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CALCRL


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Symbol:CALCRL
Name(s):calcitonin receptor-like
Type:protein-coding
Organism:Homo sapiens
Synonyms:CGRPR, CRLR
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15797661 Observational study of gene-disease association. (HuGE Navigator)
18198792 There were some differences in mRNA expression for CL-R (higher) and RAMP3 (lower) in middle cerebral artery compared to coronary artery and pulmonary artery.
17785463 Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of RAMP1.
17675298 HRS mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor
17503773 A mutated RAMP1 that cannot reach the cell surface, even in the presence of CRLR, indicating that the deficient targeting resulted from the altered conformation of the complex.
17067815 Results will facilitate structural analysis of the recombinant protein will facilitate structural analysis of human RCP (receptor component protein), and allow further understanding of RCP function
11693189 Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells
12574158 receptor activity-modifying protein 1 binds to the CRLR
15245870 TNF-alpha induced time- and dose-dependent decreases in the expression of CRLR mRNA in cultured human coronary artery smooth muscle cells, thereby diminishing AM-evoked cAMP production
12684703 findings show that human skin keratinocytes and fibroblasts express adrenomedullin and its receptors L1-R and CRLR

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDadrenomedullincalcitonin receptor-like--Pubmed
HPRDcalcitonin isoform CALCA preproproteincalcitonin receptor-like--Pubmed
HPRDcalcitonin isoform CALCA preproproteincalcitonin receptor-like--Pubmed
HPRDCGRP type 1 receptorcalcitonin gene-related peptide-receptor component protein isoform a--Pubmed
HPRDcalcitonin receptor-likeRCP9--Pubmed
HPRDcalcitonin receptor-likeReceptor activity modifying protein 3--Pubmed
HPRDcalcitonin receptor-likereceptor activity modifying protein 2 precursor--Pubmed
HPRDcalcitonin receptor-likereceptor activity-modifying protein 1 precursor--Pubmed
HPRDcalcitonin receptor-likeadrenomedullin 2 precursor--Pubmed
HPRDcalcitonin receptor-likeadrenomedullin 2 precursor--Pubmed

Recent Publications on CALCRL:

Pubmed Logo
Haploinsufficiency for adrenomedullin reduces pinopodes and diminishes uterine receptivity in mice.
Adrenomedullin (AM) is a multifunctional peptide vasodilator that signals...
7th January, 2009
Department of Cell and Molecular Physiology, The University of North Biol Reprod. 2008 Dec;79(6):1169-75. Epub 2008 Aug 20.
DOI Direct Link
Adrenomedullin in the rat testis. II: Its production, actions on inhibin secretion, regulation by follicle-stimulating hormone, and its interaction with endothelin 1 in the Sertoli cell.
The present study demonstrates the expression of adrenomedullin (ADM) in...
6th June, 2008
Department of Anatomy, the Centre of Heart, Brain, Hormone, and Healthy Biol Reprod. 2008 Apr;78(4):780-5. Epub 2007 Dec 19.
DOI Direct Link
Adrenomedullin in the rat testis. I: Its production, actions on testosterone secretion, regulation by human chorionic gonadotropin, and its interaction with endothelin 1 in the leydig cell.
Based on the finding of gene expression of adrenomedullin (Adm) and its...
6th June, 2008
Department of Anatomy, the Centre of Heart, Brain, Hormone, and Healthy Biol Reprod. 2008 Apr;78(4):773-9. Epub 2007 Dec 19.
DOI Direct Link
Intermedin (adrenomedullin-2): a novel counter-regulatory peptide in the cardiovascular and renal systems.
Intermedin (IMD) is a novel peptide related to calcitonin gene-related...
29th April, 2008
Cardiovascular Research Group, School of Medicine and Dentistry, Queen's Br J Pharmacol. 2008 Mar;153 Suppl 1:S247-62. Epub 2007 Oct 29.
DOI Direct Link
Adrenomedullin signaling is necessary for murine lymphatic vascular development.
The lymphatic vascular system mediates fluid homeostasis, immune defense,...
15th April, 2008
Department of Cell and Molecular Physiology, The University of North J Clin Invest. 2008 Jan;118(1):40-50.
DOI Direct Link

View more research publications.

BioNews Results for CALCRL

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BioPortfolio Logo
Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma
MDLinx:  Oct 28 2009 3:32PM Matching: calcrl

Clinical Trials:

Clinical Trials Logo
Pituitary Derived-Intermedin is an Estrogen-Modulated Factor for Reducing Blood Pressure

Patents:

Patents logo
US Patent No.Title
7604959 Cell-based assays employing voltage and calcium dyes
7507794 Isolated soluble corticotropin releasing factor receptor type 2 (sCRFR2)
7238213 Cell-based assays employing voltage and calcium dyes
6969702 Compounds and methods for increasing neurogenesis

CALCRL results (if any) from reagent suppliers

Google CSE Logo
C3866 Anti-Calcitonin Receptor-Like Receptor antibody produced in ...
Gene Information, human ... CALCRL(10203). rat ... Calcrl(25029). mouse ... Calcrl(54598). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C386...

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CRLR (H-42) Antibody sc-30028
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CALCRL, 10203, 2q32.1, NM_005795 ...
http://www.scbt.com/datasheet-30028-crlr-h-42-antibody.html...

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RAMP3 antibody (ab56684) | Abcam
RAMP3 (receptor calcitonin activity modifying protein 3) transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane.
...
http://www.abcam.com/RAMP3-antibody-ab56684.html...

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Cell-Based GPCR Reporter Assays
Calcitonin, CALCRL: RAMP1, PDF Download · K1437, X, cAMP. Calcitonin, CALCRL: RAMP2, PDF Download · K1438, cAMP. Calcitonin, CALCRL: RAMP3, PDF Download ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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CRLR (H-42) Antibody sc-30028
Humain, CALCRL, 10203, 2q32.1, NM_005795 · Q16602 · 114190. Souris, Calcrl, 54598, 2 D, Q9R1W5, Non disponible. Produits disponibles ...
http://www.scbt.com/fr/datasheet-30028-crlr-h-42-antibody.ht...

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SelectScreen® Cell-based GPCR Profiling Services
Calcitonin, CALCRL:RAMP1, CRE-bla Freestyle 293F. Calcitonin, CALCRL:RAMP3, CRE- bla Freestyle 293F. Calcium Sensing, CaSR, Gqo5-NFAT-bla CHO-K1 ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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CRLR (V-20) Antibody sc-18007
Humano, CALCRL, 10203, 2q32.1, NM_005795 · Q16602 · 114190. camundongo, Calcrl, 54598, 2 D, Q9R1W5, N/A. Informacoes sobre ordens ...
http://www.scbt.com/pt/datasheet-18007-crlr-v-20-antibody.ht...

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