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OLIG2


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Symbol:OLIG2
Name(s):oligodendrocyte lineage transcription factor 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:BHLHB1, OLIGO2, PRKCBP2, RACK17
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17964117 We found that genetic polymorphisms in CNP (rs2070106) and OLIG2 (rs1059004 and
16891421 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17010574 Observational study of gene-disease association. (HuGE Navigator)
17283288 Observational study of gene-disease association. (HuGE Navigator)
17934761 Observational study of gene-disease association. (HuGE Navigator)
17690840 No significan correlation was found between proliferation index in pilocytic astrocytomas and Olig-2 expression.
17917751 IL-13Ralpha2 and Olig2 have been identified and confirmed to be interesting candidate genes whose differential expression likely plays a role in malignant progression of astrocytomas
17951409 OLIG2 suppresses the motile phenotype of glioblastoma cells by activating RhoA.
17431671 OLIG2 expression was predominant over ID2 expression in oligodendroglial tumors, while ID2 expression was predominant over OLIG2 expression in astrocytic tumors.
16267213 Olig1 and Olig2 transcription factors in the human central nervous system are important not only for differentiation of the oligodendrocyte lineage, but they may also have a role in neural cell specification.

View more information from publications.

Recent Publications on OLIG2:

Pubmed Logo
[Analysis of S100beta-v-erbB transgenic rats prone to brain tumors]
We established a line of transgenic rats expressing v-erbB, the viral form...
3rd November, 2009
Department of Human Pathology, Gunma University Graduate School of Brain Nerve. 2009 Jul;61(7):765-72.
[Common mechanism underlying oligodendrocyte development and oligodendrogliomagenesis]
A number of extrinsic factors and intracellular mechanisms have been...
3rd November, 2009
RIKKEN Center for Developmental Biology, Laboratory for Cell Lineage Brain Nerve. 2009 Jul;61(7):741-51.
Differentiation of spinal motor neurons from pluripotent human stem cells.
We have devised a reproducible protocol by which human embryonic stem...
20th October, 2009
Department of Anatomy and Department of Neurology, School of Medicine and Nat Protoc. 2009;4(9):1295-304. Epub 2009 Aug 20.
DOI Direct Link
Differentiation of human oligodendrocytes from pluripotent stem cells.
We have developed a four-part protocol to differentiate human embryonic...
17th October, 2009
Department of Anatomy and Neurology, School of Medicine and Public Health, Nat Protoc. 2009;4(11):1614-22. Epub 2009 Oct 15.
DOI Direct Link
Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injury.
BACKGROUND: Contusive spinal cord injury is complicated by a delayed loss...
13th October, 2009
Brain Disease Research Center, Institute for Medical Sciences, Ajou BMC Neurosci. 2009 Sep 22;10:117.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588937 Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
7150989 Telomerase immortalized neural progenitor cells
7285415 Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
7312081 Genetic demonstration of requirement for nkx6.1, nkx2.2 and nkx6.2 in ventral neuron generation
7390659 Methods for inducing differentiation of embryonic stem cells and uses thereof

View more patents.

OLIG2 results (if any) from reagent suppliers

Google CSE Logo
Olig2 antibody (ab33427) | Abcam
Rabbit polyclonal to Olig2. Olig2 (oligodendrocyte transcription factor 2) is required for oligodendrocyte and motor neuron specification in the spinal cord
...
http://www.abcam.com/olig2-antibody-ab33427.html...

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OLIG2 antibody, OLIG2 (oligodendrocyte lineage transcription ...
Buy quality rabbit OLIG2 antibody (interacts with human), anti-OLIG2, OLIG2 ( oligodendrocyte lineage transcription factor 2) antibody, rabbit polyclonal ...
http://www.genwaybio.com/product_info.php?products_id=43089...

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OLIG2 (C-17) Antibody sc-19969
OLIG2 shRNA (h) Lentiviral Particles, sc-38147-V, 200 µl ... See how others have used OLIG2 (C-17): sc-19969 antibody and or OLIG2 (C-17) antibody ...
http://www.scbt.com/datasheet-19969-olig2-c-17-antibody.html...

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Olig2 antibody (ab33427) reviews | Abcam
Rabbit polyclonal to Olig2. Olig2 (oligodendrocyte transcription factor 2) ... Olig2 antibody (ab33427). Sample. Mouse Tissue sections (Mouse forebrain E17)
...
http://www.abcam.com/index.html?pageconfig=reviews&intAbID=3...

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Immunohistochemistry : Olig2 - R&D Systems
Olig2 was detected in 7 day differentiated RCSC using 10 µg/mL goat anti-human Olig2 affinity-purified polyclonal antibody (Catalog # AF2418). ...
http://www.rndsystems.com/ihc_molecule_images.aspx?m=2491...

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OLIG Antibody / OLIG Antibodies
OLIG2 (N-17) Antibody, sc-19967, goat IgG, N-terminus (m), WB, IF, ELISA, m, r, ... OLIG2 (X-24) Antibody, sc-133869, rabbit IgG, N/A, WB, IP, ELISA, human ...
http://www.scbt.com/table-olig.html...

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Immunohistochemistry : Oligodendrocyte Marker O4 - R&D Systems
Cells were stained for Olig2 using R&D Systems NorthernLights™-637 donkey anti- goat IgG secondary antibody (red; Catalog # NL002), and stained for O4 using ...
http://www.rndsystems.com/ihc_molecule_images.aspx?m=1929...

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