Gene Signal Company Profile
Gene Signal (www.genesignal.com) is developing a robust pipeline of novel antisense oligonucleotides, proteins and monoclonal antibodies to treat a range of conditions based on its innovative angiogenesis modulating technology. The companyâs most advanced therapeutic product is aganirsen (GS-101), an antisense oligonucleotide that has nearly completed phase III for the prevention of corneal graft rejection. Aganirsen is also entering phase II clinical trials for additional angiogenesis based diseases, such as wet age-related macular degeneration (AMD), neovascular glaucoma, and dermal indications. Antisense oligonucleotides confer distinctive advantages versus other biologics: they can be readily transported across cell membranes, are associated with low immunogenicity, and can be produced by simple chemical synthesis, unlike larger proteins and monoclonal antibodies that require cell culture and complex purification steps.
News Articles
In this episode of PharmaTelevision News Review, filmed at BioEurope 2012 in Hamburg, Germany, Fintan Walton talks to Eric Viaud, CEO at Gene Signal
[Gene Signal] completes funding through existing backers
Swiss biotech [Gene Signal International SA] (angiogenesis regulation therapies) has completed a private financing round through the same group of private investors who have funded the company since i...
Gene Signal Will Expand Antisense Ophthalmic Studies With New Funds
A topical antisense product, aganirsen, from Switzerland’s Gene Signal is to be evaluated in neovascular glaucoma, age-related macular degeneration and psoriasis following the completion of a Phase...
Gene Signal: Eric Viaud. Discovering genes involved in the regulation of angiogenesis
In this episode of PharmaTelevision News Review, filmed at BioEurope 2012 in Hamburg, Germany, Fintan Walton talks to Eric Viaud, CEO at Gene Signal
Gene Signal outlines 'aggressive' three-year plan as it completes latest funding round
Having completed its latest private funding round, Lausanne, Switzerland-based biotech firm, Gene Signal said it is set to embark on an 'aggressive' three-year clinical and commercialization plan for...
Levée vitaminée pour Gene Signal
C’est un soutien fort que la biotech suisse Gene Signal vient de recevoir de la part de ses actionnaires historiques…
Stem cell 'homing' signal may help treat heart failure patients
In the first human study of its kind, researchers activated heart failure patients' stem cells with gene therapy to improve their symptoms, heart function and quality of life, according to a study in...
Drugs and Medications
Feridex i.v. (ferumoxides injectable solution) [Bayer HealthCare Pharmaceuticals Inc.]
Feridex I.V. (ferumoxides injectable solution)
Act anticavity fluoride kids bubblegum [Chattem, Inc.]
ACT Anticavity Fluoride Rinse Kids Bubblegum
Multihance [Bracco Diagnostics Inc]
Multihance Multipack (gadobenate dimeglumine) injection, 529 mg/mL
R-gene [Pharmacia and Upjohn Company]
R-Gene 10Arginine Hydrochloride Injection, USP
Clindagel [Galderma Laboratories, L.P.]
Clindagel®(clindamycin phosphate gel)topical gel, 1%For External UseRx Only
PubMed Articles
For proper evaluation of the results of microarray experiments, it is important to understand how the signal intensities of individual probes are determined. Our previous studies revealed that signal...
This study is designed to screen the CD40 related signal transduction pathway in AGS cells and construction of gene silencing vector. Analysis results showed 414 differential genes expression, includi...
High-frequency and low-frequency effects on vibrational resonance in a synthetic gene network.
The high-frequency and low-frequency effects on vibrational resonance (VR) in a synthetic gene network are studied. Results show that the role of the high-frequency signal in VR acts as that of noise...
RNA-protein interaction plays a significant role in regulating eukaryotic translation. This phenomenon raises questions about the ability of artificial biological systems to take the advantage of prot...
Improved secretion of Candida antarctica lipase B with its native signal peptide in Pichia pastoris.
Secretion efficiency of the 85-amino acid Sacchromyces cerevisiae alpha signal peptide and the 25-amino acid Candida antarctica lipase B signal (nsB) peptide were compared. Three reporter proteins use...
Clinical Trials
This study investigates the effects of Lithium treatment on signal transduction pathways, gene expression and brain neurochemistry and structure in patients with Bipolar disorder. It is hy...
Assessment of HyperQ Signal for Detecting Ischemia During Dobutamine Stress ECG
The purpose of the study is to verify the ability of the HyperQ signal to detect Dobutamine induced Ischemia. The gold standard for ischemia will be the results of Angiography if performed...
To determine if pulsed electric field therapy reduces lower leg and foot pain associated with diabetic neuropathy and lessens the need for medication. The MedRelief device sends a sub-thr...
The purpose of this study is to explore how arterial PaCO2 effect regional Blood Oxygen Level Dependent (BOLD) signal, and indirectly the brain regional O2 level .
The purpose of this study is to determine if the forehand location for sensor placement has less episodes of signal dropout than the finger sensor location. In addition, this study will e...
Companies
Gene Signal (www.genesignal.com) is developing a robust pipeline of novel antisense oligonucleotides, proteins and monoclonal antibodies to treat a range of conditions based...
Signal Patterns develops social web applications that characterize and connect users to each other based on their interests, personality and preferences. With these scientific-based applications,...
Signal Genetics is a privately held predictive genetic testing company focused on oncology. The goal of Signal Genetics is to provide cancer patients with their correlated predictive outcome of diseas...
Gene Therapy Systems, Inc. (GTS) designs, develops and commercializes gene therapy products along with other molecular biological reagents for scientists specializing in gene therapy research. GTS is...
Founded in 1998 by scientists from The Salk Institute and The University of California, San Diego, SoftMax, Inc. finds its origins in the field of computational neurobiology. SoftMax has taken this ex...
More Information about "Gene Signal" on BioPortfolio
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