Gene Tools LLC Company Profile

00:28 EDT 22nd September 2017 | BioPortfolio

Gene Tools is the sole commercial supplier for research quantities of Morpholino antisense oligos world-wide. Our Morpholino oligos are the premier tools for gene knockdown in developmental biology labs and are the best gene-silencing reagents for cells in culture. Morpholino oligos are short chains of Morpholino subunits comprised of a nucleic acid base, a morpholine ring and a non-ionic phosphorodiamidate intersubunit linkage. Morpholinos act via a steric block mechanism (RNAse H-independent) and with their high mRNA binding affinity and exquisite specificity they yield reliable and predictable results. They either can block translation initiation in the cytosol (by targeting the 5' UTR through the first 25 bases of coding sequence) or they can modify pre-mRNA splicing in the nucleus (by targeting splice junctions). We continually develop novel delivery systems like our 'Endo-Porter' and our soon-to-be launched in vivo delivery system, making it easy to deliver Morpholinos into cultured cells and soon into animals -- making Morpholinos the best tools for genetic studies and drug target validation programs


One Summerton Way
United States of America


Phone: (541) 929-7840
Fax: (541) 929-7841

News Articles [1819 Associated News Articles listed on BioPortfolio]

Power Up! CRISPRi & CRISPRa Tools for Genome-Wide Screening

Horizon Discovery is leveraging these technologies to address novel research questions and deliver insights into essential gene function, hypomorphic expression, and gene dominance.

Like a cut-and-paste tool, CRISPR is transforming gene-editing research – The Indian Express

The Indian ExpressLike a cut-and-paste tool, CRISPR is transforming gene-editing researchThe Indian ExpressNew gene editing tools let scientists alter the DNA of living cells - from plants, animals, e...

Scientists model gene regulation with chromatin accessibility

Researchers from the Academy of Mathematics and Systems Science (AMSS) of the Chinese Academy of Sciences have teamed up with Stanford University and Tsinghua University scientists to successfully mod...

miRNA Tools and Services Market by Product [Research Tools Kits, Reagents, and Other Consumables and Services miRNA Extraction Services, Quantification Services, Microarray Services, Sequencing Services, Functional Studies Services, and Others], Technolog

miRNA is a set of small, noncoding RNA molecules that regulate gene expression post transcription. These molecules have an impact on a wide range of biological functions such as cell cycle control, st...

[Comment] Gene therapy for -mediated inherited retinal dystrophy completes phase 3

The eye is an attractive organ for gene therapy because of the small amount of tissue that needs to be transfected, surgical accessibility for gene delivery, and the inbuilt control of the second eye....

Gene drives may cause a revolution, but safeguards and public engagement are needed

A "gene drive" occurs when a specific gene is spread at an enhanced rate through an animal or plant population.

Engineering RGB color vision into Escherichia coli

Optogenetic tools use colored light to rapidly control gene expression in space and time. We designed a genetically encoded system that gives Escherichia coli the ability to distinguish between red, g...

BMS, Qiagen to Develop Gene Expression Profiles for Immuno-Oncology Therapies

Extending a partnership stretching back eight years, Bristol-Myers Squibb (BMS) and Qiagen plan to explore the use of next-generation sequencing (NGS) technology to develop gene expression profiles as...

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PubMed Articles [3516 Associated PubMed Articles listed on BioPortfolio]

Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?

Mosquito-borne pathogens place an enormous burden on human health. The existing toolkit is insufficient to support ongoing vector-control efforts towards meeting disease elimination and eradication go...

A critical assessment of topologically associating domain prediction tools.

Topologically associating domains (TADs) have been proposed to be the basic unit of chromosome folding and have been shown to play key roles in genome organization and gene regulation. Several differe...

A compilation of Web-based research tools for miRNA analysis.

Since the discovery of microRNAs (miRNAs), a class of noncoding RNAs that regulate the gene expression posttranscriptionally in sequence-specific manner, there has been a release of number of tools us...

Modern Genome Editing Technologies in Huntington's disease Research.

The development of new revolutionary technologies for directed gene editing has made it possible to thoroughly model and study human diseases at the cellular and molecular levels. Gene editing tools l...

Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut.

The gut microbiota is implicated in numerous aspects of health and disease, but dissecting these connections is challenging because genetic tools for gut anaerobes are limited. Inducible promoters are...

Clinical Trials [2118 Associated Clinical Trials listed on BioPortfolio]

CMV Disease and IRIS in HIV-1 Infected Persons

Various diagnostic methods are available for CMV infection. But none of them could be a standard and highly valuable. Our first goal is to setup a series of molecular diagnostic tools for ...

LTFU for Gene Transfer Subjects With Hemophilia B

Several subjects enrolled in a multi-site, gene transfer clinical study to evaluate the intrahepatic administration of AAV2-hFIX16 vector for the treatment of severe hemophilia B between 2...

IMPACCT for Kids' Care

Health insurance is important for children. Public insurance programs are available to many children, but some families report being confused about how to get and keep this insurance. Comm...

Genomic Structural Variation in Cancer Susceptibility

This study will look for new types of gene changes that may be related to cancer in some patients. Some gene changes (mutations) are passed on from parents to offspring (child). Other gene...

Evaluation of the Applicability of Personalized Tools About Nutrition Education for Malnourished Older People

Describe the frequency of use of nutrition education tools for undernourished older people

Companies [1275 Associated Companies listed on BioPortfolio]

Gene Tools LLC

Gene Tools is the sole commercial supplier for research quantities of Morpholino antisense oligos world-wide. Our Morpholino oligos are the premier tools for gene knockdown in developmental biology la...

Enzo Life Sciences Inc.

Enzo Biochem, Inc. is a leading life sciences and biotechnology company focused on harnessing genetic processes to develop research tools, diagnostics and therapeutics and providing reference laborato...

Welgen Incorporation

Welgen, Inc. was founded in 2002 to provide the fastest, most reliable technology available for the construction of recombinant adenoviruses and other research tools. We are currently located in a fac...

Sirion GmbH

SIRION offers tools and services for RNAi expression and solutions for customized adenovirus-mediated gene delivery. SIRIONs proprietary Q-tech technology enables efficient RNAi driven gene silencing ...


INHERINET (Gene Therapy of Hematopoietic Stem Cells for Inherited Diseases), an initiative founded by seven European research institutions, accumulates the expertise of biomedical scientists who have ...

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Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Antisense therapy
Most human diseases are caused by production of abnormal proteins or malfunctioning proteins.   Antisense therapy involves inhibiting production of these proteins.  When a gene is known to cause a specific disease and the genetic sequence ...

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

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