Lexicon Genetics Company Profile

13:17 EDT 22nd September 2017 | BioPortfolio

Lexicon is a biopharmaceutical company focused on the discovery and development of breakthrough treatments for human disease. We use our proprietary gene knockout technology to knock out, or disrupt, the function of genes in mice and then employ an integrated platform of advanced medical technologies to systematically discover the physiological and behavioral functions and pharmaceutical utility of the genes we have knocked out and the potential drug targets encoded by the corresponding human genes. For targets that we believe have high pharmaceutical value, we engage in programs for the discovery and development of potential small molecule, antibody and protein drugs. We have advanced drug candidates from two of these programs into human clinical trials, with drug candidates from two additional programs in preclinical development and a number of additional programs in various stages of preclinical research. We have identified and validated in living mammals, or in vivo, more than 100 targets with promising profiles for drug discovery in the therapeutic areas of diabetes and obesity, cardiovascular disease, psychiatric and neurological disorders, cancer, immune system disorders and ophthalmic disease. We believe that our systematic, target biology-driven approach to drug discovery will enable us to substantially expand our clinical pipeline, and we have initiated our 10TO10 program with the goal of advancing ten drug candidates into human clinical trials by the end of 2010. We are working both independently and through strategic collaborations and alliances to capitalize on our technology and drug target discoveries and to develop and commercialize drug candidates emerging from our drug discovery and development programs. We are working with Bristol-Myers Squibb Company to discover and develop new small molecule drugs in the neuroscience field. We are working with Genentech, Inc. to discover the functions of secreted proteins and potential antibody targets identified through Genentech’s internal drug discovery research, and to develop new biotherapeutic drugs based on certain targets selected from the alliance. We are working with N.V. Organon to discover, develop and commercialize new biotherapeutic drugs based on another group of secreted proteins and potential antibody targets. We are working with Takeda Pharmaceutical Company Limited for the discovery of new drugs for the treatment of high blood pressure. In addition, we have established collaborations and license agreements with other leading pharmaceutical and biotechnology companies, research institutes and academic institutions.


8800 Technology Forest Place
The Woodlands
United States of America


Phone: 281.863.3000
Fax: 281.863.8088

News Articles [671 Associated News Articles listed on BioPortfolio]

Lexicon Genetics Introduces Rapid Method for Accelerating Drug Discovery

Lexicon Genetics Inc. (The Woodlands, TX) has introduced a new approach to understanding the function of human genes and in validating potential drug targets using Lambda KOS...

Lexicon Pharma opts to co-promote sotagliflozin in USA

Texan biotech firm Lexicon Pharmaceuticals says it has exercised its option under its collaboration and…

Good readout boosts Lexicon

Texan biotech Lexicon Pharmaceuticals has announced positive top-line results from its Phase III study…

Lexicon Pharmaceuticals Reports Positive Phase III Data for Sotagliflozin

NewsSotagliflozin is an investigational dual SGLT1 and SGLT2 inhibitor targeting type 1 diabetes.Contributed

Lexicon Pharmaceuticals Reports Positive Top-Line Results for Sotagliflozin

NewsA full analysis of the results from inTandem3, including safety data, will be submitted for publication in a peer-reviewed journal.

CDMO Catalent to Commercially Manufacture Lexicon's Recently-Approved Drug

NewsCatalent provides commercial manufacturing of Lexicon Pharmaceuticals’ orphan drug XERMELO™ following FDA approval.

Lexicon Pharma opts to co─promote sotagliflozin with Sanofi in type 1 diabetes in US

Lexicon Pharmaceuticals announced that it has exercised its option under its collaboration and license agreement with Sanofi to co─promote sotagliflozin, an investigational oral dual inhibitor of so...

Lexicon's Sotagliflozin Achieves Primary Endpoint in Phase 3 Study

NewsLexicon Pharmaceuticals reports additional positive data from pivotal Phase 3 inTandem2 study of sotagliflozin.Contributed Author:

Drugs and Medications [0 Results]


PubMed Articles [697 Associated PubMed Articles listed on BioPortfolio]

Novel Creation of a Rum Flavor Lexicon Through the Use of Web-Based Material.

Flavor lexicons help both manufacturers and consumers communicate the intricacies of flavor nuances they experience within a product. Lexicon development typically requires the use of a trained sensor...

Lexicon Development, Consumer Acceptance, and Drivers of Liking of Quinoa Varieties.

Quinoa is becoming increasingly popular, with an expanding number of commercially available varieties. To compare the sensory properties of these quinoa varieties, a common sensory lexicon needs to be...

The Clinic Is My Laboratory: Life as a Clinical Geneticist.

Clinical genetics is the application of advances in genetics and medicine to real human families. It involves diagnosis, care, and counseling concerning options available to affected individuals and t...

Introduction to behavioral phenotypes in medical genetics.

25 more years.

This month, to celebrate a quarter century of excellence in genetics, we are highlighting selections from the past work we have published. We will then publish a number of forward-looking Perspectives...

Clinical Trials [282 Associated Clinical Trials listed on BioPortfolio]

Genetics Education: Preparing Physicians for the Future

This study examines the best way to teach genetics to family medicine residents. First year family medicine residents at the University of Toronto will be taught basic clinical genetics as...

Experiences of Genetics Patients With Visible Abnormalities Who Facilitate Teaching in Genetics Clinics

This study will describe the experience of patients with visible physical abnormalities in the genetics clinic when they are involved in teaching others about their condition. Information ...

Virtual Reality Intervention in Cancer Genetics

The goal of this study is to evaluate a virtual reality-based intervention for training health care providers who are not genetics specialists to effectively communicate with and counsel p...

Genetics of Asthma and Bronchial Hyperresponsiveness

To investigate the genetics of asthma by reexamining a carefully characterized population of patients with asthma, and by studying their families.

Cultural Congruence in International Genetics Research

This study will explore how cultural differences influence genetics research in developing countries. Human genetics research is becoming more common in developing countries. However, when...

Companies [39 Associated Companies listed on BioPortfolio]

Lexicon Pharmaceuticals, Inc.

Lexicon is a biopharmaceutical company focused on discovering and developing breakthrough treatments for human disease. Lexicon currently has four drug candidates in mid-stage development for diabete...

Lexicon Pharmaceuticals

Lexicon Genetics is focused on the discovery and development of breakthrough treatments for human disease. We use our proprietary gene knockout technology to systematically discover the physiological ...

AccessDNA, Inc.

AccessDNA is the leading online consumer resource for genetics. The company combines high-quality content about genetics with access to, and evaluation of, relevant testing, couns...

Pharma-Lexicon International

Pharma-Lexicon International is based in Cancun, Mexico. We also have an office in East Sussex in the United Kingdom. MediLexicon has the world's largest online database of pharmaceutical and medical ...

Ambry Genetics Corporation

Ambry Genetics is a privately held healthcare company with the industry’s most comprehensive suite of genetic testing solutions, benefiting 90% of all U.S. patients covered b...

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Biopharmaceuticals are medical drugs produced using biotechnology. They include proteins (including antibodies), nucleic acids (DNA, RNA or antisense oligonucleotides) and living microorganisms like virus and bacteria where the virulance of viruses and b...

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

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