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ABCC4
| Symbol: | ABCC4 | | Name(s): | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | EST170205, MOAT-B, MOATB, MRP4 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17404579 |
cholestasis is one major determinant of human hepatic MRP4 expression |
| 16791115 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 17083032 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18045536 |
Mrp4 knockout mice are more prone to CFTR-mediated secretory diarrhea. |
| 17682070 |
Results suggest that Bcrp and Mrp4 are partly involved in the luminal efflux of edaravone sulfate and edaravone glucuronide, respectively. |
| 17959747 |
The role of ABCC4 in the ATP-dependent efflux transport of leukotrienes B4 and C4 is shown in a number of different cell types. |
| 17939016 |
New comprehensive substrate-screening method for ABC transporters allowed the identification of 18 new substrates for MRP4. |
| 17696930 |
MRP4 protein levels were induced three-fold in primary biliary cirrhosis, whereas mRNA levels remained unchanged. |
| 17578901 |
Inhibition of renal uptake (via OAT3) and efflux processes (via MRP2 and MRP4) explains the possible sites of drug-drug interaction for methotrexate with probenecid and some NSAIDs, including their glucuronides. |
| 17878487 |
MRP-4 is induced by celecoxib in lung cancer cells | →View more information from publications. |
Recent Publications on ABCC4: |  |
Molecular characterization of cultured adult human liver progenitor cells.
Hepatic progenitor cells hold great promise as a self-renewing cell source... | 31st October, 2009
| Max Planck Institute for Molecular Genetics, Vertebrate Genomics,
| Tissue Eng Part C Methods. 2009 Oct 29.
DOI Direct Link |
Expression of ATP-binding cassette transporters at the inner blood-retinal barrier in a neonatal mouse model of oxygen-induced retinopathy.
ATP-binding cassette (ABC) transporters at the blood-brain barrier (BBB)... | 24th October, 2009
| Department of Surgery, Division of Ophthalmology, Kobe University Graduate
| Brain Res. 2009 Aug 4;1283:186-93. Epub 2009 Jun 6.
DOI Direct Link |
Pharmacogenetic association study of 30 genes with phenobarbital drug response in epileptic dogs.
BACKGROUND: Epilepsy, with a prevalence as high as 6%, is the most common... | 21st October, 2009
| aDepartment of Genetics, Gardner Hall bDepartment of Clinical Sciences,
| Pharmacogenet Genomics. 2009 Oct 16.
DOI Direct Link |
Retention of metabolites of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel anti-human immunodeficiency virus type 1 thymidine analog, in cells.
2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine (4'-Ed4T), a novel thymidine... | 20th October, 2009
| Department of Pharmacology, Yale University School of Medicine, 333 Cedar
| Antimicrob Agents Chemother. 2009 Aug;53(8):3317-24. Epub 2009 May 26.
DOI Direct Link |
Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers.
Multidrug resistance-associated proteins 2-4 (MRP2-4) are membrane efflux... | 2nd October, 2009
| University of Kansas Medical Center, Pharmacology, Toxicology, and
| Xenobiotica. 2009 Jul;39(7):514-22.
DOI Direct Link |
→View more research publications. |
ABCC4 results (if any) from reagent suppliers | 
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ABCC4 Antibody ABCC4 / MRP4
ABCC4 antibody was raised against a synthetic peptide of ABCC4.,
http://www.prosci-inc.com/shop/catalog1/ABCC4-Antibody-p-261...
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Anti-ABCC4 Monoclonal Antibody
Monoclonal Antibody against ABCC4 for use in Flow Cytometry, Immunocytochemistry , Immunohistochemistry, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...
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ABCC4 Antibody ATP-Binding Cassette, Sub-Family C
ABCC4 Antibody 51-096, ... Storage. ABCC4 antibody can be stored at 4˚C or -20˚C . Avoid repeated freezing and thawing. ...
http://www.prosci-inc.com/shop/catalog1/ABCC4-Antibody-p-338...
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Abgent - Cell and Function Antibodies
AP7436bNEW, ABCC4 Antibody (C-term), WB, E, H. AT1006a, ABCC4 monoclonal antibody (M03), ELISA,IHC-P,WB-Ce,WB-Re, H. AT1007a, ABCC6 monoclonal antibody (
M01 ...
http://www.abgent.com/products/category/cell_function...
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Cancer Antibodies :: Page 1
ABCB5 Antibody, 46-620, H, E, WB, ABCB5. ABCB9 Antibody, 45-180, H, E, IHC, ABCB9 / TAPL. ABCC4 Antibody, 45-181, H, M, R, E, WB, IHC, ABCC4 / MRP4 ...
http://www.prosci-inc.com/shop/catalog1/Cancer-Antibodies-p-...
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MRP4 antibody [M4I-10] (ab15602) | Abcam
... efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4). ...
http://www.abcam.com/MRP4-antibody-M4I-10-ab15602.html...
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Polyclonal Antibodies :: Page 2
ABCC1 Antibody, 46-794, H, M, R, D, B, E, WB, ABCC1. ABCC4 Antibody, 45-181, H, M, R, E, WB, IHC, ABCC4 / MRP4. ABCD1 Antibody, 45-182, H, E, WB, ABCD1 ...
http://www.prosci-inc.com/shop/catalog1/Polyclonal-Antibodie...
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