VTU Technology GmbH Company Profile

VTU Technology is a leading contract research and development company providing fast-track generation of high-performance industrial protein expression strains for biopharmaceuticals and other protein manufacturers. VTU applies its exclusive cutting-edge Pichia pastoris protein production platform and offers expertise and services, which span the entire range from gene or sequence to highly productive expression strains and processes, in minimum time.

VTU´s Pichia pastoris expression system - built around the technology´s stronghold, a library of synthetic promoter variants - is best suited for economic biologics production furnishing expression titers of >10 g/L of secreted target proteins with up to 90% initial purity within a few weeks of development for various proteins (e.g. serum proteins, cytokines, Fabs and other antibody derived fragments, scaffold proteins, fusion proteins, enzymes).
Our exclusive proprietary promoter library of synthetic variants of AOX1 spans a wide range of activities and expression characteristics which allows an ideal match of promoter properties and specific requirements for efficient expression of a given target protein. The potential of this particular technology is further boosted by co-expression of auxiliary proteins as a finely-tuned balance between helper and target is the key to highest levels of protein production.

Furthermore, this outstanding technology platform is complemented by novel 2nd generation AOX1 promoter variants allowing for methanol-free expression thus providing our customers high performance expression strains no longer dependent on methanol induction.

VTU researchers apply cutting-edge technologies and elaborated time saving procedures to maximize both throughput and output and thereby drastically shorten the development time from the gene to gram quantities of different proteins. VTU Technology provides effective solutions for economic protein production accompanied by sound technology transfer and comprehensive documentation ensuring regulatory compliance.

Technological features:

• Fine tuning of expression using our proprietary AOX1 promoter library (VTU`s 1st and 2nd generation AOX1 promoter libraries)
• High speed expression strain development yielding unparalleled production levels (10g/L)
• Co-expression of auxiliary proteins for maximization of protein expression
• High-throughput microscale cultivation and screening for highest-yield clones at unrivalled speed
• VTU`s 2nd generation methanol-free AOX1 promoter variants allow for effective methanol-free expression
• Optimized procedures for exploiting the full potential of Pichia pastoris

Our Specialized Services:

• Gene design and cloning
• Development of customized high performance expression strains at unrivalled speed
• Confirmation of microscale screening results in paralleled 1L-bioreactors
• Bioprocess development and process characterization
• Sound technology transfer to our customers supporting regulatory filings

Your Advantages:

• Valid and scalable results in minimum time
• Short and flexible project timelines with customized project design
• Full documentation to support your regulatory filings
• Uncompromising confidentiality
• FTO certified technology platform
 

Location

Parkring 18
Grambach
Austria
A-8074
AUT

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