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ADAM10
| Symbol: | ADAM10 | | Name(s): | ADAM metallopeptidase domain 10 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AD10, CD156c, HsT18717, MADM, kuz | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12782344 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17965014 |
SPPL2a and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 N-terminal fragment. |
| 17895248 |
the ADAM10 prodomain inhibits betacellulin shedding, demonstrating that it could be of potential use as a therapeutic agent to treat cancer. |
| 17727679 |
In human prostate cancer, the nuclear translocation of ADAM-10 coupled with the androgen receptor is involved in tumor growth and progression. |
| 17557115 |
ADAM10 and SPPL2a were identified as two proteases implicated in FasL processing and release of the FasL intracellular domain, which has been shown to be important for retrograde FasL signaling |
| 17699774 |
ADAM10 overexpression in colon cancer cells displaying endogenous L1-CAM enhanced L1-CAM cleavage and induced liver metastasis, and ADAM10 also enhanced metastasis in colon cancer cells stably transfected with L1-CAM. |
| 14636066 |
Purified cholesterol-rich microdomains from a low-density membrane fraction demonstrate gamma-secretase/ADAM10 activity, indicating that amyloid beta protein production can take place in rafts. |
| 12782344 |
variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease |
| 12815056 |
gamma secretase is regulated by nicastrin |
| 16751190 |
ADAM10 is the protease responsible for constitutive and regulated Pcdh gamma shedding events that modulate the cell adhesion role of Pcdh gamma. | →View more information from publications. |
Recent Publications on ADAM10: |  |
ADAM10 Is the Constitutive Functional Sheddase of CD44 in Human Melanoma Cells.
CD44 proteins are cell surface receptors for hyaluronic acid (HA), a... | 31st October, 2008
| 1Department of Dermatology, Venerology and Allergology, Leipzig University
| J Invest Dermatol. 2008 Oct 30.
DOI Direct Link |
Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases.
The receptor for advanced glycation end products (RAGE) is a 55 kDa type I... | 28th October, 2008
| Institute of Biochemistry, Gutenberg University Mainz, Mainz 55099.
| J Biol Chem. 2008 Oct 24.
DOI Direct Link |
The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer.
Various surface molecules undergo regulated cleavage by the disintegrin... | 28th October, 2008
| Institute for Pharmacology and Toxicology, RWTH Aachen University,
| Semin Cell Dev Biol. 2008 Sep 18.
DOI Direct Link |
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10).
The receptor for advanced glycation endproducts (RAGE) mediates responses... | 22nd October, 2008
| San Raffaele Scientific Institute, Milan, Italy.
| FASEB J. 2008 Oct;22(10):3716-27. Epub 2008 Jul 4.
DOI Direct Link |
ADAM10 is essential for proteolytic activation of Notch during thymocyte development.
Notch signaling pathway has been shown to play essential roles in T... | 16th October, 2008
| Institute of Developmental Biology and Molecular Medicine, School of Life
| Int Immunol. 2008 Sep;20(9):1181-7. Epub 2008 Jul 17.
DOI Direct Link |
→View more research publications. |
ADAM10 results (if any) from reagent suppliers | 
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ADAM10 antibody - Aminoterminal end (ab39153) datasheet | Abcam
Rabbit polyclonal to ADAM10 - Aminoterminal end. ADAM10 is a member of the ADAM (a disintegrin and metalloprotease like domain) family.
http://www.abcam.com/ab39153...
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GTX11533-ADAM10 antibody-GeneTex Inc.
ADAM10 antibody A2726-100UG GTX11533 GTX11533 Rabbit polyclonal to ADAM10 102 | ADAM10 | 602192 | O14672 | HsT18717 | MADM | kuz | ADAM10 antibody ...
http://www.genetex.com/commerce/catalog/product.jsp?product_...
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ADAM10 antibodies | Abcam
ADAM10 antibody - Prohormone convertase region. WB, ICC/IF ... ADAM10 antibody [ 11G2] - Azide free. Flow Cyt, IP, WB. Mouse monoclonal ...
http://www.abcam.com/index.html?t=6412&pt=1&c=4261...
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mouse/rat/human ADAM10 (CDw156C, KUZ, MADM) antibody: purified ...
eBioscience technical data sheet for product 14-6211 Anti-human, mouse, rat ADAM10 (CDw156C, KUZ, MADM) polyclonal Polyclonal antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_14/14-...
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ADAM10 antibody (ab1997) datasheet | Abcam
Rabbit polyclonal to ADAM10. ADAM10 is a member of the ADAM (a disintegrin and metalloprotease like domain) family. It cleaves the membrane-bound precursor ...
http://www.abcam.com/index.html?datasheet=1997...
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A3101 Anti ADAM 10 Propeptide Domain antibody produced in rabbit ...
A3101 Anti-ADAM-10, Propeptide Domain antibody produced in rabbit ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution.
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...
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ADAM10 (A-20) Antibody sc-16524
ADAM10 (A-20) P, sc-16524 P (peptide), 100 µg/0.5 ml ... ADAM10 (A-20): sc-16524 . Western blot analysis of ADAM10 expression in MH-S (A), 3T3-L1 (B), ...
http://www.scbt.com/datasheet-16524-adam10-a-20-antibody.htm...
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Anti-ADAM-10, Propeptide Domain antibody produced in rabbit (A3101 ...
propeptide domain of human ADAM10 (A Disintegrin ... the propeptide domain of ADAM10, detecting the latent. form of the enzyme. It will not recognize the ...
http://www.sigmaaldrich.com/sigma/datasheet/A3101dat.pdf...
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ADAM10 (B-3) Antibody sc-28358
ADAM10 (B-3): sc-28358. Western blot analysis of ADAM10 expression in U-937 (A), HuT 78 (B), NIH/3T3 (C), MH-S (D) and KNRK (E) whole cell lysates. ...
http://www.scbt.com/datasheet-28358-adam10-b-3-antibody.html...
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ADAM10 antibody, ADAM 10 Antibody, Rabbit IgG Polyclonal Antibody
EC 3.4.24.81; A disintegrin and metalloproteinase domain 10; Mammalian disintegrin-metalloprotease; Kuzbanian protein homolog; CDw156c antigen; ADAM10,
...
http://www.genwaybio.com/product_info.php?products_id=15039...
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