Heat Biologics, Inc. Company Profile
Heat Biologics (www.heatbio.com) (“Heat”) is a clinical-stage company immunotherapy company focused on developing its novel off-the-shelf “ImPACT” (Immune Pan-Antigen Cytotoxic Therapy) therapeutic vaccines to combat a wide range of cancers and other diseases. Heat’s ImPACT Therapy effectively reprograms tumor cells to “pump out” an important immuno-protein called “gp96-Ig” and their chaperoned antigens to robustly stimulate the immune system against the targeted disease. Heat’s ImPACT Therapy is based upon heat shock protein gp-96, a chaperone protein found in all huma cells and normally tethered to our cells with a leash called the KDEL sequence. ImPACT Therapy removes this KDEL leash, thus transforming allogeneic living cells into powerful machines that continually pump out gp96 and their chaperoned antigens to activate the immune system against the full spectrum of antigens expressed by a patient’s disease. Heat is currently in Phase IIa trials against non-small cell lung cancer. Positive prophylactic and therapeutic data against SIV (the primate equivalent of HIV) has also been generated in a large 48-primate NIH-sponsored study, the first of ImPACT’s ability to combat viral diseases. Heat plans to initiate additional clinical trials against bladder and ovarian cancer in 2012.
News Articles
Cancer company Heat Biologics Inc. (Miami Beach, Fla.) filed to raise up to $20 million in an IPO underwritten by Aegis Capital. This year, Heat Biologics plans to start Phase II testing of its lead c...
[Heat Biologics] files to go public
[Heat Biologics Inc.] (cancer and infectious disease immunotherapies) has filed for its initial public offering.
Heat Biologics, Inc.: Series A $2.8M
Heat Biologics (Chapel Hill, NC) a clinical-stage biopharmaceutical company focused on vaccines and antibodies for non-small cell lung cancer and stimulation of regulatory T cells, closed a $2.8M Seri...
Heat Biologics preclinical data
Heat wave especially dangerous for kids
Extreme heat continues to plague the nation with many areas seeing record temperatures. Though everyone needs to take precautions when it comes to dangerous heat, it’s especially important to watch...
Children at increased risk for heat-related illness
Extreme heat continues to plague the nation with many areas seeing record temperatures. Though everyone needs to take precautions when it comes to dangerous heat, it's especially important to watch yo...
Small heat-shock proteins protect from heat-stroke-associated neurodegeneration
Heat stroke triggers necrotic cell death and neurodegeneration in Caenorhabditis elegans, but hormetic preconditioning at a mildly elevated temperature strongly protects C. elegans from necrosis induc...
Drugs and Medications
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Drug Facts
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American Sales Company Cool Heat Drug Facts
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Drug Facts
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PubMed Articles
OBJECTIVE: To investigate the influence of biologics on mortality and risk factors for death in rheumatoid arthritis (RA) patients. METHODS: RA patients treated with at least one dose of biologics in...
Clinical pharmacology considerations in biologics development.
Biologics, including monoclonal antibodies (mAbs) and other therapeutic proteins such as cytokines and growth hormones, have unique characteristics compared to small molecules. This paper starts from...
Challenges and approaches for the development of safer immunomodulatory biologics.
Immunomodulatory biologics, which render their therapeutic effects by modulating or harnessing immune responses, have proven their therapeutic utility in several complex conditions including cancer an...
Strategies for non-invasive delivery of biologics.
Macromolecular therapeutics, in particular, many biologics, is the most advancing category of drugs over conventional chemical drugs. The potency and specificity of the biologics for curing certain di...
Pharmacological Approaches in Immuno-rhumatology.
Biologics have proven to be an effective treatment option for adults with rheumatoid arthritis but their use in clinical practice may be limited by concerns over severe side effect...
Clinical Trials
Ustekinumab Safety and Surveillance Program Using the Ingenix NHI Database
The patients included in this observational study will be drawn from a research database containing claims and enrollment data for members of a large, geographically diverse US health plan...
The Impact of Heat Acclimation on Pro- and Anti- Inflammatory Cytokine Response
There is growing evidence to conclude that part of the cascade leading to heatstroke is related to an inflammatory reaction triggered by the heat stress. The reduced ability to sustain hea...
Golimumab Safety and Surveillance Program Using the Ingenix NHI Database
The participants included in this observational study will be drawn from a research database containing claims and enrollment data for members of a large, geographically diverse US health...
Retrospective Evaluation of the Radiographic Efficacy of Conventional and Biologic Treatment
This study involves review and analysis of disease activity in patients with rheumatoid arthritis who where treated with either conventional DMARDs (Disease Modifying Antirheumatic Drugs)...
Heat Intolerance- A Lesson From Global Genomic Response in Lymphocytes
Heat Intolerance (HI) is a life threatening deficiency that can lead to heat exhaustion, heat stroke (and possibly death) in a large number of military and civilian occupational groups. We...
Companies
Heat Biologics (www.heatbio.com) (“Heat”) is a clinical-stage company immunotherapy company focused on developing its novel off-the-shelf “ImPACT” (Immune Pan-...
Avecia Biologics was acquired in February 2010 by MSD, the UK subsidiary of Merck & Co Inc, the world’s second largest pharmaceutical company. MSD Billingham is one of the world's leading contract...
Hothead Technologies, Inc., is an Atlanta-based company offering a patent-pending and proprietary monitoring solution termed the Heat Observation Technology (H.O.T.(TM)) System. The System is designed...
Permeon Biologics is pioneering a breakthrough class of intracellular biologics that target a broad spectrum of previously undruggable targets. Leveraging its novel IntraphilinâÂ...
Redfish Photonics is a solid-state heat pump based company dedicated to providing innovative solutions to industries worldwide.Stand-alone solid-state heat pumps are provided as well as solid-state he...
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