Gene Tools LLC Company Profile
Gene Tools is the sole commercial supplier for research quantities of Morpholino antisense oligos world-wide. Our Morpholino oligos are the premier tools for gene knockdown in developmental biology labs and are the best gene-silencing reagents for cells in culture. Morpholino oligos are short chains of Morpholino subunits comprised of a nucleic acid base, a morpholine ring and a non-ionic phosphorodiamidate intersubunit linkage. Morpholinos act via a steric block mechanism (RNAse H-independent) and with their high mRNA binding affinity and exquisite specificity they yield reliable and predictable results. They either can block translation initiation in the cytosol (by targeting the 5' UTR through the first 25 bases of coding sequence) or they can modify pre-mRNA splicing in the nucleus (by targeting splice junctions). We continually develop novel delivery systems like our 'Endo-Porter' and our soon-to-be launched in vivo delivery system, making it easy to deliver Morpholinos into cultured cells and soon into animals -- making Morpholinos the best tools for genetic studies and drug target validation programs
Location
One Summerton Way
Philomath
Oregon
97370
United States of America
Contact
Phone: (541) 929-7840
Fax: (541) 929-7841
News Articles
Computational tools for prioritizing candidate genes: boosting disease gene discovery
Various studies (such as genetic linkage or 'omics'-based approaches) generate large lists of candidate genes, of which only a minority may be biologically relevant for a phenotype or disease of inter...
New Brain Gene Born, Study Shows
An international team of researchers have discovered a new gene that helps explain how humans evolved from apes. Scientists say the gene - called miR-941 - appears to have played a crucial role in hum...
Gene-Sequencing Applications Developed for Highest-Risk form of a Childhood Cancer
Using cutting-edge gene-analysis tools, researchers have found mutations in two related genes, ARID1A and ARID1B, which are involved in...
Gene expression and peripheral blood as tools for pinpointing genes linked to autism
UCLA researchers have combined two tools - gene expression and the use of peripheral blood -- to expand scientists' arsenal of methods for pinpointing genes that play a role in autism. Published in th...
Gene Discovered That Promotes Drug Resistance In Cancer
Increased NEK2 gene expression linked to increased drug resistance, faster cancer growth, and poorer patient outcom. The finding may improve diagnostic and prognostic tools for cancer care and could l...
NanoString licenses liver cancer gene signature from The Broad Institute
NanoString Technologies, a provider of life science tools for translational research and molecular diagnostic products, has secured an option to an exclusive worldwide license for a 186-gene signature...
New tools for targeting genes linked to autism
Researchers have combined two tools – gene expression and the use of peripheral blood -- to expand scientists’ arsenal of methods for pinpointing genes that play a role in autism. The findings cou...
Horizon forms 3 new Centers of Excellence for gene editing in Asia
Horizon Discovery (Horizon), a leading provider of research tools to support the development of personalized medicines, today announced it has established three new Centers of Excellence (CoE's) for g...
Drugs and Medications
R-gene [Pharmacia and Upjohn Company]
R-Gene 10Arginine Hydrochloride Injection, USP
Adventure medical kits 1 person first aid [Tender Corp dba Adventure Medical Kits]
ANTISEPTIC TOWELETTE
Retin-a micro [Ortho-McNeil Pharmaceuticals]
RETIN-A MICRO® (tretinoin gel) microsphere, 0.1% and 0.04%
Retin-a micro [Physicians Total Care, Inc.]
RETIN-A MICRO® (tretinoin gel) microsphere, 0.1% and 0.04%
Easy care first aid [Tender Corp dba Adventure Medical Kits]
ANTISEPTIC TOWELETTE
PubMed Articles
Candidate gene association studies: a comprehensive guide to useful in silico tools.
The candidate gene approach has been a pioneer in the field of genetic epidemiology, identifying risk alleles and their association with clinical traits. With the advent of rapidly changing technology...
Stitching gene fragments with a network matching algorithm improves gene assembly for metagenomics.
One of the difficulties in metagenomic assembly is that homologous genes from evolutionarily closely related species may behave like repeats and confuse assemblers. As a result, small contigs, each re...
Tools for genetic manipulations in Corynebacterium glutamicum and their applications.
Corynebacterium glutamicum is an important industrial producer of various amino acids with great potential for the production of other metabolites. The complete genome sequences of two C. glutamicum s...
Mini-Tn7 vectors as genetic tools for single copy gene cloning in Acinetobacter baumannii.
Acinetobacter baumannii is an emerging pathogen that causes serious infections with high mortality rates in immunocompromised individuals. Genetic manipulations in this medically-relevant pathogen are...
Regulation of gene transcription by the oncoprotein MYC.
The proteins of the MYC/MAX/MAD network are central regulators of many key processes associated with basic cell physiology. These include the regulation of protein biosynthesis, energy metabolism, pro...
Clinical Trials
CMV Disease and IRIS in HIV-1 Infected Persons
Various diagnostic methods are available for CMV infection. But none of them could be a standard and highly valuable. Our first goal is to setup a series of molecular diagnostic tools for...
Combining Observational and Physiologic Sedation Assessment Tools
When a physiologic tool to measure the patient's hypnotic state is added to current practice tools is there a decrease in the amount of drug the patient receives.
Comparison of Screening Tools for Coronary Artery Disease
Coronary artery disease (CAD) is a silent killer that may go undetected for years. It is the leading cause of death with no limitation to geographic boundaries accounting to about 16.7 mil...
Genomic Structural Variation in Cancer Susceptibility
This study will look for new types of gene changes that may be related to cancer in some patients. Some gene changes (mutations) are passed on from parents to offspring (child). Other gene...
Gene Therapy in Treating Patients With Cancer of The Liver
RATIONALE: Inserting the p53 gene into a person's tumor may improve the body's ability to fight liver cancer. PURPOSE: Phase I trial to study the effectiveness of gene therapy with the p5...
Companies
Gene Tools is the sole commercial supplier for research quantities of Morpholino antisense oligos world-wide. Our Morpholino oligos are the premier tools for gene knockdown in developmental biology la...
Enzo Biochem, Inc. is a leading life sciences and biotechnology company focused on harnessing genetic processes to develop research tools, diagnostics and therapeutics and providing reference laborato...
Welgen, Inc. was founded in 2002 to provide the fastest, most reliable technology available for the construction of recombinant adenoviruses and other research tools. We are currently located in a fac...
SIRION offers tools and services for RNAi expression and solutions for customized adenovirus-mediated gene delivery. SIRIONs proprietary Q-tech technology enables efficient RNAi driven gene silencing...
INHERINET (Gene Therapy of Hematopoietic Stem Cells for Inherited Diseases), an initiative founded by seven European research institutions, accumulates the expertise of biomedical scientists who have...
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