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CDK5
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18350355 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17581253 |
Results show that Cdk5, a critical signalling effector of various neurotoxic insults in the brain, is activated by EV71 infection of neuronal cells. |
| 17713927 |
Phosphorylation on a conserved Thr14 can inhibit activities of both the kinases, but phosphorylating another conserved Tyr15, however, can lead to totally opposite inhibition and stimulation consequences in CDK2 and CDK5. |
| 17491008 |
microtubules play an important role in the control of Cdk5 activation |
| 12372407 |
CDK5 binds to roscovitine in the ATP-binding pocket |
| 12387894 |
role in phosphorylation of tau protein |
| 15741232 |
an early event in neuronal cell death is p25/Cdk5-mediated retinoblastoma phosphorylation |
| 15911879 |
These data predict that the ability of cdk5 phosphorylation to protect against htt cleavage, aggregation, and toxicity is compromised in cells expressing toxic fragments of htt. |
| 17145757 |
Cdk5 kinase supports the proliferation of the medullary thyroid carcinoma cells. |
| 17045592 |
phosphorylation of tau at Thr231 and Ser262 by cdk5 plus GSK-3, which inhibits its normal biological activity, is regulated both by its amino terminal inserts and its physical state | →View more information from publications. |
Recent Publications on CDK5: |  |
Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors.
New derivatives of the marine alkaloid leucettamine B were prepared in... | 3rd November, 2009
| Universite de Rennes 1, Sciences Chimiques de Rennes, UMR CNRS 6226,
| Eur J Med Chem. 2009 Oct 12.
DOI Direct Link |
Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors.
Cyclin-dependent kinase 5 (CDK5) is a serine-threonine protein kinase that... | 30th October, 2009
| Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive,
| Bioorg Med Chem Lett. 2009 Oct 13.
DOI Direct Link |
CDK5: The "pathfinder" for new born neurons in adult hippocampus?
Neurogenesis takes place in the mammalian hippocampus throughout the whole... | 27th October, 2009
| Joint Master in Neuroscience, Faculte des Sciences de la Vie, Universite
| Cell Adh Migr. 2009 Oct 31;3(4).
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Dynamic changes of neuroskeletal proteins in DRGs underlie impaired axonal maturation and progressive axonal degeneration in type 1 diabetes.
We investigated mechanisms underlying progressive axonal dysfunction and... | 17th October, 2009
| Department of Pathology, School of Medicine, Wayne State University,
| Exp Diabetes Res. 2009;2009:793281. Epub 2009 Oct 12.
DOI Direct Link |
The role of Cdk5 in retinoic acid-induced apoptosis of cervical cancer cell line.
Cdk5 is a small serine/threonine protein kinase which belongs to Cdk... | 17th October, 2009
| Department of Life Sciences, National Chung Hsing University, Taichung
| Chin J Physiol. 2009 Feb 28;52(1):23-30.
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→View more research publications. |
CDK5 results (if any) from reagent suppliers | 
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