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SAE1


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Symbol:SAE1
Name(s):SUMO1 activating enzyme subunit 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:AOS1, FLJ3091, HSPC140, SUA1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16421094 SUMO-1 controls the protein stability and the biological function of phosducin.
15210726 SUMO conjugation is a novel regulator of Elk-1 function through the control of its nuclear-cytoplasmic shuttling.
15192080 It is revealed with an in vitro SUMO-1 and Ad4BP/SF-1 that DNA binding activity and interaction with Sox9 are unaffected.
16631117 It shows that Ubc9 interacts with SOX4 and represses its transcriptional activity independent of its SUMO-1-conjugating activity.
15660128 structures of heterodimeric Sae1/Sae2-Mg.ATP and Sae1/Sae2-SUMO-1-Mg.ATP complexes

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDRan GTPase activating protein 1SUMO1 activating enzyme subunit 1--Pubmed
HPRDSUMO3SUMO1 activating enzyme subunit 1--Pubmed
HPRDtumor protein p53SUMO1 activating enzyme subunit 1--Pubmed
HPRDSMT3 suppressor of mif two 3 homolog 1 isoform a precursorSUMO1 activating enzyme subunit 1--Pubmed
HPRDSUMO-1 activating enzyme subunit 2SUMO1 activating enzyme subunit 1--Pubmed
HPRDSUMO-1 activating enzyme subunit 2SUMO1 activating enzyme subunit 1--Pubmed
BINDSUMO-1 activating enzyme subunit 2SUMO1 activating enzyme subunit 1Sua1 interacts with hUba2.-Pubmed
BINDSUMO-1 activating enzyme subunit 2SUMO1 activating enzyme subunit 1SAE1 interacts with SAE2. This interaction was modeled on a demonstrated interaction between SAE1 from an unspecified species and SAE2 from an unspecified species.-Pubmed
HPRDSUMO1 activating enzyme subunit 1ubiquitin-conjugating enzyme E2E 3--Pubmed

Recent Publications on SAE1:

Pubmed Logo
p53 sumoylation: Mechanistic insights from reconstitution studies.
Sumoylation represents a cascade of enzymatic reactions mediated by...
20th October, 2009
Simmons Comprehensive Cancer Center and Department of Biochemistry, Epigenetics. 2009 Oct 9;4(7).
Characterization and gene expression profiling in glioma cell lines with deletion of chromosome 19 before and after microcell-mediated restoration of normal human chromosome 19.
Nearly 10% of human gliomas are oligodendrogliomas. Deletion of chromosome...
23rd June, 2009
Department of Laboratory Medicine and Pathology, Mayo Clinic and Genes Chromosomes Cancer. 2009 Oct;48(10):854-64.
DOI Direct Link
Array-CGH detection of a de novo 0.8Mb deletion in 19q13.32 associated with mental retardation, cardiac malformation, cleft lip and palate, hearing loss and multiple dysmorphic features.
We report on a 28-year old woman carrying a 0.8 Mb de novo interstitial...
29th April, 2009
Eur J Med Genet. 2009 Jan-Feb;52(1):62-6. Epub 2008 Oct 31.
DOI Direct Link
SUMO conjugation and cardiovascular development.
SUMOs (Small Ubiquitin-like modifiers) belong to a superfamily of...
8th April, 2009
Institute of Biosciences and Technology, Texas AandM Health Science Front Biosci. 2009 Jan 1;14:1219-29.
Performing in vitro sumoylation reactions using recombinant enzymes.
Sumoylation of proteins in vitro has evolved as an indispensable tool for...
5th February, 2009
Department of Biochemistry I, Faculty of Medicine, Georg-August, Methods Mol Biol. 2009;497:187-99.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
5859807 Semiconductor integrated circuit device having a controlled overdriving circuit
6292395 Source and drain sensing
6300816 Feedforward-controlled sense amplifier
6301255 ATM switching system for multicast data communication
6359825 Dynamic memory with increased access speed and reduced chip area

View more patents.

SAE1 results (if any) from reagent suppliers

Google CSE Logo
SAE1 antibody (ab56957) | Abcam
Mouse monoclonal to SAE1 . Covalent attachment of one protein to another is one of the more prominent posttranslational modifications in respect to size and ...
http://www.abcam.com/SAE1-antibody-ab56957.html...

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SAE1 Antibody (C-term)
Western blot analysis of SAE1 (arrow) using rabbit polyclonal SAE1 Antibody (C- term)(Cat.#AP1199b). 293 cell lysates (2 ug/lane) either nontransfected (Lane
...
http://www.abgent.com/products/catalog_no/AP1199b_SAE1_Antib...

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pSAE1 Tubulin pSAE1 Tubulin
SUMO moiety is transferred from SAE1/SAE2 to the active site cysteine (Cys ... SAE1 protein by western blotting in the appropriate cell lysate or extract. ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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SAE1 Antibody (C-term)
Western blot analysis of anti-SAE1 Pab (Cat. #AP2011b) in mouse lung tissue lysate. SAE1 (Arrow) was detected using purified Pab. Secondary HRP-anti-rabbit
...
http://www.abgent.com/products/catalog_no/AP2011b_SAE1_Antib...

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SAE1 proteins and peptides: Cell Biology > Proteolysis / Ubiquitin ...
SAE1 proteins and peptides. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab23106 · SAE1 peptide (3374-346) ...
http://www.abcam.com/index.html?t=49058&pt=2&c=1007&ei=&mu=r...

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SAE1 (AOS1) Antibody (N-term)
SAE1 (AOS1) Antibody (N-term). (LEFT)The AOS1 N-term polyclonal antibody (Cat. # AP2511a) is used in Western blot to detect AOS1 in mouse liver tissue lysate ...
http://www.abgent.com/products/catalog_no/AP2511a_SAE1_AOS1_...

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SAE1/SAE2
Human SAE I[1]/SAE II[2] (LAE-E I-SUMO). (Catalog # P001; P006). Description: LAE-E I-SUMO protein is a heterodimer consisted of human SAE I (SUMO-1 ...
http://www.laebio.com/P001.asp...

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