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KuDOS Pharmaceuticals is a leader in the discovery and development of novel small molecule drugs that target DNA repair and related systems for the treatment f human diseases, in particular cancer. The company was founded by Professor Stephen Jackson of the Wellcome/Cancer Research UK Institute of the University of Cambridge, UK, an internationally renowned scientist in the field of DNA repair.
The company, including its subsidiary, ChemOvation Ltd currently employs 60 people.
KuDOS Pharmaceuticals has identified a number of naturally occurring DNA repair mechanisms and proteins that are fundamental to the control of cell growth and cell death. Whilst primarily focused on the discovery and development of novel therapeutic agents for use in cancer therapy, DNA repair inhibitors can also be used in the treatment of viral infections, ischaemia and immunosuppression.
Since May 1999, KuDOS Pharmaceuticals has established a strong scientific platform that has resulted in the identification of several new classes of promising drug candidates targeted at DNA repair enzymes for the treatment of cancer. KuDOS’ leading product, PaTrin-2, is planned to enter Phase II clinical trials in melanoma and colorectal cancer by 3-4Q 2002. AQ4N, a hypoxic cell cytotoxin, is currently in Phase I evaluation.
Other products are entering pre-clinical studies with the aim of initiating Phase I clinical trials by 2Q 2003/1Q 2004.
Each of KuDOS’ products is based on a detailed molecular understanding of tumour cells and will enhance efficacy of ionising radiation and major chemotherapy regimen.
PaTrin-2: Phase II commencing Q4 2002
AQ4N: Phase I ongoing
DNA-PK/ATM inhibitor: Pre-clinical development commencing Q2/3 2002
PARP inhibitor: Pre-clinical development commencing Q3/4 2002
KuDOS Pharmaceuticals has a range of products for development as cancer treatments and will take these forward to Phase II clinical trials prior to partnering products with major pharmaceutical companies for product approval and commercialisation. Applications for other than cancer treatment will be out-licensed at an earlier stage.
327, Cambridge Science Park, Milton Road,
Phone: 01223 719719
Fax: 01223 719720
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We have published hundreds of KuDOS Pharmaceuticals Limited news stories on BioPortfolio along with dozens of KuDOS Pharmaceuticals Limited Clinical Trials and PubMed Articles about KuDOS Pharmaceuticals Limited for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of KuDOS Pharmaceuticals Limited Companies in our database. You can also find out about relevant KuDOS Pharmaceuticals Limited Drugs and Medications on this site too.
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