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ACTR3


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Symbol:ACTR3
Name(s):ARP3 actin-related protein 3 homolog (yeast)
Type:protein-coding
Organism:Homo sapiens
Synonyms:ARP3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17576929 p120 depletion led to dramatic loss of cortactin and its partner, Arp3, from the cell leading edges
12429845 Results suggest that recruitment of factors by Wiskott-Aldrich Syndrome protein (WASP) and Scar1 stimulates cellular actin-based motility and actin nucleation with the Arp2/3 complex.
15741236 T-plastin increases Arp2/3-mediated actin-based movement
12200375 Platelets activate Arp2/3 complex, assemble actin, and change shape in the absence of WASp, indicating a more specialized role for WASp in these cells.
17524364 Taken together, our data suggest that Apr3 should play an important role in ATRA signal pathway.
15469433 signalling pathways leading to Arp2/3-dependent actin nucleation play an important role in Salmonella typhimurium invasion, but are not involved in intracellular Salmonella-induced actin assembly
15242766 The interaction between cortactin and Arp2/3 complex plays an important role in S1P-mediated remodeling of endothelial cells.
15279900 Arp2/3 complex genes have roles in actin organization and possibly in cancer phenotypes
16004967 These results indicate that interaction between the Arp2/3 complex and WASP stimulates actin polymerization and integrin beta-1-mediated adhesion during MCP-1-induced chemotaxis of THP-1 cells.
12464680 Arp2/3 complex contribution to actin filament nucleation in platelets and fibroblasts importantly requires free barbed ends generated by severing and uncapping.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCDC42ARP3 actin-related protein 3 homolog--Pubmed
HPRDcell division cycle 42 isoform 1Actin related protein 3--Pubmed
HPRDCadherin 1ARP3 actin-related protein 3 homolog--Pubmed
HPRDE-cadherinActin related protein 3--Pubmed
HPRDCortactinARP3 actin-related protein 3 homolog--Pubmed
HPRDcortactin isoform aActin related protein 3--Pubmed
HPRDactin related protein 2/3 complex subunit 4 isoform aARP3 actin-related protein 3 homolog--Pubmed
BINDactin related protein 2/3 complex subunit 4 isoform aARP3 actin-related protein 3 homologArp2/3 complex subunits p20 and Arp3 interact-Pubmed
HPRDactin related protein 2/3 complex subunit 3ARP3 actin-related protein 3 homolog--Pubmed
HPRDactin related protein 2/3 complex subunit 3ARP3 actin-related protein 3 homolog--Pubmed

Recent Publications on ACTR3:

Pubmed Logo
COXPRESdb: a database of coexpressed gene networks in mammals.
A database of coexpressed gene sets can provide valuable information for a...
18th March, 2008
Human Genome Center, Institute of Medical Science, The University of Nucleic Acids Res. 2008 Jan;36(Database issue):D77-82. Epub 2007 Oct 11.
DOI Direct Link
p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin.
The armadillo-family protein, p120 catenin (p120), binds to the...
16th January, 2008
*Department of Molecular Cell Biology, The Weizmann Institute of Science, Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10882-7. Epub 2007 Jun 18.
DOI Direct Link
SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis.
Multiple modes of endocytosis require actin-dependent remodeling of the...
19th August, 2007
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA Dev Cell. 2007 Jul;13(1):43-56.
DOI Direct Link
Helicobacter pylori CagA induces AGS cell elongation through a cell retraction defect that is independent of Cdc42, Rac1, and Arp2/3.
Helicobacter pylori, which infects over one-half the world's population,...
11th April, 2007
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, Infect Immun. 2007 Mar;75(3):1203-13. Epub 2006 Dec 28.
DOI Direct Link
MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE2.
Motility-related protein-1 (MRP-1/CD9) is involved in cell motility. We...
11th November, 2006
The Second Department of Surgery, Faculty of Medicine, Kagawa University, Oncogene. 2006 Oct 19;25(49):6480-8. Epub 2006 May 8.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598031 Method for the detection of gene transcripts in blood and uses thereof
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7231586 Multi-rate viterbi decoder

View more patents.

ACTR3 results (if any) from reagent suppliers

Google CSE Logo
ACTR3 monoclonal antibody (M02)
ACTR3 (AAH44590, 1 a.a. ~ 419 a.a) full length recombinant protein with GST ... Immunofluorescence of monoclonal antibody to ACTR3 (AT1035a) on HeLa cell . ...
http://www.abgent.com/products/catalog_no/AT1035a_ACTR3_mono...

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A5979 Monoclonal Anti-ARP3 antibody produced in mouse clone FMS338 ...
isotype, IgG2b. Gene Information, human ... ACTR3(10096). rat ... Actr3(81732). mouse ... Actr3(74117). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=A597...

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Arp3 (H-110) Antibody sc-15390
Human, ACTR3, 10096, 2q14.1, NM_005721 · P61158 · 604222. Human, ACTR3B, 57180, 7q36.1, NM_001040135, NM_020445 · NP_001035225 ...
http://www.scbt.com/datasheet-15390-arp3-h-110-antibody.html...

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Abgent - Cell and Structure Antibodies - Cell_structure
AT1034aNEW, ACTR2 monoclonal antibody (M01), ELISA,IHC-P,S-ELISA,WB-Ce,WB-Re, H. AT1035aNEW, ACTR3 monoclonal antibody (M02), ELISA,IF,IHC-P,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function/cell_s...

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Arp3 siRNA (h) sc-29739
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ACTR3, 10096, 2q14.1, NM_005721 ...
http://www.scbt.com/datasheet-29739-arp3-sirna-h.html...

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Arp3 (H-110) Antibody sc-15390
Ratón, Actr3, 74117, 1 E3, Q99JY9, No Aplicable. Ratón, Actr3b, 242894, 5 A3, Q641P0, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-15390-arp3-h-110-antibody.h...

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Arp3 (H-110) Antibody sc-15390
人类, ACTR3, 10096, 2q14.1, NM_005721 · P61158 · 604222. 人类, ACTR3B, 57180, 7q36.1, NM_001040135, NM_020445 · NP_001035225 ...
http://www.scbt.com/zh/datasheet-15390-arp3-h-110-antibody.h...

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