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ADAM10
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12782344 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17965014 |
SPPL2a and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 N-terminal fragment. |
| 17895248 |
the ADAM10 prodomain inhibits betacellulin shedding, demonstrating that it could be of potential use as a therapeutic agent to treat cancer. |
| 17727679 |
In human prostate cancer, the nuclear translocation of ADAM-10 coupled with the androgen receptor is involved in tumor growth and progression. |
| 17557115 |
ADAM10 and SPPL2a were identified as two proteases implicated in FasL processing and release of the FasL intracellular domain, which has been shown to be important for retrograde FasL signaling |
| 17699774 |
ADAM10 overexpression in colon cancer cells displaying endogenous L1-CAM enhanced L1-CAM cleavage and induced liver metastasis, and ADAM10 also enhanced metastasis in colon cancer cells stably transfected with L1-CAM. |
| 14636066 |
Purified cholesterol-rich microdomains from a low-density membrane fraction demonstrate gamma-secretase/ADAM10 activity, indicating that amyloid beta protein production can take place in rafts. |
| 12782344 |
variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease |
| 12815056 |
gamma secretase is regulated by nicastrin |
| 16751190 |
ADAM10 is the protease responsible for constitutive and regulated Pcdh gamma shedding events that modulate the cell adhesion role of Pcdh gamma. | →View more information from publications. |
Recent Publications on ADAM10: |  |
ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma.
ADAM10 (a disintegrin and metalloproteinase 10) is involved in the... | 30th October, 2009
| Pharmazentrum frankfurt/ZAFES, Department of Pharmacology, University
| J Invest Dermatol. 2009 Oct 29.
DOI Direct Link |
Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma.
MHC class I-related chain A (MICA) is a ligand for the NKG2D-activating... | 15th October, 2009
| Department of Gastroenterology and Hepatology, Osaka University Graduate
| Cancer Res. 2009 Oct 15;69(20):8050-7. Epub 2009 Oct 13.
DOI Direct Link |
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10.
Release of cell surface-bound ligands by A-Disintegrin-And-Metalloprotease... | 14th October, 2009
| Department of Biochemistry and Molecular Biology, Monash University,
| PLoS Biol. 2009 Oct;7(10):e1000215. Epub 2009 Oct 13.
DOI Direct Link |
Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells.
Triptolide, a diterpene triepoxide derived from Trypterygium wilfordii, is... | 29th September, 2009
| Department of Pharmacology and Department of Biochemistry and Molecular
| Cancer Biol Ther. 2009 Nov 14;8(21).
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Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alpha.
Tumor necrosis factor-alpha (TNF-alpha) is initially synthesized as a... | 22nd September, 2009
| Department of Pathomechanisms, Clinical Research Center, National Hospital
| Biochem Cell Biol. 2009 Aug;87(4):581-93.
DOI Direct Link |
→View more research publications. |
ADAM10 results (if any) from reagent suppliers | 
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ADAM10 antibody (ab1997) | Abcam
Rabbit polyclonal to ADAM10. ADAM10 is a member of the ADAM (a disintegrin and metalloprotease like domain) family. It cleaves the membrane-bound precursor ...
http://www.abcam.com/ADAM10-antibody-ab1997.html...
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ADAM10 Antibody (CT) TNFα converting enzyme
ADAM10 can be used for detection of ADAM10 by Western blot at 1:500 to 1:2000 dilution. An approximately 85 kDa band can be detected, which may represent ...
http://www.prosci-inc.com/shop/catalog1/ADAM10-Antibody-p-60...
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The Abcam catalog
ADAM10 antibodies. ... ADAM10 antibody - Aminoterminal end ... ADAM10 antibody [ 11G2] - Azide free. Flow Cyt, WB, IP. Mouse monoclonal ...
http://www.abcam.com/index.html?t=6412&pt=1&c=4261...
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ADAM10 Antibody A Disintegrin And Metalloproteinase Domain 10
ADAM10 antibody can be used for detection of ADAM10 by WB (minimum working dilution: 1:500 maximum working dilution: 1:2000), and ELISA (minimum working
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http://www.prosci-inc.com/shop/catalog1/ADAM10-Antibody-p-33...
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ADAM10 antibody - Aminoterminal end (ab39153) | Abcam
Rabbit polyclonal to ADAM10 - Aminoterminal end. ADAM10 is a member of the ADAM (a disintegrin and metalloprotease like domain) family.
http://www.abcam.com/ADAM10-antibody-Aminoterminal-end-ab391...
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Anti-ADAM-10, Prohormone Convertase Activation Site antibody ...
ADAM-10 antiserum by immuno-specific purification which removes essentially all rabbit serum ... ADAM10. Its role in neurogenesis involves processing ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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mouse/rat/human ADAM10 antibody, Affinity Purified conjugate
eBioscience technical data sheet for product 14-6211 Anti-human, mouse, rat ADAM10 (CD156C, KUZ, MADM) polyclonal Polyclonal antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_14/14-...
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