Adaptimmune Limited Company Profile

Adaptimmune Limited is focused on the use of T cell therapy to treat HIV and cancer. It aims to utilize the body’s own machinery – the T lymphocyte cell – to target and destroy cancerous or infected cells. Established in July 2008, Adaptimmune was set up to develop Immunocore Ltd’s (formerly Avidex/MediGeneLtd’s) unique T cell receptor engineering technology for adoptive T cell therapy. Specifically, Adaptimmune makes use of the body’s ability to recognize infected or cancerous cells by enhancing the power of the T cell receptor (TCR) on killer T cells. Cancerous or virally infected cells will typically present small parts or peptides of larger viral proteins or abnormal cancer proteins on their surface, offering a "molecular fingerprint", called an epitope, for killer T-cells from the immune system to identify. In a healthy individual, this triggers an immune response, eliminating the affected cell. However, viruses such as HIV mutate rapidly, swiftly disguising their fingerprints to allow them to hide from killer T-cells while cancer proteins are usually derived from self-proteins against which natural TCRs do not respond. Adaptimmune’s technology uniquely enhances the natural TCR affinity to either viral or cancer protein epitopes on an individual patient’s cells overcoming these obstacles for therapeutic benefit.
Adaptimmune has undertaken significant preclinical development with a number of pipeline TCRs to demonstrate their potency and specificity in vitro. The TCR in the current sarcoma study is specific to the cancer testis antigen targets NY-ESO-1 157-165 (HLA A2; SLLMWITQC). This TCR and another TCR specific for MAGE A3168-176 (HLA A1; EVDPIGHLY) were engineered using Adaptimmune’s proprietary TCR engineering platform and are already under evaluation in other clinical trials in multiple myeloma and metastatic melanoma, with other cancers in planning. Adaptimmune has a pipeline of similar TCRs in preclinical development in both cancer and HIV.

 

Location

57c Milton Park
Abingdon
Oxford
Oxfordshire
OX14 4RX
UK

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