Warm antibody hemolytic anemia - Biotech, Pharma and Life Science Channel
PubMed Articles
Limits to sustained energy intake (SusEI) during lactation in Swiss mice have been suggested to reflect the secretory capacity of the mammary glands. However, an alternative explanation is that milk p...
Structure-based histidine substitution for optimizing pH-sensitive Staphylococcus protein A.
Optimizing antibody purification is crucial to overcoming a bottleneck in the costly manufacturing process for antibody therapy. To address this issue, we designed a pH-sensitive Staphylococcus aureus...
Proteasome inhibition profoundly affects activated human B cells.
Proteasome inhibitors, although initially developed for the treatment of malignancies, have been found to affect normal plasma cells by efficaciously inducing apoptosis. One proteasome inhibitor, bort...
The question of whether cannabinoid CB2 receptors are expressed on neurons in the brain and under what circumstances they are expressed is controversial in cannabinoid neuropharmacology. While some st...
Prenatal passive transfer of maternal immunity in Asian elephants (Elephas maximus).
Asian (Elephas maximus) and African (Loxodonta africana) elephants exhibit characteristics of endotheliochorial placentation, which is common in carnivore species and is associated with modest materna...
Obstructive hydrocephalus due to CNS toxocariasis.
A 46-year-old man developed intermittent headache, diplopia, and visual obscuration for two months. Funduscopic examination showed optic disk swelling in both eyes. Brain MRI exhibited hydrocephalus a...
The Role of Hepcidin-25 in Kidney Transplantation.
BACKGROUND: Hepcidin-25 is a peptide hormone involved in iron absorption and homeostasis and found at increased serum levels in conditions involving systemic inflammation, renal dysfunction, and incre...
The mechanism by which antibodies elicited against protein-derived peptides achieve cross-reactivity with their cognate proteins remains unknown. To address this question, we have carried out the comp...
PURPOSE: The erythropoiesis-stimulating agents (ESAs), darbepoetin alfa (DA), and epoetin alfa (EA) differ with respect to dosing schedule in chemotherapy-induced anemia. DA can be administered less f...
Lower mannose-binding lectin contributes to deleterious H1N1 2009 infection in children.
Mannose-binding lectin (MBL) has broad range of activity against viruses through the mechanisms of neutralization, opsonization, and complement activation. Prior studies have demonstrated that MBL ina...
News Articles
Download Presentation: New Solutions accelerating Protein Research
Developing therapeutic monoclonal antibodies and ADC’s is a key focus of the pharmaceutical industry’s R&D. The European Antibody Congress 2012 bought together senior level executives [...]
The Cozywoggle is an innovative new coat that is safe to be worn with the car seat. It has been in development for over a year and will be available online June 26, 2013 for presale. Alexandria, VA (P...
New Ambrx CEO Discusses Latest Deal, with China’s Zhejiang Medicine
San Diego’s Ambrx, co-founded in 2003 by the prominent chemist Peter Schultz (who remains on its board), has advanced its technology for antibody-drug conjugates by forging a series of drug discover...
Zhejiang Medicine Collaborates with Ambrx and WuXi on Breast Cancer Drug
Zhejiang Medicine Co. formed a collaboration with Ambrx of San Diego to develop an Ambrx molecule that targets Her2-positive breast cancer. Ambrx genetically engineers proteins that contain new amino...
A pan-specific antibody for direct detection of protein histidine phosphorylation
Horizon, Hisun in Cell Line Pact
Will use Horizon’s GS double knock-out cell line for antibody manufacturing
Genmab, ADC Therapeutics to co-develop new antibody-drug conjugate for cancer
Denmark-based Genmab and Switzerland-based ADC Therapeutics have collaborated to jointly develop a new antibody-drug conjugate (ADC) product targeting multiple cancer indications.
Diagnosis In Rheumatoid Arthritis Improved By Novel Biomarkers
Data presented at EULAR 2013, the Annual Congress of the European League Against Rheumatism, show that novel antibody biomarkers could significantly improve diagnosis in rheumatoid arthritis (RA). Fou...
MedImmune, NGM in metabolic deal
MedImmune LLC partnered with NGM Biopharmaceuticals Inc. (South San Francisco, Calif.) to develop and commercialize peptide and antibody therapeutics to treat Type II diabetes and obesity based on a s...
Daratumumab, a CD38 monoclonal antibody study in advanced multiple myeloma
Prof Heinrich Lokhorst talks to ecancer at EHA 18 about results from a phase I/II study in advanced Multiple Myeloma. Multiple myeloma is the second most common haematological cancer. It is a cance...
Events
European Antibody Congress 2013
Discover. Develop. Get to market.
European Antibody Congress 2013
European Antibody Congress 2013 is the region’s largest event dedicated to scientific, technology and business development: an exhibition, a strategic keynote conference, real life case studies and...
6TH ANNUAL RECOMBINANT ANTIBODIES Conference
An insight into novel therapeutics and future technologies
Companies
ADC Therapeutics sarl (ADCT) is a Swiss-based oncology drug development company that specializes in the development of proprietary Antibody Drug Conjugates (ADCs) targeting major...
Avaxia is a leader in the growing field of gut-targeted therapeutics â orally administered, minimally absorbed drugs that are designed to act locally in the gastrointestinal...
Akebia Therapeutics is a discovery and development company focused on anemia and vascular disorders. Akebiaâs lead program, AKB-6548, an orally bioavailable HIF-prolyl hydrox...
BioInvent International is a unique company dedicated to working with clients to ensure their success in the discovery, development and manufacture of antibody drugs. The discovery of new drug targets...
Acorda Therapeutics, Inc. was established in March 1995 to develop therapeutic products for spinal cord injury ("SCI") and other central nervous system disorders. Acorda is focusing its initial develo...
Seattle Genetics is a clinical-stage biotechnology company focused on the development and commercialization of monoclonal antibody-based therapies for the treatment of cancer and...
Opsona is a leading immunology drug development company, focused on novel therapeutic approaches to key targets of the innate immune system associated with a wide range of majo...
DecImmune Therapeutics was founded by Michael Carroll PhD (The Immune Disease Institute, Harvard Medical School), and Francis Moore Jr. MD (Brigham and Womenâs Hospital, Harv...
Rockland Immunochemicals has supported the biopharma and diagnostic industries for over 40 years with antibodies and antibody based toolsâ¢Â for basic research, assay develo...
One Lambda Inc. is a world leader in the manufacture of HLA medical diagnostic products based in Canoga Park, California. The company is committed to develop products that improve...
Clinical Trials
This open-label single-arm study will evaluate the efficacy, safety and tolerability of methoxy polyethylene glycol epoetin beta on long-term maintenance of haemoglobin levels in patients...
This is an open-label, dose-escalation, non-randomized, phase I study in patients with histologically confirmed Stage III or IV melanoma and at least three metastatic cutaneous or subcutan...
This study will test the investigational antibody, anti-OX40, in combination with stereotactic body radiation in breast cancer patients that have liver or lung metastases and have received...
Ustekinumab for the Treatment of Patients With Active Ankylosing Spondylitis
This study is aimed at investigation of efficacy and safety of ustekinumab (monoclonal antibody against interleukin 12 and 23) treatment in patients with active ankylosing spondylitis (AS)...
Brentuximab Vedotin (SGN-35) as Salvage Treatment for CD30-positive Germ Cell Tumors
Complete responses with third-line or later salvage chemotherapy (CT) for germ cell tumors (GCT) range 0% to 10% and are usually short-lived and nearly all patients (pts) progressing after...
This study will evaluate the safety and effectiveness of treating patients with severe aplastic anemia (SAA) or myelopdysplastic syndrome (MDS) with both peripheral blood stem cells from a...
Phase 2A Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer
The purpose of the phase 2A component of this study is to determine if giving the immune molecule NPC-1C to individuals who have cancer of the pancreas or gastrointestinal tract (colon or...
We plan to study whether the 7-valent pneumococcal conjugate vaccine (Prevnar™) is safe and effective in protecting children who have had a solid organ transplantation and healthy childr...
Influenza Vaccine in Lung Transplant Patients
Research Question: How do antibody and T cell responses following influenza vaccine compare among lung transplant patients, patients waiting for lung transplantation and healthy individua...
Effects of Anemia Correction on Vascular and Monocyte Function in Renal Transplant Recipients
Correction of anaemia in renal transplant recipients by parenteral application of recombinant erythropoietin and if necessary iron will improve large artery function (endothelial function...
Videos
WAHA Warm Autoimmune Hemolytic Anemia AIHA
The most common antibody involved in warm antibody AIHA is IgG, though sometimes IgA is found. The IgG antibodies attach to a red blood cell, leaving their F...
Medical and Biotech [MESH] Definitions
Viridans Streptococci
A large heterogeneous group of mostly alpha-hemolytic streptococci. They colonize the respiratory tract at birth and generally have a low degree of pathogenicity. This group of species includes STREPTOCOCCUS MITIS; STREPTOCOCCUS MUTANS; STREPTOCOCCUS ORALIS; STREPTOCOCCUS SANGUIS; STREPTOCOCCUS SOBRINUS; and the STREPTOCOCCUS MILLERI GROUP. The latter are often beta-hemolytic and commonly produce invasive pyogenic infections including brain and abdominal abscesses.
Streptococcus Milleri Group
A subset of VIRIDANS STREPTOCOCCI, but the species in this group differ in their hemolytic pattern and diseases caused. These species are often beta-hemolytic and produce pyogenic infections.
Animal Care Committees
Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).
Mice, Biozzi
A strain of mice bred specifically as high or low antibody responders.
Vibrio Vulnificus
A species of halophilic bacteria in the genus VIBRIO, which lives in warm SEAWATER. It can cause infections in those who eat raw contaminated seafood or have open wounds exposed to seawater.
