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CDKN1B


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Symbol:CDKN1B
Name(s):cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Type:protein-coding
Organism:Homo sapiens
Synonyms:CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18334837 Large-scale analysis of cell cycle regulators in urothelial bladder cancer identifies p16 and p27 as potentially useful prognostic markers
18281541 Observational study of gene-disease association. (HuGE Navigator)
18032931 Human thyroid carcinomas positive for MAP kinase, have high p27 degradative activity and low levels of p27 protein.
12727815 Observational study of gene-disease association. (HuGE Navigator)
15061869 Observational study of gene-disease association. (HuGE Navigator)
15217930 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
15627896 Observational study of gene-disease association. (HuGE Navigator)
16480585 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16804901 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17008550 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDcyclin D1cyclin-dependent kinase inhibitor 1B--Pubmed
BINDcyclin D1cyclin-dependent kinase inhibitor 1Bp27 interacts with cyclin D.-Pubmed
BINDcyclin Acyclin-dependent kinase inhibitor 1Bp27 interacts with cyclin A.-Pubmed
HPRDcyclin Acyclin-dependent kinase inhibitor 1B--Pubmed
HPRDcyclin Acyclin-dependent kinase inhibitor 1B--Pubmed
BINDcyclin Acyclin-dependent kinase inhibitor 1Bp27 interacts with Cyc A.-Pubmed
BINDcyclin Acyclin-dependent kinase inhibitor 1Bp27 interacts with cyclin A.-Pubmed
BIND-cyclin-dependent kinase inhibitor 1Bp27 interacts with cyclin E.-Pubmed
BIND-cyclin-dependent kinase inhibitor 1Bp27 interacts with Cyc E.-Pubmed
BIND-cyclin-dependent kinase inhibitor 1BCdk2 interacts with p27.-Pubmed

Recent Publications on CDKN1B:

Pubmed Logo
Allelic loss of chromosomes 8 and 19 in MENX-associated rat pheochromocytoma.
Pheochromocytomas are neoplasias of neural crest origin that arise from...
31st October, 2009
Institute of Pathology, Helmholtz Zentrum Munchen-German Research Center Int J Cancer. 2009 Oct 28.
DOI Direct Link
Retinoblastoma 1 Protein Modulates XY Germ Cell Entry into G1/G0 Arrest During Fetal Development in Mice.
During mouse germ cell development, the first sign of sex differentiation...
30th October, 2009
Biol Reprod. 2009 Oct 28.
DOI Direct Link
Upregulated p27kip1 can downregulate survivin expression and inhibit telomerase activity in gastric carcinoma cells.
Previous study indicated that p27kip1 gene transfer can obviously inhibit...
30th October, 2009
Department of Gastroenterology, Taihe Hospital, Yunyang Medical College, Cancer Invest. 2009 Nov;27(9):898-900.
Bortezomib-mediated expression of p27Kip1 through S-phase kinase protein 2 degradation in epithelial ovarian cancer.
S-phase kinase protein 2 (SKP2), an F-box protein, targets cell-cycle...
29th October, 2009
Department of Human Cancer Genomic Research, King Fahad National Centre Lab Invest. 2009 Oct;89(10):1115-27. Epub 2009 Jul 27.
DOI Direct Link
Antiproliferative effect of flavomannin-6,6'-dimethylether from Tricholoma equestre on Caco-2 cells.
Several studies have been performed reporting antitumoral activity of...
14th October, 2009
Department of Biochemistry and Molecular Biology, Institute of Biomedicine Toxicology. 2009 Oct 29;264(3):192-7. Epub 2009 Aug 15.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Rapamycin for Immunosuppression and B Cell Modulation Post Stem Cell Transplant for Acute Lymphoblastic Leukemia (ALL)

Patents:

Patents logo
US Patent No.Title
7612196 siRNA targeting cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B)
6706867 DNA array sequence selection
6960439 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6964850 Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
7081340 Gene expression profiling in biopsied tumor tissues

View more patents.

CDKN1B results (if any) from reagent suppliers

Google CSE Logo
P2092 Monoclonal Anti-p27Kip1 antibody produced in mouse clone DCS ...
isotype, IgG1. Gene Information, human ... CDKN1B(1027). rat ... Cdkn1b(83571). mouse ... Cdkn1b(12576). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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Antibodies to Cell Cycle Regulators
ascites fluid, rat ... Cdkn1b(83571) mouse ... Cdkn1b(12576) human ... CDKN1B( 1027), rat, canine, human, mouse, monkey, ICC, IP, WB, pricing ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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CKOZFN1010 CompoZr™ Knockout ZFN Kit human CDKN1B (NM_004064)
CKOZFN1010 CompoZr Knockout ZFN Kit human CDKN1B (NM_004064) CompoZr Knockout ZFNs create targeted double strand breaks at a gene specific target locus.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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p-p27 (Thr 187) Antibody sc-16324
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CDKN1B, 1027, 12p13.1, NM_004064 ...
http://www.scbt.com/datasheet-16324-p-p27-thr-187-antibody.h...

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AKT1 peptide, Akt (Phospho-Thr308) Antibody Blocking Peptide peptide
Interacts with CDKN1B; the interaction phosphorylates CDKN1B promoting 14-3-3 binding and cell-cycle progression. Subcellular Location: Cytoplasm. Nucleus.
...
http://www.genwaybio.com/product_info.php?products_id=213052...

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Protein Modification - Ubiquitination Antibody
AP2116a, CDC34 Antibody (N-term), WB, IHC, E, H, M. AT1481aNEW, CDKN1B monoclonal antibody (M01), ELISA,IF,IHC-P,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/protein_modification...

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Validated Antibodies for Cellular Proteomics
Specific antibody for the gene product of CDKN1B, the protein Cyclin-dependent kinase inhibitor 1B, p27. Validated for specificity by gene-silencing with ...
http://www.piercenet.com/products/browse.cfm?fldID=E294B7C2-...

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