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CDH3


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Symbol:CDH3
Name(s):cadherin 3, type 1, P-cadherin (placental)
Type:protein-coding
Organism:Homo sapiens
Synonyms:CDHP, HJMD, PCAD
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18329483 This preliminary study provides evidence that the CK19/EpCAM2 and/or CK19/P-cadherin ratio(s) may be a simple and accurate prognostic indicator of clinical outcome in early-stage adenocarcinoma of the lung.
18074863 P-cadherin may be regarded as an additional immunohistochemical marker of basal-like breast carcinomas.
15805154 In summary, we have ascertained a third gene associated with ectrodactyly and have demonstrated a hitherto unrecognised role of CDH3 in shaping the human hand
15375751 An absent P-cadherin expression could constitute a hallmark of aggressive biological behaviour in oral squamous cell carcinoma.
12112590 may play a central role in the development of endometriosis by mediating endometrial-peritoneal cell interactions in a homophilic manner
12919105 Inappropriate PCAD expression in mouse mammary epithelium is compatible with normal mammary gland function.
12021924 results point to the close relationship between the de novo expression of P-cadherin and the disruption of the cadherin/catenins complex with the squamoid phenotype of mucoepidermoid carcinoma of the thyroid (MECT)
16115928 P-cadherin expression was strongly associated with tumor aggressiveness, being a good indicator of clinical outcome, and the aberrant expression of P-cadherin in breast cancer might be regulated by gene promoter hypomethylation.
12800191 Regulated expression of P-cadherin/beta-catenin complexes in ovarian tumor cells may represent a key step in disease progression
11891861 high levels of 80 kDa sP-cadherin in human milk.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCadherin 3catenin, delta 1 isoform 1B--Pubmed
HPRDCadherin 3catenin, beta 1, 88kDa--Pubmed
HPRDcadherin 3, type 1 preproproteinBeta catenin--Pubmed
HPRDcadherin 3, type 1 preproproteinCatenin, delta 1--Pubmed
HPRDcadherin 3, type 1 preproproteincadherin 3, type 1 preproprotein--Pubmed

Recent Publications on CDH3:

Pubmed Logo
BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer.
Expression profiling of BRCA1-deficient tumours has identified a pattern...
3rd November, 2009
Department of Oncology, Centre for Cancer Research and Cell Biology, Breast Cancer Res Treat. 2009 Oct 31.
DOI Direct Link
Molecular characterization of cultured adult human liver progenitor cells.
Hepatic progenitor cells hold great promise as a self-renewing cell source...
31st October, 2009
Max Planck Institute for Molecular Genetics, Vertebrate Genomics, Tissue Eng Part C Methods. 2009 Oct 29.
DOI Direct Link
Frequent CDH3 demethylation in advanced gastric carcinoma.
BACKGROUND: We recently found that CDH3 was frequently demethylated in...
23rd October, 2009
Department of Surgery, Showa University Fujigaoka Hospital, 1-30 Anticancer Res. 2009 Oct;29(10):3945-7.
Regulated expression of a transgene introduced on an oriP/EBNA-1 PAC shuttle vector into human cells.
BACKGROUND: Sequencing of the human genome has led to most genes being...
20th October, 2009
Department of Medical Genetics, Ulleval University Hospital and Faculty of BMC Biotechnol. 2009 Oct 16;9:88.
DOI Direct Link
Demethylation of the CDH3 gene is frequently detected in advanced colorectal cancer.
BACKGROUND: Recently, it has been proven that the CDH3 promoter was...
25th September, 2009
Department of Surgery, Showa University Fujigaoka Hospital, Aoba-ku, Anticancer Res. 2009 Jun;29(6):2215-7.

View more research publications.

Clinical Trials:

Clinical Trials Logo
Differential Regulation of VEGF, Cadherin, Angiopietin 2 by Trigger Oocyte Maturation With GnRHa vs hCG in Donors

Patents:

Patents logo
US Patent No.Title
7411037 Polypeptides encoded by a nucleic acid underexpressed in melanoma
7427667 PRO9835 antibodies
7429640 PRO6181 polypeptides
7429641 PRO9830 polypeptides
7432345 PRO1475 polypeptide

View more patents.

CDH3 results (if any) from reagent suppliers

Google CSE Logo
CDH3 Antibody (N-term)
Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with CDH3 antibody (N-term) (Cat.#AP1499a), which was peroxidase-conjugated to
...
http://www.abgent.com/products/catalog_no/AP1499a_CDH3_Antib...

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C1821 Monoclonal Anti-Pan Cadherin antibody produced in mouse ...
CDH1(999), CDH2(1000), CDH3(1001). rat ... Cdh1(83502), Cdh2(83501), Cdh3(116777 ). mouse ... Cdh1(12550), Cdh2(12558), Cdh3(12560). shipped in, dry ice ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C182...

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Abgent - Stem Cell
AP1498b, CDH2 Antibody (C-term), WB, E, H. AP1499b, CDH3 Antibody (C-term), WB, IHC, E, H. AP1499aNEW, CDH3 Antibody (N-term), IHC, E, H ...
http://www.abgent.com/products/category/stem_cell...

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P-cadherin (H-105) Antibody sc-7893
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, CDH3, 1001, 16q22.1, NM_001793 ...
http://www.scbt.com/datasheet-7893-p-cadherin-h-105-antibody...

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P Cadherin antibody, P Cadherin [NCC-CAD-299] Antibody, Mouse ...
Disease: Defects in CDH3 are the cause of hypotrichosis with juvenile macular dystrophy (HJMD) [MIM:601553]. HJMD is a rare autosomal recessive disorder ...
http://www.genwaybio.com/product_info.php?products_id=190755...

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pan-cadherin (C-19) Antibody sc-1499
Mouse, Cdh3, 12560, 8 D3, P10287, N/A. Mouse, Cdh4, 12561, 2 H4, P39038, N/A. Mouse, Cdh6, 12563, 15 A1, P97326, N/A. Ordering Information ...
http://www.scbt.com/datasheet-1499-pan-cadherin-c-19-antibod...

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CD-CY
HPA001767, Anti-CDH3 antibody produced in rabbit, affinity isolated antibody, human ... CDH3(1001), human, IHC (p), PA, pricing ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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