Ligand Pharmaceuticals Incorporated Company Profile
Ligand discovers and develops new drugs that address critical unmet medical needs of patients for a broad spectrum of diseases including hepatitis, muscle wasting, Alzheimer's, inflammatory diseases, anemia, COPD, asthma, rheumatoid arthritis and osteoporosis. Ligand's proprietary drug discovery and development programs are based on advanced cell-based assays, gene-expression tools, ultra-high throughput screening and one of the world's largest combinatorial chemical libraries. Ligand has strategic alliances with major pharmaceutical and biotechnology companies, including GlaxoSmithKline, Merck, Pfizer, Roche, Bristol-Myers Squibb, and Cephalon and more than 30 programs are in various stages of development by its partners.
News Articles
Adenosylcobalamin is a form of vitamin B12 that serves as a coenzyme in different reactions and as a ligand for riboswitches to control bacterial gene expression. The crystal structure of a B12 ribosw...
Ligand buys future Selexis royalties
San Diego-based Ligand Pharmaceuticals bought the rights to future milestone and royalty payments for more than 15 biologic development programs from Selexis to access the private Swiss firm's underl...
San Diego’s Ligand Takes Advantage of the Great Recession to Build New Drug Pipeline
Aside from the name, there isn’t much at Ligand Pharmaceuticals (NASDAQ: LGND) that resembles the San Diego biotech that went public in 1992. During the 15 years that followed its IPO, Ligand br...
Spectrum Licenses Ligand Multiple Myeloma Drug
From Associated Press (March 14, 2013) NEW YORK -- Spectrum Pharmaceuticals Inc. said Thursday it licensed a potential treatment for multiple myeloma from Ligand Pharmaceuticals Inc. Ligand’s dr...
Ligand gets priority review for new Promacta use
Shares of Ligand Pharmaceuticals Inc. rose Wednesday after the drugmaker said its medicine Promacta will receive priority review from U.S. regulators for a new use against blood-related complications...
Ligand captures another Captisol partner in melphalan deal with Spectrum
Ligand Pharmaceuticals earned a $3 million license fee and may receive more than $50 million in milestone payments plus double-digit royalties from Spectrum Pharmaceuticals for its Captisol-enabled...
Ligand Pharma getting $2M payment from Merck
Ligand Pharmaceuticals Inc. said Monday that it will get a $2 million payment from Merck & Co., which is starting a new clinical trial of a cancer drug.Ligand said Merck is beginning a new study of t...
Ligand pharma partners with Spectrum for melphalan
Ligand Pharmaceuticals pharma partners with the signing of global license and supply agreements with Spectrum Pharmaceuticals for the development and commercialization of Ligand’s Captisol-enabled...
Drugs and Medications
Targretin (bexarotene) capsules, 75 mg [Cardinal Health]
Targretin (bexarotene) capsules, 75 mg
Eloxatin(oxaliplatin injection) [sanofi-aventis U.S. LLC]
ELOXATIN(oxaliplatin injection)
Targretin (bexarotene) gel 1% [Ligand Pharmaceuticals Inc.]
Targretin (bexarotene) gel 1%
PubMed Articles
Highly luminescent tris[β-diketonate (HFA, 1,1,1,5,5,5-hexafluoropentane-2,4-dione)] europium(III) complexes containing a chiral bis(oxazolinyl) pyridine (pybox) ligand-[(Eu(III)(R)-Ph-pybox)(HFA)(3)...
Ligand entry pathways in the ligand binding domain of PPARγ receptor.
To address the question of ligand entry process, we report targeted molecular dynamics simulations of the entry of the flexible ionic ligand GW0072 in the ligand binding domain of the nuclear receptor...
Iridium Complexes of the Doubly Cyclometalated NHC Ligand IMes''
Two consecutive C-H bond activations at the coordination sphere of Ir transform the commonly employed NHC ligand IMes into the new κ(3)-C fac-coordinating ligand IMes''. The preparation and structure...
Molecular Docking with Ligand Attached Water Molecules.
A novel approach to incorporate water molecules in protein-ligand docking is proposed. In this method, the water molecules display the same flexibility during the docking simulation as the ligand. The...
Solvothermal reaction of a partially flexible ligand, H(4)L, and Cu(NO(3))(2)·2.5H(2)O afforded two cross-linked Kagomé lattices of formula [Cu(2)(L)](n): an acs net sustained by novel trigonal pris...
Clinical Trials
Biological Therapy in Treating Patients With Metastatic Melanoma or Metastatic Kidney Cancer
RATIONALE: Biological therapies such as flt3L and CD40-ligand use different ways to stimulate the immune system and stop cancer cells from growing. Biological therapy may be an effective t...
PET Study Examining the Dopaminergic Activity of Armodafinil in Adults
The specific aims of this study are 1) to document the DAT receptor occupancy of armodafinil using PET scanning with C-11 altropane as the ligand and 2) to document the increased intrasyna...
Treatment With Local PPARgamma Ligand in Distal Ulcerative Colitis
Treatment with PPARgamma ligands have been shown to reduces intestinal inflammation in murine models of colitis. The aim of this study was to evaluate the effect of treatment with local PP...
The purpose of this study is to induce anti-myeloma responses in patients with high risk or relapsed myeloma using combination chemo- and immunotherapy comprising sequentially: 1) lymphoid...
Treatment of B-CLL With Human IL-2 and CD40 Ligand and Plasmid Gene Modified Autologous Tumor Cells
This study is for patients that have chronic lymphocytic leukemia (CLL). This research study aims to determine the safety and dosage of special cells that may make the patients own immune...
Companies
Ligand is an emerging specialty pharmaceutical company that discovers, develops and markets innovative small molecule drugs to address critical, unmet medical needs. Ligand markets four oncology and d...
Ligand Pharmaceuticals Incorporated
Ligand discovers and develops new drugs that address critical unmet medical needs of patients for a broad spectrum of diseases including hepatitis, muscle wasting, Alzheimer's, in...
Clinical Ligand Assay Society's
The Clinical Ligand Assay Society's mission is to establish and promote high standards in the science and application of ligand assay technology by encouraging research, educating practitioners, and f...
Neurogen Corporation & Ligand Pharmaceuticals
Ligand discovers and develops new drugs that address critical unmet medical needs of patients with muscle wasting, frailty, hormone-related diseases, osteoporosis, inflammatory di...
MISSION The Clinical Ligand Assay Society mission is to establish and promote high standards in the science and application of ligand assay technology by encouraging research, educating practitione...
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