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ABCC5
| Symbol: | ABCC5 | | Name(s): | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ABC33, DKFZp686C1782, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17803828 |
analysis of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5) |
| 17540771 |
cGMP may be a physiological regulator of hyaluronan export at the level of the export MRP5 |
| 16156793 |
Plant flavonoids were able to reverse drug resistance in human cells transfected with ABCC5 |
| 17521428 |
We have isolated three novel ABCC5 splice variants and characterized their role in the regulation of ABCC5 gene expression. One ABCC5 splice variant produces a truncated ABCC5 protein isoform with thus far unknown functional properties in the retina. |
| 14507663 |
Localized in cardiac and cardiovascular myocytes as well as endothelial cells with increased expression in ischemic cardiomyopathy. MRP5-mediated cellular export may represent novel, disease-dependent pathway for cGMP removal from cardiac cells. |
| 15631998 |
MRP5 expression depends on gestational age and varies throughout the differentiation process. |
| 12646196 |
MRP1 and MRP5 increase with trophoblast maturation, suggesting a particular role for these proteins in the organ functional developmen |
| 15688370 |
Upregulation of MRP5 expression is associated with pancreatic carcinoma |
| 15861033 |
analysis of linkage disequilibrium at the nucleotide analogue transporter ABCC5 gene locus |
| 12637526 |
MRP4 and MRP5 are low affinity cyclic nucleotide transporters that may at best function as overflow pumps, decreasing steep increases in cGMP levels under conditions where cGMP synthesis is strongly induced and phosphodiesterase activity is limiting | →View more information from publications. |
Recent Publications on ABCC5: |  |
The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells.
Fasudil, an inhibitor of Rho kinase, is known to suppress tumorigenicity... | 3rd November, 2009
| Department of Thoracic Surgery, Fourth Affiliated Hospital, China Medical
| Biomed Pharmacother. 2009 Oct 17.
DOI Direct Link |
Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function.
Cytochrome P450 (P450) enzymes and ATP-binding cassette (ABC) transporters... | 29th September, 2009
| Universite Paris Descartes, Paris, France.
| Drug Metab Dispos. 2009 Jul;37(7):1528-38. Epub 2009 Apr 9.
DOI Direct Link |
Cellular efflux of cAMP and cGMP - a question about selectivity.
The present paper reviews and discusses selectivity of ABCC4 (MRP4), ABCC5... | 23rd September, 2009
| Faculty of Medicine, Institute of Medical Biology, Department of
| Mini Rev Med Chem. 2009 Jul;9(8):1009-13.
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The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group.
We explored the impact of mutations in the NOTCH1, FBW7 and PTEN genes on... | 22nd September, 2009
| Graduate Program in Cancer Biology, Wayne State University School of
| Leukemia. 2009 Aug;23(8):1417-25. Epub 2009 Apr 2.
DOI Direct Link |
Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure.
The human ATP-binding cassette (ABC) transporters ABCB1, ABCC4 and ABCC5... | 8th September, 2009
| Department of Medical Pharmacology and Toxicology, Institute of Medical
| Theor Biol Med Model. 2009 Sep 4;6:20.
DOI Direct Link |
→View more research publications. |
ABCC5 results (if any) from reagent suppliers | 
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Antibodies to Drug Efflux Pumps
ABCC5(10057), human, ICC, IHC (f), WB, pricing. M6067, Monoclonal Anti-MRP5 antibody produced in rat, M5I-1 (monoclonal), tissue culture supernatant ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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MRP5 (C-17) Antibody sc-5780
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ABCC5, 10057, 3q27.1, NM_001023587,
...
http://www.scbt.com/ko/datasheet-5780-mrp5-c-17-antibody.htm...
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Multidrug Resistance Antibodies
M6442, Monoclonal Anti-MRP5 antibody produced in rat, M5II-54, tissue culture supernatant, human ... ABCC5(10057), human, ICC, IHC (f), WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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MRP5 (C-17) Antibody sc-5780
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, ABCC5, 10057, 3q27.1, NM_001023587, ...
http://www.scbt.com/ja/datasheet-5780-mrp5-c-17-antibody.htm...
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Antibodies, Proteins and Peptides By Name (a)
ABCC4 · MA1-35682, Hu, Ms, FACS, ICC, IHC (F), WB, $625.87. ABCC5 · MA1-35683, Hu, FACS, ICC, IHC (F), WB, $625.87. ABCC5 · MA1-35684, Hu, FACS, ICC, ...
http://www.bioreagents.com/products/productLists/byNameProdu...
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MRP5 (H-100) Antibody sc-20769
Humano, ABCC5, 10057, 3q27.1, NM_001023587, NM_005688 · O15440 · 605251. Ratón, Abcc5, 27416, 16 A3, Q9R1X5, No Aplicable ...
http://www.scbt.com/es/datasheet-20769-mrp5-h-100-antibody.h...
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Blood & Coagulation System Antibodies
MA1-35682 · ABCC4, Hu, Ms, FACS, ICC, IHC (F), WB, $625.87. MA1-35683 · ABCC5, Hu, FACS, ICC, IHC (F), WB, $625.87. MA1-35684 · ABCC5, Hu, FACS, ICC, ...
http://www.bioreagents.com/products/productLists/productBrow...
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