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CDH2


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Symbol:CDH2
Name(s):cadherin 2, type 1, N-cadherin (neuronal)
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD325, CDHN, CDw325, NCAD
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17348027 EGCG downregulated N-cadherin in a dose-dependent manner where reduction in N-cadherin expression paralleled declining migratory potential.
18269586 The level of expression of N-cadherin between types of lung tumours does not appear to indicate malignant potential or aggressive behaviour.
17171299 engagement of N-cadherin provides a stop signal for breast carcinoma cell migration
17868645 In conclusion, N-cadherin modifies Kv1.5 channel activity and is thus a novel candidate signaling molecule participating in the regulation of a variety of functions including cardiac action potential and vascular tone.
17646933 Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells.
14559901 the comparable region of N-cadherin can substitute for this required region in E-cadherin and is required for suppression by the mutant form of N-cadherin that is capable of suppressing
16819153 N-cadherin was selectively expressed on epithelial cells of the thymus, pituitary, pancreas, liver, adrenal, endometrium of the uterus, ovary, and stomach as well as in neuronal tissues.
16173043 demonstrated for the first time that N-cadherin switching occurs in higher grade prostate cancer and correlates significantly with increasing Gleason patterns; N-cadherin may be a useful biomarker of aggressive PC
15987741 N-cadherin plays a key role in the transendothelial migration of melanoma cells
17389597 abnormal activation of glycogen synthase kinase 3beta can reduce neuronal viability and synaptic plasticity via modulating Presenilin 1/N-cadherin/beta-catenin interaction and thus have important implications in the pathophysiology of Alzheimer disease.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDarmadillo repeat proteincadherin 2, type 1 preproprotein--Pubmed
HPRDarmadillo repeat proteincadherin 2, type 1 preproprotein--Pubmed
HPRDCadherin 2cadherin 4, type 1 preproprotein--Pubmed
HPRDCadherin 2cadherin 11, type 2 preproprotein--Pubmed
HPRDCadherin 2guanine nucleotide binding protein, alpha 13--Pubmed
HPRDCadherin 2NMDA receptor 1 isoform NR1-3 precursor--Pubmed
HPRDCadherin 2guanine nucleotide binding protein alpha 12--Pubmed
HPRDCadherin 2Rho GTPase-activating protein--Pubmed
HPRDCadherin 2glutamate receptor, ionotropic, kainate 2 isoform 1 precursor--Pubmed
HPRDcadherin 2, type 1 preproproteinCadherin 4--Pubmed

Recent Publications on CDH2:

Pubmed Logo
Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis.
The transcription factors Pax6 and Sox2 have been implicated in early...
3rd November, 2009
Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Development. 2009 Sep;136(17):2977-85.
DOI Direct Link
MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex.
The radial glial cells serve as neural progenitors and as a migratory...
3rd November, 2009
UNC Neuroscience Center and the Department of Cell and Molecular Development. 2009 Sep;136(17):2965-75.
DOI Direct Link
Accurate potential energy surface and calculated spectroscopic properties for CdH2 isotopomers.
Ab initio calculations employing the coupled cluster method CCSD(T), in...
24th October, 2009
Institut fur Physikalische Chemie, Universitat Gottingen, Tammannstrasse J Phys Chem A. 2009 Oct 29;113(43):11772-82.
DOI Direct Link
Epithelial to mesenchymal transition of lung cancer cells.
Ab initio calculations employing the coupled cluster method CCSD(T), in...
7th October, 2009
Division of Pulmonary Medicine, Infection Diseases and Oncology, Graduate J Nippon Med Sch. 2009 Aug;76(4):181.
N-cadherin in the maintenance of human corneal limbal epithelial progenitor cells in vitro.
PURPOSE: To demonstrate the role of N-cadherin (N-cad) in maintaining the...
3rd October, 2009
Cornea Center, Tokyo Dental College, Chiba, Japan. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4640-5. Epub 2009 May 6.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
A Study of the Safety and Effects of ADH-1 Given Intravenously as a Single Agent

Patents:

Patents logo
US Patent No.Title
7598051 Compositions and methods for the therapy and diagnosis of ovarian cancer
6706867 DNA array sequence selection
6960439 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6964850 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
7049072 Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state

View more patents.

CDH2 results (if any) from reagent suppliers

Google CSE Logo
C1821 Monoclonal Anti-Pan Cadherin antibody produced in mouse ...
CDH1(999), CDH2(1000), CDH3(1001). rat ... Cdh1(83502), Cdh2(83501), Cdh3(116777 ). mouse ... Cdh1(12550), Cdh2(12558), Cdh3(12560). shipped in, dry ice ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C182...

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C2542 Monoclonal Anti-N-Cadherin antibody produced in mouse Anti-A ...
isotype, IgG1. Gene Information, human ... CDH2(1000). rat ... Cdh2(83501). mouse ... Cdh2(12558). shipped in, dry ice. storage temp. −20°C ...
https://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C25...

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N-cadherin (H-63) Antibody sc-7939
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CDH2, 1000, 18q12.1, NM_001792 ...
http://www.scbt.com/datasheet-7939-n-cadherin-h-63-antibody....

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Abgent - Stem Cell
AP1473a, CDH12 Antibody (N-term), WB, IHC, E, H. AP1435aNEW, CDH15 Antibody (N- term), IHC, E, H. AP1498b, CDH2 Antibody (C-term), WB, E, H ...
http://www.abgent.com/products/category/stem_cell...

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Antibody Products - IgG Monoclonal Antibodies - GenWay
Mouse monoclonal [GC - 4] to N Cadherin; 414745; CDH2;; Cadherin-2, IgG Monoclonal IF, WB, Source: Mouse Reactivity: Cross-reacts with Chicken. ...
http://www.genwaybio.com/all_monoclonal_antibodies.php?fl=N...

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pan-cadherin (C-19) Antibody sc-1499
Mouse, Cdh2, 12558, 18 A1, P15116, N/A. Mouse, Cdh3, 12560, 8 D3, P10287, N/A. Mouse, Cdh4, 12561, 2 H4, P39038, N/A. Mouse, Cdh6, 12563, 15 A1, P97326 ...
http://www.scbt.com/datasheet-1499-pan-cadherin-c-19-antibod...

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Antibody Products - IgG Polyclonal Antibodies - GenWay
N Cadherin; 1000; CDH2; 114020; P19022; CDHN; NCAD; - Rabbit polyclonal to N Cadherin; 1000; CDH2; 114020; P19022; CDHN; NCAD;; Cadherin-2, IgG Polyclonal
...
http://www.genwaybio.com/all_polyclonal_antibodies.php?fl=N...

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