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M6PRBP1


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Symbol:M6PRBP1
Name(s):mannose-6-phosphate receptor binding protein 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC11117, MGC2012, PP17, TIP47
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17003132 These results show that TIP47 is a cellular cofactor that plays an essential role in Env incorporation, allowing the encounter and the physical association between HIV-1 Gag and Env proteins during the viral assembly process.
12631276 Data show that placental protein 17b (PP17b)is a neutral lipid droplet-associated protein, and its expression is regulated by PKC- and PKA-dependent pathways
12768012 TIP47 binding to HIV-1 envelope glycoprotein (ENV) is required for ENV transport to the trans-golgi network and for its incorportaion into virions and its pathogenicity
15545278 TIP47 and adipophilin are components of many, but not all, the lipid droplets in THP-1 cells
16741517 we report the identity of an inhibitor, TIP47, which prevents retinylester hydrolysis catalyzed by GS2 lipase and hormone-sensitive lipase
12077142 can co-localize with lipid storage proteins
15456905 Rab9 GTPase stability on late endosomes required interaction with TIP47
16769818 Binding of the effector protein TIP47 is important for Rab9 localization.
16808905 The results suggested that the putative hydrophobic cleft is critical for the unique characteristics of TIP47.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDIGF II receptormannose 6 phosphate receptor binding protein 1--Pubmed
HPRDinsulin-like growth factor 2 receptorTIP47--Pubmed
BINDinsulin-like growth factor 2 receptormannose 6 phosphate receptor binding protein 1M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).-Pubmed
BINDinsulin-like growth factor 2 receptormannose 6 phosphate receptor binding protein 1M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).-Pubmed
BINDinsulin-like growth factor 2 receptormannose 6 phosphate receptor binding protein 1M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).-Pubmed
BINDinsulin-like growth factor 2 receptormannose 6 phosphate receptor binding protein 1M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).-Pubmed
BINDinsulin-like growth factor 2 receptormannose 6 phosphate receptor binding protein 1M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR).-Pubmed
BINDinsulin-like growth factor 2 receptormannose 6 phosphate receptor binding protein 1TIP47 interacts with CI-MPR. This interaction was modeled on a demostrated interaction between a modified synthetic peptide representing human TIP47 and CI-MPR from an unspecified species.-Pubmed
BINDcation-dependent mannose-6-phosphate receptor precursormannose 6 phosphate receptor binding protein 1M6PRBP1 (TIP47) interacts with M6PR (CD-MPR).-Pubmed
BINDcation-dependent mannose-6-phosphate receptor precursormannose 6 phosphate receptor binding protein 1M6PRBP1 (TIP47) interacts with M6PR (CD-MPR).-Pubmed

Recent Publications on M6PRBP1:

Pubmed Logo
Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus.
SETTING: A disordered lipid metabolism is implicated in the development of...
21st October, 2009
NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of J Clin Endocrinol Metab. 2009 Oct;94(10):4077-85. Epub 2009 Jul 14.
DOI Direct Link
Coatomer-dependent protein delivery to lipid droplets.
Lipid droplets (LDs) are cytoplasmic organelles that store neutral lipids...
15th September, 2009
Cell Biology and Metabolism Program, Eunice Kennedy Shriver National J Cell Sci. 2009 Jun 1;122(Pt 11):1834-41.
DOI Direct Link
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
The PAT family of lipid droplet proteins includes 5 members in mammals:...
11th September, 2009
Center for Diabetes and Obesity Research, Brown Foundation Institute of Biochim Biophys Acta. 2009 Jun;1791(6):419-40. Epub 2009 Apr 16.
DOI Direct Link
RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport.
Rho GTPases are key regulators of the actin-based cytoskeleton; Rab...
23rd June, 2009
Department of Biochemistry, Stanford University School of Medicine, Cell. 2009 May 29;137(5):938-48.
DOI Direct Link
TIP47 functions in the biogenesis of lipid droplets.
TIP47 (tail-interacting protein of 47 kD) was characterized as a cargo...
23rd June, 2009
Institute for Biochemistry II, University of Gottingen, 37073 Gottingen, J Cell Biol. 2009 May 18;185(4):641-55.
DOI Direct Link

View more research publications.

M6PRBP1 results (if any) from reagent suppliers

Google CSE Logo
Anti-M6PRBP1 Polyclonal Antibody
Polyclonal Antibody against M6PRBP1 for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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NEMO antibody, NFkappaB essential modulator Antibody, Rabbit ...
M6prbp1 (mouse), IgG · SOCS 1, IgG · SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. ...
http://www.genwaybio.com/product_info.php?products_id=30027...

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TIP47 Antibody / TIP47 Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. TIP47 (C-20) Antibody, sc-14726, goat IgG, C-terminus (h), WB, IF, ELISA, m, r, h, pig ...
http://www.scbt.com/ko/table-tip47.html...

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Abcam antibodies and reagents product map
... LMAN2L antibodies (1) · LZTR2 antibodies (1) · M6PRBP1 antibodies (4) · M6PRBP1 proteins and peptides (2) · MADM antibodies (4) · MAN1A2 antibodies (2)
...
http://www.abcam.com/index.html?cl=2105&pageconfig=productma...

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TIP47 (C-20) Antibody sc-14726
Humano, M6PRBP1, 10226, 19p13.3, NM_005817 · O60664 · 602702. Ratón, M6prbp1, 66905, 17 D, Q9DBG5, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-14726-tip47-c-20-antibody.h...

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TIP47 (C-20) Antibody sc-14726
Humano, M6PRBP1, 10226, 19p13.3, NM_005817 · O60664 · 602702. camundongo, M6prbp1, 66905, 17 D, Q9DBG5, N/A. Informacoes sobre ordens ...
http://www.scbt.com/pt/datasheet-14726-tip47-c-20-antibody.h...

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TIP47 (C-20) Antibody sc-14726
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, M6PRBP1, 10226, 19p13.3, NM_005817 ...
http://www.scbt.com/ja/datasheet-14726-tip47-c-20-antibody.h...

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