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WASF2
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17591693 |
Results decribe a mechanism in which signals from the T cell receptor produce WAVE2-ARP2/3-mediated de novo actin polymerization, leading to integrin clustering and high-affinity binding through the recruitment of vinculin and talin. |
| 17459058 |
Colocalization of Arp2 and WAVE2 is an independent risk factor for liver metastasis of colorectal carcinoma. |
| 17020969 |
WAVE2 expression is elevated in HCC tissues, which correlates with a poor prognosis, suggesting WAVE2 as a candidate prognostic marker of HCC. |
| 15107862 |
Results suggest that phosphatidylinositol (3,4,5)-triphosphate recruits WAVE2 to the polarized membrane and that this recruitment is essential for lamellipodium formation at the leading edge. |
| 16638851 |
Coexpression of Arp2 and WAVE2 is correlated with poorer patient outcome. |
| 15070726 |
reconstitution of the Wave-2 complex and a study of the molecular architecture |
| 16401421 |
WAVE2 is a key component of the actin regulatory machinery in T cells and that it also participates in linking intracellular calcium store depletion to calcium release-activated calcium (CRAC) channel activation. |
| 15670045 |
WAVE-2 and WAVE-3 expression was not changed by the megakaryocytic differentiation; WAVE-1 and WAVE-2 moved from a detergent-soluble cytosolic fraction to insoluble cytoskeleton fraction after platelet aggregation |
| 15048123 |
The WAVE2-Abi1-Nap1-PIR121 complex is as active as the WAVE2-Abi1 sub-complex in stimulating Arp2/3, and after Rac activation it is re-localized to the leading edge of ruffles in vivo. |
| 16702231 |
Therefore, IRSp53 optimizes the activity of the WAVE2 complex in the presence of activated Rac and PIP(3). | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Bruton's tyrosine kinase | WAS protein family, member 2 | - | - | Pubmed |
| HPRD | Bruton agammaglobulinemia tyrosine kinase | Wiskott Aldrich syndrome protein family, member 2 | - | - | Pubmed |
| HPRD | CDC42 | WAS protein family, member 2 | - | - | Pubmed |
| HPRD | cell division cycle 42 isoform 1 | Wiskott Aldrich syndrome protein family, member 2 | - | - | Pubmed |
| HPRD | Dedicator of cytokinesis 1 | WAS protein family, member 2 | - | - | Pubmed |
| HPRD | dedicator of cytokinesis 1 | Wiskott Aldrich syndrome protein family, member 2 | - | - | Pubmed |
| HPRD | Fyn | WAS protein family, member 2 | - | - | Pubmed |
| HPRD | protein-tyrosine kinase fyn isoform a | Wiskott Aldrich syndrome protein family, member 2 | - | - | Pubmed |
| HPRD | Grb2 | WAS protein family, member 2 | - | - | Pubmed |
| HPRD | growth factor receptor-bound protein 2 isoform 1 | Wiskott Aldrich syndrome protein family, member 2 | - | - | Pubmed |
Recent Publications on WASF2: |  |
The FOXF2 pathway in the human prostate stroma.
BACKGROUND: Forkhead box 2 (FOXF2) is a member of the large family of... | 24th September, 2009
| Department of Urology, Josephine Nefkens Institute, Erasmus MC, Rotterdam,
| Prostate. 2009 Oct 1;69(14):1538-47.
DOI Direct Link |
cDNA microarray reveals the alterations of cytoskeleton-related genes in osteoblast under high magneto-gravitational environment.
The diamagnetic levitation as a novel ground-based model for simulating a... | 22nd September, 2009
| Key Laboratory for Space Bioscience and Biotechnology, Faculty of Life
| Acta Biochim Biophys Sin (Shanghai). 2009 Jul;41(7):561-77.
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Rac-mediated macropinocytosis is a critical route for naked plasmid DNA transfer in mice.
We have recently discovered the potential for in vivo naked plasmid DNA... | 18th September, 2009
| Graduate School of Biomedical Sciences, Nagasaki University, 1-14
| Mol Pharm. 2009 Jul-Aug;6(4):1170-9.
DOI Direct Link |
The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.
The Rho GTPase family members play essential roles in hematopoiesis. Of... | 25th July, 2009
| Division of Stem Cell Therapy, Center for Stem Cell and Regenerative
| Stem Cells. 2009 May;27(5):1120-9.
DOI Direct Link |
BetaPIX and GIT1 regulate HGF-induced lamellipodia formation and WAVE2 transport.
Formation of lamellipodia is the first step during cell migration, and... | 16th May, 2009
| Molecular Cell Biology Division, Kanagawa Cancer Center Research
| Biochem Biophys Res Commun. 2009 May 8;382(3):614-9. Epub 2009 Mar 19.
DOI Direct Link |
→View more research publications. |
WASF2 results (if any) from reagent suppliers | 
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WASF2 proteins and peptides: Cancer > Signal transduction > Other ...
WASF2 proteins and peptides. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab48672 · WASF2 peptide ...
http://www.abcam.com/index.html?t=196238&pt=2&c=4295&ei=&mu=...
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WASP Antibody #4860
WAVE-2 (WASF2) is widely distributed, while WAVE-1 and WAVE-3 are strongly expressed in brain (5). WAVE-3 may act as a tumor suppressor in neuroblastoma,
...
http://www.cellsignal.com/products/4860.html...
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WAVE2 (C-14) Antibody sc-10394
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, WASF2, 10163, 1p36.11, NM_006990 ...
http://www.scbt.com/datasheet-10394-wave2-c-14-antibody.html...
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Abgent - Cell and Structure Antibodies - Cell_structure
AT4525aNEW, WASF2 monoclonal antibody (M01), ELISA,WB-Ce, H. AT4526aNEW, WASF2 monoclonal antibody (M02), ELISA,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function/cell_s...
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Abcam antibodies and reagents product map
... Testin proteins and peptides (1) · WASF2 antibodies (2) · WASF2 proteins and peptides (1) · WASP antibodies (10) · WASP proteins and peptides (3) ...
http://www.abcam.com/index.html?c=2105...
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WAVE (H-180) Antibody sc-5557
Human, WASF1, 8936, 6q21, NM_001024934, NM_001024935, NM_001024936, NM_003931 · Q92558 · 605035. Human, WASF2, 10163, 1p36.11, NM_006990 · Q9Y6W5 ...
http://www.scbt.com/ko/datasheet-5557-wave-h-180-antibody.ht...
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Abcam antibodies and reagents product map
... TRAF2 proteins and peptides (3) · WASF2 antibodies (2) · WASF2 proteins and peptides (1) · WNT2 antibodies (1) · WNT2 proteins and peptides (1) ...
http://www.abcam.com/index.html?pageconfig=productmap&cl=228...
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