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ABI1


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Symbol:ABI1
Name(s):abl-interactor 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:ABI-1, E3B1, NAP1BP, SSH3BP, SSH3BP1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17951403 ABI-1 plays an important role in the spread of breast cancer and this role may be mediated via the phosphatidylinositol 3-kinase pathway.
16182283 Overexpression of e3B1 in NIH3T3/EGFR cells sensitized EGF-induced activation of Rac1, whereas it had no impact on EGF-induced activation of p21Ras.
15591787 Abi enhances Abl-mediated downregulation and phosphorylation of Cdc2 kinase
15769844 We demonstrate a cell-type-dependent requirement for various WASP-related proteins in Listeria entry and InlB-induced membrane ruffling; Abi1, a key component of WAVE complexes, is recruited at the entry site
12547160 t(10;11)(p11.2;q23) involving MLL and this gene is associated with congenital acute monocytic leukemia
12672821 Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins
15893754 Abi-1 promotes Abl-mediated BCAP phosphorylation and suggest that Abi-1 in general coordinates kinase-substrate interactions
16225669 results suggest that the Eps8/Abi1 complex is capable of regulating the localization and/or activity of actin nucleators
16899465 c-Abl activates WAVE2 via tyrosine phosphorylation to promote actin remodeling in vivo; Abi-1 forms the crucial link between these two factors
15048123 Abi1 interacts directly with the WHD domain of WAVE2, increases WAVE2 actin polymerization activity and mediates the assembly of a WAVE2-Abi1-Nap1-PIR121 complex.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BIND-hNap1 Binding ProteinhNap1BP interacts with Abl.-Pubmed
HPRDv-abl Abelson murine leukemia viral oncogene homolog 1 isoform aabl-interactor 1--Pubmed
BIND-abl-interactor 1An unspecified isoform of Dyn2 interacts with Abi-1. This interaction was modeled on a demonstrated interaction between human Dyn2 and Abi-1 from an unspecified species.-Pubmed
HPRDepidermal growth factor receptor pathway substrate 8abl-interactor 1--Pubmed
HPRDepidermal growth factor receptor pathway substrate 8abl-interactor 1--Pubmed
HPRDheat shock 70kDa protein 8 isoform 1abl-interactor 1--Pubmed
HPRDNCK adaptor protein 1abl-interactor 1--Pubmed
HPRDNCK adaptor protein 1abl-interactor 1--Pubmed
HPRDPAK2abl-interactor 1--Pubmed
HPRDp21-activated kinase 2ABL interactor 1--Pubmed

Recent Publications on ABI1:

Pubmed Logo
Three SnRK2 Protein Kinases are the Main Positive Regulators of Abscisic Acid Signaling in Response to Water Stress in Arabidopsis.
Responses to water stress are thought to be mediated by transcriptional...
3rd November, 2009
Biological Resources Division, Japan International Research Center for Plant Cell Physiol. 2009 Oct 30.
DOI Direct Link
Expression of ABA signalling genes and ABI5 protein levels in imbibed Sorghum bicolor caryopses with contrasting dormancy and at different developmental stages.
BACKGROUND AND AIMS: Pre-harvest sprouting susceptibility in grain sorghum...
3rd November, 2009
IFEVA (CONICET-UBA) Facultad de Agronomia, C1417DSE, Buenos Aires, Ann Bot. 2009 Oct;104(5):975-85. Epub 2009 Jul 28.
DOI Direct Link
PYR/PYL/RACR family members are major in vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis.
Summary Abscisic acid (ABA) mediates resistance to abiotic stress and...
31st October, 2009
Division of Biological Sciences, Cell and Developmental Biology Section, Plant J. 2009 Oct 26.
DOI Direct Link
Structural basis of abscisic acid signalling.
The phytohormone abscisic acid (ABA) mediates the adaptation of plants to...
27th October, 2009
[1] Department of Applied Biological Chemistry, Graduate School of Nature. 2009 Oct 23.
DOI Direct Link
Protein Phosphatases 2C Regulate the Activation of the Snf1-Related Kinase OST1 by Abscisic Acid in Arabidopsis.
The plant hormone abscisic acid (ABA) orchestrates plant adaptive...
27th October, 2009
Centre National de la Recherche Scientifique, Institut des Sciences du Plant Cell. 2009 Oct 23.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7038111 Method for increasing stress tolerance in plants
7009590 Display apparatus and display method
6852906 Assay for measuring enzyme activity in vivo
6808874 Methods of monitoring enzyme activity

View more patents.

ABI1 results (if any) from reagent suppliers

Google CSE Logo
A5106 Anti-ABI1 antibody produced in rabbit ~1.5 mg/mL, affinity ...
A5106 Anti-ABI1 antibody produced in rabbit ~1.5mg/mL, affinity isolated antibody, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=A510...

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Abi-1 (T-15) Antibody sc-20323
See how others have used Abi-1 (T-15): sc-20323 antibody and or Abi-1 (T-15) ... Western blot analysis of Abi-1 expression in HeLa whole cell lysate. ...
http://www.scbt.com/datasheet-20323-abi-1-t-15-antibody.html...

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ABI1 Antibody Bethyl Laboratories
Abl interactor 1 (ABI1) interacts with the ABL1 and/or ABL2 nonreceptor tyrosine kinases and is involved in Ras to Rac signal transduction. ...
http://www.bethyl.com/product/A301-197A/ABI1_Antibody/AAAAAA...

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Abi Antibody / Abi Antibodies
Abi-1 (H-80) Antibody, sc-30038, rabbit IgG, 271-350 (h), WB, IP, IF, ELISA ... Abi-1 (2B82) Antibody, sc-69990, mouse IgG2b, FL (h), discontinued, m, r, h ...
http://www.scbt.com/table-abi.html...

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Anti-ABI1 (A5106) - Data Sheet
Anti-ABI1 specifically recognizes human and rat ABI1 by immunoblotting (~65 kDa) . ... specific activities.7,8 ABI1 is essential for the formation ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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Abi-1 siRNA (h) sc-40306
Click here for details. suitable control antibody: Abi-1 (T-15): sc-20323; sqRT- PCR Primer also available: Abi-1 (h)-PR: sc-40306-PR, 20 µl ...
http://www.scbt.com/datasheet-40306-abi-1-sirna-h.html...

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Anti-Nap1 (N-terminal) (N3788) - Data Sheet
Nap1 along with Sra1 and Abi1 is involved in stabilizing. WAVE2. Removal of Nap1 or Sra1 by RNAi ... Nap1 interacts directly with Abi1. It has been shown ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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