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CDK2

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Symbol:	CDK2
Name(s):	cyclin-dependent kinase 2
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	p33(CDK2)
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
18281541	Observational study of gene-disease association. (HuGE Navigator)
17409409	Observational study of gene-disease association. (HuGE Navigator)
18174243	Observational study of gene-disease association. (HuGE Navigator)
18156799	cdk2 activity is necessary for the survival of human DLBCL.
18042686	The conserved rigid regions are important for nucleotide binding, catalysis, and substrate recognition; most flexible regions correlate with those where large conformational changes occur during CDK2 regulation processes.
16912201	Breast cancer cells lacking cancer predisposition genes BRCA1 are more sensitive to CDK2 inhibitors.
17713927	Phosphorylation on a conserved Thr14 can inhibit activities of both the kinases, but phosphorylating another conserved Tyr15, however, can lead to totally opposite inhibition and stimulation consequences in CDK2 and CDK5.
14551212	CDK2 activation process through phosphorylation is examined using 2D PAGE
17038621	functional interaction between CDK2 and FOXO1 provides a mechanism that regulates apoptotic cell death after DNA strand breakage
12954644	Inhibition of Cdk2 by 1,25-(OH)2D3 may thus involve two mechanisms: 1) reduced nuclear Cdk2 available for cyclin binding and activation and 2) impairment of cyclin E-Cdk2-dependent p27 degradation through cytoplasmic mislocalization of Cdk2.
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	Bcl 2	cyclin-dependent kinase 2 isoform 1	-	-	Pubmed
HPRD	B-cell lymphoma protein 2 alpha isoform	Cyclin dependent kinase 2	-	-	Pubmed
BIND	breast cancer 1, early onset isoform 1	cyclin-dependent kinase 2 isoform 1	BRCA1 associates with CDK2	-	Pubmed
HPRD	Cyclin A2	cyclin-dependent kinase 2 isoform 1	-	-	Pubmed
BIND	cyclin A	-	CDK2 interacts with CCNA2 (cyclin A) to form a complex.	-	Pubmed
BIND	cyclin A	-	CCNA2 (cyclin A) interacts with Cdk2.	-	Pubmed
BIND	cyclin A	-	Cyclin A interacts with cdk2.	-	Pubmed
HPRD	cyclin A	Cyclin dependent kinase 2	-	-	Pubmed
BIND	cyclin A	-	Cdk2 interacts with Cyc A.	-	Pubmed
BIND	cyclin A	cyclin-dependent kinase 2 isoform 1	Interaction between CDK2 (PDB ID: 1JST_C) and Cyclin A2 (PDB ID: 1JST_B).	-	Pubmed

Recent Publications on CDK2:
Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives. A series of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted...	3rd November, 2009	Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito	Eur J Med Chem. 2009 Oct 13. DOI Direct Link
Human testicular orphan receptor 4 enhances thyroid hormone receptor signaling. The thyroid hormone receptor (TR) and human testicular orphan receptor 4...	28th October, 2009	Department of Biochemistry, School of Medicine, Chang-Gung University,	J Cell Physiol. 2009 Oct 26. DOI Direct Link
A bi-functional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export. Sophisticated models for the regulation of mitotic entry are lacking for...	28th October, 2009	Department of Medicine, Epigenetics and Progenitor Cell Keystone Program,	Mol Cell Biol. 2009 Oct 26. DOI Direct Link
Selective upregulation of CDK2 is critical for TLR9 signaling stimulated proliferation of human lung cancer cell. Accumulating data suggested that functional TLR9 was expressed in various...	27th October, 2009	Department of Immunology, Zunyi Medical College, Guizhou, China.	Immunol Lett. 2009 Oct 22. DOI Direct Link
A relationship between p27kip1 and Skp2 following adult brain injury: implications for glial proliferation. Skp2 (S-phase-associated kinase protein-2) is involved in ubiquitination...	27th October, 2009	Nantong University, The Jiangsu Province Key Laboratory of	J Neurotrauma. 2009 Oct 23. DOI Direct Link
→View more research publications.

Press Releases on CDK2:
First Patient Dosed in Phase I Clinical Trial of Tigris Pharmaceuticals' GGTI-2418	1st May, 2009	Tigris Pharmaceuticals, Inc.	BONITA SPRINGS, Fla., May 1 /PRNewswire/ -- Tigris Pharmaceuticals, Inc., a privately held drug development company, announced today that dosing has started in a Phase I clinical trial of GGTI-2418
FDA Accepts Investigational New Drug (IND) Application for Tigris Pharmaceutical's GGTI-2418	4th March, 2009	Tigris Pharmaceuticals, Inc.	BONITA SPRINGS, Fla., March 4 /PRNewswire/ -- Tigris Pharmaceuticals, Inc., a privately held drug development company, today announced that its Investigational New Drug (IND) application for the
Tigris Pharmaceuticals Files IND Application for GGTI-2418	6th February, 2009	Tigris Pharmaceuticals, Inc.	BONITA SPRINGS, Fla., Feb. 6 /PRNewswire/ -- Tigris Pharmaceuticals, Inc., a privately held drug development company, announced today that it has filed an Investigational New Drug (IND) application

BioNews Results for CDK2 :
DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2	Oncogene: Oct 19 2009 12:07PM Matching: cdk2
Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cy	Drug Metabolism And Disposition: Oct 6 2009 7:34AM Matching: cdk2

Patents:
US Patent No.	Title
7576206	Proteasome inhibitors and methods of using the same
7588771	Microorganisms for therapy
7589101	Compounds and compositions as protein kinase inhibitors
7592342	Quinoxaline derivatives as PI3 kinase inhibitors
7592507	Method to modify cell number, architecture and yield of plants by overexpressing the E2F transcription factor
→View more patents.

CDK2 results (if any) from reagent suppliers

Cdk2 antibody (ab7954) \| Abcam Rabbit polyclonal to Cdk2. Cdk2 is a member of the Ser/Thr protein kinase family . It is highly similar to the gene products of S. cerevisiae cdc28, ... http://www.abcam.com/cdk2-antibody-ab7954.html...
Cdk2 (D-12) Antibody sc-6248 See how others have used Cdk2 (D-12): sc-6248 antibody and or Cdk2 (D-12) antibody ... Antibodies tested include phospho-specific antibody, p-Cdk2 ... http://www.scbt.com/datasheet-6248-cdk2-d-12-antibody.html...
Phospho-CDK2 (Thr160) Antibody #2561 Phospho-CDK2 (Thr160) Antibody detects endogenous levels of CDK2 only when phosphorylated at threonine 160. The antibody weakly cross-reacts with cdc2 ... http://www.cellsignal.com/products/2561.html...
The Abcam catalog Cdk2 antibodies. ... Cdk2 (phospho T14) antibody [EP2234Y]. IHC-P, ICC, WB, IP ... Cdk2 antibody [2B6] - BSA and Azide free. IHC-P, WB, ICC/IF ... http://www.abcam.com/index.html?t=14620&pt=1&c=4212...
CDK2 Antibody Specific antibody for the gene product of CDK2, the protein Cyclin-dependent kinase 2. Validated for specificity by gene-silencing with siRNA followed by ... http://www.piercenet.com/products/browse.cfm?fldID=43EFA1A3-...
Anti-Cdk2 Polyclonal Antibody Polyclonal Antibody against Cdk2 for use in Immunofluorescence, Western Blot. http://www.bioreagents.com/products/productDetails/productDe...
Purified Anti-Cdk2 Antibody - BioLegend Purified Anti-Cdk2 Antibody - Cdk2 (Cyclin dependent kinase 2) belongs to the Ser/Thr protein kinase superfamily, CDC2/CDKX subfamily, and predicted ... http://www.biolegend.com/purified-anti-cdk2-antibody-4379.ht...

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CDK2

Gene Information from Publications

Interacting gene products

Recent Publications on CDK2:

Press Releases on CDK2:

BioNews Results for CDK2

Patents:

CDK2 results (if any) from reagent suppliers