types of protein toxins and enzymes produced and/or secreted from pathogenic bacteria. Major categories include cytotoxins, neurotoxins, and enterotoxins.

Siderophores: Siderophores are iron-binding factors that allow some bacteria to compete with the host for iron, which is bound to hemoglobin, transferrin, and lactoferrin.

Source; NCBI

PubMed Articles [11405 Associated PubMed Articles listed on BioPortfolio]

Changes and tracking of bone mineral density in late adolescence: the Tromsø Study, Fit Futures.

Areal bone mineral density (aBMD) predicts future fracture risk. This study explores the development of aBMD and associated factors in Norwegian adolescents. Our results indicate a high degree of trac...

The influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futures.

The influence of birth weight and length on bone mineral parameters in adolescence is unclear. We found a positive association between birth size and bone mineral content, attenuated by lifestyle fact...

Modifiable lifestyle factors associated with osteoporosis in Korean men: a case-control study.

The prevention, education, and treatment of osteoporosis are all recognized as important components in men as well as women. This study revealed that the lifestyle factors associated with male osteopo...

Impact of structural and economic factors on hospitalization costs, inpatient mortality, and treatment type of traumatic hip fractures in Switzerland.

The assessment of structural and potentially economic factors determining cost, treatment type, and inpatient mortality of traumatic hip fractures are important health policy issues. We showed that in...

Perception of injury risk among amateur Muay Thai fighters.

Muay Thai is a style of kickboxing that allows full-contact blows to an unprotected head, torso and legs, and, as in any combat sport, there is an inherent risk of injury. Previous observational studi...

Costs of productivity loss due to occupational cancer in Canada: estimation using claims data from Workers' Compensation Boards.

Cancer is a leading cause of illness globally, yet our understanding of the financial implications of cancer caused by working conditions and environments is limited. The goal of this study is to esti...

Evaluation of effectiveness of concentrated growth factor on osseointegration.

Growth factor-containing products have been reported to increase implant stability and accelerate osseointegration. Concentrated growth factor (CGF) can be used for this purpose with the growth factor...

Management of respiratory tract infections in young children-A qualitative study of primary care providers' perspectives.

Respiratory tract infections in young children are the most common cause of general practice visits in Australia. Despite the availability of clinical practice guidelines, the treatment and management...

Microarray meta-analysis to explore abiotic stress-specific gene expression patterns in Arabidopsis.

Abiotic stresses are the major limiting factors that affect plant growth, development, yield and final quality. Deciphering the underlying mechanisms of plants' adaptations to stresses using few datas...

Assimilates mobilization, stable canopy temperature and expression of expansin stabilizes grain weight in wheat cultivar LOK-1 under different soil moisture conditions.

Grain yield of wheat is primarily determined by both grain number and grain weight, which often influence each other in response to environmental stimuli. Some of the genotypes are capable of maintain...

News Articles [2051 Associated News Articles listed on BioPortfolio]

Asthma Therapeutics in AsiaPacific Markets to 2023 High Prevalence and Highly Priced Existing Upcoming Biologics will Drive the Market [Report Updated: 01062017] Prices from USD $4995

Asthma Therapeutics in AsiaPacific Markets to 2023 High Prevalence and Highly Priced Existing Upcoming Biologics will Drive the MarketSummaryAsthma is a common chronic inflammatory disease of the ai...

Chronic kidney disease CKD Epidemiology Forecast To 2023 [Report Updated: 31052017] Prices from USD $2338

DelveInsight Chronic kidney disease CKD Epidemiology Forecast To 2023 provides an overview of the epidemiology trends of Chronic kidney disease CKD in seven major markets US, France, Germany, Italy, ...

Benign prostatic hyperplasia BPH Epidemiology Forecast To 2023 [Report Updated: 31052017] Prices from USD $2338

DelveInsight Benign prostatic hyperplasia BPH Epidemiology Forecast To 2023 provides an overview of the epidemiology trends of Benign prostatic hyperplasia BPH in seven major markets US, France, Germ...

Are doctors disregarding racial genetic risk factors when treating patients?

Alcoholic Beverages Market by Type Beer, Distilled Spirits, Wine and by Distribution Channel Convenience Stores, On Premises, Retailers, and Supermarkets Global Opportunity Analysis and Industry Forecast, 20142022 [Report Updated: 23032017] Prices from U

The global alcoholic beverages market was valued at $1,375 billion in 2015, and is expected to reach $1,594 billion by 2022, registering a CAGR of 2.1% from 2016 to 2022. Alcoholic beverages are consu...

Automotive Lubricants Market by Base Oil Mineral Oil, Synthetic, Semisynthetic, and BioBased Lubricants, Application Engine Oil, Gear Brake Oil, Transmission Fluids, Greases, and Others, and Vehicle Type Passenger Cars, Light Commercial Vehicles, Heavy C

The Global Automotive Lubricants Market Was Valued At $64,716 Million In 2015, And Is Projected To Reach $89,585 Million By 2022, Growing At A Cagr Of 4.8% From 2016 To 2022. Automotive Lubricants Are...

HeadMounted Display Market by Technology AR, VR, Application Consumer, Commercial, Enterprise Industry, Engineering Design, Military, Medical, Product Head Mounted, Eyewear, Component, Connectivity, and Geography Global Forecast to 2022 [Report Updated

HMD market expected to grow at a CAGR of 38.8% between 2017 and 2022The HMD market was valued at USD 3.25 billion in 2016 and is expected to reach USD 25.01 billion by 2022, at a CAGR of 38.8% between...

Stem Cell Supplement Approved In Taiwan

IRVING, Texas, Aug. 27, 2012 /PRNewswire/ -- RBC Life Sciences, Inc. (OTCQB: RBCL) announced today that the Company's stem cell supplement, Stem-Kine™, has been approved for importation and sale...

Schizophrenia Epidemiology Forecast To 2023 [Report Updated: 31052017] Prices from USD $2338

DelveInsight Schizophrenia Epidemiology Forecast To 2023 provides an overview of the epidemiology trends of Schizophrenia in seven major markets US, France, Germany, Italy, Spain, UK and Japan. It in...

Sangui and SastoMed Complement Licensing Agreement in View of Increasing Sales Success

WITTEN, Germany, August 27, 2012 /PRNewswire/ -- Sangui BioTech GmbH and SastoMed GmbH cordially adjusted the existing sales strategy as the introduction of Granulox to professional circles proves to...

Events [0 Results]

None

Companies [47 Associated Companies listed on BioPortfolio]

The Lisa Colagrossi Foundation

The Lisa Colagrossi Foundation (TLCF) is the leader in raising awareness and education to help diagnose and treat brain aneurysms. TLCF's primary focus is to communicate the si...

RF IDeas Inc.

RF IDeas, founded in 1995, is the innovator of WaveID®, the new standard for badge-based authentication and identification solutions powered by RF IDeas readers. Under the Wave...

Telephus Medical LLC

Telephus Medical, located in San Diego, California, is developing a suite of monoclonal antibody products designed to neutralize key staphylococcal enzymes used to attach to host ...

Design SHIFT

Design SHIFT is a Menlo Park-based product design firm founded in 2009 with the simple idea that with passion and focus, small teams can deliver breakthrough products on a global ...

Integra ServiceConnect®, LLC

Integra ServiceConnect® connects people to services they need to improve their health. With the recognition that 80% of health outcomes are driven by non-clinical social factor...

Conceivable

Conceivable is the first modern fertility program that radically improves a woman’s natural ability to get and stay pregnant. The Conceivable program helps women identify, un...

Tenet Healthcare Corporation and Health Net, Inc.

This release contains “forward-looking statements” – that is, statements that relate to future, not past, events. In this context, forward-looking statements often ...

N of One: Autism Research Foundation

N of One: Autism Research Foundation was founded in 2014, with a mission to facilitate and sponsor breakthrough autism medical research. N of One emphasizes research that treats t...

Stemedica Cell Technologies, Inc.

Stemedica Cell Technologies, Inc. (www.stemedica.com) is a specialty biopharmaceutical company that is committed to the development and manufacturing of best-in-class adult stem cells and stem cell fa...

Stemedica International S.A.

Founded in Epalinges, Switzerland, in 2008, Stemedica International S.A. is a global biotechnology company that develops therapeutic applications for the treatment and prevention ...

Clinical Trials [1800 Associated Clinical Trials listed on BioPortfolio]

Efficacy of Postoperative Adjuvant Chemotherapy for Stage II Colon Cancer With High Risk Factors(EPAC1)

The purpose of this study is to design a prospective randomized clinical trial to explore whether postoperative adjuvant chemotherapy may provide survival benefit for stage II colon cancer...

Early Diagnosis and Treatment Standardization of Delirium

1. Observe the characteristics of delirium patients, searching for early diagnostic methods or finding risk factors 2. Design a guideline for delirium, diagnosis or treatment

Reaching Latino Family Dyads to Increase Physical Activity and Healthy Eating

The goal of this research study is to learn about factors that may affect healthy eating and physical activity for Latino families in Houston. Researchers will use this information to desi...

Omega-3 and Cardiovascular Risk Factors

: findings have been reported about the benefits of omega-3 fatty acids on decreasing the incidence of cardiovascular disease (CVD). The objective was to compared the effects of walnut (pl...

Characterization of Heart Failure With Preserved Ejection Fraction

The goals of this research will be to define some of the mechanisms underlying the progression and complications of heart failure (HF) with preserved left ventricular ejection fraction (HF...

Białystok PLUS - Polish Longitudinal University Study

The main goal of study is to provide a unique multidimensional picture of the health of the population with simultaneous optimal standards of sampling, processing and storing of data and b...

Tooth Wear and Associated Risk Factors

This study compares the associated risk factors between adults with tooth wear and age- and sex-matched controls without tooth wear.

Involvement of Plasmatic Factors in the Peripheral Muscle Dysfunction of COPD Patients - In Vitro Study

Chronic Obstructive Pulmonary Patients is a defined by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airway...

Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Unit

Delirium is one of main adverse events in ventilated patients who receive long-term usage of mono-sedative. Sequential sedation may reduce these adverse effects. This study aimed to evalua...

Understanding Mechanisms of Health Behavior Change

This research seeks to examine psychological factors that may impact relationship between incentives and health behavior engagement, specifically fruit and vegetable consumption. Additiona...

Videos

None available.

Medical and Biotech [MESH] Definitions

The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.

One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.

One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLATE CYCLASE and hemolysin components.

Infections resulting from the use of catheters. Proper aseptic technique, site of catheter placement, material composition, and virulence of the organism are all factors that can influence possible infection.

Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)

Quick Search
Advertisement
 

Relevant Topics

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Bioinformatics
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

review and buy Virulence Factors market research data and corporate reports here

Channels Quicklinks