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UBE4B


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Symbol:UBE4B
Name(s):ubiquitination factor E4B (UFD2 homolog, yeast)
Type:protein-coding
Organism:Homo sapiens
Synonyms:E4, HDNB1, KIAA0684, UBOX3, UFD2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16870146 we have identified a novel domain (the MPAC domain: Mitotically Phosphorylated, Apoptotically Cleaved) present at the N-terminus of Ufd2a, which is regulated both by cleavage during cell death, and by phosphorylation during mitosis.
15466860 E4B serves as a ubiquitin ligase for FEZ1 and thereby regulates its function but not its degradation
12700669 A splice site mutation was found in UBE4b. UBE4B expression was diminished in the high-stage/poor-outcome tumors.UBE4B stands out as the strongest candidate NBL tumor suppressor gene in the region at this stage.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDValosin containing proteinHomo sapiens ubiquitin-fusion degradation protein 2 mRNA, complete cds.--Pubmed

Recent Publications on UBE4B:

Pubmed Logo
Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo.
Axonal degeneration is a key component of a variety of neurological...
9th June, 2009
Department of Pathology and Immunology, Washington University School of J Neurosci. 2009 May 20;29(20):6526-34.
DOI Direct Link
Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide.
Axonal degeneration is a hallmark of many neurological disorders. Studies...
6th June, 2009
Department of Pathology and Immunology, Washington University School of J Neurosci. 2009 Apr 29;29(17):5525-35.
DOI Direct Link
Fine deletion analysis of 1p36 chromosomal region in oral squamous cell carcinomas.
BACKGROUND: Squamous cell carcinoma is the most common cancer type of the...
23rd May, 2009
Department of Oral Pathology and Medicine, Graduate School of Medicine, J Oral Pathol Med. 2009 Jan;38(1):94-8. Epub 2008 Mar 19.
DOI Direct Link
Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins.
Endoplasmic reticulum (ER)-associated degradation (ERAD) is a...
9th April, 2009
Laboratory of Molecular Signalling, The Babraham Institute, Cambridge, UK. FEBS J. 2009 Mar;276(5):1208-20.
DOI Direct Link
Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration.
Slow Wallerian degeneration (Wld(S)) encodes a chimeric Ube4b/nicotinamide...
4th March, 2009
Department of Neurobiology, University of Massachusetts Medical School, J Cell Biol. 2009 Feb 23;184(4):501-13.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases

UBE4B results (if any) from reagent suppliers

Google CSE Logo
UBE4B Antibody (N-term)
#AP2111a) is used in Western blot to detect UBE4B in mouse kidney tissue lysate. UBE4B Antibody (N-term). Formalin-fixed and paraffin-embedded human cancer ...
http://www.abgent.com/products/catalog_no/AP2111a...

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UFD Antibody / UFD Antibodies
제품명, 카탈로그 번호, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. UFD1 (5e2) Antibody, sc-81630, mouse IgM, FL (m), WB, IP, IF, m, h ...
http://www.scbt.com/ko/table-ufd.html...

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Protein Modification - Ubiquitination Antibody
AP2111b, UBE4B Antibody (C-term), IHC, E, H. AP2111a, UBE4B Antibody (N-term), WB, IHC, E, H, M. AP2129b, UBL4 Antibody (C-term), WB, IHC, E, H ...
http://www.abgent.com/products/category/protein_modification...

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UFD2 (N-16) Antibody sc-30838
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, UBE4B, 10277, 1p36.22, NM_006048 ...
http://www.scbt.com/ko/datasheet-30838-ufd2-n-16-antibody.ht...

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Ubiquitin (Ub) is a 76 amino acid highly conserved eukaryotic ...
UBE4B C-term Antibody. AP2139c. USP11 C-term Antibody. AP2159b. EPS15 C-term Antibody ... UBE4B N-term Antibody. AP2140b. USP12 C-term Antibody. AP2159a ...
http://www.abgent.com/downloads/Ubiquitination.pdf...

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UFD2 (7) Antibody sc-136115
... Numéro d'accès de la protéine, Numéro OMIM™. Humain, UBE4B, 10277, 1p36.22, O95155, n/a. Souris, Ube4b, 63958, 4 E2, Q9ES00, Non disponible ...
http://www.scbt.com/fr/datasheet-136115-ufd2-7-antibody.html...

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Abgent Antibodies and Peptides
AP2100b, UbcH7-BP (C-term), IHC, H. AP2156a, UBE2V (N-term), WB, H. AP2111b, UBE4B (C-term), IHC, H. AP2111a, UBE4B (N-term), IHC, WB, H, M ...
http://www.abgent.com/docs/kits_neurosciences...

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