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ACTR2


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Symbol:ACTR2
Name(s):ARP2 actin-related protein 2 homolog (yeast)
Type:protein-coding
Organism:Homo sapiens
Synonyms:ARP2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17459058 High mRNA levels of Arp2 were significantly associated with liver metastasis of colorectal cancer.
12429845 Results suggest that recruitment of factors by Wiskott-Aldrich Syndrome protein (WASP) and Scar1 stimulates cellular actin-based motility and actin nucleation with the Arp2/3 complex.
15741236 T-plastin increases Arp2/3-mediated actin-based movement
16638851 Coexpression of Arp2 and WAVE2 is correlated with poorer patient outcome.
12200375 Platelets activate Arp2/3 complex, assemble actin, and change shape in the absence of WASp, indicating a more specialized role for WASp in these cells.
15469433 signalling pathways leading to Arp2/3-dependent actin nucleation play an important role in Salmonella typhimurium invasion, but are not involved in intracellular Salmonella-induced actin assembly
15242766 The interaction between cortactin and Arp2/3 complex plays an important role in S1P-mediated remodeling of endothelial cells.
16004967 These results indicate that interaction between the Arp2/3 complex and WASP stimulates actin polymerization and integrin beta-1-mediated adhesion during MCP-1-induced chemotaxis of THP-1 cells.
12672817 cortactin links receptor endocytosis to actin polymerization by binding both CD2AP and the Arp2/3 complex, which may facilitate the trafficking of internalized growth factor receptors
12464680 Arp2/3 complex contribution to actin filament nucleation in platelets and fibroblasts importantly requires free barbed ends generated by severing and uncapping.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDActin alpha, cardiac muscleactin-related protein 2 isoform b--Pubmed
HPRDcardiac muscle alpha actin 1 proproteinActin related protein 2--Pubmed
HPRDhematopoietic cell-specific Lyn substrate 1actin-related protein 2 isoform b--Pubmed
HPRDhematopoietic cell-specific Lyn substrate 1actin-related protein 2 isoform b--Pubmed
BINDactin related protein 2/3 complex subunit 5actin-related protein 2 isoform bArp2/3 complex subunits p16 and Arp2 interact-Pubmed
HPRDactin related protein 2/3 complex subunit 4 isoform aactin-related protein 2 isoform b--Pubmed
BINDactin related protein 2/3 complex subunit 4 isoform aactin-related protein 2 isoform bArp2/3 complex subunits p20 and Arp2 interact-Pubmed
HPRDactin related protein 2/3 complex subunit 3actin-related protein 2 isoform b--Pubmed
HPRDactin related protein 2/3 complex subunit 3actin-related protein 2 isoform b--Pubmed
HPRDactin related protein 2/3 complex subunit 1Bactin-related protein 2 isoform b--Pubmed

Recent Publications on ACTR2:

Pubmed Logo
Newly identified cytoskeletal components are associated with dynamic changes of podocyte foot processes.
BACKGROUND: Proteinuria, one of the main manifestations of nephrotic...
21st July, 2009
1Department of Pediatrics, Peking University First Hospital, Beijing Nephrol Dial Transplant. 2009 Nov;24(11):3297-305. Epub 2009 Jul 17.
DOI Direct Link
SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis.
Multiple modes of endocytosis require actin-dependent remodeling of the...
19th August, 2007
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA Dev Cell. 2007 Jul;13(1):43-56.
DOI Direct Link
Helicobacter pylori CagA induces AGS cell elongation through a cell retraction defect that is independent of Cdc42, Rac1, and Arp2/3.
Helicobacter pylori, which infects over one-half the world's population,...
11th April, 2007
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, Infect Immun. 2007 Mar;75(3):1203-13. Epub 2006 Dec 28.
DOI Direct Link
MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE2.
Motility-related protein-1 (MRP-1/CD9) is involved in cell motility. We...
11th November, 2006
The Second Department of Surgery, Faculty of Medicine, Kagawa University, Oncogene. 2006 Oct 19;25(49):6480-8. Epub 2006 May 8.
DOI Direct Link
Coexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline-homologous protein 2 in adenocarcinoma of the lung.
PURPOSE: Highly invasive and metastatic cancer cells, such as...
31st October, 2006
Department of Diagnostic Pathology, Tokyo Medical University, Tokyo, Clin Cancer Res. 2006 Apr 15;12(8):2449-54.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
6759039 Culturing pancreatic stem cells having a specified, intermediate stage of development
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
7101546 In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development

View more patents.

ACTR2 results (if any) from reagent suppliers

Google CSE Logo
A1232 Anti-ACTR2 (331-345) antibody produced in rabbit IgG ...
A1232 Anti-ACTR2 (331-345) antibody produced in rabbit IgG fraction of antiserum , buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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Abgent - Cell and Structure Antibodies - Cell_structure
AP6533bNEW, ACTR2 Antibody (C-term), WB, E, H ... AT1034a, ACTR2 monoclonal antibody (M01), ELISA,IHC-P,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function/cell_s...

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Search Results
Anti-ACTR2 (52-65) antibody produced in rabbit (1). Synonym: Anti-Actin-related protein 2 isoform b ... Anti-ACTR2 (331-345) antibody produced in rabbit (1) ...
http://www.sigmaaldrich.com/catalog/search/SearchResultsPage...

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Arp2 (K-15) Antibody sc-10127
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, ACTR2, 10097, 2p14, NM_001005386, ...
http://www.scbt.com/datasheet-10127-arp2-k-15-antibody.html...

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Activin Receptor Type IIA antibody [149/1] - BSA and Azide free ...
Monoclonal antibodies that recognize the type-2 activin receptor, ACTR2. Hybridoma 13:199-203 (1994). PubMed: 7927363 McCarthy SA & Bicknell R Activin-A
...
http://www.abcam.com/Activin-Receptor-type-II-antibody-149-1...

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