Aptagen Incorporated Company Profile

23:58 EDT 25th September 2017 | BioPortfolio

Aptagen's Gene Forge (TM) designs and builds custom synthetic genes or double stranded DNA of any size, optimizes the codon usage for maximum expression in the organism of your choice, and performs a number of other manipulations to make your research more productive and your product development less costly. Aptagen's Gene Forge is state of the art and enables us to perform the entire process, delivering time and cost savings, predictability, reallocation of critical scientific assets, superior patentable product, and significantly enhanced gene expression all in a single synthesis. The cost of our product is less than you would expect, and you do not pay more for our design capabilities or our customer service.

The Gene Forge consists of proprietary technologies which permit us to customize transcriptional and translational control regions, insert or remove protein trafficking sequences, add, remove or shuffle protein domains and insert or delete restriction sites, all in a single synthesis. We have developed specialized algorithms for calculating appropriate codon usage, and methods of considering isolates outside of the regional coding domains which directly affect expression. We utilize new treatments for RNA armor codons which block both translation and transcription. We look at ribosome binding sites, mRNA degradation sites, and we can reduce or eliminate secondary structure within the mRNA. Our treatment of tandem repeat codons (which can cause regional depletion of tRNA) is also unique. Finally, we adapt the customized gene to the host in which it is to be expressed. In short, we design and build your "perfect" gene, either for research or product development.


2190 Foxmill Rd.
United States of America


Phone: 703 793-8000
Fax: 703 793-8037

News Articles [1 Associated News Articles listed on BioPortfolio]

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PubMed Articles [1 Associated PubMed Articles listed on BioPortfolio]


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Companies [37 Associated Companies listed on BioPortfolio]

Aptagen, LLC

Aptagen, LLC, based in Jacobus, Pennsylvania, is an early-stage biotechnology company specializing in the development of nucleic-acid based biopharmaceuticals called aptabodies. Formed in 2004, our a...

Aptagen Incorporated

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