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UBA2


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Symbol:UBA2
Name(s):ubiquitin-like modifier activating enzyme 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:ARX, FLJ13058, HRIHFB2115, SAE2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15660128 structures of heterodimeric Sae1/Sae2-Mg.ATP and Sae1/Sae2-SUMO-1-Mg.ATP complexes

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDneural precursor cell expressed, developmentally down-regulated 8SUMO-1 activating enzyme subunit 2--Pubmed
HPRDSUMO3SUMO-1 activating enzyme subunit 2--Pubmed
BIND-SUMO-1 activating enzyme subunit 2SAE2 and an unspecified isoform of SUMO-1 form thioester bond. This interaction was modeled on a demonstrated interaction between SAE2 from an unspecified species and SUMO-1 from an unspecified species.-Pubmed
HPRDSMT3 suppressor of mif two 3 homolog 1 isoform a precursorSUMO-1 activating enzyme subunit 2--Pubmed
HPRDSUMO-1 activating enzyme subunit 2SUMO1 activating enzyme subunit 1--Pubmed
HPRDSUMO-1 activating enzyme subunit 2SUMO1 activating enzyme subunit 1--Pubmed
BINDSUMO-1 activating enzyme subunit 2SUMO1 activating enzyme subunit 1Sua1 interacts with hUba2.-Pubmed
BINDSUMO-1 activating enzyme subunit 2SUMO1 activating enzyme subunit 1SAE1 interacts with SAE2. This interaction was modeled on a demonstrated interaction between SAE1 from an unspecified species and SAE2 from an unspecified species.-Pubmed

Recent Publications on UBA2:

Pubmed Logo
Sumo-2/3-ylation following in vitro modeled ischemia is reduced in delayed ischemic tolerance.
Several recent studies suggest that sumo-2/3 modification of proteins...
8th August, 2009
Robert S. Dow Neurobiology Laboratories, Legacy Clinical Research and Brain Res. 2009 May 26;1272:71-80. Epub 2009 Mar 28.
DOI Direct Link
Molecular mimicry of SUMO promotes DNA repair.
Rad60 family members contain functionally enigmatic, integral SUMO-like...
30th May, 2009
Department of Molecular Biology, The Scripps Research Institute, La Jolla, Nat Struct Mol Biol. 2009 May;16(5):509-16. Epub 2009 Apr 12.
DOI Direct Link
Analysis of in vitro SUMOylation using bioluminescence resonance energy transfer (BRET).
We demonstrated in vitro small ubiquitin-like modifier (SUMO)-mediated...
16th May, 2009
Department of Biological Sciences, Korea Advanced Institute of Science and Biochem Biophys Res Commun. 2009 May 8;382(3):530-4. Epub 2009 Mar 14.
DOI Direct Link
Expression of genes involved in sumoylation in the Drosophila germline.
Post-translational modification of proteins by the covalent addition of...
20th March, 2009
Okazaki Institute for Integrative Bioscience, National Institute for Basic Gene Expr Patterns. 2009 Jan;9(1):50-3. Epub 2008 Aug 9.
DOI Direct Link
Performing in vitro sumoylation reactions using recombinant enzymes.
Sumoylation of proteins in vitro has evolved as an indispensable tool for...
5th February, 2009
Department of Biochemistry I, Faculty of Medicine, Georg-August, Methods Mol Biol. 2009;497:187-99.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7127591 Instruction control device and method therefor
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
6984486 Synthetic peptide of regulatory virus protein R (VPR) of human immunodeficiency virus type 1 (HIV-1) and the utilization thereof
6979551 Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents

View more patents.

UBA2 results (if any) from reagent suppliers

Google CSE Logo
UBA2 Antibody (N-term)
The anti-UBA2 Pab (Cat. #AP1065a) is used in Western blot to detect UBA2 in mouse brain tissue lysate. UBA2 Antibody (N-term) ...
http://www.abgent.com/products/catalog_no/AP1065a_UBA2_Antib...

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AOS1+UBA2 protein (ab3804) | Abcam
AOS1+UBA2 protein. E1-SUMO protein is a heterodimer consisted of human AOS1 and UBA2. The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, ...
http://www.abcam.com/AOS1-UBA2-protein-ab3804.html...

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Uba Antibody / Uba Antibodies
UBA2 (C-20) Antibody, sc-47540, goat IgG, C-terminus (h), WB, IF, ELISA, m, h. UBA2 (N-16) Antibody, sc-47542, goat IgG, N-terminus (h), WB, IF, ELISA, m, h
...
http://www.scbt.com/table-uba.html...

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pSAE1 Tubulin pSAE1 Tubulin
Gong,L., Li,B., Millas,S. and Yeh,E.T. (1999) Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin- ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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UBA2 siRNA (m) sc-61741
Click here for details. contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: UBA2 (m)-PR: sc-61741-PR, 20 µl ...
http://www.scbt.com/ja/datasheet-61741-uba2-sirna-m.html...

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Protein Modification - Ubiquitination Antibody
AP1065a, UBA2 Antibody (N-term), WB, IHC, E, H, M. AP1065c, UBA2/SAE2 Antibody ( C-term A600), WB, IHC, E, H. AP2108a, UBCE7IP4 Antibody (N-term), WB, IHC, E ...
http://www.abgent.com/products/category/protein_modification...

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Topoisomerase I antibody (ab3825) | Abcam
7 Sep 2005 ... Be aware that Uba 2 contains his-rich regions which might ... During western analysis with anti-6x-His antibodies, Uba 2 at 80 kDa might be ...
http://www.abcam.com/Topoisomerase-I-antibody-ab3825.html...

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