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CDK7
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 11062157 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 17707548 |
These results suggested that genetic variants in CAK genes, Cdk7, cyclin H, MAT1, might modulate the risk of lung cancer in a gene-gene interaction mode, which consist to the biochemical interaction of corresponding proteins. |
| 17628022 |
Retinoic-acid-induced RAR-CAK signaling events appear to proceed intrinsically during granulocytic development of normal primitive hematopoietic cells. ALDH-governed RA availability may mediate this process by initiating RAR-CAK signaling. |
| 17012222 |
The reduced CDK7 kinase activity is responsible for the inactivation of CDC2/p34 kinase and the irreversible G(2)/M phase cell-cycle arrest of a human gastric carcinoma cell line. |
| 15695176 |
Confocal microscopy revealed the co-localization of PKC-iota with CAK/cdk7 in both the cytoplasm and nucleus of U-373 MG glioma cells, supporting its role in cell signaling |
| 15530371 |
determined the crystal structure of human CDK7 in complex with ATP at 3 A resolution |
| 16327805 |
Cdk7 accomplishes dual functions in cell-cycle control and transcription not through promiscuity but through distinct, stringent modes of substrate recognition. |
| 12140753 |
The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H. |
| 17386261 |
Different modes of CDK activation by Cdk7 at two distinct execution points in the cell cycle. |
Recent Publications on CDK7: |  |
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
BACKGROUND: Dysregulation of the cell cycle is a hallmark of many cancers... | 29th October, 2009
| Department of Laboratory Medicine and Pathology, Mayo Clinic College of
| Br J Cancer. 2009 Oct 20;101(8):1461-8. Epub 2009 Sep 8.
DOI Direct Link |
The NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5.
NuA4, the major H4 acetyltransferase (KAT) complex in budding yeast, is... | 14th October, 2009
| Laboratory of Gene Regulation and Development, National Institute of Child
| Mol Cell Biol. 2009 Oct 12.
DOI Direct Link |
Inhibition of CDKS by roscovitine suppressed LPS-induced *NO production through inhibiting NFkappaB activation and BH4 biosynthesis in macrophages.
In inflammatory diseases, tissue damage is critically associated with... | 6th October, 2009
| Division of Pediatric Surgery, Department of Surgery, Medical College of
| Am J Physiol Cell Physiol. 2009 Sep;297(3):C742-9. Epub 2009 Jun 24.
DOI Direct Link |
Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.
The homologous cyclin-dependent kinases (CDK) CDK4 and CDK6 integrate... | 26th September, 2009
| Institute of Interdisciplinary Research, Universite Libre de Bruxelles,
| Mol Cell Biol. 2009 Aug;29(15):4188-200. Epub 2009 Jun 1.
DOI Direct Link |
The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity.
Normal progression through the cell cycle requires the sequential action... | 12th September, 2009
| Department of Oncology and Chemistry, Imperial College London, London,
| Cancer Res. 2009 Aug 1;69(15):6208-15. Epub 2009 Jul 28.
DOI Direct Link |
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