TREM Rx, Inc. Company Profile
TREM Rx is a biotechnology company with a proprietary technology platform to create and administer highly effective vaccines that are delivered to the upper layers of skin, rather than to deeper layers of skin, subcutaneous tissue, or muscle as conventional vaccines are delivered. The companyâs novel approach is based on the discoveries of its scientific founder and his colleagues, who found that powerful cells of the immune system called TREMs (T Resident Effector Memory cells) reside in skin and other epithelial tissues, and can mediate a dramatically strong and effective memory immune response against pathogens. In addition to an innovative route of administration into the skin, TREM Rx vaccines are created using safer engineered replication-deficient viruses that are effective at generating TREMs in epithelial tissues. The company is pursuing the application of its novel vaccines to a wide range of diseases, including important infectious diseases and cancers with unmet medical needs.
News Articles
Silencing the TREM-1 Gene Protects Mice from Developing Liver Cancer
Blocking the activity of the proinflammatory enzyme TREM-1 protected mice from developing chemically induced liver cancer.
A novel, inhibitory platelet surface protein known as TREM (Triggering Receptors in Myeloid) like Transcript (TLT-1). TLT-1 is the first inhibitory receptor discovered to reside within the TREM gene l...
Cancer Treatment And Prevention By Targeting Inflammation
Researchers at the Georgia Health Sciences University Cancer Center have identified a gene that disrupts the inflammatory process implicated in liver cancer. Laboratory mice bred without the gene lac...
Cancer Prevention, Treatment By Targeting Inflammation
Researchers at the Georgia Health Sciences University Cancer Center have identified a gene that disrupts the inflammatory process implicated in liver cancer. Laboratory mice bred without the gene lack...
TREM-1 as a Potential Therapeutic Target in Psoriasis
Plasma TREM-1 doesn't indicate sepsis on its own
NEW YORK (Reuters Health) - The presence in plasma of sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) had only "moderate" diagnostic performance in differentiating sepsi...
TREM-1 gene disrupts inflammatory process implicated in liver cancer
Researchers at the Georgia Health Sciences University Cancer Center have identified a gene that disrupts the inflammatory process implicated in liver cancer.
An Inflammatory Protein Plays An Unexpected Role In Lung Infections
The immune system responds to infections in the lungs by recruiting neutrophils, a group of immune cells that are responsible for recognizing and eliminating pathogens, to the site of infection. In ad...
Drugs and Medications
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PubMed Articles
Expression of TREM-1 is inhibited by PGD(2) and PGJ(2) in macrophages.
TREM-1 is a super-immunoglobulin receptor present on neutrophils and monocytes that plays an important role in the amplification of inflammation. The natural ligands for TREM-1 have not been identifie...
Transcriptional regulation of mouse TREM-1 gene in RAW264.7 macrophage-like cells.
Triggering receptor expressed on myeloid cells (TREM)-1 is expressed in macrophages, and functions as an amplifying molecule in inflammatory responses. TREM-1 is constitutively expressed in macrophage...
Triggering receptor expressed on myeloid cells-1 (TREM-1) is highly expressed in inflammatory lesions caused by infectious agents such as bacteria and fungi but not in normal tissues or non-infectious...
Soluble triggering receptor expressed on myeloid cells (s-TREM-1) is upregulated on the surface of inflammatory cells in the presence of bacterial infections, apparently excluding those due to Mycobac...
ABSTRACT: BACKGROUND: Current knowledge on the exact ligand causing expression of TREM-1 on neutrophils and monocytes is limited. The present study aimed at the role of underlying infection and of th...
Clinical Trials
Use of TREM-1 Protein to Differentiate Viral and Bacterial Pneumonias in Intubated Children
The purpose of this study is to determine whether a protein called TREM-1 can be used to differentiate viral and bacterial pneumonias in children who are on ventilator support. We propose...
Serial Changes in sTREM-1 During Ventilator-associated Pneumonia (VAP)
Triggering receptor expressed on myeloid cells (TREM)-1 is a recently described molecule that plays an important role in myeloid cell-activated inflammatory responses. The aim of this stud...
The Trauma Recovery and Empowerment Model for Treating Post-Traumatic Stress Disorder in Women
This study will determine the effectiveness of the Trauma Recovery and Empowerment Model in reducing the severity of post-traumatic stress disorder symptoms in women with mental disorders...
Companies
TREM Rx is a biotechnology company with a proprietary technology platform to create and administer highly effective vaccines that are delivered to the upper layers of skin, rather...
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